Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines

Cancer Letters

Volumn 314, Issue 1, 2012, Pages 34-40

  Hong, Zhen Yu ^a,b   Lee, Hyeon Jung ^a,b   Shin, Dong Yeob ^a,b   Kim, Suk Kyoung ^a,b   Seo, MiRan ^a,b   Lee, Eun Jig ^a,b,c  

^a Yonsei University College of Medicine   (South Korea)

^b Brain Korea 21 Project for Medical Science   (South Korea)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Follicular thyroid cancer; FOXO3a; Gene therapy

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CONTROLLED STUDY; ENZYME INHIBITION; GENE THERAPY; GENETIC TRANSDUCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUDE MOUSE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THYROID FOLLICULAR CARCINOMA; TUMOR VOLUME; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GENE THERAPY; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THYROID NEOPLASMS;

ADENOVIRIDAE; MUS;

EID: 82355169496     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.09.010     Document Type: Article

References (29)

1. Cooper D.S., Doherty G.M., Haugen B.R., Kloos R.T., Lee S.L., Mandel S.J., et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009, 19(11):1167-1214.
2. De Vita G., Berlingieri M.T., Visconti R., Castellone M.D., Viglietto G., Baldassarre G., et al. Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects. Cancer Res. 2000, 60(14):3916-3920.
3. Saito J., Kohn A.D., Roth R.A., Noguchi Y., Tatsumo I., Hirai A., et al. Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling. Thyroid 2001, 11(4):339-351.
4. Nicholson K.M., Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell. Signal. 2002, 14(5):381-395.
5. Yuan T.L., Cantley L.C. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008, 27(41):5497-5510.
6. Xing M. Recent advances in molecular biology of thyroid cancer and their clinical implications. Otolaryngol Clin North Am 2008;41(6):1135-46, ix.
7. Liu D., Hou P., Liu Z., Wu G., Xing M. Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin. Cancer Res. 2009, 69(18):7311-7319.
8. Weigel D., Jurgens G., Kuttner F., Seifert E., Jackle H. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 1989, 57(4):645-658.
9. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999, 96(6):857-868.
10. Tang E.D., Nunez G., Barr F.G., Guan K.L. Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 1999, 274(24):16741-16746.
11. Biggs W.H., Meisenhelder J., Hunter T., Cavenee W.K., Arden K.C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 1999, 96(13):7421-7426.
12. Kops G.J., de Ruiter N.D., De Vries-Smits A.M., Powell D.R., Bos J.L., Burgering B.M. Direct control of the forkhead transcription factor AFX by protein kinase B. Nature 1999, 398(6728):630-634.
13. Skurk C., Maatz H., Kim H.S., Yang J., Abid M.R., Aird W.C., et al. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J. Biol. Chem. 2004, 279(2):1513-1525.
14. Mader S.L. Influence of animal age on the beta-adrenergic system in cultured rat aortic and mesenteric artery smooth muscle cells. J. Gerontol. 1992, 47(2):B32-B36.
15. Ansari B., Coates P.J., Greenstein B.D., Hall P.A. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J. Pathol. 1993, 170(1):1-8.
16. Medema R.H., Kops G.J., Bos J.L., Burgering B.M. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000, 404(6779):782-787.
17. Gilley J., Coffer P.J., Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 2003, 162(4):613-622.
18. Park K.W., Kim D.H., You H.J., Sir J.J., Jeon S.I., Youn S.W., et al. Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27. Arterioscler. Thromb. Vasc. Biol. 2005, 25(4):742-747.
19. Karger S., Weidinger C., Krause K., Sheu S.Y., Aigner T., Gimm O., et al. FOXO3a: a novel player in thyroid carcinogenesis?. Endocr. Relat. Cancer 2009, 16(1):189-199.
20. Lee E.J., Jameson J.L. Cell-specific Cre-mediated activation of the diphtheria toxin gene in pituitary tumor cells: potential for cytotoxic gene therapy. Hum. Gene Ther. 2002, 13(4):533-542.
21. Lee E.J., Jakacka M., Duan W.R., Chien P.Y., Martinson F., Gehm B.D., et al. Adenovirus-directed expression of dominant negative estrogen receptor induces apoptosis in breast cancer cells and regression of tumors in nude mice. Mol. Med. 2001, 7(11):773-782.
22. Lee E.J., Russell T., Hurley L., Jameson J.L. Pituitary transcription factor-1 induces transient differentiation of adult hepatic stem cells into prolactin-producing cells in vivo. Mol. Endocrinol. 2005, 19(4):964-971.
23. Nikiforova M.N., Nikiforov Y.E. Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis. Expert Rev. Mol. Diagn. 2008, 8(1):83-95.
24. Klippel A., Escobedo M.A., Wachowicz M.S., Apell G., Brown T.W., Giedlin M.A., et al. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol. Cell. Biol. 1998, 18(10):5699-5711.
25. De Ruiter N.D., Burgering B.M., Bos J.L. Regulation of the forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Mol. Cell. Biol. 2001, 21(23):8225-8235.
26. Nakamura N., Ramaswamy S., Vazquez F., Signoretti S., Loda M., Sellers W.R. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 2000, 20(23):8969-8982.
27. Stahl M., Dijkers P.F., Kops G.J., Lens S.M., Coffer P.J., Burgering B.M., et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 2002, 168(10):5024-5031.
28. Tanaka M., Kirito K., Kashii Y., Uchida M., Watanabe T., Endo H., et al. Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling. J. Biol. Chem. 2001, 276(18):15082-15089.
29. Modur V., Nagarajan R., Evers B.M., Milbrandt J. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 2002, 277(49):47928-47937.