-
1
-
-
33644545381
-
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
-
DOI 10.1038/nrc1821, PII N1821
-
Overall, C. M. and Kleifeld, O. (2006) Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and antitargets for cancer therapy. Nat. Rev. Cancer 6, 227-239 (Pubitemid 43292566)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.3
, pp. 227-239
-
-
Overall, C.M.1
Kleifeld, O.2
-
2
-
-
79955458657
-
The calpain system and cancer
-
Storr, S. J. et al. (2011) The calpain system and cancer. Nat. Rev. Cancer 11, 364-374
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 364-374
-
-
Storr, S.J.1
-
3
-
-
51449088226
-
Src and focal adhesion kinase as therapeutic targets in cancer
-
Brunton, V. G. and Frame, M. C. (2008) Src and focal adhesion kinase as therapeutic targets in cancer. Curr. Opin. Pharmacol. 8, 427-432
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 427-432
-
-
Brunton, V.G.1
Frame, M.C.2
-
4
-
-
0030798679
-
Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
-
Gianelli, G. et al. (1997) Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277, 225-228
-
(1997)
Science
, vol.277
, pp. 225-228
-
-
Gianelli, G.1
-
5
-
-
35548966350
-
A rapid screening method for population-specific neuronal motogens, substrates and associated signaling pathways
-
DOI 10.1016/j.jneumeth.2007.07.008, PII S0165027007003639, Neurobiology of Attention-Deficit Hyperactivity Disorder (ADHD): From Gene to Therapy
-
Hassoun, A. T. et al. (2007) A rapid screening method for populationspecific neuronal motogens, substrates and associated signaling pathways. J. Neurosci. Methods 166, 178-194 (Pubitemid 350016397)
-
(2007)
Journal of Neuroscience Methods
, vol.166
, Issue.2
, pp. 178-194
-
-
Hassoun, A.T.1
Erdelyi, F.2
Szabo, G.3
Davis, M.I.4
-
6
-
-
13244255307
-
A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods
-
Yarrow, J. C. et al. (2004) A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 4, 21
-
(2004)
BMC Biotechnol.
, vol.4
, pp. 21
-
-
Yarrow, J.C.1
-
7
-
-
62449181023
-
Imaging and quantifying the dynamics of tumorassociated proteolysis
-
Sameni, M. et al. (2009) Imaging and quantifying the dynamics of tumorassociated proteolysis. Clin. Exp. Metastasis 26, 299-309
-
(2009)
Clin. Exp. Metastasis
, vol.26
, pp. 299-309
-
-
Sameni, M.1
-
8
-
-
34547569807
-
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
-
DOI 10.1038/ncb1616, PII NCB1616
-
Wolf, K. et al. (2007) Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat. Cell Biol. 9, 893-904 (Pubitemid 47190444)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.8
, pp. 893-904
-
-
Wolf, K.1
Wu, Y.I.2
Liu, Y.3
Geiger, J.4
Tam, E.5
Overall, C.6
Stack, M.S.7
Friedl, P.8
-
9
-
-
62449097150
-
Profiling distinct mechanisms of tumour invasion for drug discovery: Imaging adhesion, signalling and matrix turnover
-
Carragher, N. O. (2009) Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover. Clin. Exp. Metastasis 26, 381-397
-
(2009)
Clin. Exp. Metastasis
, vol.26
, pp. 381-397
-
-
Carragher, N.O.1
-
10
-
-
1542359873
-
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
-
Umezu-Goto, M. et al. (2002) Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158, 227-233
-
(2002)
J. Cell Biol.
, vol.158
, pp. 227-233
-
-
Umezu-Goto, M.1
-
11
-
-
70349234110
-
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands
-
Zabel, B. A. et al. (2009) Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J. Immunol. 183, 3204-3211
-
(2009)
J. Immunol.
, vol.183
, pp. 3204-3211
-
-
Zabel, B.A.1
-
12
-
-
67650429727
-
Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion
-
Singh, S. et al. (2009) Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 283, 29-35
-
(2009)
Cancer Lett.
, vol.283
, pp. 29-35
-
-
Singh, S.1
-
13
-
-
79951979271
-
A quantitative, facile, and high-throughput imagebased cell migration method is a robust alternative to the scratch assay
-
Gough, W. et al. (2011) A quantitative, facile, and high-throughput imagebased cell migration method is a robust alternative to the scratch assay. J. Biomol. Screen 16, 155-163
-
(2011)
J. Biomol. Screen
, vol.16
, pp. 155-163
-
-
Gough, W.1
-
14
-
-
82455204124
-
Product focus: Screening robotics and automation
-
McGee, J. et al. (2011) Product focus: screening robotics and automation. Mol. J. Biomol. Screen. 16, 134-137
-
(2011)
Mol. J. Biomol. Screen.
, vol.16
, pp. 134-137
-
-
McGee, J.1
-
15
-
-
33748948921
-
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: A link to integrin function
-
DOI 10.1038/sj.onc.1209582, PII 1209582
-
Carragher, N. O. et al. (2006) Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 25, 5726-5740 (Pubitemid 44435250)
-
(2006)
Oncogene
, vol.25
, Issue.42
, pp. 5726-5740
-
-
Carragher, N.O.1
Walker, S.M.2
Carragher, L.A.S.3
Harris, F.4
Sawyer, T.K.5
Brunton, V.G.6
Ozanne, B.W.7
Frame, M.C.8
-
16
-
-
0027996872
-
Fos-transformation activates genes associated with invasion
-
Hennigan, R. F. et al. (1994) Fos-transformation activates genes associated with invasion. Oncogene 9, 3591-3600 (Pubitemid 24359397)
-
(1994)
Oncogene
, vol.9
, Issue.12
, pp. 3591-3600
-
-
Hennigan, R.F.1
Hawker, K.L.2
Ozanne, B.W.3
-
17
-
-
0037455576
-
Compensation mechanism in tumor cell migration: Mesenchymal-amoeboid transition after blocking of pericellular proteolysis
-
DOI 10.1083/jcb.200209006
-
Wolf, K. et al. (2003) Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol. 160, 267-277 (Pubitemid 36254960)
-
(2003)
Journal of Cell Biology
, vol.160
, Issue.2
, pp. 267-277
-
-
Wolf, K.1
Mazo, I.2
Leung, H.3
Engelke, K.4
Von Andrian, U.H.5
Deryugina, E.I.6
Strongin, A.Y.7
Brocker, E.-B.8
Friedl, P.9
-
18
-
-
0042354574
-
Differing modes for tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
-
DOI 10.1038/ncb1019
-
Sahai, E. and Marshall, C. J. (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat. Cell Biol. 5, 711-719 (Pubitemid 36986778)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.8
, pp. 711-719
-
-
Sahai, E.1
Marshall, C.J.2
-
19
-
-
36749013537
-
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
-
DOI 10.1038/ncb1658, PII NCB1658
-
Gaggioli, C. et al. (2007) Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat. Cell Biol. 9, 1392-1400 (Pubitemid 350201752)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.12
, pp. 1392-1400
-
-
Gaggioli, C.1
Hooper, S.2
Hidalgo-Carcedo, C.3
Grosse, R.4
Marshall, J.F.5
Harrington, K.6
Sahai, E.7
-
20
-
-
37549070672
-
Cysteine cathepsin proteases as pharmacological targets in cancer
-
Palermo, C. and Joyce, J. A. (2008) Cysteine cathepsin proteases as pharmacological targets in cancer. Trends Pharmacol. Sci. 29, 22-28
-
(2008)
Trends Pharmacol. Sci.
, vol.29
, pp. 22-28
-
-
Palermo, C.1
Joyce, J.A.2
-
21
-
-
23944454839
-
Calpain proteases in cell adhesion and motility
-
Wells, A. et al. (2005) Calpain proteases in cell adhesion and motility. Int. Rev. Cytol. 245, 1-16
-
(2005)
Int. Rev. Cytol.
, vol.245
, pp. 1-16
-
-
Wells, A.1
-
22
-
-
2342472716
-
Focal adhesion and actin dynamics: A place where kinases and proteases meet to promote invasion
-
DOI 10.1016/j.tcb.2004.03.011, PII S0962892404000856
-
Carragher, N. O. and Frame, M. C. (2004) Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol. 14, 241-249 (Pubitemid 38591328)
-
(2004)
Trends in Cell Biology
, vol.14
, Issue.5
, pp. 241-249
-
-
Carragher, N.O.1
Frame, M.C.2
-
23
-
-
0031455371
-
Regulation of cell migration by the calcium-dependent protease calpain
-
DOI 10.1074/jbc.272.52.32719
-
Huttenlocher, A. et al. (1997) Regulation of cell migration by the calciumdependent protease calpain. J. Biol. Chem. 272, 32719-32722 (Pubitemid 28023599)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.52
, pp. 32719-32722
-
-
Huttenlocher, A.1
Palecek, S.P.2
Lu, Q.3
Zhang, W.4
Mellgren, R.L.5
Lauffenburger, D.A.6
Ginsberg, M.H.7
Horwitz, A.F.8
-
24
-
-
0024262906
-
A murine model of experimental metastasis to bone and bone marrow
-
Arguello, F. et al. (1988) A murine model of experimental metastasis to bone and bone marrow. Cancer Res. 48, 6876-6881 (Pubitemid 19012221)
-
(1988)
Cancer Research
, vol.48
, Issue.23
, pp. 6876-6881
-
-
Arguello, F.1
Baggs, R.B.2
Frantz, C.N.3
-
26
-
-
0028282991
-
A murine model for bone marrow metastasis established by an i.v. injection of C-1300 neuroblastoma in A/J mice
-
DOI 10.1007/BF01753891
-
Iwakawa, M. et al. (1994) A murine model for bone marrow metastasis established by an i.v. injection of C-1300 neuroblastoma in A/J mice. Clin. Exp. Metastasis 12, 231-237 (Pubitemid 24196032)
-
(1994)
Clinical and Experimental Metastasis
, vol.12
, Issue.3
, pp. 231-237
-
-
Iwakawa, M.1
Ando, K.2
Ohkawa, H.3
Koike, S.4
Chen, Y.5
-
27
-
-
0033500248
-
Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: A bridge to the clinic
-
DOI 10.1023/A:1006326203858
-
Hoffman, R. M. (1999) Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest. New Drugs 17, 343-359 (Pubitemid 30135902)
-
(1999)
Investigational New Drugs
, vol.17
, Issue.4
, pp. 343-359
-
-
Hoffman, R.M.1
-
28
-
-
16244367163
-
Modeling metastasis in vivo
-
DOI 10.1093/carcin/bgh261
-
Khanna, C. and Hunter, K. (2005) Modeling metastasis in vivo. Carcinogenesis 26, 513-523 (Pubitemid 41214139)
-
(2005)
Carcinogenesis
, vol.26
, Issue.3
, pp. 513-523
-
-
Khanna, C.1
Hunter, K.2
-
29
-
-
0022655033
-
Brain tumours in mice, with particular reference to astrocytoma
-
DOI 10.1016/0278-6915(86)90344-3
-
Fraser, H. (1986) Brain tumours in mice, with particular reference to astrocytoma. Food Chem. Toxicol. 24, 105-111 (Pubitemid 16167135)
-
(1986)
Food and Chemical Toxicology
, vol.24
, Issue.2
, pp. 105-111
-
-
Fraser, H.1
-
30
-
-
43949100999
-
Metastatic cancer cells with macrophage properties: Evidence from a new murine tumor model
-
DOI 10.1002/ijc.23492
-
Huysentruyt, L. C. et al. (2008) Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model. Int. J. Cancer 123, 73-84 (Pubitemid 351705194)
-
(2008)
International Journal of Cancer
, vol.123
, Issue.1
, pp. 73-84
-
-
Huysentruyt, L.C.1
Mukherjee, P.2
Banerjee, D.3
Shelton, L.M.4
Seyfried, T.N.5
-
31
-
-
62449135386
-
Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins
-
Hoffman, R. M. (2009) Imaging cancer dynamics in vivo at the tumor and cellular level with fluorescent proteins. Clin. Exp. Metastasis 26, 345-355
-
(2009)
Clin. Exp. Metastasis
, vol.26
, pp. 345-355
-
-
Hoffman, R.M.1
-
32
-
-
78549246804
-
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: Effects on E-cadherin dynamics
-
Canel, M. et al. (2010) Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res. 70, 9413-9422
-
(2010)
Cancer Res.
, vol.70
, pp. 9413-9422
-
-
Canel, M.1
-
33
-
-
31544468879
-
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
-
DOI 10.1158/0008-5472.CAN-05-1242
-
Xue, C. et al. (2006) Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res. 66, 192-197 (Pubitemid 43166025)
-
(2006)
Cancer Research
, vol.66
, Issue.1
, pp. 192-197
-
-
Xue, C.1
Wyckoff, J.2
Liang, F.3
Sidani, M.4
Violini, S.5
Tsai, K.-L.6
Zhang, Z.-Y.7
Sahai, E.8
Condeelis, J.9
Segall, J.E.10
-
34
-
-
66149100509
-
Real-time study of E-cadherin and membrane dynamics in living animals: Implications for disease modeling and drug development
-
Serrels, A. et al. (2009) Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res. 69, 2714-2719
-
(2009)
Cancer Res.
, vol.69
, pp. 2714-2719
-
-
Serrels, A.1
-
35
-
-
79551561001
-
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53
-
Timpson, P. et al. (2011) Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res. 71, 747-757
-
(2011)
Cancer Res.
, vol.71
, pp. 747-757
-
-
Timpson, P.1
-
36
-
-
48349122161
-
Invasion emerges from cancer cell adaptation to competitive microenvironments: Quantitative predictions from multiscale mathematical models
-
Quaranta, V. et al. (2008) Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Semin. Cancer Biol. 18, 338-348
-
(2008)
Semin. Cancer Biol.
, vol.18
, pp. 338-348
-
-
Quaranta, V.1
-
37
-
-
33845502729
-
Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration
-
DOI 10.1007/s10439-006-9205-6
-
Zaman, M. H. et al. (2007) Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration. Ann. Biomed. Eng. 35, 91-100 (Pubitemid 44916318)
-
(2007)
Annals of Biomedical Engineering
, vol.35
, Issue.1
, pp. 91-100
-
-
Zaman, M.H.1
Matsudaira, P.2
Lauffenburger, D.A.3
-
38
-
-
0036337710
-
Molecular imaging of MMP expression and therapeutic MMP inhibition
-
DOI 10.1016/S1076-6332(03)80214-3
-
Bremer, C. et al. (2002) Molecular imaging of MMP expression and therapeutic MMP inhibition. Acad. Radiol. 2 (Suppl.), S314-S315 (Pubitemid 34857705)
-
(2002)
Academic Radiology
, vol.9
, Issue.SUPPL. 2
-
-
Bremer, C.1
Tung, C.-H.2
Weissleder, R.3
-
39
-
-
0037112183
-
Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer
-
DOI 10.1200/JCO.2002.02.108
-
Shepherd, F. A. et al. (2002) Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer. J. Clin. Oncol. 20, 4434-4439 (Pubitemid 35334754)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.22
, pp. 4434-4439
-
-
Shepherd, F.A.1
Giaccone, G.2
Seymour, L.3
Debruyne, C.4
Bezjak, A.5
Hirsh, V.6
Smylie, M.7
Rubin, S.8
Martins, H.9
Lamont, A.10
Krzakowski, M.11
Sadura, A.12
Zee, B.13
-
40
-
-
0032951071
-
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
-
DOI 10.1038/7933
-
Weissleder, R. et al. (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 17, 375-378 (Pubitemid 29166041)
-
(1999)
Nature Biotechnology
, vol.17
, Issue.4
, pp. 375-378
-
-
Weissleder, R.1
Tung, C.-H.2
Mahmood, U.3
Bogdanov Jr., A.4
|