Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs

Journal of Biomedical Materials Research - Part A

Volumn 95, Issue 4, 2010, Pages 1150-1158

  Brown, Justin L ^a   Peach, M Sean ^b   Nair, Lakshmi S ^c   Kumbar, Sangamesh G ^c   Laurencin, Cato T ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

biomaterials; microsphere; nanofiber; osteoblast; polyphosphazene

Indexed keywords

BIOMIMETIC PROPERTIES; CELL MIGRATION; COMPOSITE SCAFFOLDS; FOCAL ADHESION KINASE; MASS LOSS; MATRIX; MECHANICAL ASPECTS; MECHANICAL ENVIRONMENT; MECHANICAL MODULUS; NOVEL STRUCTURES; OSTEOBLAST MARKERS; OSTEOBLAST PROGENITORS; OSTEOCALCIN; POLYPHOSPHAZENES; TRABECULAR BONES;

ADHESION; BIOLOGICAL MATERIALS; BIOMIMETICS; BONE; COMPRESSIVE STRENGTH; CYTOLOGY; MECHANICAL PROPERTIES; MICROSPHERES; NANOFIBERS; SINTERING; TISSUE ENGINEERING; TRANSCRIPTION FACTORS;

SCAFFOLDS;

FOCAL ADHESION KINASE; MICROSPHERE; NANOFIBER; OSTEOCALCIN; TISSUE SCAFFOLD; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BIOMECHANICS; BIOMIMETICS; CELL MIGRATION; COMPOSITE MATERIAL; COMPRESSIVE STRENGTH; CONTROLLED STUDY; ENZYME ACTIVITY; OSTEOBLAST; PHENOTYPE; STEM CELL; TISSUE ENGINEERING; TRABECULAR BONE;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL MARKERS; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE KNOCKDOWN TECHNIQUES; MATERIALS TESTING; MECHANICAL PHENOMENA; MICE; MICROSPHERES; NANOFIBERS; OSTEOBLASTS; PHENOTYPE; TISSUE SCAFFOLDS;

EID: 78449309123     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32934     Document Type: Article

References (33)

1. Langer R, Vacanti JP,. Tissue engineering. Science 1993; 260: 920-926.
2. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
3. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT,. Tissue engineering of bone: material and matrix considerations. J Bone Joint Surg Am 2008; 90 (Suppl 1): 36-42.
4. Ge Z, Jin Z, Cao T,. Manufacture of degradable polymeric scaffolds for bone regeneration. Biomed Mater 2008; 3: 22001.
5. Laurencin C, Borden M,. Methods for using microsphere polymers in bone replacement matrixes and composition produced thereby. U.S. 1999; 9: 96-749772.
6. Borden M, El-Amin SF, Attawia M, Laurencin CT,. Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 2003; 24: 597-609.
7. Borden M, Attawia M, Khan Y, El-Amin SF, Laurencin CT,. Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix. J Bone Joint Surg Br 2004; 86: 1200-1208.
8. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
9. Woo KM, Jun J, Chen VJ, Seo J, Baek JH, Ryoo HM, Kim GS, Somerman MJ, Ma PX,. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 2007; 28: 335-343.
10. Hu J, Liu X, Ma PX,. Induction of osteoblast differentiation phenotype on poly(L-lactic acid) nanofibrous matrix. Biomaterials 2008; 29: 3815-3821.
11. Christenson EM, Anseth KS, van den Beucken JJ, Chan CK, Ercan B, Jansen JA,. Nanobiomaterial applications in orthopedics. J Orthop Res 2007; 25: 11-22.
12. Song JH, Kim HE, Kim HW,. Electrospun fibrous web of collagen-apatite precipitated nanocomposite for bone regeneration. J Mater Sci Mater Med 2008; 19: 2925-2932.
13. Yoshimoto H, Shin YM, Terai H, Vacanti JP,. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 2003; 24: 2077-2082.
14. Ma Z, Kotaki M, Inai R, Ramakrishna S,. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng 2005; 11: 101-109.
15. Kjelstrup-Hansen J, Hansen O, Rubahn HG, Boggild P,. Mechanical properties of organic nanofibers. Small 2006; 2: 660-666.
16. Toole BP, Linsenmayer TF,. Newer knowledge of skeletogenesis: macromolecular transitions in the extracellular matrix. Clin Orthop Relat Res 1977; 129: 258-278.
17. Ma PX, Zhang R,. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 1999; 46: 60-72.
18. Brown JL, Nair LS, Laurencin CT,. Solvent/non-solvent sintering: A novel route to create porous microsphere scaffolds for tissue regeneration. J Biomed Mater Res B Appl Biomater 2008; 86B: 396-406.
19. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543.
20. Burkersroda Fv, Schedl L, GÃpferich A,. Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials 2002; 23: 4221-4231.
21. Kim K, Yu M, Zong X, Chiu J, Fang D, Seo YS,. Control of degradation rate and hydrophilicity in electrospun non-woven poly(D,L-lactide) nanofiber scaffolds for biomedical applications. Biomaterials 2003; 24: 4977-4985.
22. Allcock HR, Pucher SR, Scopelianos AG,. Poly[(amino acid ester)phosphazenes]: Synthesis, crystallinity, and hydrolytic sensitivity in solution and the solid state. Macromolecules 1994; 27: 1071-1075.
23. Bilezikian JP, Raisz LG, Rodan GA,. Princ Bone Biol 2002; 1
24. Franz-Odendaal TA, Hall BK, Witten PE,. Buried alive: How osteoblasts become osteocytes. Dev Dyn 2006; 235: 176-190.
25. Kim JB, Leucht P, Luppen CA, Park YJ, Beggs HE, Damsky CH, Helms JA,. Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone 2007; 41: 39-51.
26. Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Gothert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA,. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol 2008; 181: 43-50.
27. Wozniak MA, Modzelewska K, Kwong L, Keely PJ,. Focal adhesion regulation of cell behavior. BBA-Mol Cell Res 2004; 1692: 103-119.
28. Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS,. An inhibitory role for FAK in regulating proliferation: A link between limited adhesion and RhoA-ROCK signaling. J Cell Biol 2006; 174: 277-288.
29. Boutahar N, Guignandon A, Vico L, Lafage-Proust MH,. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem 2004; 279: 30588-30599.
30. Bartlett DW, Davis ME,. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res 2006; 34: 322-333.
31. Schroeder TM, Jensen ED, Westendorf JJ,. Runx2: A master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res Part C Embryo Today 2005; 75: 213-225.
32. Makita N, Suzuki M, Asami S, Takahata R, Kohzaki D, Kobayashi S,., Hakamazuka T, Hozumi N,. Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells. Gene 2008; 413: 8-17.
33. Cowles EA, DeRome ME, Pastizzo G, Brailey LL, Gronowicz GA,. Mineralization and the expression of matrix proteins during in vivo bone development. Calcif Tissue Int 1998; 62: 74-82.