Osterix is regulated by Erk1/2 during osteoblast differentiation

Biochemical and Biophysical Research Communications

Volumn 415, Issue 3, 2011, Pages 472-478

  Choi, You Hee ^a   Gu, Young Mi ^a   Oh, Jae Wook ^b   Lee, Kwang Youl ^a  

^a Chonnam National University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Differentiation; Erk1 2; Osteoblast; Osterix; Protein stability

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR OSTERIX;

ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BUTADIENES; CELL DIFFERENTIATION; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRILES; OSTEOBLASTS; OSTEOGENESIS; PROTEIN STABILITY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 82355190077     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.097     Document Type: Article

References (26)

1. Katagiri T., Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis. 2002, 8:147-159.
2. Kawamura N., Kugimiya F., Oshima Y., Ohba S., Ikeda T., Saito T., Shinoda Y., Kawasaki Y., Ogata N., Hoshi K., Akiyama T., Chen W.S., Hay N., Tobe K., Kadowaki T., Azuma Y., Tanaka S., Nakamura K., Chung U.I., Kawaguchi H. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2007, 2:e1058.
3. Heino T.J., Hentunen T.A. Differentiation of osteoblasts and osteocytes from mesenchymal stem cells. Curr. Stem Cell Res. Ther. 2008, 3:131-145.
4. Chen D., Zhao M., Mundy G.R. Bone morphogenetic proteins. Growth Factors 2004, 22:233-241.
5. Yamaguchi A., Komori T., Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr. Rev. 2000, 21:393-411.
6. Franceschi R.T., Ge C., Xiao G., Roca H., Jiang D. Transcriptional regulation of osteoblasts. Ann. N. Y. Acad. Sci. 2007, 1116:196-207.
7. Fu H., Doll B., McNelis T., Hollinger J.O. Osteoblast differentiation in vitro and in vivo promoted by Osterix. J. Biomed. Mater. Res. A 2007, 83:770-778.
8. Kim Y.J., Kim H.N., Park E.K., Lee B.H., Ryoo H.M., Kim S.Y., Kim I.S., Stein J.L., Lian J.B., Stein G.S., van Wijnen A.J., Choi J.Y. The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. Gene 2006, 366:145-151.
9. Tu Q., Valverde P., Chen J. Osterix enhances proliferation and osteogenic potential of bone marrow stromal cells. Biochem. Biophys. Res. Commun. 2006, 341:1257-1265.
10. Hatta M., Yoshimura Y., Deyama Y., Fukamizu A., Suzuki K. Molecular characterization of the zinc finger transcription factor, Osterix. Int. J. Mol. Med. 2006, 17:425-430.
11. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., De Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108:17-29.
12. Mebratu Y., Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer?. Cell Cycle 2009, 8:1168-1175.
13. Jun J.H., Yoon W.J., Seo S.B., Woo K.M., Kim G.S., Ryoo H.M., Baek J.H. BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J. Biol. Chem. 2010, 285:36410-36419.
14. Park O.J., Kim H.J., Woo K.M., Baek J.H., Ryoo H.M. FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization. J. Biol. Chem. 2010, 285:3568-3574.
15. Miraoui H., Oudina K., Petite H., Tanimoto Y., Moriyama K., Marie P.J. Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J. Biol. Chem. 2009, 284:4897-4904.
16. Ge C., Xiao G., Jiang D., Franceschi R.T. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J. Cell Biol. 2007, 176:709-718.
17. Matsushita T., Chan Y.Y., Kawanami A., Balmes G., Landreth G.E., Murakami S. Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol. Cell. Biol. 2009, 29:5843-5857.
18. Kanno T., Takahashi T., Tsujisawa T., Ariyoshi W., Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J. Cell. Biochem. 2007, 101:1266-1277.
19. Gallea S., Lallemand F., Atfi A., Rawadi G., Ramez V., Spinella-Jaegle S., Kawai S., Faucheu C., Huet L., Baron R., Roman-Roman S. Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone 2001, 28:491-498.
20. Xiao G., Gopalakrishnan R., Jiang D., Reith E., Benson M.D., Franceschi R.T. Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J. Bone Miner. Res. 2002, 17:101-110.
21. Lee M.H., Kwon T.G., Park H.S., Wozney J.M., Ryoo H.M. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem. Biophys. Res. Commun. 2003, 309:689-694.
22. Matsubara T., Kida K., Yamaguchi A., Hata K., Ichida F., Meguro H., Aburatani H., Nishimura R., Yoneda T. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J. Biol. Chem. 2008, 283:29119-29125.
23. Ulsamer A., Ortuno M.J., Ruiz S., Susperregui A.R., Osses N., Rosa J.L., Ventura F. BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. J. Biol. Chem. 2008, 283:3816-3826.
24. Dacic S., Kalajzic I., Visnjic D., Lichtler A.C., Rowe D.W. Col1a1-driven transgenic markers of osteoblast lineage progression. J. Bone Miner. Res. 2001, 16:1228-1236.
25. Chakravarti D., Ogryzko V., Kao H.Y., Nash A., Chen H., Nakatani Y., Evans R.M. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell 1999, 96:393-403.
26. Choi Y.H., Jeong H.M., Jin Y.H., Li H., Yeo C.Y., Lee K.Y. Akt phosphorylates and regulates the osteogenic activity of Osterix. Biochem. Biophys. Res. Commun. 2011, 411:637-641.