Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice

Hepatology

Volumn 49, Issue 1, 2009, Pages 240-249

  Yuan, Haixin ^a,b   Zhang, Hong ^a,b   Wu, Xunwei ^c   Zhang, Zhe ^a   Du, Dan ^a,b   Zhou, Wenchao ^a,b   Zhou, Shuhua ^a,b   Brakebusch, Cord ^d   Chen, Zhengjun ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN E; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; RAC1 PROTEIN; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; CYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DNA SYNTHESIS; ENZYME ACTIVATION; FEMALE; GENE DELETION; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; LIPID STORAGE; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; LIVER; LIVER DISEASE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CYCLINS; FEMALE; GENE DELETION; HEPATECTOMY; LIVER; LIVER DISEASES; LIVER REGENERATION; MALE; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 58949104651     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22610     Document Type: Article

References (43)

1. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276:60-66.
2. Servillo G, Della Fazia MA, Sassone-Corsi P. Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver. Genes Dev 1998;12:3639-3643.
3. Taub R. Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 2004;5:836-847.
4. Michalopoulos GK, Khan Z. Liver regeneration, growth factors, and amphiregulin. Gastroenterology 2005;128:503-506.
5. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. HEPATOLOGY 2006; 43:S45-S53.
6. Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. HEPATOLOGY 2004;40:1322-1332.
7. Fernandez MA, Albor C, Ingelmo-Torres M, Nixon SJ, Ferguson C, Kurzchalia T, et al. Caveolin-1 is essential for liver regeneration. Science 2006; 313:1628-1632.
8. Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006;312:233-236.
9. Olson MF, Ashworth A, Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995;269:1270-1272.
10. Bauerfeld CP, Hershenson MB, Page K. Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes. Am J Physiol Lung Cell Mol Physiol 2001;280:L974-L982.
11. Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001;3:950-957.
12. Gjoerup O, Lukas J, Bartek J, Willumsen BM. Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retino-blastoma susceptibility gene product hyperphosphorylation. J Biol Chem 1998;273:18812-18818.
13. Bagrodia S, Cerione RA. Pak to the future. Trends Cell Biol 1999;9:350-355.
14. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995;81:1137-1146.
15. Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GT-Pases Rac and Cdc42Hs. Cell 1995;81:1147-1157.
16. Chou MM, Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 1996;85:573-583.
17. Fang Y, Park IH, Wu AL, Du G, Huang P, Frohman MA, et al. PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol 2003;13:2037-2044.
18. Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420:629-635.
19. Tsukamoto K, Hirano K, Yamashita S, Sakai N, Ikegami C, Zhang Z, et al. Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: A possible function of Cdc42 in mediating intracellular lipid transport. Arterioscler Thromb Vasc Biol 2002;22:1899-1904.
20. van Hengel J, D'Hooge P, Hooghe B, Wu X, Libbrecht L, De Vos R, et al. Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. Gastroenterology 2008;134:781-792.
21. Benard V, Bohl BP, Bokoch GM. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem 1999;274:13198-13204.
22. Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004;126:322-342.
23. Fausto N. Liver regeneration. J Hepatol 2000;32:19-31.
24. Nofer JR, Remaley AT, Feuerborn R, Wolinnska I, Engel T, von Eckardstein A, et al. Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J Lipid Res 2006;47:794-803.
25. Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995;81:53-62.
26. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, et al. Phosphorylation and activation of p70s6k by PDK1. Science 1998;279:707-710.
27. Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A 1998;95:1432-1437.
28. Cimica V, Batusic D, Chen Y, Hollemann T, Pieler T, Ramadori G. Transcriptome analysis of rat liver regeneration in a model of oval hepatic stem cells. Genomics 2005;86:352-364.
29. Czuchra A, Wu X, Meyer H, van Hengel J, Schroeder T, Geffers R, et al. Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells. Mol Biol Cell 2005;16: 4473-4484.
30. Yang L, Wang L, Zheng Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol Biol Cell 2006;17:4675-4685.
31. Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, et al. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 2005;7:270-277.
32. Stolz DB, Mars WM, Petersen BE, Kim TH, Michalopoulos GK. Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Cancer Res 1999;59:3954-3960.
33. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007;28:940-946.
34. Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 2007;67:863-867.
35. Chou MM, Masuda-Robens JM, Gupta ML. Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression. J Biol Chem 2003;278:35241-35247.
36. Li W, Chong H, Guan KL. Function of the Rho family GTPases in Ras-stimulated Raf activation. J Biol Chem 2001;276:34728-34737.
37. Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, et al. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol Biol Cell 1998;9:561-573.
38. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, et al. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. HEPATOLOGY 2003; 37:824-832.
39. Bessard A, Coutant A, Rescan C, Ezan F, Fremin C, Courselaud B, et al. An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway. HEPATOLOGY 2006;44:152-163.
40. Coutant A, Rescan C, Gilot D, Loyer P, Guguen-Guillouzo C, Baffet G. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. HEPATOLOGY 2002;36:1079-1088.
41. Liu Y, Gorospe M, Kokkonen GC, Boluyt MO, Younes A, Mock YD, et al. Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes. Exp Cell Res 1998;240:40-48.
42. Volarevic S, Stewart MJ, Ledermann B, Zilberman F, Terracciano L, Montini E, et al. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science 2000;288:2045-2047.
43. Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110:163-175.