Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: Report from a referral centre in Israel

British Journal of Haematology

Volumn 126, Issue 3, 2004, Pages 320-337

  Stark, Batia ^a   Jeison, Marta ^a   Gabay, Leticia Glazer ^a   Mardoukh, Jacques ^a   Luria, Drorit ^a,b   Bar Am, Irit ^c   Avrahami, Gali ^a   Kapeliushnik, Yossef ^d   Sthoeger, Dalia ^e   Herzel, Gavriel ^f   Steinberg, David M ^b   Cohen, Ian J ^a   Goshen, Yacov ^a   Stein, Jerry ^a   Zaizov, Rina ^a   Yaniv, Isaac ^a  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Applied Spectral Imaging   (Israel)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e KAPLAN HOSPITAL   (Israel)

^f HAEMEK MEDICAL CENTER   (Israel)

Author keywords

Childhood acute myeloid leukaemia; Cytogenetics

Indexed keywords

ANTIINFECTIVE AGENT; BUSULFAN; CD45 ANTIGEN; CYCLOPHOSPHAMIDE; MELPHALAN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CHEMOTHERAPY; CHILDHOOD LEUKEMIA; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOGENETICS; DOWN SYNDROME; DYSPLASIA; FEMALE; HUMAN; HYBRIDIZATION; INCIDENCE; INFANT; ISRAEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CHROMOSOME DISORDERS; CLINICAL PROTOCOLS; CYTOGENETIC ANALYSIS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INFANT, NEWBORN; ISRAEL; KARYOTYPING; LEUKEMIA, MYELOID; MALE; METAPHASE; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 3442887156     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.05038.x     Document Type: Article

References (80)

1. Arceci, R.J. (2002) Progress and controversies in the treatment of pediatric acute myelogenous leukemia. Current Opinion in Hematology, 9, 353-360.
2. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. & Sultan, C. (1985a) Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American- British Cooperative Group. Annals of Internal Medicine, 103, 620-629.
3. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R. & Sultan, C. (1985b) Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Annals of Internal Medicine, 103, 460-462.
4. Bernstein, J., Dastugue, N., Haas, O.A., Harbott, J., Heerema, N.A., Huret, J.L., Landman-Parker, J., LeBeau, M.M., Leonard, C., Mann, G., Pages, M.P., Perot, C., Pirc-Danoewinata, H., Roitzheim, B., Rubin, C.M., Slociak, M. & Viguie, F. (2000) Nineteen cases of the t(1;22)(p13;q13) acute megakaryoblastic leukaemia of infants/ children and a review of 39 cases: report from a t(1;22) study group. Leukemia, 14, 216-218.
5. Biondi, A., Rovelli, A., Cantù-Rajnoldi, A., Fenu, S., Basso, G., Luciano, A., Rondelli, R., Mandelli, F., Masera, G. & Testi, A.M. for the Associazione Italiana di Ematologia e Oncologia Pediatricá (AIEOP) (1994) Acute promyelocytic leukemia in children: experience of the Italian Pediatric Hematology and Oncology Group (AIEOP). Leukemia, 8, 1264-1268.
6. Bloomfield, C.D., Shuma, C., Regal, L., Philip, P.P., Hossfeld, D.K., Hageneijer, A.M., Garson, O.M., Peterson, B.A., Sakurai, M., Alimena, G., Berger, R., Rowley, J.D., Ruutu, T., Mitelman, F., Dewald, G.W. & Swansbury, J. (1997) Long-term survival of patients with acute myeloid leukemia. A third follow-up of the Fourth International Workshop on Chromosomes in Leukemia. Cancer, 80, 2191-2198.
7. Bloomfield, C.D., Lawrence, D., Byrd, J.C., Carroll, A., Pettenati, M.J., Tantravahi, R., Patil, S.R., Davey, F.R., Berg, D.T., Schiffer, C.A., Arthur, D.C. & Mayer, R.J. (1998) Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Research, 58, 4173-4179.
8. Byrd, J.C., Lawrence, D., Arthur, D.C, Pettenati, M.J., Tantravahi, R., Qumsiyeh, M., Stamberg, J., Davey, F.R., Schiffer, C.A. & Bloomfield, C.D. (1998) Patients with isolated trisomy 8 in acute myeloid leukemia are not cured with cytarabine-based chemotherapy: results from Cancer and Leukemia Group B 8461. Clinical Cancer Research, 4, 1235-1241.
9. Byrd, J.C., Dodge, R.K., Carroll, A., Baer, M.R., Edwards, C., Stamberg, J., Qumsiyeh, M., Moore, J.O., Mayer, R.J., Davey, F., Schiffer, C.A. & Bloomfield, C.D. (1999) Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. Journal of Clinical Oncology, 17, 3767-3775.
10. Byrd, J.C., Mrózek, K., Dodge, R.K., Carroll, A.J., Edwards, C.G., Arthur, D.C., Pettenati, M.J., Patil, S.R., Rao, K.W., Watson, M.S., Koduru, P.R.K., Moore, J.O., Stone, R.M., Mayer, R.J., Feldman, E.J., Davey, F.R., Schiffer, C.A., Larson, R.A. & Bloomfield, C.D. (2002) Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood, 100, 4325-4336.
11. Chessells, J.M., Harrison, C.J., Kempski, H., Webb, D.K.H., Wheatley, K., Hann, I.M., Stevens, R.F., Harrison, G. & Gibson, B.E. (2002) Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party. Leukemia, 16, 776-784.
12. Cox, D.R. (1972) Regression models and life-tables (with discussion). Journal of the Royal Statistical Society, Series B, 34, 187-220.
13. Creutzig, U., Zimmermann, M., Ritter, J., Henze, G., Graf, N., Löffler, H. & Schellong, G. (1999) Definition of a standard-risk group in children with AML. British Journal of Haematology, 104, 630-639.
14. Creutzig, U., Ritter, J., Zimmermann, M., Reinhardt, D., Jermann, J., Berthold, F., Henze, G., Jürgens, H., Kabisch, H., Havers, W., Reiter, A., Kluba, U., Niggli, F. & Gadner, H. for the Acute Myeloid Leukemia-Berlin-Frankfurt-Münster Study Group (2001) Improved treatment results in high-risk pediatric acute myeloid leukemia patients after intensification with high-dose cytarabine and mitoxantrone: results of study Acute Myeloid Leukemia-Berlin-Frankfurt-Münster 93. Journal of Clinical Oncology, 19, 2705-2713.
15. Cuneo, A., Bigoni, R., Cavazzini, F., Bardi, A., Roberti, M.G., Agostini, P., Tammiso, E., Ciccone, N., Mancini, M., Nanni, M., De Cuia, R., Divona, M., La Starza, R., Crescenzi, B., Testoni, N., Rege Cambrin, G., Mecucci, C., Lo Coco, F., Saglio, G. & Castoldi, G. (2002) Incidence and significance of crytpic chromosome aberrations detected by fluorescence in situ hybridization in acute myeloid leukemia with normal karyotype. Leukemia, 16, 1745-1751.
16. Dastugue, N., Duchayne, E., Kuhlein, E., Rubie, H., Demur, C., Aurich, J., Robert, A. & Sie, P. (1997) Acute basophilic leukemia and translocation t(X;6)(p11;q23). British Journal of Haematology, 98, 170-176.
17. Dastugue, N., Lafage-Pochitaloff, M., Pagès, M.-P., Radford, I., Bastard, C., Talmant, P., Mozziconacci, M.J., Leonard, C., Bilhou-Nabéra, C., Cabrol, C., Capodano, A.-M., Cornillet-Lefebvre, P., Lessard, M., Mugneret, F., Pérot, C., Taviaux, S., Fenneteaux, O., Duchayne, E. & Berger, R. (2002) Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood, 100, 618-626.
18. Delaunay, J., Vey, N., Leblanc, T., Fenaux, P., Rigal-Huguet, F., Witz, F., Lamy, T., Auvrignon, A., Blaise, D., Pigneux, A., Mugneret, F., Bastard, C., Dastugue, N., Van den Akker, J., Fière, D., Reiffers, J., Castaigne, S., Leverger, G., Harousseau, J.-L. & Dombret, H. for the French Acute Myeloid Leukemia (AML) Intergroup (2003) Prognosis of inv(16)/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup. Blood, 102, 462-469.
19. Douer, D., Preston-Martin, S., Chang, E., Nichols, P.W., Watkins, K.J. & Levine, A.M. (1996) High frequency of acute promyelocytic leukemia among latinos with acute myeloid leukemia. Blood, 87, 308-313.
20. Felice, M.S., Zubizarreta, P.A., Alfaro, E.M., Gallego, M.S., Cygler, A.M., Rosso, D.A., Rossi, J.G. & Sackmann-Muriel, F. (2000) Good outcome of children with acute myeloid leukemia and t(8;21)(q22;q22), even when associated with granulocytic sarcoma. A report from a single institution in Argentina. Cancer, 88, 1939-1944.
21. + acute leukemia of myeloid and T lymphoid lineage. Leukemia, 10, 1990-1992.
22. Forestier, E., Heim, S., Blennow, E., Borgström, G., Holmgren, G., Heinonen, K., Johannsson, J., Kerndrup, G., Klarskov Anderson, M., Lundin, C., Nordgren, A., Rosenquist, R., Swolin, B. & Johansson, B. on behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO), the Swedish Cytogenetic Leukaemia Study Group (SCLSG) and the NOPHO Leukaemia Cytogenetic Study Group (NLCSG) (2003) Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001. British Journal of Haematology, 121, 566-577.
23. Fröhling, S., Skelin, S., Liebisch, C., Scholl, C., Schlenk, R.F., Döhner, H. & Döhner, K. for the Acute Myeloid Leukemia Study Group Ulm (2002) Comparison of cytogenetic and molecular cytogenetic detection of chromosome abnormalities in 240 consecutive adult patients with acute myeloid leukemia. Journal of Clinical Oncology, 20, 2480-2485.
24. Gibson, B., Webb, D., de-Graaf, S. & Wheatley, K. (2002) Improved outcome in MRC AML 12 paediatrics. Has the limit of conventional chemotherapy been reached? Blood, 100, 35a.
25. Grimwade, D. (2001) The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia. Best Practice and Research Clinical Haematology, 14, 497-529.
26. Grimwade, D., Walker, H., Oliver, F., Wheatley, K., Harrison, C., Harrison, G., Rees, J., Hann, I., Stevens, R., Burnett, A. & Godstone, A. on behalf of the Medical Research Council Adult and Children's Leukaemia Working Parties (1998) The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood, 92, 2322-2333.
27. Grimwade, D., Walker, H., Harrison, G., Oliver, F., Chatters, S., Harrison, C.J., Wheatley, K., Burnett, A.K. & Goldstone, A.H. on behalf of the Medical Research Council Adult Leukaemia Working Party (2001) The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood, 98, 1312-1320.
28. Grimwade, D., Moorman, A.V., Holt, M.P., Walker, H., Chatters, S., Harrison, C.J., Hann, I., Rees, J., Stevens, R., Webb, D.K.H., Gibson, B.E., Goldstone, A.H., Burnett, A.K. & Wheatley, K. (2002) Refinement of cytogenetic classification in AML: determination of prognostic significance of rare recurring chromosomal abnormalities amongst patients entered into the UK MRC AML10 and 12 trials. Blood, 100, 195a.
29. Haferlach, T., Bennett, J.M., Löffler, H., Gassmann, W., Andersen, J.W., Tuzuner, N., Casslleth, P.A., Fonatsch, C., Schoch, C., Schlegelberger, B., Becher, R., Thiel, E., Ludwig, W.-D., Sauerland, M.C., Heinecke, A. & Büchner, T. for the AML Cooperative Group and ECOG (1996) Acute myeloid leukemia with translocation (8;21). Cytomorphology, dysplasia and prognostic factors in 41 cases. Leukemia and Lymphoma, 23, 227-234.
30. Haferlach, T., Kohlmann, A., Kern, W., Hiddemann, W., Schnittger, S. & Schoch, C. (2003) Gene expression profiling as a tool for the diagnosis of acute leukemias. Seminars in Hematology, 40, 281-295.
31. Harris, N.L., Jaffe, E.S., Diebold, J., Flandrin, G., Muller-Hermelink, H.K., Vardiman, J., Lister, T.A. & Bloomfield, C.D. (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting - Airlie House, Virginia, November 1997. Journal of Clinical Oncology, 17, 3835-3849.
32. Harrison, C.J., Moorman, A.V., Hills, R.K., Hann, I.M., Grimwade, D., Webb, D.K.H., Stevens, R., Wheatley, K. & Gibson, B.E. on behalf of the UK NCRI Childhood Leukaemia Working Party (2003) Cytogenetics of childhood AML from UK Medical Research Council Treatment trials. Blood, 102, 98a.
33. Holm, S. (1979) A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics, 6, 65-70.
34. Hrušák, O. & Porwit-MacDonald, A. (2002) Antigen expression patterns reflecting genotype of acute leukemias. Leukemia, 16, 1233-1258.
35. Johansson, B., Mertens, F. & Mitelman, F. (1991) Geographic heterogeneity of neoplasia-associated chromosome aberrations. Genes Chromosomes and Cancer, 3, 1-7.
36. Johansson, B., Fioretos, T., Kullendorff, C.-M., Wiebe, T., Békássy, A.N., Garwicz, S., Forestier, E., Roos, G., Akerman, M., Mitelman, F. & Billström, R. (2000) Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements. Genes, Chromosomes and Cancer, 27, 136-142.
37. Kalbfleisch, J.D. & Prentice, R.L. (1982) The Statistical Analysis of Failure Time Data. John Wiley & Sons, New York.
38. Kaplan, E.L. & Meier, P. (1958) Non-parametric estimation from incomplete observations. Journal of the American Statistical Association, 53, 457-481.
39. Kim, H.J., Cho, H.I., Kim, E.C., Ko, E.K., See, C.J., Park, S.Y. & Lee, D.S. (2002) A study of 289 consecutive Korean patients with acute leukaemias revealed fluorescence in situ hybridization detects the MLL translocation without cytogenetic evidence both initially and during follow-up. British Journal of Haematology, 119, 930-939.
40. Kojima, K., Omoto, E., Hara, M., Sasaki, K., Katayama, Y., Nawa, Y., Kimura, Y., Azuma, T., Takimoto, H. & Harada, M. (1998) Myelodysplastic syndrome with translocation (8;21): a distinct myelodysplastic syndrome entity or M2-acute myeloid leukemia with extensive myeloid maturation? Annals of Hematology, 76, 279-282.
41. Levis, M. & Small, D. (2003) FLT3: it does matter in leukemia. Leukemia, 17, 1738-1752.
42. Lie, S.O., Abrahamsson, J., Clausen, N., Forestier, E., Hasle, H., Hovi, L., Jonmundsson, G., Mellander, L. & Gustafsson, G. (2003) Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: results of NOPHO-AML trials. British Journal of Haematology, 122, 217-225.
43. Marlton, P., Keating, M., Kantarjian, H., Pierce, S., O'Brien, S., Freireich, E.J. & Estey, E. (1995) Cytogenetic and clinical correlates in AML patients with abnormalities of chromosome 16. Leukemia, 9, 965-971.
44. Martinez-Climent, J.A., Lane, N.J., Rubin, C.M., Morgan, E., Johnstone, H.S., Mick, R., Murphy, S.B., Vardiman, J.W., Larson, R.A., Le Beau, M.M. & Rowley, J.D. (1995a) Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo. Leukemia, 9, 95-101.
45. Martinez-Climent, J.A., Espinosa, R. III, Thirman, M.J., Le Beau, M.M. & Rowley, J.D. (1995b) Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival. Journal of Pediatric Hematology/Oncology, 17, 277-283.
46. Mitelman, F. (1995) ISCN. An International System for Human Cytogenetic Nomenclature (ed. by F. Mitelman), S. Karger, Basel.
47. Mrózek, K., Heinonen, K. & Bloomfield, C.D. (2001) Clinical importance of cytogenetics in acute myeloid leukaemia. Best Practice and Research Clinical Haematology, 14, 19-47.
48. Nakamura, H., Kuriyama, K., Sadamori, N., Mine, M., Itoyama, T., Sasagawa, I., Matsumoto, K., Tsuji, Y., Asou, N., Kageyama, S.-I., Sakamaki, H., Emi, N., Ohno, R. & Tomonaga, M. (1997) Morphological subtyping of acute myeloid leukemia with maturation (AML-M2): homogeneous pink-colored cytoplasm of mature neutrophils is most characteristic of AML-M2 with t(8;21). Leukemia, 11, 651-655.
49. Nakase, K., Bradstock, K., Sartor, M., Gottlieb, D., Byth, K., Kita, K., Shiku, H., Kamada, N. and the Japanese Cooperative Group of Leukemia/Lymphoma (2000) Geographic heterogeneity of cellular characteristics of acute myeloid leukemia: a comparative study of Australian and Japanese adult cases. Leukemia, 14, 163-168.
50. Pui, C.-H., Raimondi, S.C., Srivastava, D.K., Tong, X., Behm, F.G., Razzouk, B., Rubnitz, J.E., Sandlund, J.T., Evens, W.E. & Ribeiro, R. (2000) Prognostic factors in infants with acute myeloid leukemia. Leukemia, 14, 684-687.
51. Raimondi, S.C., Chang, M.N., Ravindranath, Y., Behm, F.G., Gresik, M.V., Steuber, C.P., Weinstein, J.H. & Carroll, A.J. for the Pediatric Oncology Group (1999) Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a Cooperative Pediatric Oncology Group Study - POG 8821. Blood, 94, 3707-3716.
52. Razzouk, B.I., Raimondi, S.C., Srivastava, D.K., Pritchard, M., Behm, F.G., Tong, X., Sandlund, J.T., Rubnitz, J.E. & Pui, C.-H. (2001) Impact of treatment of the outcome of acute myeloid leukemia with in version 16: a single institution's experience. Leukemia, 15, 1326-1330.
53. Rowley, J.D. (2000) Cytogenetic analysis in leukemia and lymphoma: an introduction. Seminars in Hematology, 37, 315-319.
54. Rowley, J.D. (2001) Chromosome translocations: dangerous liaisons revisited. Nature Reviews, 1, 245-250.
55. Rubnitz, J.E., Raimondi, S.C., Tong, X., Srivastava, D.K., Razzouk, B.I., Shurtleff, S.A., Downing, J.R., Pui, C.-H., Ribeiro, P.C. & Behm, F.G. (2002) Favorable impact of the t(9;11) in childhood acute myeloid leukemia. Journal of Clinical Oncology, 20, 2302-2309.
56. Schoch, C., Haase, D., Haferlach, T., Gudat, H., Büchner, T., Freund, M., Link, H., Lengfelder, E., Wandt, H., Sauerland, M.C., Löffler, H. & Fonatsch, C. (1996) Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor. Leukemia, 10, 1288-1295.
57. Schoch, C., Haferlach, T., Schnittger, S., Kern, W., Dugas, M. & Hiddemann, W. (2001a) AML with recurring chromosome abnormalities as defined in the new WHO classification: incidence of subgroups, additional genetic abnormalities, FAB subtype and age distribution in an unselected series of 1897 cytogenetically and molecular genetically analysed AML. Blood, 98, 457a.
58. Schoch, C., Haferlach, T., Haase, D., Fonatsch, C., Löffler, H., Schlegelberger, B., Staib, P., Sauerland, M.C., Heinecke, A., Büchner, T. & Hiddemann, W. for the German AML Cooperative Study Group (2001b) Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients. British Journal of Haematology, 112, 118-126.
59. Schoch, C., Schnittger, S., Klaus, M., Kern, W., Hiddemann, W. & Haferlach, T. (2003) AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenically analyzed AML cases. Blood, 120, 2395-2402.
60. Schwyzer, R., Sherman, G.G., Cohn, R.J., Poole, J.E. & Willem, P. (1998) Granulocytic sarcoma in children with acute myeloblastic leukemia and t(8;21). Medical and Pediatric Oncology, 31, 144-149.
61. Sekeres, M.A., Dodge, R.K., Bloomfield, C.D., Larson, R.A. & Stone, R.M. (2002) Racial differences in prognostic factors and outcome in acute myeloid leukemia (AML): a Cancer and Leukemia Group B (CALGB) Study. Blood, 100, 88a.
62. Shvidel, L., Shaft, D., Stark, B., Shtalrid, M., Berrebi, A. & Resnitzky, P. (2003) Acute basophilic leukaemia: eight unsuspected new cases diagnosed by electron microscopy. British Journal of Haematology, 120, 774-781.
63. Slovak, M.L., Kopecky, K.J., Cassileth, P.A., Harrington, D.H., Theil, K.S., Mohamed, A., Paietta, E., Willman, C.L., Head, D.R., Rowe, J.M., Forman, S.J. & Appelbaum, F.R. (2000) Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood, 96, 4075-4083.
64. Smith, M.T., Wang, Y., Kane, E., Rollinson, S., Wiemels, J.L., Roman, E., Roddam, P., Cartwright, R. & Morgan, G. (2001) Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults. Blood, 97, 1422-1426.
65. Stark, B., Resnitzky, P., Jeison, M., Luria, D., Blau, O., Avigad, S., Shaft, D., Kodman, Y., Gobuzov, R., Ash, S., Stein, J., Yaniv, I., Barak, Y. & Zaizov, R. (1995) A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13) - case report and review of the literature. Leukemia Research, 19, 367-379.
66. Stark, B., Jeison, M., Gobuzov, R., Finkelshtein, S., Ash, S., Avrahami, G., Cohen, I.J., Stein, J., Yaniv, I., Zaizov, R. & Bar-Am, I. (2000) Apparently unrelated clones shown by spectral karyotyping to represent clonal evolution of cryptic t(10;11)(p13;q23) in a patient with acute monoblastic leukemia. Cancer, Genetics and Cytogenetics, 120, 105-110.
67. Stark, B., Jeison, M., Preudhomme, C., Fenaux, P., Ash, S., Korek, Y., Stein, J., Zaizov, R. & Yaniv, I. (2002) Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins. British Journal of Haematology, 118, 1082-1086.
68. Taj, A.S., Ross, F.M., Vickers, M., Choudhury, D.N., Harvey, J.F., Barber, J.C.K., Barton, C. & Smith, A.G. (1995) t(8;21) myelodysplasia, an early presentation of M2 AML. British Journal of Haematology, 89, 890-892.
69. Tallman, M.S., Andersen, J.W., Schiffer, C.A., Appelbaum, F.R., Feusner, J.H., Woods, W.G., Ogden, A., Weinstein, H., Shepherd, L., Willman, C., Bloomfield, C.D., Rowe, J.M. & Wiernik, P.H. (2002) All-trans retinoic acid in acute promeylocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood, 100, 4298-4302.
70. Tchinda, J., Volpert, S., Neumann, T., Kennerknecht, I., Ritter, J., Büchner, T., Berdel, W.E. & Horst, J. (2002) Novel der(1)t(1;19) in two patients with myeloid neoplasias. Cancer Genetics and Cytogenetics, 133, 61-65.
71. Vardiman, J.W., Harris, N.L. & Brunning, R.D. (2002) The World Health Organization (WHO) classification of the myeloid neoplasms. Blood, 100, 2292-2302.
72. Wan, T.S.K., Ma, E.S.K., Lam, C.C.K., Chan, L.C., Lee, K.K. & Au, W.Y. (2003) Deletion 9q as the sole karyotypic abnormality in myelocytic disorders: a new case of myelodysplastic syndrome and its prognostic implications in acute myelocytic leukemia. Cancer Genetics and Cytogenetics, 145, 184-186.
73. Webb, D.K.H., Harrison, G., Stevens, R.F., Gibson, B.G., Hann, I.M. & Wheatley, K. (2001) Relationships between age at diagnosis, clinical features, and outcome of therapy in children treatment in the Medical Research Council AML 10 and 12 trials for acute myeloid leukemia. Blood, 98, 1714-1720.
74. Wells, R.J., Arthur, D.C., Srivastava, A., Heerema, N.A., Le Beau, M., Alonzo, T.A., Buxton, A.B., Woods, W.G., Howells, W.B., Benjamin, D.R., Betcher, D.L., Buckley, J.D., Feig, S.A., Kim, T., Odom, L.F., Ruymann, F.B., Smithson, W.A., Tannous, R., Whitt, J.K., Wolff, L., Tjoa, T. & Lampkin, B.C. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia, 16, 601-607.
75. Willman, C.L. (2001) Targeted AML therapy: new biologic paradigms and therapeutic opportunities. Leukemia, 15, 690-694.
76. Wolman, S.R., Gundacker, H., Appelbaum, F.R. & Slovak, M.L. for the Southwest Oncology Group (2002) Impact of trisomy 8(+8) on clinical presentation, treatment response, and survival in acute myeloid leukemia: a Southwest Oncology Group Study. Blood, 100, 29-35.
77. Woods, G.W., Neudorf, S., Gold, S., Sanders, J., Buckley, J.D., Barnard, D.R., Dusenbery, K., DeSwarte, J., Arthur, D.C., Lange, B.J. & Kobrinsky, N.L. (2001) A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission; a report from the Children's Cancer Group. Blood, 97, 56-62.
78. Yagi, T., Morimoto, A., Eguchi, M., Hibi, S., Sako, M., Ishii, E., Mizutani, S., Imashuku, S., Ohki, M. & Ichikawa, H. (2003) Identification of a gene expression signature associated with pediatric AML prognosis. Blood, 102, 1849-1856.
79. Zwaan, C.M., Kaspers, G.J.L., Pieters, R., Hählen, K., Huismans, D.R., Zimmermann, M., Harbott, J., Slater, R.M., Creutzig, U. & Veerman, A.J.P. (2002) Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities. Blood, 100, 3352-3360.
80. Zwaan, C.M., Meshinchi, S., Radich, J.P., Veerman, A.J.P., Huismans, D.R., Munske, L., Podleschny, M., Hählen, K., Pieters, R., Zimmermann, M., Reinhardt, D., Harbott, J., Creutzig, U., Kaspers, G.J.L. & Griesinger, F. (2003) FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. Blood, 102, 2387-2394.