Novel mechanically competent polysaccharide scaffolds for bone tissue engineering

Biomedical Materials

Volumn 6, Issue 6, 2011, Pages

  Kumbar, S G ^a,b   Toti, U S ^a   Deng, M ^a   James, R ^a   Laurencin, C T ^a,b   Aravamudhan, A ^a   Harmon, M ^a,b   Ramos, D M ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEARINGS (MACHINE PARTS); BIOCOMPATIBILITY; BONE; CELLULOSE; COMPRESSIVE STRENGTH; DIALYSIS; DIALYSIS MEMBRANES; FUNCTIONAL POLYMERS; HYDROGEN; HYDROGEN BONDS; LACTIC ACID; MECHANICAL PROPERTIES; OSTEOBLASTS; PHOSPHATASES; SINTERING; STRESS-STRAIN CURVES; THREE DIMENSIONAL; TISSUE;

3D SCAFFOLDS; ALKALINE PHOSPHATASE; BIOLOGICAL PROPERTIES; BONE REGENERATION; BONE TISSUE ENGINEERING; COMPRESSIVE MODULI; ELASTIC REGION; GLYCOSIDIC LINKAGES; HUMAN OSTEOBLAST; HUMAN TRABECULAR BONE; LOAD-BEARING; MEDICAL HISTORY; OSTEOBLAST PHENOTYPE; PHARMACEUTICAL EXCIPIENT; PORE PROPERTY; THREE-DIMENSIONAL (3D); TIME POINTS; TISSUE ENGINEERING APPLICATIONS; WEIGHT LOSS;

SCAFFOLDS (BIOLOGY);

ALKALINE PHOSPHATASE; CELLULOSE; POLYGLACTIN; POLYSACCHARIDE; TISSUE SCAFFOLD;

ARTICLE; BONE REGENERATION; BONE TISSUE ENGINEERING; CELL CULTURE; CELL GROWTH; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEGRADATION; ELASTICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROTECHNOLOGY; MINERALIZATION; OSTEOBLAST; PROTEIN EXPRESSION; TENSILE STRENGTH; TISSUE ENGINEERING; TRABECULAR BONE; BONE DEVELOPMENT; BONE PROSTHESIS; CHEMISTRY; COMPRESSIVE STRENGTH; EQUIPMENT; HARDNESS; INSTRUMENTATION; MATERIALS TESTING; PHYSIOLOGY; PROSTHESIS; SYNTHESIS; YOUNG MODULUS;

BONE SUBSTITUTES; CELLS, CULTURED; COMPRESSIVE STRENGTH; ELASTIC MODULUS; EQUIPMENT FAILURE ANALYSIS; HARDNESS; HUMANS; MATERIALS TESTING; OSTEOBLASTS; OSTEOGENESIS; POLYSACCHARIDES; PROSTHESIS DESIGN; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 81855220911     PISSN: 17486041     EISSN: 1748605X     Source Type: Journal    
DOI: 10.1088/1748-6041/6/6/065005     Document Type: Article

References (55)

1. Jahangir A A, Nunley R M, Mehta S and Sharan A 2008 Bone-graft substitutes in orthopaedic surgery AAOS Now 2 http://www.aaos.org/news/aaosnow/ jan08/reimbursement2. asp
2. Deng M, Kumbar S G, Wan Y, Toti U S, Allcock H R and Laurencin C T 2010 Polyphosphazene polymers for tissue engineering: an analysis of material synthesis, characterization and applications Soft Matter 6 3119-32
3. Jiang T et al. 2010 Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: in vitro degradation and in vivo bone regeneration studies Acta Biomater. 6 3457-70
4. Deng M, Kumbar S G, Nair L S, Weikel A L, Allcock H R and Laurencin C T 2011 Biomimetic structures: biological implications of dipeptide-substituted polyphosphazene-polyester blend nanofiber matrices for load-bearing bone regeneration Adv. Funct. Mater. 21 2641-51
5. Svensson A et al. 2005 Bacterial cellulose as a potential scaffold for tissue engineering of cartilage Biomaterials 26 419-31 (Pubitemid 38951109)
6. Fricain J C, Granja P L, Barbosa M A, de JÈso B, Barthe N and Baquey C 2002 Cellulose phosphates as biomaterials: in vivo biocompatibility studies Biomaterials 23 971-80
7. Deng M et al. 2010 Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering Biomaterials 31 4898-908
8. Kofron M D, Griswold A, Kumbar S G, Martin K, Wen X J and Laurencin C T 2009 The implications of polymer selection in regenerative medicine: a comparison of amorphous and semi-crystalline polymer for tissue regeneration Adv. Funct. Mater. 19 1351-9
9. Kofron M D, Cooper J A Jr, Kumbar S G and Laurencin C T 2007 Novel tubular composite matrix for bone repair J. Biomed. Mater. Res. A 82 415-25 (Pubitemid 47051673)
10. Brown J L, Peach M S, Nair L S, Kumbar S G and Laurencin C T 2010 Composite scaffolds: bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs J. Biomed. Mater. Res A 95 1150-8
11. Hamadouche M and Sedel L 2000 Ceramics in orthopaedics J. Bone Joint Surg. Br. 82 1095-9
12. Deng M, Kumbar S G, Lo K W H, Ulery B D and Laurencin C T 2011 Novel polymer-ceramics for bone repair and regeneration Recent Pat. Biomed. Eng. 4 168-84
13. Laurencin C, Khan Y and El-Amin S F 2005 Bone graft substitutes Expert Rev. Med. Devices 3 49-57
14. Borden M, Attawia M, Khan Y, El-Amin S F and Laurencin CT 2004 Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix J. Bone Joint Surg. Br. 86 1200-8 (Pubitemid 39545613)
15. Borden M, El-Amin S F, Attawia M and Laurencin C T 2003 Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair Biomaterials 24 597-609 (Pubitemid 35346389)
16. Attawia MA, Uhrich K E, Botchwey E, Langer R and Laurencin C T 1996 In vitro bone biocompatibility of poly(anhydride-co-imides) containing pyromellitylimidoalanine J Orthop. Res. 14 445-54 (Pubitemid 26199834)
17. Kumbar S G, Bhattacharyya S, Nukavarapu S P, Khan Y M, Nair L S and Laurencin C T 2006 In vitro and in vivo characterization of biodegradable poly(organophosphazenes) for biomedical applications J. Inorg. Organomet. Polym. Mater. 16 365-85
18. Chao Z et al. 2006 A study on a tissue-engineered bone using rhBMP-2 induced periosteal cells with a porous nano-hydroxyapatite/collagen/poly(L- lactic acid) scaffold Biomed. Mater. 1 56
19. Athanasiou K A, Agrawal C M, Barber FA and Burkhart S S 1998 Orthopaedic applications for PLA-PGA biodegradable polymers Arthroscopy 14 726-37 (Pubitemid 28465604)
20. Taylor M S, Daniels A U, Andriano K P and Heller J 1994 Six bioabsorbable polymers: in vitro acute toxicity of accumulated degradation products J. Appl. Biomater. 5 151-7
21. Mano J F et al. 2007 Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends J. R. Soc. Interface 4 999-1030 (Pubitemid 350303872)
22. Zigang G et al. 2008 Manufacture of degradable polymeric scaffolds for bone regeneration Biomed. Mater. 3 022001
23. Lv Q, Nair L and Laurencin C T 2009 Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors. J. Biomed. Mater. Res. A 91 679-91
24. Athanasiou K A, Zhu C-F, Lanctot D R, Agrawal C M and Wang X 2000 Fundamentals of biomechanics in tissue engineering of bone Tissue Eng. 6 361-81 (Pubitemid 30655946)
25. Arpornmaeklong P, Pripatnanont P and Suwatwirote N 2008 Properties of chitosan-collagen sponges and osteogenic differentiation of rat-bone-marrow stromal cells Int. J. Oral Maxillofac. Surg. 37 357-66 (Pubitemid 351446104)
26. Kucharska M, Walenko K, Butruk B, Brynk T, Heljak M and Ciach T 2010 Fabrication and characterization of chitosan microspheres agglomerated scaffolds for bone tissue engineering Mater. Lett. 64 1059-62
27. Gomes M E, Godinho J S, Tchalamov D, Cunha A M and Reis R L 2002 Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties Mater. Sci. Eng. C 20 19-26 (Pubitemid 34718474)
28. Voet D, Voet J G and Pratt C W 2006 Fundamentals of Biochemistry: Life at The Molecular Level (New York: Wiley)
29. Entcheva E, Bien H, Yin L, Chung CYC-Y, Farrell M and Kostov Y 2004 Functional cardiac cell constructs on cellulose-based scaffolding Biomaterials 25 5753-62 (Pubitemid 38624455)
30. Märtson M, Viljanto J, Hurme T, Laippala P and Saukko P 1999 Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat Biomaterials 20 1989-95 (Pubitemid 29447620)
31. Märtson M, Viljanto J, Hurme T and Saukko P 2000 Biocompatibility of cellulose sponge with bone Eur. Surg. Res. 30 426-32 (Pubitemid 28561063)
32. Jiang T, Abdel-Fattah W I and Laurencin C T 2006 In vitro evaluation of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering Biomaterials 27 4894-903 (Pubitemid 43866923)
33. Deng M et al. 2008 Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid) Biomaterials 29 337-49 (Pubitemid 350060980)
34. Deng M et al. 2010 Biomimetic, bioactive etheric polyphosphazene- poly(lactide-co-glycolide) blends for bone tissue engineering J. Biomed. Mater. Res. A 92 114-25
35. Brown J L, Nair L S and Laurencin C T 2008 Solvent/non-solvent sintering: a novel route to create porous microsphere scaffolds for tissue regeneration J. Biomed. Mater. Res. B 86 396-406
36. Nukavarapu S P et al. 2008 Polyphosphazene/nanohydroxyapatite composite microsphere scaffolds for bone tissue engineering Biomacromolecules 9 1818-25
37. Carter D R and Hayes W C 1977 The compressive behavior of bone as a two-phase porous structure J. Bone Joint Surg. 59 954-62 (Pubitemid 8218257)
38. Yanoso-Scholl L et al. 2010 Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering J. Biomed. Mater. Res. A 95 717-26
39. Spence J 1941 Solvents and the structures of cellulosic sheets J. Phys. Chem. 45 401-10
40. Franz G 1986 Polysaccharides in pharmacy Adv. Polym. Sci. 76 1-30
41. Dumitriu S 1996 Polysaccharides in Medicinal Applications (Boca Raton, FL: CRC Press)
42. Krässig H and Stannett V 1965 Graft Co-Polymerization To Cellulose And Its Derivatives (Berlin Heidelberg: Springer) pp 111-56
43. Miyamoto T, Takahashi S, Ito H, Inagaki H and Noishiki Y 1989 Tissue biocompatibility of cellulose and its derivatives J. Biomed. Mater. Res. 23 125-33 (Pubitemid 19031257)
44. Granja P, De JÈso B, Bareille R, Rouais F, Baquey C and Barbosa M 2005 Mineralization of regenerated cellulose hydrogels induced by human bone marrow stromal cells Eur. Cell Mater. 10 31-9
45. Dias G, Peplow P and Teixeira F 2003 Osseous regeneration in the presence of oxidized cellulose and collagen J. Mater. Sci. Mater. Med. 14 739-45 (Pubitemid 37047067)
46. Uysal A, Ozbek S and Ozcan M 2003 Comparison of the biological activities of high-density porous polyethylene implants and oxidized regenerated cellulose-wrapped diced cartilage grafts Plast. Reconstr. Surg. 112 540
47. Galgut P 1990 Oxidized cellulose mesh: I. Biodegradable membrane in periodontal surgery Biomaterials 11 561-4 (Pubitemid 20367831)
48. Granja P, Ribeiro C, De JÈso B, Baquey C and Barbosa M 2001 Mineralization of regenerated cellulose hydrogels J. Mater. Sci. Mater. Med. 12 785-91
49. Hulbert S, Young F, Mathews R, Klawitter J, Talbert C and Stelling F 1970 Potential of ceramic materials as permanently implantable skeletal prostheses J. Biomed. Mater. Res. 4 433-56
50. Martins A M et al. 2009 Natural stimulus responsive scaffolds/cells for bone tissue engineering: influence of lysozyme upon scaffold degradation and osteogenic differentiation of cultured marrow stromal cells induced by CaP coatings Tissue Eng. A 15 1953-63
51. Guohua Z, Ya L, Cuilan F, Min Z, Caiqiong Z and Zongdao C 2006 Water resistance, mechanical properties and biodegradability of methylated-cornstarch/ poly(vinyl alcohol) blend film Polym. Deg. Stab. 91 703-11 (Pubitemid 43052738)
52. Gopferich A 1996 Mechanisms of polymer degradation and erosion Biomaterials 17 103-14 (Pubitemid 26031366)
53. Deng M et al. 2010 In situ porous structures: a unique polymer erosion mechanism in biodegradable dipeptide-based polyphosphazene and polyester blends producing matrices for regenerative engineering Adv. Funct. Mater. 20 2794-806
54. Elcin A E 2006 In vitro and in vivo degradation of oxidized acetyl- and ethyl-cellulose sponges Artif. Cells Blood Substit. Immobil. Biotechnol. 34 407-18 (Pubitemid 44024994)
55. Kim U J, Kuga S, Wada M, Okano T and Kondo T 2000 Periodate oxidation of crystalline cellulose Biomacromolecules 1 488-92