Focus issue: Fine-tuning Hedgehog signaling in development and disease

Science Signaling

Volumn 4, Issue 200, 2011, Pages

  VanHook, Annalisa M ^a  

^a AAAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TUMOR PROTEIN;

CELL MIGRATION; CELL SURVIVAL; DROSOPHILA; EMBRYO DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; EDITORIAL; HOMEOSTASIS; HUMAN; METABOLISM; NEOPLASM;

ANIMALIA; ERINACEIDAE;

ANIMALS; HEDGEHOG PROTEINS; HOMEOSTASIS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 81855206551     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002653     Document Type: Review

References (19)

1. A. M. Ashique, Y. Choe, M. Karlen, S. R. May, K. Phamluong, M. J. Solloway, J. Ericson, A. S. Peterson, The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci. Signal. 2, ra70 (2009).
2. A. Casali, Self-induced Patched receptor down-regulation modulates cell sensitivity to the Hedgehog morphogen gradient. Sci. Signal. 3, ra63 (2010).
3. H. O.-L. Cheung, X. Zhang, A. Ribeiro, R. Mo, S. Makino, V. Puviindran, K. K. L. Law, J. Briscoe, C.-c. Hui, The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian Hedgehog signaling. Sci. Signal. 2, ra29 (2009).
4. M. Evangelista, T. Y. Lim, J. Lee, L. Parker, A. Ashique, A. S. Peterson, W. Ye, D. P. Davis, F. J. de Sauvage, Kinome siRNA screen identifies regulators of ciliogenesis and Hedgehog signal transduction. Sci. Signal. 1, ra7 (2008).
5. L. S. Jacob, X. Wu, M. E. Dodge, C.-W. Fan, O. Kulak, B. Chen, W. Tang, B. Wang, J. F. Amatruda, L. Lum, Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci. Signal. 4, ra4 (2011).
6. D. S. Parker, M. A. White, A. I. Ramos, B. A. Cohen, S. Barolo, The cis-regulatory logic of Hedgehog gradient responses: Key roles for Gli binding affinity, competition, and cooperativity. Sci. Signal. 4, ra38 (2011).
7. Y. Su, J. K. Ospina, J. Zhang, A. P. Michelson, A. M. Schoen, A. J. Zhu, Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Sci. Signal. 4, ra43 (2011).
8. M. V. Chao, Dependence receptors: What is the mechanism? Sci. STKE 2003, pe38 (2003).
9. E. M. De Robertis, Wnt signaling in axial patterning and regeneration: Lessons from planaria. Sci. Signal. 3, pe21 (2010).
10. P. Francis-West, R. Hill, Uncoupling the role of Sonic hedgehog in limb development: Growth and specification. Sci. Signal. 1, pe34 (2008).
11. S. Mackem, M. Lewandoski, Limb development takes a measured step toward systems analysis. Sci. Signal. 2, pe33 (2009).
12. A. M. Michelson, Running interference for Hedgehog signaling. Sci. STKE 2003, pe30 (2003).
13. L. Milenkovic, M. P. Scott, Not lost in space: Trafficking in the Hedgehog signaling pathway. Sci. Signal. 3, pe14 (2010).
14. T. Whitington, A. Jolma, J. Taipale, Beyond the balance of activator and repressor. Sci. Signal. 4, pe29 (2011).
15. M. D. Resh, Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci. STKE 2006, re14 (2006).
16. P. Mehlen, D. E. Bredesen, Meeting report: Cellular dependence-old concept, new mechanisms. Sci. STKE 2003, pe55 (2003).
17. E. F. Smith, R. Rohatgi, Cilia 2010: The surprise organelle of the decade. Sci. Signal. 4, mr1 (2011).
18. L. Jacob, L. Lum, Hedgehog signaling pathway. Sci. STKE 2007, cm6 (2007).
19. L. Jacob, L. Lum, Hedgehog signaling pathway in Drosophila. Sci. STKE 2007, cm7 (2007).