Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia

Blood

Volumn 88, Issue 6, 1996, Pages 2183-2191

  Jurlander, Jesper ^b   Caligiuri, Michael A ^a   Ruutu, Tapani ^b   Baer, Maria R ^b   Strout, Matthew P ^b   Oberkircher, Adam R ^b   Hoffmann, Lise ^b   Ball, Edward D ^b   Frei Lahr, Debra A ^b   Christiansen, Neal P ^b   Block, AnneMarie W ^b   Knuutila, Sakari ^b   Herzig, Geoffrey P ^b   Bloomfield, Clara D ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; HYBRID PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER REGRESSION; CHIMERA; CHROMOSOME TRANSLOCATION 8; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GRAFT VERSUS HOST REACTION; HUMAN; LYMPHOCYTE DEPLETION; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD;

EID: 9544257262     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.6.2183.bloodjournal8862183     Document Type: Article

References (41)

1. Mitelman F, Heim S: Cancer Cytogenetics (ed 2). New York, NY, Wiley Liss, 1995
2. Gao J, Erickson P, Gardiner K, LeBeau MM, Diaz MO, Patterson D, Rowley JD, Drabkin HA: Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia. Proc Natl Acad Sci USA 88:4882, 1991
3. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M: t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 88:10431, 1991
4. Ichikawa H, Shimizu K, Saito A, Wang DN, Oliva R, Kobayashi H, Kaneko Y, Miyoshi H, Smith CL, Cantor CR, Ohki M: Long-distance restriction mapping of the proximal long arm of human chromosome 21 with NOT 1 linking clones. Proc Natl Acad Sci USA 89:23, 1992
5. Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley JD, Drabkin H: Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to a drosophila segmentation gene, runt. Blood 80:1825, 1992
6. Nucifora G, Birn DJ, Erickson P, Gao J, LeBeau MM, Drabkin HA, Rowley D: Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia. Blood 81:883, 1992
7. Nisson PE, Watkins PC, Sacchi N: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogenet 66:81, 1993
8. Yaspo ML, Theophile D, Aurias A, Créte N, Créau-Goldberg N, Bastard C, Suberville AM, Valensi F, Viguier F, Berger R, Sinet PM, Delabar JM: Molecular analysis of 12 patients with the t(8;21) translocation and M2 acute mylogenous leukemia. Genes Chromosom Cancer 5:166, 1992
9. Shimizu K, Miyoshi H, Kozu T, Nagata J, Enomoto K, Maseki N. Kaneko Y: Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation. Cancer Res 52:6945, 1993
10. Downing JR, Head DR, Curcio-Brint AM, Hulshof MG, Motroni TA, Raimondi SC, Carroll AJ, Drabkin HA, Willman C, Theil KS, Civin CI, Erickson P: An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood 81:2860, 1993
11. Meyers S, Downing JR, Hiebert SW: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336, 1993
12. Meyers S, Lenny N, Hiebert SW: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol 15:1974, 1995
13. Sakakura C, Yamaguchi-Iwai Y, Satake M, Bae SC, Takahashi A, Ogawa E, Hagiwara A, Takahashi T, Murakami A, Makino K, Nakagawa T, Kamada N, Ito Y: Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci USA 91:11723, 1994
14. Bitter MA, Le Beau MM, Rowley JD, Larson RA, Golomb HM, Vardiman JW: Associations between morphology, karyotype and clinical features in myeloid leukemias. Hum Pathol 18:211, 1987
15. Nucifora G, Dickstein JI, Torbenson V, Roulston D, Rowley JD, Vardiman JW: Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21). Leukemia 8:1533, 1994
16. Hurwitz CA, Raimondi SC, Head D, Krance R, Mirro J Jr, Kalwinsky DK, Ayers GD, Behm FG: Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood 80:3182, 1992
17. Bloomfield CD, Lawrence D, Arthur DC, Berg DT, Schiffer CA, Mayer RJ: Curative impact of intensification with high-dose cytarabine (HiDAC) in acute myeloid leukemia (AML) varies by cytogenetic group. Blood 84:111a, 1994 (abstr)
18. Nucifora G, Larson RA, Rowley JD: Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. Blood 82:712, 1993
19. Satake N, Maseki N, Kozu T, Sakashita A, Kobayashi H, Sakurai M, Ohki M, Kaneko Y: Disappearance of AML1/ MTG8(ETO) fusion transcripts in acute myeloid leukaemia patients with t(8;21) in long-term remission. Br J Haematol 91:892, 1995
20. Saunders MJ, Tobal K, Liu Yin JA: Detection of t(8;21) by reverse transcriptase polymerase chain reaction in patients in remission of acute myeloid leukaemia type M2 after chemotherapy or bone marrow transplantation. Leuk Res 18:891, 1994
21. Kusec R, Laczika K, Knöbl P, Friedl J, Greinix H, Kahls P, Linkesch W, Schwarzinger I, Mitterbauer G, Purtscher B, Hass OA, Lechner K, Jaeger U: AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation. Leukemia 8:735, 1994
22. Chang KS, Fan YH, Stass SA, Estey EH, Wang G, Trujillo JM, Erickson P, Drabkin H: Expression of AML1-ETO fusion transcripts and detection of minimal residual disease in t(8;21)-positive acute myeloid leukemia. Oncogene 8:983, 1993
23. de Greef GE, Hagemeijer A, Morgan R, Wijsman J, Hoefsloot LH, Sandberg AA, Sacchi N: Identical fusion transcript associated with different breakpoints in the AML1 gene in simple and variant t(8;21) acute myeloid leukemia. Leukemia 9:282, 1995
24. Kwong YL, Chan V, Wong KF, Chan TK: Use of the polymerase chain reaction in the detection of AML1/ETO fusion transcript in t(8;21). Cancer 75:821, 1995
25. Maruyama F, Stass SA, Estey EH, Cork A, Hirano M, Ino T, Freirich EJ, Yang P, Chang KS: Detection of AML1/ETO fusion transcript as a tool for diagnosing t(8;21) positive acute myelogenous leukemia. Leukemia 8:40, 1994
26. Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M: Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood 82:1270, 1993
27. Miyamoto T, Nagafuji K, Harada M, Eto T, Fujisaki T, Kubota A, Akashi K, Mizuno SI, Takenaka K, Kanaji T, Gondo H, Okamura T, Inaba S, Niho Y: Quantitative analysis of AML1/ETO transcripts in peripheral blood stem cell harvests from patients with t(8;21) acute myelogenous leukemia. Br J Haematol 91:132, 1995
28. Guerrasio A, Rosso C, Martinelli G, Lo Coco F, Pampinella M, Santoro A, Lanza C, Allione B, Resegotti L, Saglio G: Polyclonal haemopoiesis associated with long-term persistence of the AML1/ ETO transcript in patients with FAB M2 acute myeloid leukemia in continous clinical remission. BrJ Haematol 90:364, 1995
29. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British cooperative group. Ann Intern Med 103:620, 1985
30. Mitelman F (ed): ISCN 1995: An International System for Human Cytogenetic Nomenclature. Basel, Switzerland, S. Karger AG, 1995
31. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 339:237, 1989
32. Asou H, Tashiro S, Hamamoto K, Otsuji A, Kita K, Kamada N: Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation. Blood 77:2031, 1991
33. Lozzio CB, Lossio BB: Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood 45:321, 1985
34. Oberkircher AR, Strout MP, Herzig GP, Fritz PD, Caligiuri MA: Description of an efficient and highly informative method for the evaluation of hematopoietic chimerism following allogeneic bone marrow transplantation. Bone Marrow Transplant 16:695, 1995
35. Cremer T, Lichter P, Borden J, Ward DC, Manuelidis L: Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes. Hum Genet 80:235, 1988
36. Kita K, Nakase K, Miwa H, Masuya M, Nishii K, Morita N, Takakura N, Otsuji A, Shirakawa S, Ueda T, Nasu K, Kyo T, Dohy H, Kamada N: Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: Frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood 80:470, 1992
37. Hurwitz CA, Raimondi SC, Head D, Krance R, Mirro J, Kalwinsky DK, Ayers GD, Behm FG: Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood 80:3182, 1992
38. Porwit-MacDonald A, Janossy G, Ivory K, Swirsky D, Peters R, Wheatley K, Walker H, Turker A, Goldstone AH, Burnett A: Leukemia-associated changes identified by quantitative flow cytometry. IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21). Blood 87:1162, 1996
39. Porter DL, Roth MS, McGarigle C, Ferrara JL, Antin JH: Induction of graft-versus-host disease as immunotherapy for relapsed chronic myeloid leukemia. N Engl J Med 333:100, 1994
40. Pichert G, Roy D-C, Gonin R, Alyea EP, Bélanger R, Gyger M, Perreault C, Yvette B, Lerra I, Murray C, Soiffer RJ, Ritz J: Distinct patterns of minimal residual disease associated with graft-versus-host disease after allogeneic bone marrow transplantation for chronic myelogenous leukemia. J Clin Oncol 13:1704, 1995
41. Lapidot T, Sirard C, Vormoor J, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE: Development of an in vivo assay for human AML stem cells by transplantation into SCID mice. Nature 367:645, 1994