Visualization of outflow tract development in the absence of Tbx1 using an Fgf10 enhancer trap transgene

Developmental Dynamics

Volumn 236, Issue 3, 2007, Pages 821-828

  Kelly, Robert G ^a,b   Papaioannou, Virginia E ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Cardiac outflow tract (OFT); Fgf10; Heart; Mouse; T box; Tbx1

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; DIGEORGE SYNDROME; EMBRYO; EMBRYO DEVELOPMENT; FGF10 ENHANCER TRAP TRANSGENE; FGF10 GENE; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; HEART DEVELOPMENT; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART RIGHT VENTRICLE OUTFLOW TRACT; HEART VENTRICLE SEPTUM; HETEROZYGOTE; HOMOZYGOTE; MESODERM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TBX1 GENE; TRANSGENE;

ANIMALS; FIBROBLAST GROWTH FACTOR 10; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; MYOCARDIUM; T-BOX DOMAIN PROTEINS;

EID: 33947362415     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21063     Document Type: Article

References (39)

1. Abu-Issa R, Waldo K, Kirby ML. 2004. Heart fields: one, two or more? Dev Biol 272:281-285.
2. Baldini A. 2005. Dissecting contiguous gene defects: TBX1. Curr Opin Genet Dev 15:279-284.
3. Buckingham M, Meilhac S, Zaffran S. 2005. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6:826-835.
4. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. 2003. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 5:877-889.
5. Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thomas J, Bollag RJ, Silver LM, Papaioannou VE. 1996. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn 206: 379-390.
6. Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH. 1995. The Hox11 gene is essential for cell survival during spleen development. Development 121:2909-2915.
7. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D. 2001. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol 235: 62-73.
8. Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D. 2004. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development 131: 5491-5502.
9. Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN. 2006. Fgf8 is required for anterior heart field development. Development 133:2435-2445.
10. Jerome LA, Papaioannou VE. 2001. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet 27:286-291.
11. Kelly RG, Buckingham ME. 2002. The anterior heart-forming field: voyage to the arterial pole of the heart. Trends Genet 18:210-216.
12. Kelly RG, Brown NA, Buckingham ME. 2001. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell 1:435-440.
13. Kelly RG, Jerome-Majewska LA, Papaioannou VE. 2004. The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet 13:2829-2840.
14. Lindsay EA. 2001. Chromosomal microdeletions: dissecting del22q11 syndrome. Nat Rev Genet 2:858-868.
15. Lindsay EA, Baldini A. 2001. Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region. Hum Mol Genet 10:997-1002.
16. Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland HF, Scambler PJ, Bradley A, Baldini A. 2001. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 410:97-101.
17. Mailleux AA, Kelly R, Veltmaat JM, De Langhe SP, Zaffran S, Thiery JP, Bellusci S. 2005. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132:2157-2166.
18. Marguerie A, Bajolle F, Zaffran S, Brown NA, Dickson C, Buckingham ME, Kelly RG. 2006. Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc Res 71:50-60.
19. Meilhac SM, Esner M, Kelly RG, Nicolas JF, Buckingham ME. 2004. The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev Cell 6:685-698.
20. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104:619-629.
21. Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS. 1998. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12:3156-3161.
22. Mjaatvedt CH, Nakaoka T, Moreno-Rodriguez R, Norris RA, Kern MJ, Eisenberg CA, Turner D, Markwald RR. 2001. The outflow tract of the heart is recruited from a novel heart-forming field. Dev Biol 238:97-109.
23. Ohuchi H, Hori Y, Yamasaki M, Harada H, Sekine K, Kato S, Itoh N. 2000. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun 277:643-649.
24. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. 2006. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 133:2419-2433.
25. Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM. 1996. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84:309-320.
26. Reifers F, Walsh EC, Leger S, Stainier DY, Brand M. 2000. Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). Development 127:225-235.
27. Sekine K, Ohuchi H, Fujiwara M, Yamasaki M, Yoshizawa T, Sato T, Yagishita N, Matsui D, Koga Y, Itoh N, Kato S. 1999. Fgf10 is essential for limb and lung formation. Nat Genet 21:138-141.
28. Srivastava D, Olson EN. 2000. A genetic blueprint for cardiac development. Nature 407:221-226.
29. Verzi MP, McCulley DJ, De Val S, Dodou E, Black BL. 2005. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol 287:134-145.
30. Vitelli F, Morishima M, Taddei I, Lindsay EA, Baldini A. 2002a. Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet 11:915-922.
31. Vitelli F, Taddei I, Morishima M, Meyers EN, Lindsay EA, Baldini A. 2002b. A genetic link between Tbx1 and fibroblast growth factor signaling. Development 129: 4605-4611.
32. Vitelli F, Zhang Z, Huynh T, Sobotka A, Mupo A, Baldini A. 2006. Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol 295:559-570.
33. Waldo KL, Kumiski DH, Wallis KT, Stadt HA, Hutson MR, Platt DH, Kirby ML. 2001. Conotruncal myocardium arises from a secondary heart field. Development 128:3179-3188.
34. Ward C, Stadt H, Hutson M, Kirby ML. 2005. Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. Dev Biol 284:72-83.
35. Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A. 2004. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 131:3217-3227.
36. Xu H, Cerrato F, Baldini A. 2005. Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 132:4387-4395.
37. Yagi H, Furutani Y, Hamada H, Sasaki T, Asakawa S, Minoshima S, Ichida F, Joo K, Kimura M, Imamura S, Kamatani N, Momma K, Takao A, Nakazawa M, Shimizu N, Matsuoka R. 2003. Role of TBX1 in human del22q11.2 syndrome. Lancet 362:1366-1373.
38. Yelbuz TM, Waldo KL, Kumiski DH, Stadt HA, Wolfe RR, Leatherbury L, Kirby ML. 2002. Shortened outflow tract leads to altered cardiac looping after neural crest ablation. Circulation 106:504-510.
39. Zhang Z, Huynh T, Baldini A. 2006. Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development 133:3587-3595.