Biomimetic, bioactive etheric polyphosphazenepoly(lactide-co-glycolide) blends for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 1, 2010, Pages 114-125

  Deng, Meng ^a,b   Nair, Lakshmi S ^a   Nukavarapu, Syam P ^a   Kumbar, Sangamesh G ^a   Brown, Justin L ^c   Krogman, Nicholas R ^d   Weikel, Arlin L ^d   Allcock, Harry R ^d   Laurencin, Cato T ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b University of Virginia   (United States)

^c University of Virginia   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Bioactive; Bone tissue engineering; Poly(lactide co glycolide); Polymer blends; Polyphosphazenes

Indexed keywords

APATITE LAYERS; ATOMIC RATIO; BIOACTIVE BONE; BIOACTIVE MATERIAL; BIODEGRADABLE BLENDS; BIOMIMETIC POLYMERS; BIOMIMICRY; BLEND SYSTEM; BONE LIKE APATITE; BONE REGENERATION; BONE TISSUE ENGINEERING; DEGRADABLE BIOMATERIALS; DEGRADATION PRODUCTS; GLYCOLIDE; HIGH-STRENGTH; LACTIDES; LONG-TERM GOALS; NEUTRAL PH; ORTHOPEDIC APPLICATIONS; OSTEOBLAST ADHESION; PHENOTYPIC EXPRESSION; PHOSPHAZENES; POLY LACTIDE-CO-GLYCOLIDE; POLYPHOSPHAZENES; WEIGHT RATIOS;

APATITE; BIOLOGICAL MATERIALS; BIOMIMETICS; BONE; DEGRADATION; FUNCTIONAL POLYMERS; PHOSPHATE MINERALS; TENSILE STRENGTH; TISSUE ENGINEERING;

POLYMER BLENDS;

ALKALINE PHOSPHATASE; APATITE; ETHERIC POLYPHOSPHAZENE POLYGLACTIN; POLYGLACTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIODEGRADABILITY; BIOMIMETICS; BONE REGENERATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SYNTHESIS; ENZYME ACTIVITY; GLASS TRANSITION TEMPERATURE; NONHUMAN; OSTEOBLAST; PH MEASUREMENT; RAT; TENSILE STRENGTH; TISSUE ENGINEERING; YOUNG MODULUS;

ALKALINE PHOSPHATASE; ANIMALS; APATITES; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; ETHERS; MATERIALS TESTING; MECHANICAL PHENOMENA; ORGANOPHOSPHORUS COMPOUNDS; OSTEOBLASTS; POLYGLACTIN 910; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING; TRANSITION TEMPERATURE;

EID: 73549124799     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32334     Document Type: Article

References (45)

1. Hubbell JA. Biomaterials in tissue engineering. Nat Biotechnol 1995;13:565-576.
2. Laurencin CT, Ambrosio AMA, Borden MD, Cooper JA. Tissue engineering: Orthopedic applications. Annu Rev Biomed Eng 1999;1:19-46.
3. Cooper JA, Jr, Sahota JS, Gorum WJ, II, Carter J, Doty SB, Laurencin CT. Biomimetic tissue-engineered anterior cruciate ligament replacement. Proc Natl Acad Sci USA 2007;104:3049-3054.
4. Elgendy HM, Norman ME, Keaton AR, Laurencin CT. Osteoblast-like cell (MC3T3-E1) proliferation on bioerodible polymers: An approach towards the development of a bone-bioerodible polymer composite material. Biomaterials 1993;14:263-269.
5. Attawia MA, Herbert KM, Laurencin CT. Osteoblast-like cell adherance and migration through three-dimensional porous polymer matrices. Biochem Biophys Res Commun 1995;213:639-644.
6. Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci USA 2004;101:11203-11208.
7. Hench LL, Polak JM. Third-generation biomedical materials. Science 2002;295:1014-1017.
8. Murphy WL, Mooney DJ. Bioinspired growth of crystalline carbonate apatite on biodegradable polymer substrata. J Am Chem Soc 2002;124:1910-1917.
9. Ohgushi H, Caplan AI. Stem cell technology and bioceramics: From cell to gene engineering. J Biomed Mater Res 1999;48:913-927.
10. Fu K, Pack DW, Klibanov AM, Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res 2000;17:100-106.
11. Bostman OM. Osteoarthritis of the ankle after foreign-body reaction to absorbable pins and screws: A three- to nine-year follow-up study. J Bone Joint Surg Br 1998;80:333-338.
12. Allcock HR. Chemistry and Applications of Polyphosphazenes. Hoboken, New Jersey: Wiley; 2003.
13. Kumbar S, Bhattacharyya S, Nukavarapu S, Khan Y, Nair L, Laurencin C. In vitro and in vivo characterization of biodegradable poly(organophosphazenes) for biomedical applications. J Inorg Organomet Polym Mater 2006;16:365-385.
14. Lakshmi S, Katti DS, Laurencin CT. Biodegradable polyphosphazenes for drug delivery applications. Adv Drug Deliv Rev 2003;55:467-482.
15. Singh A, Krogman NR, Sethuraman S, Nair LS, Sturgeon JL, Brown PW, Laurencin CT, Allcock HR. Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes. Biomacromolecules 2006;7:914-918.
16. Laurencin CT, Norman ME, Elgendy HM, El-Amin SF, Allcock HR, Pucher SR, Ambrosio AMA. Use of polyphosphazenes for skeletal tissue regeneration. J Biomed Mater Res 1993;27:963-973.
17. Laurencin CT, El-Amin SF, Ibim SE, Willoughby DA, Attawia MA, Allcock HR, Ambrosio AMA. A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration. J Biomed Mater Res 1996;30:133-138.
18. Deng M, Nair LS, Nukavarapu SP, Kumbar SG, Jiang T, Krogman NR, Singh A, Allcock HR, Laurencin CT. Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid). Biomaterials 2008;29:337-349.
19. Ibim SEM, Ambrosio AMA, Kwon MS, El-Amin SF, Allcock HR, Laurencin CT. Novel polyphosphazene/poly(lactide-coglycolide) blends: Miscibility and degradation studies. Biomaterials 1997;18:1565-1569.
20. Ambrosio AMA, Allcock HR, Katti DS, Laurencin CT. Degradable polyphosphazene/poly(a-hydroxyester) blends: Degradation studies. Biomaterials 2002;23:1667-1672.
21. Allcock HR, Pucher SR, Turner ML, Fitzpatrick RJ. Poly(organophosphazenes) with poly(alkyl ether) side groups: A study of their water solubility and the swelling characteristics of their hydrogels. Macromolecules 1992;25:5573-5577.
22. Landry CJT, Ferrar WT, Teegarden DM, Coltrain BK. Novel miscible blends of etheric polyphosphazenes with acidic polymers. Macromolecules 1993;26:35-46.
23. Allcock HR, Fitzpatrick RJ, Visscher K, Salvati L. Thin-layer grafts of poly[bis((methoxyethoxy)ethoxy)phosphazene] on organic polymer surfaces. Chem Mater 1992;4:775-780.
24. Attwood D, Collett JH, Tait CJ. The micellar properties of the poly(oxyethylene)-poly(oxypropylene) copolymer Pluronic F127 in water and electrolyte solution. Int J Pharm 1985;26:25-33.
25. Park TG, Cohen S, Langer R. Poly(L-lactic acid)/Pluronic blends: Characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrixes. Macromolecules 1992;25:116-122.
26. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 2006;27:2907-2915.
27. Zhu P, Masuda Y, Koumoto K. The effect of surface charge on hydroxyapatite nucleation. Biomaterials 2004;25:3915-3921.
28. Sato K, Kumagai Y, Tanaka J. Apatite formation on organic monolayers in simulated body environment. J Biomed Mater Res 2000;50:16-20.
29. Brown JL, Nair LS, Bender J, Allcock HR, Laurencin CT. The formation of an apatite coating on carboxylated polyphosphazenes via a biomimetic process. Mater Lett 2007;61:3692-3695.
30. Krogman NR, Singh A, Nair LS, Laurencin CT, Allcock HR. Miscibility of bioerodible polyphosphazene/poly(lactide-coglycolide) blends. Biomacromolecules 2007;8:1306-1312.
31. Schwartz E. Culture of Animal Cells. New York: Wiley; 1987.
32. Marra KG, Szem JW, Kumta PN, DiMilla PA, Weiss LE. In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering. J Biomed Mater Res 1999;47:324-335.
33. Svetina M, Colombi Ciacchi L, Sbaizero O, Meriani S, De Vita A. Deposition of calcium ions on rutile (110): A first-principles investigation. Acta Mater 2001;49:2169-2177.
34. Zhang K, Washburn NR, Simon J, Carl G. Cytotoxicity of three-dimensionally ordered macroporous sol-gel bioactive glass (3DOM-BG). Biomaterials 2005;26:4532-4539.
35. 5 bioglass system-Preparation and in vitro characterization. J Biomed Mater Res B Appl Biomater 2007;83:546-553.
36. Wiedmann-Al-Ahmad M, Gutwald R, Gellrich N-C, Hubner U, Schmelzeisen R. Search for ideal biomaterials to cultivate human osteoblast-like cells for reconstructive surgery. J Mater Sci: Mater Med 2005;16:57-66.
37. Anselme K. Osteoblast adhesion on biomaterials. Biomaterials 2000;21:667-681.
38. Webb K, Hlady V, Tresco PA. Relative importance of surface wettability and charged functional groups on NIH 3T3 fibroblast attachment, spreading, and cytoskeletal organization. J Biomed Mater Res 1998;41:422-430.
39. Zhang M, Li XH, Gong YD, Zhao NM, Zhang XF. Properties and biocompatibility of chitosan films modified by blending with PEG. Biomaterials 2002;23:2641-2648.
40. Ajiro H, Watanabe J, Akashi M. Cell adhesion and proliferation on poly(n-vinylacetamide) hydrogels and double network approaches for changing cellular affinities. Biomacromolecules 2008;9:426-430.
41. Anderson SI, Downes S, Perry CC, Caballero AM. Evaluation of the osteoblast response to a silica gel in vitro. J Mater Sci: Mater Med 1998;9:731-735.
42. Hatano K, Inoue H, Kojo T, Matsunaga T, Tsujisawa T, Uchiyama C, Uchida Y. Effect of surface roughness on proliferation and alkaline phosphatase expression of rat calvarial cells cultured on polystyrene. Bone 1999;25:439-445.
43. Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF. Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials 2001;22:87-96.
44. Olmo N, Martin AI, Salinas AJ, Turnay J, Vallet-Regi M, Lizarbe MA. Bioactive sol-gel glasses with and without a hydroxycarbonate apatite layer as substrates for osteoblast cell adhesion and proliferation. Biomaterials 2003;24:3383-3393.
45. Yamaguchi D, Green J, Kleeman C, Muallem S. Properties of the depolarization-activated calcium and barium entry in osteoblast-like cells. J Biol Chem 1989;264:197-204.