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Volumn 11, Issue 12, 2011, Pages 1935-1944

Towards personalized therapy for patients with glioblastoma

Author keywords

elderly patients; glioblastoma; MGMT; personalized therapy; radiotherapy; targeting therapy; temozolomide

Indexed keywords

6 O BENZYLGUANINE; BEVACIZUMAB; BIOLOGICAL MARKER; BORTEZOMIB; CARMUSTINE; CILENGITIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; HYDROXYUREA; IMATINIB; IRINOTECAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TALAMPANEL; TEMOZOLOMIDE; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VORINOSTAT;

EID: 82355184374     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.11.103     Document Type: Review
Times cited : (17)

References (72)
  • 1
    • 35348954846 scopus 로고    scopus 로고
    • Epidemiology of Brain Tumors
    • DOI 10.1016/j.ncl.2007.07.002, PII S0733861907000746, Brain Tumors in Adults
    • Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors. Neurol. Clin. 25(4), 867-890 (2007). (Pubitemid 47603275)
    • (2007) Neurologic Clinics , vol.25 , Issue.4 , pp. 867-890
    • Fisher, J.L.1    Schwartzbaum, J.A.2    Wrensch, M.3    Wiemels, J.L.4
  • 6
    • 0028809782 scopus 로고
    • The increasing incidence of malignant gliomas and primary central nervous system lymphoma in the elderly
    • Werner MH, Phuphanich S, Lyman GH. The increasing incidence of malignant gliomas and primary central nervous system lymphoma in the elderly. Cancer 76(9), 1634-1642 (1995).
    • (1995) Cancer , vol.76 , Issue.9 , pp. 1634-1642
    • Werner, M.H.1    Phuphanich, S.2    Lyman, G.H.3
  • 7
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
    • DOI 10.1016/S0140-6736(02)08091-1
    • Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359(9311), 1011-1018 (2002). (Pubitemid 34286538)
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 1011-1018
    • Stewart, L.A.1
  • 8
    • 0034005995 scopus 로고    scopus 로고
    • Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma
    • Agarwala SS, Kirkwood JM. Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma. Oncologist 5(2), 144-151 (2000). (Pubitemid 30238234)
    • (2000) Oncologist , vol.5 , Issue.2 , pp. 144-151
    • Agarwala, S.S.1    Kirkwood, J.M.2
  • 11
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized Phase III study: 5-year analysis of the eortc-ncic trial
    • Stupp R, Hegi ME, Mason WP et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized Phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10(5), 4189-4199 (2009).
    • (2009) Lancet Oncol. , vol.10 , Issue.5 , pp. 4189-4199
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 12
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59(4), 793-797 (1999). (Pubitemid 29086728)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 13
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6-methylguanine methyltransferase MGMT promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi ME, Liu L, Herman JG et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J. Clin. Oncol. 26(25), 4189-4199 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.25 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3
  • 15
    • 62449096923 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus O6-benzylguanine in adults with recurrent temozolomide-resistant malignant glioma
    • Quinn JA, Jiang SX, Reardon DA et al. Phase II trial of temozolomide plus O6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J. Clin. Oncol. 27(8), 1262-1267 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.8 , pp. 1262-1267
    • Quinn, J.A.1    Jiang, S.X.2    Reardon, D.A.3
  • 17
    • 68949085460 scopus 로고    scopus 로고
    • Randomized Phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma
    • Clarke JL, Iwamoto FM, Sul J et al. Randomized Phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma. J. Clin. Oncol. 27(23), 3861-3867 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.23 , pp. 3861-3867
    • Clarke, J.L.1    Iwamoto, F.M.2    Sul, J.3
  • 18
    • 78049515473 scopus 로고    scopus 로고
    • Temozolomide versus procarbazine lomustine and vincristine in recurrent high-grade glioma
    • Brada M, Stenning S, Gabe R et al. Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. J. Clin. Oncol. 28(30), 4601-4608 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.30 , pp. 4601-4608
    • Brada, M.1    Stenning, S.2    Gabe, R.3
  • 19
    • 33846218204 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-mediated signal transduction in the development and therapy of gliomas
    • DOI 10.1158/1078-0432.CCR-06-0874
    • Nicholas MK, Lukas RV, Jafri NF, Faoro L, Salgia R. Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas. Clin. Cancer Res. 12(24), 7261-7270 (2006). (Pubitemid 46095397)
    • (2006) Clinical Cancer Research , vol.12 , Issue.24 , pp. 7261-7270
    • Nicholas, M.K.1    Lukas, R.V.2    Jafri, N.F.3    Faoro, L.4    Salgia, R.5
  • 21
    • 62449150719 scopus 로고    scopus 로고
    • Randomized Phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • van den Bent MJ, Brandes AA, Rampling R et al. Randomized Phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J. Clin. Oncol. 27(8), 1268-1274 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.8 , pp. 1268-1274
    • Van Den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3
  • 22
    • 34249275824 scopus 로고    scopus 로고
    • An update of Phase II results from RTOG0211: A Phase I/II study of gefitinib with radiotherapy in newly diagnosed glioblastoma
    • Chakravarti A, Berkey B, Robins H et al. An update of Phase II results from RTOG0211: a Phase I/II study of gefitinib with radiotherapy in newly diagnosed glioblastoma. J. Clin. Oncol. 24(Suppl. 18) 1527 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.18 , pp. 1527
    • Chakravarti, A.1    Berkey, B.2    Robins, H.3
  • 23
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    • Brown PD, Krishnan S, Sarkaria JN et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J. Clin. Oncol. 26(34), 5603-5609 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.34 , pp. 5603-5609
    • Brown, P.D.1    Krishnan, S.2    Sarkaria, J.N.3
  • 24
    • 59149086517 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    • Prados MD, Chang SM, Butowski N et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J. Clin. Oncol. 27(4), 579-584 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.4 , pp. 579-584
    • Prados, M.D.1    Chang, S.M.2    Butowski, N.3
  • 31
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9(6), 669-676 (2003). (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 32
    • 0035688408 scopus 로고    scopus 로고
    • Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograt
    • DOI 10.1023/A:1013329832067
    • Stefanik DF, Fellows WK, Rizkalla LR et al. Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograft. J. Neurooncol. 55(2), 91-100 (2001). (Pubitemid 34065325)
    • (2001) Journal of Neuro-Oncology , vol.55 , Issue.2 , pp. 91-100
    • Stefanik, D.F.1    Fellows, W.K.2    Rizkalla, L.R.3    Rizkalla, W.M.4    Stefanik, P.P.5    Deleo, A.B.6    Welch, W.C.7
  • 33
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66(16), 7843-7848 (2008).
    • (2008) Cancer Res. , vol.66 , Issue.16 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 36
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman HS, Prados MD, Wen PY et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27(28), 4733-4740 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.28 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 37
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J. Clin. Oncol. 27(5), 740-745 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.5 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 38
    • 67649099677 scopus 로고    scopus 로고
    • Antiangiogenic strategies for treatment of malignant gliomas
    • Chi AS, Norden AD, Wen PY. Antiangiogenic strategies for treatment of malignant gliomas. Neurotherapeutics 6(3), 513-526 (2009).
    • (2009) Neurotherapeutics , vol.6 , Issue.3 , pp. 513-526
    • Chi, A.S.1    Norden, A.D.2    Wen, P.Y.3
  • 40
    • 38349155463 scopus 로고    scopus 로고
    • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    • Sathornsumetee S, Cao Y, Marcello JE et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J. Clin. Oncol. 26(2), 271-278 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.2 , pp. 271-278
    • Sathornsumetee, S.1    Cao, Y.2    Marcello, J.E.3
  • 41
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
    • Lai A, Filka E, McGibbon B et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int. J. Radiat. Oncol. Biol. Phys. 71(5), 1372-1380 (2008).
    • (2008) Int. J. Radiat. Oncol. Biol. Phys. , vol.71 , Issue.5 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 42
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai A, Tran A, Nghiemphu PL et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J. Clin. Oncol. 29(2), 142-148 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.2 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3
  • 43
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European organisation for research and treatment of cancer brain tumor group study
    • Raymond E, Brandes AA, Dittrich C et al. Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group study. J. Clin. Oncol. 26(28), 4659-4665 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.28 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3
  • 44
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Dresemann G, Weller M, Rosenthal MA et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J. Neurooncol. 96(3), 393-402 (2010).
    • (2010) J. Neurooncol. , vol.96 , Issue.3 , pp. 393-402
    • Dresemann, G.1    Weller, M.2    Rosenthal, M.A.3
  • 46
    • 33846251309 scopus 로고    scopus 로고
    • Talampanel
    • DOI 10.1016/j.nurt.2006.11.001, PII S1933721306001802, New Antiepileptic Drugs: Discovery, Development, and Update
    • Howes JF, Bell C. Talampanel. Neurotherapeutics 4(1), 126-129 (2007). (Pubitemid 46107320)
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 126-129
    • Howes, J.F.1    Bell, C.2
  • 48
    • 70249128040 scopus 로고    scopus 로고
    • Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: A multicenter Phase II trial
    • Grossman SA, Ye X, Chamberlain M et al. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter Phase II trial. J. Clin. Oncol. 27(25), 4155-4161 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.25 , pp. 4155-4161
    • Grossman, S.A.1    Ye, X.2    Chamberlain, M.3
  • 49
    • 33845628019 scopus 로고    scopus 로고
    • Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice
    • DOI 10.1227/01.NEU.0000245622.70344.BE, PII 0000612320061200000018
    • Yamada S, Bu XY, Khankaldyyan V, Gonzales-Gomez I, McComb JG, Laug WE. Effect of the angiogenesis inhibitor cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 59(6), 1304-1312 (2006). (Pubitemid 44949775)
    • (2006) Neurosurgery , vol.59 , Issue.6 , pp. 1304-1312
    • Yamada, S.1    Bu, X.-Y.2    Khankaldyyan, V.3    Gonzales-Gomez, I.4    McComb, J.G.5    Laug, W.E.6
  • 50
    • 57149108506 scopus 로고    scopus 로고
    • Randomized Phase II study of cilengitide an integrin-targeting arginine-glycine-aspartic acid peptide in recurrent glioblastoma multiforme
    • Reardon DA, Fink KL, Mikkelsen T et al. Randomized Phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J. Clin. Oncol. 26(34), 5610-5617 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.34 , pp. 5610-5617
    • Reardon, D.A.1    Fink, K.L.2    Mikkelsen, T.3
  • 51
    • 77954924659 scopus 로고    scopus 로고
    • Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
    • Stupp R, Hegi ME, Neyns B et al. Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J. Clin. Oncol. 28(16), 2712-2718 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.16 , pp. 2712-2718
    • Stupp, R.1    Hegi, M.E.2    Neyns, B.3
  • 52
    • 78049253211 scopus 로고    scopus 로고
    • Cilengitide in newly diagnosed glioblastoma with MGMT promoter methylation: Protocol of a multicenter randomized open-label controlled Phase III trial centric
    • Abstract TPS152
    • Stupp R, Van Den Bent M, Erridge S et al. Cilengitide in newly diagnosed glioblastoma with MGMT promoter methylation: protocol of a multicenter, randomized, open-label, controlled Phase III trial (CENTRIC). J. Clin. Oncol. 28(Suppl. 15) (2010) (Abstract TPS152).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15
    • Stupp, R.1    Van Den Bent, M.2    Erridge, S.3
  • 53
    • 79952744794 scopus 로고    scopus 로고
    • Cilengitide in patients with newly diagnosed glioblastoma multiforme and unmethylated MGMT gene promoter: Protocol of a multicenter randomized open-label controlled Phase II study
    • Abstract TPS151
    • Nabors L, Fink K, Reardon D et al. Cilengitide in patients with newly diagnosed glioblastoma multiforme and unmethylated MGMT gene promoter: protocol of a multicenter, randomized, open-label, controlled Phase II study. J. Clin. Oncol. 28(Suppl. 15) (2010) (Abstract TPS151).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15
    • Nabors, L.1    Fink, K.2    Reardon, D.3
  • 54
    • 13244262655 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
    • DOI 10.1038/sj.onc.1208225
    • Yin D, Zhou H, Kumagai T et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene 24(3), 344-354 (2005). (Pubitemid 40188583)
    • (2005) Oncogene , vol.24 , Issue.3 , pp. 344-354
    • Yin, D.1    Zhou, H.2    Kumagai, T.3    Liu, G.4    Ong, J.M.5    Black, K.L.6    Koeffler, H.P.7
  • 56
    • 67349138194 scopus 로고    scopus 로고
    • Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies
    • Kubicek GJ, Werner-Wasik M, Machtay M et al. Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies. Int. J. Radiat. Oncol. Biol. Phys. 74(2), 433-439 (2009).
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.74 , Issue.2 , pp. 433-439
    • Kubicek, G.J.1    Werner-Wasik, M.2    Machtay, M.3
  • 57
    • 33847372445 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: Effects on gene expression and growth of glioma cells in vitro and in vivo
    • DOI 10.1158/1078-0432.CCR-06-1261
    • Yin D, Ong JM, Hu J et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clin Cancer Res. 13(3), 1045-1052 (2007). (Pubitemid 46340384)
    • (2007) Clinical Cancer Research , vol.13 , Issue.3 , pp. 1045-1052
    • Yin, D.1    Ong, J.M.2    Hu, J.3    Desmond, J.C.4    Kawamata, N.5    Konda, B.M.6    Black, K.L.7    Koeffler, H.P.8
  • 58
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: A north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ et al. Phase II trial of vorinostat in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J. Clin. Oncol. 27(12), 2052-2058 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.12 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3
  • 59
    • 77951003656 scopus 로고    scopus 로고
    • Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States
    • Grossman SA, Ye X, Piantadosi S et al. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin. Cancer. Res. 16(8), 2443-2449 (2010).
    • (2010) Clin. Cancer. Res. , vol.16 , Issue.8 , pp. 2443-2449
    • Grossman, S.A.1    Ye, X.2    Piantadosi, S.3
  • 62
    • 18444392698 scopus 로고    scopus 로고
    • What is the appropriate radiotherapy protocol for older patients with newly diagnosed glioblastoma? [7]
    • DOI 10.1200/JCO.2005.05.238
    • Lutterbach J, Ostertag C. What is the appropriate radiotherapy protocol for older patients with newly diagnosed glioblastoma? J. Clin. Oncol. 23(12), 2869-2870 (2005). (Pubitemid 46179485)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.12 , pp. 2869-2870
    • Lutterbach, J.1    Ostertag, C.2
  • 63
    • 0037403996 scopus 로고    scopus 로고
    • Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas
    • DOI 10.1002/cncr.11323
    • Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD. Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97(9), 2262-2266 (2003). (Pubitemid 36444070)
    • (2003) Cancer , vol.97 , Issue.9 , pp. 2262-2266
    • Glantz, M.1    Chamberlain, M.2    Liu, Q.3    Litofsky, N.S.4    Recht, L.D.5
  • 65
    • 77956662315 scopus 로고    scopus 로고
    • Glioblastoma GBM in elderly patients: A randomized Phase III trial comparing survival in patients treated with 6-week radiotherapy RT versus hypofractionated RT over 2 weeks versus temozolomide single-agent chemotherapy TMZ
    • Abstract LBA2002
    • Malmstrom A, Grønberg BH, Stupp R et al. Glioblastoma (GBM) in elderly patients: a randomized Phase III trial comparing survival in patients treated with 6-week radiotherapy (RT) versus hypofractionated RT over 2 weeks versus temozolomide single-agent chemotherapy (TMZ). J. Clin. Oncol. 28(Suppl. 18) (2010) (Abstract LBA2002).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.18
    • Malmstrom, A.1    Grønberg, B.H.2    Stupp, R.3
  • 66
    • 77957937625 scopus 로고    scopus 로고
    • NOA-08 randomized Phase III trial of 1-week-on/1-week-off temozolomide versus involved-field radiotherapy in elderly older than age 65 patients with newly diagnosed anaplastic astrocytoma or glioblastoma Methusalem
    • Abstract LBA2001
    • Wick W, Engel C, Combs SE et al. NOA-08 randomized Phase III trial of 1-week-on/1-week-off temozolomide versus involved-field radiotherapy in elderly (older than age 65) patients with newly diagnosed anaplastic astrocytoma or glioblastoma (Methusalem). J. Clin. Oncol. 28(Suppl. 18) (2010) (Abstract LBA2001).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.18
    • Wick, W.1    Engel, C.2    Combs, S.E.3
  • 69
    • 68149182696 scopus 로고    scopus 로고
    • Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: Correlation with MGMT promoter methylation status
    • Brandes AA, Franceschi E, Tosoni A et al. Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 115(15), 3512-3518 (2009).
    • (2009) Cancer , vol.115 , Issue.15 , pp. 3512-3518
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 71
    • 71949106203 scopus 로고    scopus 로고
    • Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme
    • Roa W, Xing JZ, Small C et al. Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme. Expert Rev. Anticancer Ther. 9(11), 1643-1650 (2009).
    • (2009) Expert Rev. Anticancer Ther. , vol.9 , Issue.11 , pp. 1643-1650
    • Roa, W.1    Xing, J.Z.2    Small, C.3
  • 72
    • 58149340543 scopus 로고    scopus 로고
    • Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer
    • Dowsett M, Dunbier AK. Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer. Clin. Cancer Res. 14(24), 8019-8026 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8019-8026
    • Dowsett, M.1    Dunbier, A.K.2


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