Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway

Cancer Letters

Volumn 314, Issue 1, 2012, Pages 82-91

  Tambe, Yukihiro ^a   Okuyama, Naomi ^a   Nakagawa, Tatsuya ^a   Muramoto, Akifumi ^a   Hasebe, Masahiro ^a,b   Chano, Tokuhiro ^a   Inoue, Hirokazu ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Drs; GADD34; Host defense; Knockout mouse; MTOR pathway

Indexed keywords

DRS PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; S6 KINASE; TRANSCRIPTION FACTOR; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRS GENE; FIBROBLAST; HERPES SIMPLEX VIRUS 1; HOST RESISTANCE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; TUMOR SUPPRESSOR GENE; UPREGULATION; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; EUKARYOTIC INITIATION FACTOR-2; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS; VESICULAR STOMATITIS INDIANA VIRUS; VIRUS DISEASES; VIRUS REPLICATION;

VESICULAR STOMATITIS VIRUS;

EID: 82355190263     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.09.015     Document Type: Article

References (39)

1. Pan J., Nakanishi K., Yutsudo M., Inoue H., Li Q., Oka K., Yoshioka N., Hakura A. Isolation of a novel gene down-regulated by v-src. FEBS Lett. 1996, 383:21-25.
2. Inoue H., Pan J., Hakura A. Suppression of v-Src transformation by the drs gene. J. Virol. 1998, 72:2532-2537.
3. Yamashita A., Hakura A., Inoue H. Suppression of anchorage-independent growth of human cancer cell lines by the drs gene. Oncogene 1999, 18:4777-4787.
4. Shimakage M., Kawahara K., Kikkawa N., Sasagawa T., Yutsudo M., Inoue H. Downregulation of drs mRNA in human colon adenocarcinomas. Int. J. Cancer 2000, 87:5-11.
5. Shimakage M., Takami K., Kodama K., Mano M., Yutsudo M., Inoue H. Expression of drs mRNA in human lung adenocarcinomas. Hum. Pathol. 2002, 33:615-619.
6. Kim C.J., Shimakage M., Kushima R., Mukaisho K., Shinka T., Okada Y., Inoue H. Down-regulation of drs mRNA in human prostate carcinomas. Hum. Pathol. 2003, 34:654-657.
7. Shimakage M., Inoue N., Oshima K., Kawahara K., Yamamoto N., Oka T., Tambe Y., Yasui K., Matsumoto K., Yutsudo M., Inoue H. Down-regulation of drs mRNA is associated with the progression of adult T-cell leukemia/lymphoma. Int. J. Oncol. 2007, 30:1343-1348.
8. Shimakage M., Kodama K., Kawahara K., Kim C.J., Ikeda Y., Yutsudo M., Inoue H. Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. Oncol. Rep. 2009, 21:1367-1372.
9. Tambe Y., Yoshioka-Yamashita A., Mukaisho K., Haraguchi S., Chano T., Isono T., Kawai T., Suzuki Y., Kushima R., Hattori T., Goto M., Yamada S., Kiso M., Saga Y., Inoue H. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Carcinogenesis 2007, 28:777-784.
10. Tambe Y., Isono T., Haraguchi S., Yoshioka-Yamashita A., Yutsudo M., Inoue H. A novel apoptotic pathway induced by the drs tumor suppressor gene. Oncogene 2004, 23:2977-2987.
11. Tambe Y., Yamamoto A., Isono T., Chano T., Fukuda M., Inoue H. The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. Cancer Lett. 2009, 283:74-83.
12. Everett H., McFadden G. Apoptosis: an innate immune response to virus infection. Trends Microbiol. 1999, 7:160-165.
13. Roulston A., Marcellus R.C., Branton P.E. Viruses and apoptosis. Annu. Rev. Microbiol. 1999, 53:577-628.
14. Barber G.N. Host defense, viruses and apoptosis. Cell Death Differ. 2001, 8:113-126.
15. Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol. 2005, 26:523-528.
16. Shoji-Kawata S., Levine B. Autophagy, antiviral immunity, and viral countermeasures. Biochim. Biophys. Acta 2009, 1793:1478-1484.
17. Lin L.T., Dawson P.W., Richardson C.D. Viral interactions with macroautophagy: a double-edged sword. Virology 2010, 402:1-10.
18. Nguyen M.L., Kraft R.M., Aubert M., Goodwin E., DiMaio D., Blaho J.A. P53 and hTERT determine sensitivity to viral apoptosis. J. Virol. 2007, 81:12985-12995.
19. Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H. Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. J. Virol. 2007, 81:11106-11115.
20. Pierce J.H., Aaronson S.A., Anderson S.M. Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc. Natl Acad. Sci. USA 1984, 81:2374-2378.
21. R.T. Kaufman, The double-stranded RNA-activated protein kinase PKR, in: N. Sonenberg, J.W.B. Hershey, M.B. Mathews (Eds.), Translational Control of Gene Expression, Cold Spring Harbor Laboratory Press, Cold Spring Harber, NY, 2000, pp. 503-527.
22. Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
23. Inoki K., Ouyang H., Li Y., Guan K.L. Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 2005, 69:79-100.
24. Ma X.M., Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 2009, 10:307-318.
25. Inoki K., Li Y., Zhu T., Wu J., Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 2002, 4:648-657.
26. D. Ron, H.P. Harding, PERK and translational control by stress in the endoplasmic reticulum, in: N. Sonenberg, J.W.B. Hershey, M.B. Mathews (Eds.), Translational Control of Gene Expression, Cold Spring Harbor Laboratory Press, Cold Spring Harber, NY, 2000, pp. 547-560.
27. Baltzis D., Qu L.K., Papadopoulou S., Blais J.D., Bell J.C., Sonenberg N., Koromilas A.E. Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2α kinases PERK and PKR. J. Virol. 2004, 78:12747-12761.
28. Watanabe R., Tambe Y., Inoue H., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. Int. J. Mol. Med. 2007, 19:475-483.
29. Farassati F., Yang A.D., Lee P.W. Oncogenes in Ras signaling pathway dictate host-cell permissiveness to herpes simplex virus 1. Nat. Cell Biol. 2001, 3:745-750.
30. Kopecky S.A., Willingham M.C., Lyles D.S. Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus. J. Virol. 2001, 75:12169-12181.
31. Ahmed M., Cramer S.D., Lyles D.S. Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses. Virology 2004, 330:34-49.
32. Noser J.A., Mael A.A., Sakuma R., Ohmine S., Marcato P., Lee P.W., Ikeda Y. The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. Mol. Ther. 2007, 15:1531-1536.
33. Vaehae-Koskela M.J., Heikkilae J.E., Hinkkanen A.E. Oncolytic viruses in cancer therapy. Cancer Lett. 2007, 254:178-216.
34. Guo Z.S., Thorne S.H., Bartlett D.L. Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochim. Biophys. Acta 2008, 1785:217-231.
35. Cooray S. The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival. J. Gen. Virol. 2004, 85:1065-1076.
36. Buchkovich N.J., Yu Y., Zampieri C.A., Alwine J.C. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat. Rev. Microbiol. 2008, 6:266-275.
37. Oliere S., Arguello M., Mesplede T., Tumilasci V., Nakhaei P., Stojdl D., Sonenberg N., Bell J., Hiscott J. Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. J. Virol. 2008, 82:5735-5749.
38. Mamane Y., Petroulakis E., Rong L., Yoshida K., Ler L.W., Sonenberg N. eIF4E - from translation to transformation. Oncogene 2004, 23:3172-3179.
39. Proud C.G. The multifaceted role of mTOR in cellular stress response. DNA Repair 2004, 3:927-934.