Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 12, 2011, Pages 875-882

  Zhao, Xi ^a,b   Chao, Yong Lie ^a   Wan, Qian Bing ^a   Chen, Xin Min ^a   Su, Peng ^b   Sun, Jian ^b   Tang, Yaxiong ^b  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU INSTITUTE OF BIOLOGY   (China)

Author keywords

ACC 2; Apoptosis; Bcl 2; Bim; Flavokawain B (FKB)

Indexed keywords

BIM PROTEIN; CASPASE 3; CYTOCHROME C; FLAVOKAWAIN B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; BCL2L15 PROTEIN, HUMAN; CHALCONE; FLAVONOID; MEMBRANE PROTEIN; ONCOPROTEIN;

ADENOID CYSTIC CARCINOMA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; IC50; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MITOCHONDRION; MOUTH TUMOR; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, ADENOID CYSTIC; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONE; DOWN-REGULATION; FLAVONOIDS; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INHIBITORY CONCENTRATION 50; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE PROTEINS; MITOCHONDRIA; MOUTH NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; UP-REGULATION;

EID: 82155192852     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y11-088     Document Type: Article

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