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Volumn 26, Issue 12, 2011, Pages 1740-1748

Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2)

Author keywords

Bile acid metabolism; Biliary physiology; Intestinal lipid and bile acid transport

Indexed keywords

APICAL SODIUM DEPENDENT BILE ACID TRANSPORTER; BILE ACID; CELL SURFACE PROTEIN; GENOMIC DNA; MESSENGER RNA; ORGANIC ANION TRANSPORTER; SLC10A2 PROTEIN; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

EID: 81855206320     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.06805.x     Document Type: Article
Times cited : (26)

References (35)
  • 2
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: molecular characterization, function, and regulation
    • Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol. Rev. 2003; 83: 633-71.
    • (2003) Physiol. Rev. , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 3
    • 0030462843 scopus 로고    scopus 로고
    • Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids
    • Koop I, Schindler M, Bosshammer A, Scheibner J, Stange E, Koop H. Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids. Gut 1996; 39: 661-7.
    • (1996) Gut , vol.39 , pp. 661-667
    • Koop, I.1    Schindler, M.2    Bosshammer, A.3    Scheibner, J.4    Stange, E.5    Koop, H.6
  • 4
    • 0030595095 scopus 로고    scopus 로고
    • Effect of intraduodenal taurodeoxycholate and L-phenylalanine on pancreatic secretion and on gastroenteropancreatic peptide release in man
    • Riepl RL, Fiedler F, Ernstberger M, Teufel J, Lehnert P. Effect of intraduodenal taurodeoxycholate and L-phenylalanine on pancreatic secretion and on gastroenteropancreatic peptide release in man. Eur. J. Med. Res. 1996; 1: 499-505.
    • (1996) Eur. J. Med. Res. , vol.1 , pp. 499-505
    • Riepl, R.L.1    Fiedler, F.2    Ernstberger, M.3    Teufel, J.4    Lehnert, P.5
  • 5
    • 77953339910 scopus 로고    scopus 로고
    • Missing link identified: GpBAR1 is a neuronal bile acid receptor
    • Keely SJ. Missing link identified: GpBAR1 is a neuronal bile acid receptor. Neurogastroenterol. Motil. 2010; 22: 711-17.
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. 711-717
    • Keely, S.J.1
  • 6
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • Poole DP, Godfrey C, Cattaruzza F etal. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol. Motil. 2010; 22: 814-18.
    • (2010) Neurogastroenterol. Motil. , vol.22 , pp. 814-818
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 8
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 2009; 89: 147-91.
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 10
    • 1242317691 scopus 로고    scopus 로고
    • The sodium bile salt cotransport family SLC10
    • Hagenbuch B, Dawson P. The sodium bile salt cotransport family SLC10. Pflugers Arch. 2004; 447: 566-70.
    • (2004) Pflugers Arch. , vol.447 , pp. 566-570
    • Hagenbuch, B.1    Dawson, P.2
  • 12
    • 0141818009 scopus 로고    scopus 로고
    • Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice
    • Dawson PA, Haywood J, Craddock AL etal. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J. Biol. Chem. 2003; 278: 33920-7.
    • (2003) J. Biol. Chem. , vol.278 , pp. 33920-33927
    • Dawson, P.A.1    Haywood, J.2    Craddock, A.L.3
  • 13
    • 0030944084 scopus 로고    scopus 로고
    • Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
    • Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J. Clin. Invest. 1997; 99: 1880-7.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1880-1887
    • Oelkers, P.1    Kirby, L.C.2    Heubi, J.E.3    Dawson, P.A.4
  • 14
    • 0031916146 scopus 로고    scopus 로고
    • Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter
    • Craddock AL, Love MW, Daniel RW etal. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am. J. Physiol. 1998; 274: G157-G169.
    • (1998) Am. J. Physiol. , vol.274
    • Craddock, A.L.1    Love, M.W.2    Daniel, R.W.3
  • 15
    • 0032567523 scopus 로고    scopus 로고
    • Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic
    • Weinman SA, Carruth MW, Dawson PA. Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J. Biol. Chem. 1998; 273: 34691-5.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34691-34695
    • Weinman, S.A.1    Carruth, M.W.2    Dawson, P.A.3
  • 16
    • 0033380340 scopus 로고    scopus 로고
    • Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. II. A reliable 3D QSAR pharmacophore model for the ileal Na(+)/bile acid cotransporter
    • Baringhaus KH, Matter H, Stengelin S, Kramer W. Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. II. A reliable 3D QSAR pharmacophore model for the ileal Na(+)/bile acid cotransporter. J. Lipid Res. 1999; 40: 2158-68.
    • (1999) J. Lipid Res. , vol.40 , pp. 2158-2168
    • Baringhaus, K.H.1    Matter, H.2    Stengelin, S.3    Kramer, W.4
  • 17
    • 0032822957 scopus 로고    scopus 로고
    • Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters
    • Kramer W, Stengelin S, Baringhaus KH etal. Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters. J. Lipid Res. 1999; 40: 1604-17.
    • (1999) J. Lipid Res. , vol.40 , pp. 1604-1617
    • Kramer, W.1    Stengelin, S.2    Baringhaus, K.H.3
  • 18
    • 67649838598 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis for total serum bilirubin levels
    • Johnson AD, Kavousi M, Smith AV etal. Genome-wide association meta-analysis for total serum bilirubin levels. Hum. Mol. Genet. 2009; 18: 2700-10.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2700-2710
    • Johnson, A.D.1    Kavousi, M.2    Smith, A.V.3
  • 19
    • 77949319448 scopus 로고    scopus 로고
    • A variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone disease
    • Renner O, Harsch S, Schaeffeler E etal. A variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone disease. PLoS ONE 2009; 4: e7321.
    • (2009) PLoS ONE , vol.4
    • Renner, O.1    Harsch, S.2    Schaeffeler, E.3
  • 20
    • 67349228148 scopus 로고    scopus 로고
    • Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression
    • Renner O, Harsch S, Schaeffeler E etal. Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression. Hum. Genet. 2009; 125: 381-91.
    • (2009) Hum. Genet. , vol.125 , pp. 381-391
    • Renner, O.1    Harsch, S.2    Schaeffeler, E.3
  • 21
    • 1342304081 scopus 로고    scopus 로고
    • Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition
    • Ho RH, Leake BF, Roberts RL, Lee W, Kim RB. Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J. Biol. Chem. 2004; 279: 7213-22.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7213-7222
    • Ho, R.H.1    Leake, B.F.2    Roberts, R.L.3    Lee, W.4    Kim, R.B.5
  • 22
    • 0028866988 scopus 로고
    • Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity
    • Wong MH, Oelkers P, Dawson PA. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J. Biol. Chem. 1995; 270: 27228-34.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27228-27234
    • Wong, M.H.1    Oelkers, P.2    Dawson, P.A.3
  • 23
    • 0012158586 scopus 로고    scopus 로고
    • Windau lecture. Intestinal bile acid transport: molecules, mechanism, and malabsorption
    • In: Paumgartner G, Stiehl A, Gerok W, Keppler D, Leuschner U, eds. Boston: Kluwer Academic Publishers
    • DPA. Adolf Windau lecture. Intestinal bile acid transport: molecules, mechanism, and malabsorption. In: Paumgartner G, Stiehl A, Gerok W, Keppler D, Leuschner U, eds. Falk Symposium 108: Bile Acids in Cholestasis. Boston: Kluwer Academic Publishers, 1999; 1-28.
    • (1999) Falk Symposium 108: Bile Acids in Cholestasis , pp. 1-28
    • Adolf, D.P.A.1
  • 24
    • 14844291348 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
    • Dawson PA, Hubbert M, Haywood J etal. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J. Biol. Chem. 2005; 280: 6960-8.
    • (2005) J. Biol. Chem. , vol.280 , pp. 6960-6968
    • Dawson, P.A.1    Hubbert, M.2    Haywood, J.3
  • 25
    • 79956346067 scopus 로고    scopus 로고
    • Genetic polymorphisms in Na(+)-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations
    • Pan W, Song IS, Shin HJ etal. Genetic polymorphisms in Na(+)-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. Xenobiotica 2011; 41: 501-10.
    • (2011) Xenobiotica , vol.41 , pp. 501-510
    • Pan, W.1    Song, I.S.2    Shin, H.J.3
  • 26
    • 0034878273 scopus 로고    scopus 로고
    • Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption
    • Montagnani M, Love MW, Rossel P, Dawson PA, Qvist P. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand. J. Gastroenterol. 2001; 36: 1077-80.
    • (2001) Scand. J. Gastroenterol. , vol.36 , pp. 1077-1080
    • Montagnani, M.1    Love, M.W.2    Rossel, P.3    Dawson, P.A.4    Qvist, P.5
  • 28
    • 0034852774 scopus 로고    scopus 로고
    • An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas
    • Wang W, Xue S, Ingles SA etal. An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas. Cancer Epidemiol. Biomarkers Prev. 2001; 10: 931-6.
    • (2001) Cancer Epidemiol. Biomarkers Prev. , vol.10 , pp. 931-936
    • Wang, W.1    Xue, S.2    Ingles, S.A.3
  • 29
    • 20544471895 scopus 로고    scopus 로고
    • Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)
    • Banerjee A, Ray A, Chang C, Swaan PW. Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2). Biochemistry 2005; 44: 8908-17.
    • (2005) Biochemistry , vol.44 , pp. 8908-8917
    • Banerjee, A.1    Ray, A.2    Chang, C.3    Swaan, P.W.4
  • 30
    • 70249083096 scopus 로고    scopus 로고
    • The cytosolic half of helix III forms the substrate exit route during permeation events of the sodium/bile acid cotransporter ASBT
    • Hussainzada N, Claro Da ST, Swaan PW. The cytosolic half of helix III forms the substrate exit route during permeation events of the sodium/bile acid cotransporter ASBT. Biochemistry 2009; 48: 8528-39.
    • (2009) Biochemistry , vol.48 , pp. 8528-8539
    • Hussainzada, N.1    Claro Da, S.T.2    Swaan, P.W.3
  • 31
    • 33645119837 scopus 로고    scopus 로고
    • The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships
    • Geyer J, Wilke T, Petzinger E. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch. Pharmacol. 2006; 372: 413-31.
    • (2006) Naunyn Schmiedebergs Arch. Pharmacol. , vol.372 , pp. 413-431
    • Geyer, J.1    Wilke, T.2    Petzinger, E.3
  • 32
    • 33751290454 scopus 로고    scopus 로고
    • Transmembrane domain VII of the human apical sodium-dependent bile acid transporter ASBT (SLC10A2) lines the substrate translocation pathway
    • Hussainzada N, Banerjee A, Swaan PW. Transmembrane domain VII of the human apical sodium-dependent bile acid transporter ASBT (SLC10A2) lines the substrate translocation pathway. Mol. Pharmacol. 2006; 70: 1565-74.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1565-1574
    • Hussainzada, N.1    Banerjee, A.2    Swaan, P.W.3
  • 33
    • 38549107239 scopus 로고    scopus 로고
    • Conformational flexibility of helix VI is essential for substrate permeation of the human apical sodium-dependent bile acid transporter
    • Hussainzada N, Khandewal A, Swaan PW. Conformational flexibility of helix VI is essential for substrate permeation of the human apical sodium-dependent bile acid transporter. Mol. Pharmacol. 2008; 73: 305-13.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 305-313
    • Hussainzada, N.1    Khandewal, A.2    Swaan, P.W.3
  • 34
    • 30844471761 scopus 로고    scopus 로고
    • Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers
    • Bergheim I, Harsch S, Mueller O, Schimmel S, Fritz P, Stange EF. Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J. Lipid Res. 2006; 47: 42-50.
    • (2006) J. Lipid Res. , vol.47 , pp. 42-50
    • Bergheim, I.1    Harsch, S.2    Mueller, O.3    Schimmel, S.4    Fritz, P.5    Stange, E.F.6
  • 35
    • 33244460809 scopus 로고    scopus 로고
    • Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis
    • Hruz P, Zimmermann C, Gutmann H etal. Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. Gut 2006; 55: 395-402.
    • (2006) Gut , vol.55 , pp. 395-402
    • Hruz, P.1    Zimmermann, C.2    Gutmann, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.