Mixed infection with cagA positive and cagA negative strains of Helicobacter pylori lowers disease burden in The Gambia

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Secka, Ousman ^a   Antonio, Martin ^a   Berg, Douglas E ^c   Tapgun, Mary ^a   Bottomley, Christian ^d   Thomas, Vivat ^a   Walton, Robert ^a   Corrah, Tumani ^a   Thomas, Julian E ^b   Adegbola, Richard A ^a,e  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e BILL AND MELINDA GATES FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL PAIN; ADULT; ARTICLE; BACTERIAL GENE; BACTERIAL LOAD; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CAGA GENE; CONTROLLED STUDY; DNA EXTRACTION; DUODENUM DISEASE; DYSPEPSIA; FEMALE; GAMBIA; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; VACA TOXIN GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CHILD; COINFECTION; COST OF ILLNESS; GAMBIA; GENES, BACTERIAL; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MIDDLE AGED; STOMACH DISEASES; TREATMENT OUTCOME; VIRULENCE; YOUNG ADULT;

EID: 82255195427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027954     Document Type: Article

References (40)

1. Taylor NS, Fox JG, Akopyants NS, Berg DE, Thompson N, et al. (1995) Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting. J Clin Microbiol 33: 918-923.
2. Campbell DI, Warren BF, Thomas JE, Figura N, Telford JL, et al. (2001) The African enigma: low prevalence of gastric atrophy, high prevalence of chronic inflammation in West African adults and children. Helicobacter 6: 263-267.
3. Jemilohun AC, Otegbayo JA, Ola SO, Oluwasola OA, Akere A, (2010) Prevalence of Helicobacter pylori among Nigerian patients with dyspepsia in Ibadan. Pan Afr Med J 6: 18.
4. Thomas JE, Dale A, Harding M, Coward WA, Cole TJ, et al. (1999) Helicobacter colonization during early life. Pediatric Res 45: 218-223.
5. Holcombe C, (1992) Helicobacter pylori: The African enigma. Gut 33: 429-431.
6. Yamaoka Y, Tadashi Kodama, Gutierrez O, Kim J, Kashima K, et al. (1999) Relationship between Helicobacter pylori iceA, cagA, and vacA Status and Clinical Outcome: Studies in Four Different Countries. J Clin Microbiol 37: 2274-2279.
7. Linz B, Balloux F, Moodley Y, Manica A, Liu H, et al. (2007) An African origin for the intimate association between humans and Helicobacter pylori. Nature 445: 915-918.
8. Blaser MJ, Berg DE, (2001) Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest 107: 767-773.
9. Sugimoto M, Yamaoka Y, (2009) The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin Microbiol Infect 15: 835-842.
10. Rieder G, Fischer W, Haas R, (2005) Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules. Curr Opin Microbiol 8: 67-73.
11. Agha A, Graham DY, (2005) Evidence-based examination of the African enigma in relation to Helicobacter pylori infection. Scand J Gastroenterol 40: 523-529.
12. Graham DY, Lu H, Yamaoka Y, (2009) African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths. J Dig Dis 10: 77-84.
13. Boyanova L, Markovska R, Yordanov D, Marina M, Ivanova K, et al. (2009) High prevalence of virulent Helicobacter pylori strains in symptomatic Bulgarian patients. Diag Microbio Infect Dis 64: 374-380.
14. Kim YS, Kim N, Kim JM, Kim MS, Park JH, et al. (2009) Helicobacter pylori genotyping findings from multiple cultured isolates and mucosal biopsy specimens: strain diversities of Helicobacter pylori isolates in individual hosts. Eur J Gastroenterol & Hepatol 21: 522-528.
15. Matteo MJ, Granados G, Pe'rez CV, Olmos M, Sanchez C, et al. (2007) Helicobacter pylori cag pathogenicity island genotype diversity within the gastric niche of a single host. J Med Microbiol 56: 664-669.
16. Miernyk K, Morris J, Bruden D, McMahon B, Hurlburt D, et al. (2011) Characterization of Helicobacter pylori cagA and vacA Genotypes among Alaskans and Their Correlation with Clinical Disease. J Clin Microbiol 49: 3114-3121.
17. Momynaliev K, Smirnova O, Govorun V, (2003) Helicobacter pylori Genotypes in Russia. Eur J Clin Microbiol Infect Dis 22: 573-574.
18. Ahmed N, Sechi L, (2005) Helicobacter pylori and gastroduodenal pathology: new threats of the old friend. Ann Clin Microbiol Antimicrob 4: 1.
19. Owen RJ, Hurtado A, Banatvala N, Abdi Y, Davies GR, et al. (1994) Conservation of the cytotoxin-associated (cagA) gene of Helicobacter pylori and investigation of association with vacuolating-cytotoxin activity and gastroduodenal disease. FEMS Immunol Med Microbiol 9: 307-315.
20. van Doorn L, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, et al. (1998) Clinical Relevance of the cagA, vacA, and iceA Status of Helicobacter pylori. Gastroenterol 115: 58-66.
21. Akada JK, Ogura K, Dailidiene D, Dailide G, Cheverud JM, et al. (2003) Helicobacter pylori tissue tropism: mouse-colonizing strains can target different gastric niches. Microbiology 149: 1901-1909.
22. Secka O, Antonio M, Tapgun M, Berg DE, Bottomley C, et al. (2011) PCR-based genotyping of Helicobacter pylori of Gambian children and adults directly from biopsy specimens and bacterial cultures. Gut Pathog 3: 5.
23. Mukhopadhyay AK, Kersulyte D, Datta S, Ito Y, Chowdhury A, et al. (2002) Distinctiveness of genotypes of Helicobacter pylori in Calcutta. J Bacteriol 182: 3219-27.
24. Yamaoka Y, Kato M, Asaka M, (2008) Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains. Intern Med 47: 1077-1083.
25. Segal I, Ally R, Mitchell H, (2001) Helicobacter pylori-an African perspective. Q J Med 94: 561-565.
26. Chen XJ, Yan J, Shen YF, (2005) Dominant cagA/vacA genotypes and coinfection frequency of H. pylori in peptic ulcer or chronic gastritis patients in Zhejiang province and correlations among different genotypes, coinfection and severity of the diseases. Chin Med J (Engl) 20: 460-467.
27. Kumar S, Kumar A, Dixit VK, (2010) Diversity in the cag pathogenicity island of Helicobacter pylori isolates in populations from North and South India. J Med Microbiol 59: 32-40.
28. Nguyen LT, Uchida T, Murakami K, Fujioka T, Moriyama M, (2008) Helicobacter pylori virulence and the diversity of gastric cancer in Asia. J Med Microbiol 57: 1445-53.
29. Pan ZJ, Berg DE, van der Hulst RW, Su WW, Raudonikiene A, et al. (1998) Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J Infect Dis 178: 220-226.
30. Taniha NF, McMillan M, Naidooc N, Ndipd LM, Weaver LT, et al. (2010) Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in South African patients with upper gastrointestinal diseases. Acta Tropica 116: 68-73.
31. Park CY, Minjung K, Gutierrez O, Graham GY, Yamaoka Y, (2003) Comparison of Genotyping Helicobacter pylori Directly from Biopsy Specimens and Genotyping from Bacterial Cultures. J Clin Microbiol 41: 3336-3338.
32. Smith SI, Kirch C, Kola S, Arigbabu AO, Coker AO, et al. (2002) Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in Nigerian patients with duodenal ulcer disease. J Med Microbiol 51: 851-854.
33. Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, et al. (2009) Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol 11: 488-505.
34. Alam SI, Bansod S, Singh L, (2008) Immunization against Clostridium perfringens cells elicits protection against Clostridium tetani in mouse model: identification of cross-reactive proteins using proteomic methodologies. BMC Microbiology 8: 194.
35. Berg S, Trollfors B, Persson E, Backhaus E, Larsson P, et al. (2006) Serotypes of Streptococcus pneumoniae isolated from blood and cerebrospinal fluid related to vaccine serotypes and to clinical characteristics. Scand J Infect Dis 38: 427-432.
36. Panangala VS, Shoemaker CA, Klesius PH, Mitra A, Russo R, (2009) Cross-protection elicited in channel catfish (Ictalurus punctatus Rafinesque) immunized with a low dose of virulent Edwardsiella ictaluri strains. Aquaculture Research 40: 915-926.
37. Serge B, Boivin R, Menanteau P, Lantier F, (2002) Cross-protection of Salmonella abortusovis, S. choleraesuis, S. dublin and S. gallinarum in mice induced by S. abortusovis and S. gallinarum: bacteriology and humoral immune response. Vet Res 33: 55-69.
38. Figueiredo C, Van Doorn LJ, Nogueira C, Soares JM, Pinho C, et al. (2001) Helicobacter pylori Genotypes Are Associated with Clinical Outcome in Portuguese Patients and Show a High Prevalence of Infections with Multiple Strains. Scand J Gastenterol 36: 128-135.
39. Palacios G, Hornig M, Cisterna D, Savji N, Bussetti AV, et al. (2009) Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza. PloS One 4: E8540.
40. Soto G, Bautista CT, Roth DE, Gilman RH, Velapatiño B, et al. (2003) Helicobacter pylori reinfection is common in Peruvian adults after antibiotic eradication therapy. J Infect Dis 188: 1263-1275.