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Volumn 103, Issue 8, 2004, Pages 3200-3207

Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN HEAVY CHAIN; PROTEIN CBF BETA; PROTEIN PEBP2 BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

EID: 1842474806     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-07-2188     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
    • Miyoshi H, Shimizu K, Kozu T, et al. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A. 1991;88:10431-10434.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10431-10434
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3
  • 2
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278:1059-1064.
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 3
    • 0027220003 scopus 로고
    • PEBp2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    • Ogawa E, Maruyama M, Kagoshima H, et al. PEBp2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A. 1993;90:6859-6863.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6859-6863
    • Ogawa, E.1    Maruyama, M.2    Kagoshima, H.3
  • 4
    • 0027184229 scopus 로고
    • Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
    • Ogawa E, Inuzuka M, Maruyama M, et al. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology. 1993;194:314-331.
    • (1993) Virology , vol.194 , pp. 314-331
    • Ogawa, E.1    Inuzuka, M.2    Maruyama, M.3
  • 5
    • 0020550724 scopus 로고
    • Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association
    • Le Beau MM, Larson RA, Bitter MA, et al. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association. N Engl J Med. 1983;309:630-636.
    • (1983) N Engl J Med , vol.309 , pp. 630-636
    • Le Beau, M.M.1    Larson, R.A.2    Bitter, M.A.3
  • 6
    • 0028952036 scopus 로고
    • Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia
    • Liu PP, Hajra A, Wijmenga C, Collins FS. Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia. Blood. 1995;85:2289-2302.
    • (1995) Blood , vol.85 , pp. 2289-2302
    • Liu, P.P.1    Hajra, A.2    Wijmenga, C.3    Collins, F.S.4
  • 7
    • 0027373893 scopus 로고
    • Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia
    • Liu P, Tarle SA, Hajra A, et al. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041-1044.
    • (1993) Science , vol.261 , pp. 1041-1044
    • Liu, P.1    Tarle, S.A.2    Hajra, A.3
  • 8
    • 0030061554 scopus 로고    scopus 로고
    • AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    • Okuda T, van-Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
    • (1996) Cell , vol.84 , pp. 321-330
    • Okuda, T.1    Van-Deursen, J.2    Hiebert, S.W.3    Grosveld, G.4    Downing, J.R.5
  • 9
    • 0029918597 scopus 로고    scopus 로고
    • Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    • Wang Q, Stacy T, Binder M, et al. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996;93:3444-3449.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3444-3449
    • Wang, Q.1    Stacy, T.2    Binder, M.3
  • 10
    • 0030588487 scopus 로고    scopus 로고
    • The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
    • Wang Q, Stacy T, Miller JD, et al. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell. 1996;87:697-708.
    • (1996) Cell , vol.87 , pp. 697-708
    • Wang, Q.1    Stacy, T.2    Miller, J.D.3
  • 11
    • 0030915268 scopus 로고    scopus 로고
    • Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor
    • Niki M, Okada H, Takano H, et al. Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci U S A. 1997;94:5697-5702.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5697-5702
    • Niki, M.1    Okada, H.2    Takano, H.3
  • 12
    • 0027218725 scopus 로고
    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • Miyoshi H, Kozu T, Shimizu K, et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 1993;12:2715-2721.
    • (1993) EMBO J , vol.12 , pp. 2715-2721
    • Miyoshi, H.1    Kozu, T.2    Shimizu, K.3
  • 13
    • 0028267241 scopus 로고
    • The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor
    • Erickson PF, Robinson M, Owens G, Drabkin HA. The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor. Cancer Res. 1994;54:1782-1786.
    • (1994) Cancer Res , vol.54 , pp. 1782-1786
    • Erickson, P.F.1    Robinson, M.2    Owens, G.3    Drabkin, H.A.4
  • 14
    • 0031025416 scopus 로고    scopus 로고
    • Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene
    • Yergeau DA, Hetherington CJ, Wang Q, et al. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet. 1997;15:303-306.
    • (1997) Nat Genet , vol.15 , pp. 303-306
    • Yergeau, D.A.1    Hetherington, C.J.2    Wang, Q.3
  • 15
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the Runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemia
    • Osato M, Asou N, Abdalla E, et al. Biallelic and heterozygous point mutations in the Runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemia. Blood. 1999;93:1817-1824.
    • (1999) Blood , vol.93 , pp. 1817-1824
    • Osato, M.1    Asou, N.2    Abdalla, E.3
  • 16
    • 0034667690 scopus 로고    scopus 로고
    • High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
    • Preudhomme C, Warot-Loze D, Roumier C, et al. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood. 2000;96:2862-2869.
    • (2000) Blood , vol.96 , pp. 2862-2869
    • Preudhomme, C.1    Warot-Loze, D.2    Roumier, C.3
  • 17
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
    • Song W-J, Sullivan MG, Legare RD, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999;23:166-175.
    • (1999) Nat Genet , vol.23 , pp. 166-175
    • Song, W.-J.1    Sullivan, M.G.2    Legare, R.D.3
  • 18
    • 0037082499 scopus 로고    scopus 로고
    • In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: Implications for mechanisms of pathogenesis
    • Michaud J, Wu F, Osato M, et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Blood. 2002;99:1364-1372.
    • (2002) Blood , vol.99 , pp. 1364-1372
    • Michaud, J.1    Wu, F.2    Osato, M.3
  • 19
    • 16144362555 scopus 로고    scopus 로고
    • Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
    • Castilla LH, Wijmenga C, Wang Q, et al. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell. 1996;87:687-696.
    • (1996) Cell , vol.87 , pp. 687-696
    • Castilla, L.H.1    Wijmenga, C.2    Wang, Q.3
  • 20
    • 0032878921 scopus 로고    scopus 로고
    • The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
    • Castilla LH, Garrett L, Adya N, et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet. 1999;23;144-146.
    • (1999) Nat Genet , vol.23 , pp. 144-146
    • Castilla, L.H.1    Garrett, L.2    Adya, N.3
  • 21
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukaemia
    • Higuchi M, O'Brien D, Kumaravelu P, et al. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukaemia. Cancer Cell. 2002;1:63-74.
    • (2002) Cancer Cell , vol.1 , pp. 63-74
    • Higuchi, M.1    O'Brien, D.2    Kumaravelu, P.3
  • 22
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PFBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • Huang G, Shigesada K, Ito K, et al. Dimerization with PFBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001;20:723-733,
    • (2001) EMBO J , vol.20 , pp. 723-733
    • Huang, G.1    Shigesada, K.2    Ito, K.3
  • 23
    • 0028839054 scopus 로고
    • Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF
    • Lu J, Maruyama M, Satake M, et al. Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol Cell Biol. 1995;15:1651-1661.
    • (1995) Mol Cell Biol , vol.15 , pp. 1651-1661
    • Lu, J.1    Maruyama, M.2    Satake, M.3
  • 24
    • 0030927824 scopus 로고    scopus 로고
    • A novel transcript encoding an N-terminally truncated AML1/PEBP2αB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells
    • Zhang Y-W, Bae S-C, Huang G, et al. A novel transcript encoding an N-terminally truncated AML1/PEBP2αB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells. Mol Cell Biol. 1997;17:4133-4145.
    • (1997) Mol Cell Biol , vol.17 , pp. 4133-4145
    • Zhang, Y.-W.1    Bae, S.-C.2    Huang, G.3
  • 25
    • 0031835437 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor α (CBFα) subunit by the leukemia-related PEBP2/CBFβ-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation
    • Kanno Y, Kanno T, Sakakura C, Bae S-C, Ito Y. Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor α (CBFα) subunit by the leukemia-related PEBP2/CBFβ-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation. Mol Cell Biol. 1998;18:4252-4261.
    • (1998) Mol Cell Biol , vol.18 , pp. 4252-4261
    • Kanno, Y.1    Kanno, T.2    Sakakura, C.3    Bae, S.-C.4    Ito, Y.5
  • 26
    • 0033522472 scopus 로고    scopus 로고
    • A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
    • Yagi R, Chen LF, Shigesada K, Murakami Y, Ito Y. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999;18:2551-2562.
    • (1999) EMBO J , vol.18 , pp. 2551-2562
    • Yagi, R.1    Chen, L.F.2    Shigesada, K.3    Murakami, Y.4    Ito, Y.5
  • 27
    • 12644307234 scopus 로고    scopus 로고
    • Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity
    • Kagoshima H, Akamatsu Y, Ito Y, Shigesada K. Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity. J Biol Chem. 1996;271:33074-33082.
    • (1996) J Biol Chem , vol.271 , pp. 33074-33082
    • Kagoshima, H.1    Akamatsu, Y.2    Ito, Y.3    Shigesada, K.4
  • 28
    • 0032757710 scopus 로고    scopus 로고
    • Standardized RT-PCR analysis of fusion gene transcripts train chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia
    • van Dongen JJ, Macintyre EA, Gabert JA, et al. Standardized RT-PCR analysis of fusion gene transcripts train chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. 1999;13:1901-1928.
    • (1999) Leukemia , vol.13 , pp. 1901-1928
    • Van Dongen, J.J.1    Macintyre, E.A.2    Gabert, J.A.3
  • 29
    • 0032553528 scopus 로고    scopus 로고
    • The core binding factor (CBF) α interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFβ-SMMHC are both required to slow cell proliferation
    • Cao W, Adya N, Britos-Bray M, Liu PP, Friedman AD. The core binding factor (CBF) α interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFβ-SMMHC are both required to slow cell proliferation. J Biol Chem. 1998;273:31534-31540.
    • (1998) J Biol Chem , vol.273 , pp. 31534-31540
    • Cao, W.1    Adya, N.2    Britos-Bray, M.3    Liu, P.P.4    Friedman, A.D.5
  • 30
    • 0031782323 scopus 로고    scopus 로고
    • The leukemic protein core binding factor β (CBFβ) -smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates
    • Adya N, Stacy T, Speck NA, Liu PP. The leukemic protein core binding factor β (CBFβ)-smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates. Mol Cell Biol. 1998;18:7432-7443.
    • (1998) Mol Cell Biol , vol.18 , pp. 7432-7443
    • Adya, N.1    Stacy, T.2    Speck, N.A.3    Liu, P.P.4
  • 31
    • 0031581843 scopus 로고    scopus 로고
    • A 29 residue region of the sarcomeric myosin rod is necessary for filament formation
    • Sohn RL, Vikstrom KL, Strauss M, et al. A 29 residue region of the sarcomeric myosin rod is necessary for filament formation. J Mol Biol. 1997;266:317-330.
    • (1997) J Mol Biol , vol.266 , pp. 317-330
    • Sohn, R.L.1    Vikstrom, K.L.2    Strauss, M.3
  • 32
    • 0036889143 scopus 로고    scopus 로고
    • Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFβ-smooth muscle myosin heavy chain myeloid leukemia oncoprotein
    • Kummalue T, Lou J, Friedman AD. Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFβ-smooth muscle myosin heavy chain myeloid leukemia oncoprotein. Mol Cell Biol. 2002;22:8278-8291.
    • (2002) Mol Cell Biol , vol.22 , pp. 8278-8291
    • Kummalue, T.1    Lou, J.2    Friedman, A.D.3
  • 33
    • 0035839495 scopus 로고    scopus 로고
    • The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin
    • Ikebe M, Komatsu S, Woodhead JL, et al. The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin. J Biol Chem. 2001;276:30293-30300.
    • (2001) J Biol Chem , vol.276 , pp. 30293-30300
    • Ikebe, M.1    Komatsu, S.2    Woodhead, J.L.3
  • 34
    • 0029680098 scopus 로고    scopus 로고
    • Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemic cells
    • Liu PP, Wijmenga C, Hajira A, et al. Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemic cells. Gene Chrom Cancer. 1996;16:77-87.
    • (1996) Gene Chrom Cancer , vol.16 , pp. 77-87
    • Liu, P.P.1    Wijmenga, C.2    Hajira, A.3
  • 35
    • 9844239378 scopus 로고    scopus 로고
    • CBF β-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells
    • Cao W, Britos-Bray M, Claxton DF, et al. CBF β-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells. Oncogene. 1997;15:1315-1327.
    • (1997) Oncogene , vol.15 , pp. 1315-1327
    • Cao, W.1    Britos-Bray, M.2    Claxton, D.F.3
  • 36
    • 0033607165 scopus 로고    scopus 로고
    • The inv(16) encodes an acute myeloid leukemia 1 transcriptional compressor
    • Lutterbach B, Hou Y, Durst KL, Hiebert SW. The inv(16) encodes an acute myeloid leukemia 1 transcriptional compressor. Proc Natl Acad Sci U S A. 1999;96:12822-12827.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12822-12827
    • Lutterbach, B.1    Hou, Y.2    Durst, K.L.3    Hiebert, S.W.4
  • 37
    • 0035871809 scopus 로고    scopus 로고
    • Core-binding factor β (CBFβ), but not CBFβ-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFβ-deficient embryonic stem cells
    • Miller JD, Stacy T, Liu PP, Speck NA. Core-binding factor β (CBFβ), but not CBFβ-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFβ-deficient embryonic stem cells. Blood. 2001;97:2248-2256.
    • (2001) Blood , vol.97 , pp. 2248-2256
    • Miller, J.D.1    Stacy, T.2    Liu, P.P.3    Speck, N.A.4
  • 38
    • 18544369151 scopus 로고    scopus 로고
    • Altered affinity of CBFβ-SMMHC for Runx1 explains its role in leukemogenesis
    • Lukasik SM, Zhang L, Corpora T, et al. Altered affinity of CBFβ-SMMHC for Runx1 explains its role in leukemogenesis. Nat Struct Biol. 2002;9:674-679.
    • (2002) Nat Struct Biol , vol.9 , pp. 674-679
    • Lukasik, S.M.1    Zhang, L.2    Corpora, T.3
  • 39
    • 0037220731 scopus 로고    scopus 로고
    • The inv(16) fusion protein associates with compressors via a smooth muscle myosin heavy-chain domain
    • Durst KL, Lutterbach B, Kummalue T, Friedman AD, Hiebert SW. The inv(16) fusion protein associates with compressors via a smooth muscle myosin heavy-chain domain. Mol Cell Biol. 2003;23:607-619.
    • (2003) Mol Cell Biol , vol.23 , pp. 607-619
    • Durst, K.L.1    Lutterbach, B.2    Kummalue, T.3    Friedman, A.D.4    Hiebert, S.W.5
  • 40
    • 0021250602 scopus 로고
    • Conformational states of smooth muscle myosin: Effects of light chain phosphorylation and ionic strength
    • Trybus KM, Lowey S. Conformational states of smooth muscle myosin: effects of light chain phosphorylation and ionic strength. J Biol Chem. 1984;259:8564-8571.
    • (1984) J Biol Chem , vol.259 , pp. 8564-8571
    • Trybus, K.M.1    Lowey, S.2
  • 42
    • 0031859607 scopus 로고    scopus 로고
    • Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: Rare events related to DNA-topoisomerase II inhibitors?
    • Dissing M, Le Beau MM, Pedersen-Bjergaard J. Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: rare events related to DNA-topoisomerase II inhibitors? J Clin Oncol. 1998;16:1890-1896.
    • (1998) J Clin Oncol , vol.16 , pp. 1890-1896
    • Dissing, M.1    Le Beau, M.M.2    Pedersen-Bjergaard, J.3
  • 43
    • 85044554931 scopus 로고    scopus 로고
    • Acute myeloblastic leukemia (AML) with inv (16)(p13;q22) and the rare I type CBFβ-MYH11 transcript: Report of two new cases
    • Grardel N, Roumier C, Soenen V, et al. Acute myeloblastic leukemia (AML) with inv (16)(p13;q22) and the rare I type CBFβ-MYH11 transcript: report of two new cases. Leukemia. 2002;16:150-151.
    • (2002) Leukemia , vol.16 , pp. 150-151
    • Grardel, N.1    Roumier, C.2    Soenen, V.3


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