Effect of Glycine on the cyclooxygenase pathway of the kidney arachidonic acid metabolism in a rat model of metabolic syndrome

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 12, 2011, Pages 899-910

  Pérez Torres, Israel ^a   Ibarra, Blanca ^a   Soria Castro, Elizabeth ^a   Torrico Lavayen, Rocío ^a   Pavón, Natalia ^a   Diaz Diaz, Eulises ^b   Flores, Pedro L ^a   Infante, Oscar ^a   Baños, Guadalupe ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Arachidonic acid; Cyclooxigenase; Eicosanoids; Glycine; Glycine receptor; Metabolic syndrome; Renal failure

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; GLUCOSE; GLYCINE; INSULIN; PROSTAGLANDIN SYNTHASE; SUCROSE; TRIACYLGLYCEROL; ANTIINFLAMMATORY AGENT;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; HYPERTENSION; KIDNEY MASS; KIDNEY METABOLISM; KIDNEY PERFUSION; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; ANIMAL; BLOOD PRESSURE; BODY WEIGHT; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; BLOOD PRESSURE; BODY WEIGHT; DISEASE MODELS, ANIMAL; GLYCINE; KIDNEY; MALE; METABOLIC SYNDROME X; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 82155197278     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y11-086     Document Type: Article

References (48)

1. Alavi, F.K., Zawada, E.T., and Simmons, J.L. 1995. Renal hemodynamic and histological consequences of diets high in unsaturated fat, protein or sucrose in obese Zucker rats. Clin. Nephrol. 43(2): 122-130 PMID:7736674.
2. Baines, A.D., Shaikh, N., and Ho, P. 1990. Mechanisms of perfusedkidney cytoprotection by alanine and glycine. Am. J. Physiol. 259(1): F80-F87PMID:2375394.
3. Balsinde, J., and Balboa, M.A. 2005. Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells. Cell. Signal. 17(9): 1052-1062doi:10.1016/j.cellsig.2005.03.002. PMID:15993747.
4. Baños, G., Carvajal, K., Cardoso, G., Zamora, J., and Franco, M. 1997. Vascular reactivity and effect of serum in a rat model of hypertriglyceridemia and hypertension. Am. J. Hypertens. 10(4): 379-388PMID:9128203.
5. Baños, G., Pérez-Torres, I., and El Hafidi, M. 2008. Medicinal agentsin the metabolic syndrome. Cardiovasc. Hematol. Agents Med. Chem. 6(4): 237-252doi:10.2174/187152508785909465. PMID: 18855636.
6. BenGershôm, E. 1975. Screening for albuminuria: A case for estimation of albumin in urine. Clin. Chem. 21(12): 1795-1798. PMID:1182999.
7. Brawley, L., Torrens, C., Anthony, F.W., Itoh, S., Wheeler, T.,Jackson, A.A., et al. 2004. Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. J. Physiol. 554(2): 497-504. doi:10.1113/jphysiol.2003.052068. PMID: 14578485.
8. Carvajal Sandoval, G., Medina Santillán, R., Juárez, E., RamosMartínez, G., and Carvajal Juárez, M.E. 1999. Effect of glycine on hemoglobin glycation in diabetic patients. Proc. West. Pharmacol. Soc. 42: 31-32PMID:10697680.
9. Danysz, W., and Parsons, C.G. 1998. Glycine and N-methyl-Daspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev. 50(4): 597-664. PMID:9860805.
10. Dey, A., Williams, R.S., Pollock, D.M., Stepp, D.W., Newman, J.W.,Hammock, B.D., and Imig, J.D. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes. Res. 12(8): 1278-1289. doi:10.1038/oby. 2004.162. PMID:15340111.
11. Dubois, R.N., Abramson, S.B., Crofford, L., Gupta, R.A., Simon, L.S., Van De Putte L.B., and Lipsky, P.E. 1998. Cyclooxygenase in biology and disease. FASEB J. 12(12): 1063-1073PMID:9737710
12. El Hafidi, M., Pérez-Torres, I., Zamora, J., Soto, V., Carvajal-Sandoval, G., and Baños, G. 2004. Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287(6): R1387-R1393doi:10.1152/ajpregu.00159.2004. PMID:15331379.
13. El Hafidi, M., Pérez-Torres, I., and Baños, G. 2006. Is glycine effective against elevated blood pressure? Curr. Opin. Clin. Nutr. Metab. Care, 9(1): 26-31. doi:10.1097/01.mco.0000196143. 72985.9a. PMID:16444815.
14. Folch, L.M., and Sloane-Stanley, C.H. 1957. A simple method for theisolation and purification of total lipids from animal tissues. J. Biol. Chem. 226(1): 697-709.
15. Froh, M., Thurman, R.G., and Wheeler, M.D. 2002. Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283(4): G856-G863. PMID:12223345.
16. Gannon, M.C., Nuttall, J.A., and Nuttall, F.Q. 2002. The metabolicresponse to ingested glycine. Am. J. Clin. Nutr. 76(6): 1302-1307.PMID:12450897.
17. Garaulet, M., Pérez-Llamas, F., Pérez-Ayala, M., Martínez, P., deMedina, F.S., Tebar, F.J., and Zamora, S. 2001. Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am. J. Clin. Nutr. 74(5): 585-591. PMID: 11684525.
18. Hao, C.M., and Breyer, M.D. 2004. Hypertension and cyclooxygen-ase-2 inhibitors target: the renal medulla. Hypertension, 44(4): 396-397. doi:10.1161/01.HYP.0000140925.73081.4c. PMID: 15314033.
19. Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N.,and Breyer, M.D. 1994. Cyclooxygenase-2 is associated with the macula densa in rat kidney and increases with salt restriction. J. Clin. Invest. 94(6): 2504-2510. doi:10.1172/JCI117620 PMID: 7989609.
20. Inyard, A.C., Chong, D.G., Klibanov, A.L., and Barrett, E.J. 2009. Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance. Diabetes, 58(11): 2457-2463. doi:10.2337/db08-1077. PMID:19675134.
21. Li, X., Bradford, B.U., Wheeler, M.D., Stimpson, S.A., Pink, H.M.,Brodie, T.A., et al. 2001. Dietary glycine prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role forglycine-gated chloride channel. Infect. Immun. 69(9): 5883-5891. doi:10.1128/IAI.69.9.5883-5891.2001. PMID:11500467
22. Lin, C.Y., Chen, M.F., Lin, L.Y., Liau, C.S., Lee, Y.T., and Su, T.C. 2008. Insulin resistance is the major determinant for microalbuminuria in severe hypertriglyceridemia: implication for high-risk stratification. Intern. Med. 47(12): 1091-1097. doi:10.2169/ internalmedicine.47.0696. PMID:18552465.
23. Maruyama, Y. 1990. Inhibitory effects of arachidonic acid on muscarinic current response in single pancreatic acinar cells of rats. J. Physiol. 430: 471-482. PMID:2086771.
24. Matilla, B., Mauriz, J.L., Culebras, J.M., González-Gallego, J., andGonzález, P. 2002. La glicina: un nutriente antioxidante protector celular [Glycine: a cell-protecting anti-oxidant nutrient.] Nutr. Hosp. 17(1): 2-9. PMID:11939124.
25. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., and Turner, R.C. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7): 412-419. doi:10.1007/BF00280883. PMID:3899825.
26. Müller, W.A., Aoki, T.T., and Cahill, G.F., Jr. 1975. Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man. J. Clin. Endocrinol. Metab. 40(3): 418-425. doi:10. 1210/jcem-40-3-418. PMID:1117054.
27. Nielsen, C.B., Flyvbjerg, A., Bruun, J.M., Forman, A., Wogensen, L.,and Thomsen, K. 2003. Decreases in renal functional reserve and proximal tubular fluid output in conscious oophorectomized rats: normalization with sex hormone substitution. J. Am. Soc. Nephrol. 14(12): 3102-3110. doi:10.1097/01.ASN.0000096262.18679.25. PMID:14638909.
28. Pan, C., Bai, X., Fan, L., Ji, Y., Li, X., and Chen, Q. 2005. Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells. Biochem. J. 390(2): 447-453. doi:10.1042/BJ20050141. PMID:15836436.
29. Pérez-Torres, I., El Hafidi, M., Sanchez, C., and Baños, G. 1999. Effect or sugar-induced hypertension in rats on the pattern of serum arachidonic, dihomo-g-linoleic and linoleic acids. Med. Sci. Res. 27: 847-849.
30. Pérez-Torres, I., El Hafidi, M., Zamora-González, J., Infante, O.,Chavira, R., and Baños, G. 2007. Modulation of aortic vascular reactivity by sex hormones in a male rat model of metabolic syndrome. Life Sci. 80(23): 2170-2180. doi:10.1016/j.lfs.2007.04. 006. PMID:17499811.
31. Pérez-Torres, I., Roque, P., El Hafidi, M., Diaz-Diaz, E., and Baños,G. 2009. Association of renal damage and oxidative stress in a rat model of metabolic syndrome: Influence of gender. Free Radic. Res. 43(8): 761-771. doi:10.1080/10715760903045296. PMID: 19526391.
32. Pérez-Torres, I., El Hafidi, M., Pavón, N., Infante, O., Avila-Casado, M.C., and Baños, G. 2010. Effect of gonadectomy on the metabolism of arachidonic acid in isolated kidney of a rat model of metabolic syndrome. Metabolism, 59(3): 414-423
33. Pérez-Torres, I., Guarner, V., El Hafidi, M., and Baños, G. 2011. Sexhormones, metabolic syndrome and hidney. Curr. Top. Med. Chem. 11(13): 1694-1705. doi:10.2174/156802611796117577. PMID:21463253.
34. Qu, W., Ikejima, K., Zhong, Z., Waalkes, M.P., and Thurman, R.G.2002. Glycine blocks the increase in intracellular free Ca2+ due to vasoactive mediators in hepatic parenchymal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 283(6): G1249-G1256. PMID: 12388211
35. Quilley, J., and Chen, Y. 2003. Role of COX-2 in the enhancedvasoconstrictor effect of arachidonic acid in the diabetic rat kidney. Hypertension, 42(4): 837-843. doi:10.1161/01.HYP.0000085650. 29823.F2. PMID:12900435.
36. Reaven, G.M., and Ho, H. 1991. Sugar-induced hypertension inSprague-Dawley rats. Am. J. Hypertens. 4(7): 610-614. PMID: 1873016.
37. Silva, P., Rosen, S., Spokes, K., and Epstein, F.H. 1991. Effect ofglycine on medullary thick ascending limb injury in perfused kidneys. Kidney Int. 39(4): 653-658. doi:10.1038/ki.1991.78. PMID:2051722.
38. Soodvilai, S., Jia, Z., and Yang, T. 2007. Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2. Am. J. Physiol. Renal Physiol. 293(5): F1571-F1576. doi:10.1152/ajprenal.00132.2007. PMID:17699556.
39. Tajiri, Y., Inoguchi, T., Umeda, F., and Nawata, H. 1990. Reductionurinary albumin excretion by thromboxane synthetase inhibitor, OKY-046, through modulating renal prostaglandins in patients with diabetic nephropathy. Diabetes Res. Clin. Pract. 10(3): 231-239. doi:10.1016/0168-8227(90)90066-3. PMID:2073870.
40. Tijsen, M.J., Peters, S.M., Bindels, R.J., Van Os, C.H., and Wetzels, J. F. 1997. Glycine protection against hypoxic injury in isolated ratproximal tubules: the role of proteases. Nephrol. Dial. Transplant.12(12): 2549-2556. doi:10.1093/ndt/12.12.2549. PMID:9430850
41. Vázquez, B., López, P., Talamás, P., and Escalante, B. 2000. Increased renal vasoconstriction and gene expression of cyclooxygenase-1 inrenovascular hypertension. J. Cardiovasc. Pharmacol. 36(5): 577-583. doi:10.1097/00005344-200011000-00006. PMID:11065217
42. Weinberg, J.M., Davis, J.A., Abarzua, M., Smith, R.K., and Kunkel, R. 1990. Ouabain-induced lethal proximal tubule cell injury is prevented by glycine. Am. J. Physiol. 258(2): F346-F355
43. Wheeler, M.D., Ikejema, K., Enomoto, N., Stacklewitz, R.F., Seabra,V., Zhong, Z., et al. 1999. Glycine: a new anti-inflammatory immunonutrient. Cell. Mol. Life Sci. 56(9-10): 843-856 doi:10. 1007/s000180050030. PMID:11212343
44. Zeman, M., Vecka, M., Jáchymová, M., Jirák, R., Tvrzická, E.,Stanková, B., and Zák, A. 2009. Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression. Tohoku J. Exp. Med. 217(4): 287-293. doi:10.1620/tjem.217.287. PMID:19346733
45. Zewde, T., and Mattson, L. 2004. Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension. Hypertension, 44(4): 424-428. doi:10.1161/01.HYP.0000140924. 91479.03. PMID:15314032.
46. Zhong, Z., Arteel, G.E., Connor, H.D., Yin, M., Frankenberg, M.V., Stachlewitz, R.F., et al. 1998. Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am. J. Physiol. 275(4): F595-F604 PMID:9755131
47. Zhong, Z., Connor, H.D., Yin, M., Moss, N., Mason, R.P., Bunzendahl, H., et al. 1999. Dietary glycine and renal denervation prevents cyclosporin A-induced hydroxyl radical production in rat kidney. Mol. Pharmacol. 56(3): 455-463. PMID:10462532.
48. Zhong, Z., Wheeler, M.D., Li, X., Froh, M., Schemmer, P., Yin, M., et al. 2007. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr. Opin. Clin. Nutr. Metab. Care 6(2): 550-562. PMID:12589194.