Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration

Hepatology Research

Volumn 41, Issue 12, 2011, Pages 1230-1239

  Wu, Yizhou ^a   Guo, Fuzheng ^a   Liu, Jin ^a   Xiao, Xueyuan ^a   Huang, Lingyun ^a   He, Dacheng ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Cell cycle; Hepatocyte; Kinetics; Liver regeneration; Proliferation

Indexed keywords

BROXURIDINE; CLOXURIDINE; IDOXURIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; LIVER CELL; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; STIMULATION;

EID: 82255181567     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00876.x     Document Type: Article

References (37)

1. Torre C, Perret C, Colnot S. Molecular determinants of liver zonation. In: Klaus HK, ed. Progress in Molecular Biology and Translational Science. New York: Academic Press, 2010; 127-50.
2. Jungermann K, Katz N. Functional specialization of different hepatocyte populations. Physiol Rev 1989; 69: 708-64.
3. Jungermann K, Katz N. Functional hepatocellular heterogeneity. Hepatology 1982; 2: S385-95.
4. Katz N. Methods for the study of liver cell heterogeneity. Histochem J 1989; 21: 517-29.
5. Racine L, Scoazec JY, Moreau A, Bernuau D, Feldmann G. Effects of digitonin on the intracellular content of rat hepatocytes: implications for its use in the study of intralobular heterogeneity. J Histochem Cytochem 1993; 41: 991-1001.
6. Braeuning A, Ittrich C, Köhle C etal. Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J 2006; 273: 5051-61.
7. Benhamouche S, Decaens T, Godard C etal. Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell 2006; 10: 759-70.
8. Grisham JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res 1962; 22: 842-9.
9. Baratta B, Rizzoli R, Galliani I etal. Early events of liver regeneration in rats: a multiparametric analysis. Histochem Cell Biol 1996; 105: 61-9.
10. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 2004; 5: 836-47.
11. Michalopoulos GK. Liver regeneration. J Cell Physiol 2007; 213: 286-300.
12. Michalopoulos GK. Liver regeneration. In: Monga S, ed. Molecular Pathology of Liver Diseases. New York: Springer US, 2011; 261-78.
13. Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010; 176: 2-13.
14. Higgins G, Anderson R. Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186-202.
15. Martins PNA, Theruvath TP, Neuhaus P. Rodent models of partial hepatectomies. Liver Int 2008; 28: 3-11.
16. Rotstein J, Macdonald PD, Rabes HM, Farber E. Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res 1984; 44: 2913-17.
17. Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 2001; 435: 406-17.
18. Kiel MJ, He S, Ashkenazi R etal. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature 2007; 449: 238-42.
19. Scimone ML, Meisel J, Reddien PW. The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development 2010; 137: 1231-41.
20. Emonet SF, Garidou L, McGavern DB, de la Torre JC. Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest. Proc Natl Acad Sci USA 2009; 106: 3473-8.
21. Croce AC, Ferrigno A, Vairetti M, Bertone R, Freitas I, Bottiroli G. Autofluorescence properties of isolated rat hepatocytes under different metabolic conditions. Photochem Photobiol Sci 2004; 3: 920-6.
22. March S, Graupera M, Rosa Sarrias M etal. Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule. Am J Pathol 2007; 170: 176-87.
23. Do H, Healey JF, Waller EK, Lollar P. Expression of factor VIII by murine liver sinusoidal endothelial cells. J Biol Chem 1999; 274: 19587-92.
24. Enomoto H, Nakamura H, Liu W etal. Hepatoma-derived growth factor is induced in liver regeneration. Hepatol Res 2009; 39: 988-97.
25. Yuan H, Zhang H, Wu X etal. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2009; 49: 240-9.
26. Kedem A, Perets A, Gamlieli-Bonshtein I, Dvir-Ginzberg M, Mizrahi S, Cohen S. Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes. Tissue Eng 2005; 11: 715-22.
27. Apte U, Gkretsi V, Bowen WC etal. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 2009; 50: 844-51.
28. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 60-6.
29. Sell S. Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 2001; 33: 738-50.
30. Marubashi S, Sakon M, Nagano H etal. Effect of portal hemodynamics on liver regeneration studied in a novel portohepatic shunt rat model. Surgery 2004; 136: 1028-37.
31. Yokoyama S, Yokoyama Y, Kawai T etal. Biphasic activation of liver regeneration-associated signals in an early stage after portal vein branch ligation. Biochem Biophys Res Commun 2006; 349: 732-9.
32. Lin PW. Hemodynamic changes after hepatectomy in rats studied with radioactive microspheres. J Formos Med Assoc 1990; 89: 177-81.
33. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-53.
34. Alison M. Liver stem cells: a two compartment system. Curr Opin Cell Biol 1998; 10: 710-15.
35. Alison MR, Islam S, Lim S. Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly. J Pathol 2009; 217: 282-98.
36. Guo F, Nian H, Zhang H etal. Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics 2006; 6: 3075-86.
37. Zhang Z, Chen J, Guo F etal. A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS ONE 2008; 3: e2991.