Wnt signaling in axial patterning and regeneration: Lessons from planaria

Science Signaling

Volumn 3, Issue 127, 2010, Pages

  De Robertis, Edward M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; SMAD4 PROTEIN; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

BIOLOGY; CELL PROLIFERATION; DEVELOPMENT; GENETIC TRANSCRIPTION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REGENERATION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TURBELLARIA; WOUND;

ANIMALS; BODY PATTERNING; CELL DIVISION; HEAD; HOMEOSTASIS; MORPHOGENESIS; PLANARIANS; REGENERATION; SIGNAL TRANSDUCTION; TAIL; WNT PROTEINS;

ERINACEIDAE; PLANARIA; TURBELLARIA;

EID: 77956623819     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3127pe21     Document Type: Review

References (32)

1. R. A. Wineberg, Biology of Cancer (Garland Science, Hamden, CT, 2006), pp. 119-158.
2. E. M. De Robertis, Evo-devo: Variations on ancestral themes. Cell132, 185-195 (2008).
3. C. P. Petersen, P. W. Reddien, A wound-induced Wnt expression program controls planarian regeneration polarity. Proc. Natl. Acad. Sci. U.S.A. 106, 17061-17066 (2009).
4. J. C. Rink, K. A. Gurley, S. A. Elliott, A. Sánchez Alvarado, Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia. Science326, 1406-1410 (2009).
5. P. W. Reddien, A. L. Bermange, A. M. Kicza, A. Sánchez Alvarado, BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134, 4043-4051 (2007).
6. J. Baguña, E. Saló, C. Auladell, Regeneration and pattern formation in planarians III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells. Development 107, 77-86 (1989).
7. P. W. Reddien, A. Sánchez Alvarado, Fundamentals of planarian regeneration. Annu. Rev. Cell Dev. Biol.20, 725-757 (2004).
8. J. S. Huxley, G. R. de Beer, The Elements of Experimental Embryology (Cambridge Univ. Press, Cambridge, 1934).
9. C. Kiecker, C. Niehrs, A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 128, 4189-4201 (2001).
10. C. Niehrs, On growth and form: A Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. Development 137, 845-857 (2010).
11. C. P. Petersen, P. W. Reddien, Wnt signaling and the polarity of the primary body axis. Cell 139, 1056-1068 (2009).
12. P. A. Newmark, P. W. Reddien, F. Cebrià, A. Sánchez Alvarado, Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc. Natl. Acad. Sci. U.S.A.100 (suppl. 1), 11861-11865 (2003).
13. P.W. Reddien, A. L. Bermange, K. J. Murfitt, J. R. Jennings, A. Sánchez Alvarado, Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev. Cell 8, 635-649 (2005).
14. K. A. Gurley, J. C. Rink, A. Sánchez Alvarado, β-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science 319, 323-327 (2008).
15. C. P. Petersen, P. W. Reddien, Smed-β-catenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319, 327-330 (2008).
16. T. Adell, E. Saló, M. Boutros, K. Bartscherer, Smed-Evi/Wntless is required for β-catenin-dependent and -independent processes during planarian regeneration. Development 136, 905-910 (2009).
17. T. H. Morgan, Experimental studies on the regeration of Planaria maculata. Dev. Genes Evol.7, 364-397 (1898).
18. T. Lengfeld, H. Watanabe, O. Simakov, D. Lindgens, L. Gee, L. Law, H. A. Schmidt, S. Ozbek, H. Bode, T.W. Holstein, Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev. Biol.330, 186-199 (2009).
19. R. Nusse, C. Fuerer, W. Ching, K. Harnish, C. Logan, A. Zeng, D. ten Berge, Y. Kalani, Wnt signaling and stem cell control. Cold Spring Harb. Symp. Quant. Biol.73, 59-66 (2008).
20. F. Kuhnert, C. R. Davis, H. T. Wang, P. Chu, M. Lee, J. Yuan, R. Nusse, C. J. Kuo, Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. U.S.A.101, 266-271 (2004).
21. S. Minear, P. Leucht, J. Jiang, B. Liu, A. Zeng, C. Fuerer, R. Nusse, J. A. Helms, Wnt proteins promote bone regeneration. Sci. Transl. Med. 2, 29ra30 (2010).
22. B. Christen, J. M. Slack, Spatial response to fibroblast growth factor signalling in Xenopus embryos. Development126, 119-125 (1999).
23. E. M. De Robertis, E. A. Morita, K.W.Y. Cho, Gradient fields and homeobox genes. Development 112, 669-678 (1991).
24. E. M. De Robertis, Spemann's organizer and the self-regulation of embryonic fields. Mech. Dev. 126, 925-941 (2009).
25. L. C. Fuentealba, E. Eivers, A. Ikeda, C. Hurtado, H. Kuroda, E. M. Pera, E. M. De Robertis, Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131, 980-993 (2007).
26. E. Eivers, H. Demagny, E. M. De Robertis, Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. Cytokine Growth Factor Rev.20, 357-365 (2009).
27. M. D. Molina, E. Saló, F. Cebrià, The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians. Dev. Biol. 311, 79-94 (2007).
28. H. Demagny, E. M. De Robertis, unpublished observations.
29. X. Guo, A. Ramirez, D. S.Waddell, Z. Li, X. Liu, X. F.Wang, Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling. Genes Dev.22, 106-120 (2008).
30. A. Agathon, C. Thisse, B. Thisse, The molecular nature of the zebrafish tail organizer. Nature424, 448-452 (2003).
31. S. Piccolo, E. Agius, L. Leyns, S. Bhattacharyya, H. Grunz, T. Bouwmeester, E. M. De Robertis, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature397, 707-710 (1999).
32. Funding: Work in our laboratory is supported by NIH grant HD21502-23. E.M.D.R. is a Howard Hughes Medical Institute investigator.