Biomarker validation-room air variation during human breath investigations

International Journal for Ion Mobility Spectrometry

Volumn 13, Issue 3, 2010, Pages 177-184

  Bödeker, Bertram ^a   Davies, Antony N ^b   Maddula, Sasidhar ^c   Baumbach, Jörg Ingo ^a,c  

^a TU DORTMUND UNIVERSITY   (Germany)

^b UNIVERSITY OF GLAMORGAN   (United Kingdom)

^c KIST Europe   (Germany)

Author keywords

Biomarker validation; Breath analysis; Room air quality control

Indexed keywords

AMBIENT AIR; ANALYTE CONCENTRATION; ANALYTES; BEFORE AND AFTER; BREATH ANALYSIS; CLINICAL STAFF; CLINICAL STUDY; DAILY CHANGE; DETECTION LIMITS; DIRECT MEASUREMENT; EXPERIMENTAL DESIGN; HUMAN BREATH; ION MOBILITY SPECTROMETER; ION MOBILITY SPECTROMETRY; MEAN VALUES; MEASUREMENT TIME; MEDICAL ANALYSIS; MULTI-CAPILLARY COLUMNS; PEAK INTENSITY; ROOM AIR; SIGNAL INTENSITIES; SYNTHETIC AIR; TRACE COMPONENTS; VALIDATION STRATEGIES; VENTILATION SYSTEMS;

AIR QUALITY; BIOMARKERS; CHROMATOGRAPHIC ANALYSIS; SPECTROMETRY; TIME SERIES; TRACE ANALYSIS; VENTILATION;

QUALITY CONTROL;

EID: 78649904727     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-010-0044-7     Document Type: Article

References (44)

1. Amann A, Schmid A, Scholl-Buergi S, Telser S, Hinterhuber H (2005) Breath analysis for medical diagnosis and therapeutic monitoring. Spectrosc Eur 17: 18-20.
2. Amann A, Spanel P, Smith D (2007) Breath analysis: the approach towards clinical applications. Mini-Rev Med Chem 7: 115-129.
3. Buszewski B, Kesy M, Ligor T, Amann A (2007) Human exhaled air analytics: biomarkers of diseases. Biomed Chromatogr 21: 553-566.
4. Bajtarevic A, et al (2009) Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer 9, doi: 10. 1186/1471-2407-9-348.
5. Ligor M et al (2009) Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry. Clin Chem Lab Med 47: 550-560. doi: 10. 1515/cclm. 2009. 133.
6. Westhoff M et al (2009) Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study. Thorax 64: 744-748.
7. Vautz W, Baumbach JI (2008) Analysis of bio-processes using ion mobility spectrometry. Eng Life Sci 8: 19-25.
8. Davies AN, Baumbach JI (2008) Early lung cancer diagnostics by ion mobility spectrometry data handling. Spectrosc Eur 20: 18-21.
9. Risby TH, Solga SF (2006) Current status of clinical breath analysis. Appl Phys B: Lasers Opt 85: 421-426.
10. Baumbach JI (2006) Process analysis using ion mobility spectrometry. Anal Bioanal Chem 384: 1059-1070.
11. Zolotov YA (2005) Breath analysis. J Anal Chem 60: 497.
12. Ruzsanyi V et al (2005) Detection of human metabolites using multi-capillary columns coupled to ion mobility spectrometers. J Chromatogr A 1084: 145-151.
13. Basanta M et al (2010) Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst 135: 315-320. doi: 10. 1039/b916374c.
14. Phillips M et al (2008) Detection of lung cancer using weighted digital analysis of breath biomarkers. Clin Chim Acta 393: 76-84.
15. Phillips M et al (2007) Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomarkers 3: 95-109.
16. Phillips M et al (2003) Volatile markers of breast cancer in the breath. Breast J 9: 184-191.
17. Phillips M et al (1999) Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353: 1930-1933.
18. Phillips M, Erickson GA, Sabas M, Smith JP, Greenberg J (1995) Volatile organic compounds in the breath of patients with schizophrenia. J Clin Pathol 48: 466-469.
19. Smith D, et al (2010) Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS. J Breath Res 4, 017101/017101-017101/017107.
20. Enderby B, et al (2009) Concentrations of some metabolites in the breath of healthy children aged 7-18 years measured using selected ion flow tube mass spectrometry (SIFT-MS). J Breath Res 3, 036001/036001-036001/036011.
21. Spanel P, Smith D (2008) Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. J Breath Res 2, 046003/046001-046003/046010.
22. Spanel P, Dryahina K, Smith D (2007) The concentration distributions of some metabolites in the exhaled breath of young adults. J Breath Res 1: 1-8.
23. Dryahina K, Polasek M, Spanel P (2004) A selected ion flow tube, SIFT, study of the ion chemistry of H3O+, NO+ and O2+• ions with several nitroalkanes in the presence of water vapour. Int J Mass Spectrom 239: 57-65.
24. Thekedar B, Szymczak W, Hoellriegl V, Hoeschen C, Oeh U (2009) Investigations on the variability of breath gas sampling using PTR-MS. J Breath Res 3, 027007/027001-027007/027011.
25. Schwarz K, Filipiak W, Amann A (2009) Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS. J Breath Res 3, 027002/027001-027002/027015.
26. Wisthaler A (2004) PTR-MS: a new tool for the rapid detection and quantification of VOCs in air at ultra-trace levels. Institut für Ionenphysik, Leopold-Franzens-Universität Innsbruck, Innsbruck.
27. Lindinger W, Hansel A, Jordan A (1998) Proton-transfer-reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at pptv levels. Chem Soc Rev 27: 347-354.
28. Lindinger W, Hansel A, Jordan A (1998) On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS).-Medical applications, food control and environmental research. Int J Mass Spectrom Ion Proc 173: 191-241.
29. Buszewski B, Ulanowska A, Ligor T, Denderz N, Amann A (2009) Analysis of exhaled breath from smokers, passive smokers and non-smokers by solid-phase microextraction gas chromatography/mass spectrometry. Biomed Chromatogr 23: 551-556.
30. Ligor T, et al (2008) The analysis of healthy volunteers' exhaled breath by the use of solid-phase microextraction and GC-MS. J Breath Res 2, 046006/046001-046006/046008.
31. Schubert JK et al (2007) Determination of antibiotic drug concentrations in circulating human blood by means of solid phase micro-extraction. Clin Chim Acta 386: 57-62.
32. Jünger M, Bödeker B, Baumbach JI (2010) Peak assignment in multi-capillary column-ion mobility spectrometry using comparative studies with gas chromatography-mass spectrometry for exhalred breath analysis. Anal Bioanal Chem 396: 471-482. doi: 10. 1007/s00216-009-3168-z.
33. Maddula S, Blank L, Schmid A, Baumbach JI (2009) Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry. Anal Bioanal Chem 394: 791-800.
34. Baumbach JI (2009) Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath. J Breath Res 3: 1-16.
35. Bödeker B, Vautz W, Baumbach JI (2008) Peak comparison in MCC/IMS-data-searching for potential biomarkers in human breath data. Int J Ion Mobility Spectrom 11: 89-93.
36. Baumbach JI, Westhoff M (2006) Ion mobility spectrometry to detect lung cancer and airway infections. Spectrosc Eur 18: 22-27.
37. Ligor T (2009) Analytical methods for breath investigation. Crit Rev Anal Chem 39: 2-12.
38. Ligor T, Szeliga J, Jackowski M, Buszewski B (2007) Preliminary study of volatile organic compounds from breath and stomach tissue by means of solid phase microextraction and gas chromatography-mass spectrometry. J Breath Res 1: R1-R6.
39. Steeghs MML, Cristescu SM, Munnik P, Zanen P, Harren FJM (2007) An off-line breath sampling and analysis method suitable for large screening studies. Physiol Meas 28: 503-514.
40. Buszewski B, Kesy M, Ligor T, Amann A (2007) Human exhaled air analytics: biomarker of diseases. Biomed Chromatogr 21: 553-566.
41. Amann A et al (2004) Applications of breath gas analysis in medicine. Int J Mass Spectrom 239: 227-233.
42. Lee J-H, Hwang SM, Lee DW, Heo GS (2002) Determination of volatile organic compounds (VOCs) using tedlar bag/solid-phase microextraction/gas chromatography/mass spectrometry (SPME/GC/MS) in ambient and workplace air. Bull Korean Chem Soc 23: 488-495.
43. Filipiak W, et al (2009) Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. Cancer Cell Int.
44. Filipiak W et al (2008) Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. Cancer Cell Int 8: 17.