Inhibitory Effects of Corticosterone in the Hypothalamic Paraventricular Nucleus (PVN) on Stress-Induced Adrenocorticotrophic Hormone Secretion and Gene Expression in the PVN and Anterior Pituitary

Journal of Neuroendocrinology

Volumn 23, Issue 12, 2011, Pages 1231-1240

  Weiser, M J ^a   Osterlund, C ^a   Spencer, R L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

C fos; Corticotrophin releasing hormone; Glucocorticoids; Paraventricular nucleus; Proopiomelanocortin

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HETEROGENEOUS NUCLEAR RNA; PROLACTIN; PROOPIOMELANOCORTIN; PROTEIN C FOS;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORTICOTROPIN RELEASE; GENE EXPRESSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RAT; STRESS;

ADRENALECTOMY; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CORTICOSTERONE; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; INFUSIONS, INTRAVENTRICULAR; MALE; MICROINJECTIONS; MODELS, BIOLOGICAL; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PITUITARY GLAND, ANTERIOR; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL;

EID: 81855194745     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2011.02217.x     Document Type: Article

References (50)

1. Lightman SL, Wiles CC, Atkinson HC, Henley DE, Russell GM, Leendertz JA, McKenna MA, Spiga F, Wood SA, Conway-Campbell BL. The significance of glucocorticoid pulsatility. Eur J Pharmacol 2008; 583: 255-262.
2. McEwen BS. Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 2008; 583: 174-185.
3. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions Endocr Rev 2000; 21: 55-89.
4. Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N. Regulation of ACTH secretion: variations on a theme of B. Recent Prog Horm Res 1987; 43: 113-173.
5. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 1999; 160: 1-12.
6. Barden N. Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. J Psychiatry Neurosci 2004; 29: 185-193.
7. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M. Brain corticosteroid receptor balance in health and disease. Endocr Rev 1998; 19: 269-301.
8. Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 2005; 4: 141-194.
9. Hodges JR, Jones MT. Corticotrophin release in the cortisol-treated rat. J Physiol 1962; 163: 391-398.
10. Sayers G, Sayers MA. Regulation of pituitary adrenocorticotrophic activity during the response of the rat to acute stress. Endocrinology 1947; 40: 265-273.
11. Yates FE, Leeman SE, Glenister DW, Dallman MF. Interaction between plasma corticosterone concentration and adrenocorticotropin-releasing stimuli in the rat: evidence for the reset of an endocrine feedback control. Endocrinology 1961; 69: 67-80.
12. Akana SF, Scribner KA, Bradbury MJ, Strack AM, Walker CD, Dallman MF. Feedback sensitivity of the rat hypothalamo-pituitary-adrenal axis and its capacity to adjust to exogenous corticosterone. Endocrinology 1992; 131: 585-594.
13. Ginsberg AB, Campeau S, Day HE, Spencer RL. Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 2003; 15: 1075-1083.
14. Pace TW, Gaylord RI, Jarvis E, Girotti M, Spencer RL. Differential glucocorticoid effects on stress-induced gene expression in the paraventricular nucleus of the hypothalamus and ACTH secretion in the rat. Stress 2009; 12: 400-411.
15. Ginsberg AB, Frank MG, Francis AB, Rubin BA, O'Connor KA, Spencer RL. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol 2006; 18: 129-138.
16. Osterlund C, Spencer RL. Corticosterone pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis activity via multiple actions that vary with time, site of action, and de novo protein synthesis. J Endocrinol 2011; 208: 311-322.
17. Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 1984; 5: 1-24.
18. Watts AG. Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback. Front Neuroendocrinol 2005; 26: 109-130.
19. Buckingham JC. The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone. J Physiol 1979; 286: 331-342.
20. Dallman MF. Adrenocortical function, feedback, and alphabet soup. Am J Physiol Endocrinol Metab 2005; 289: E361-E362.
21. Boyle MP, Kolber BJ, Vogt SK, Wozniak DF, Muglia LJ. Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J Neurosci 2006; 26: 1971-1978.
22. Furay AR, Bruestle AE, Herman JP. The role of the forebrain glucocorticoid receptor in acute and chronic stress. Endocrinology 2008; 149: 5482-5490.
23. Schmidt MV, Sterlemann V, Wagner K, Niederleitner B, Ganea K, Liebl C, Deussing JM, Berger S, Schutz G, Holsboer F, Muller MB. Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences. Endocrinology 2009; 150: 2709-2716.
24. Jacobson L, Akana SF, Cascio CS, Shinsako J, Dallman MF. Circadian variations in plasma corticosterone permit normal termination of adrenocorticotropin responses to stress. Endocrinology 1988; 122: 1343-1348.
25. Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP. Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 2010; 151: 4811-4819.
26. Feldman S, Weidenfeld J. The dorsal hippocampus modifies the negative feedback effect of glucocorticoids on the adrenocortical and median eminence CRF-41 responses to photic stimulation. Brain Res 1993; 614: 227-232.
27. Nicholson WE, Davis DR, Sherrell BJ, Orth DN. Rapid radioimmunoassay for corticotropin in unextracted human plasma. Clin Chem 1984; 30: 259-265.
28. Paxinos G, Watson CS. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press, 1998.
29. Kovacs KJ, Makara GB. Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 1988; 474: 205-210.
30. Jones MT, Hillhouse EW, Burden JL. Dynamics and mechanics of corticosteroid feedback at the hypothalamus and anterior pituitary gland. J Endocrinol 1977; 73: 405-417.
31. Ginsberg AB, Pecoraro NC, Warne JP, Horneman HF, Dallman MF. Rapid alteration of stress-induced hypothalamic-pituitary-adrenal hormone secretion in the rat: a comparison of glucocorticoids and cannabinoids. Stress 2010; 13: 248-257.
32. Feldman S, Weidenfeld J. Further evidence for the central effect of dexamethasone at the hypothalamic level in the negative feedback mechanism. Brain Res 2002; 958: 291-296.
33. Fink G, Robinson IC, Tannahill LA. Effects of adrenalectomy and glucocorticoids on the peptides CRF-41, AVP and oxytocin in rat hypophysial portal blood. J Physiol 1988; 401: 329-345.
34. Plotsky PM, Otto S, Sapolsky RM. Inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation by delayed glucocorticoid feedback. Endocrinology 1986; 119: 1126-1130.
35. Buckingham JC, Hodges JR. Production of corticotrophin releasing hormone by the isolated hypothalamus of the rat. J Physiol 1977; 272: 469-479.
36. Takebe K, Kunita H, Sakakura M, Horiuchi Y, Mashimo K. Suppressive effect of dexamethasone on the rise of CRF activity in the median eminence induced by stress. Endocrinology 1971; 89: 1014-1019.
37. Osterlund CD, Jarvis E, Chadayammuri A, Unnithan R, Weiser MJ, Spencer RL. Tonic, but not phasic corticosterone constrains stress activated extracellular-regulated-kinase 1/2 immunoreactivity within the hypothalamic paraventricular nucleus. J Neuroendocrinol. Accepted Article.
38. Jiang YQ, Kawashima H, Iwasaki Y, Uchida K, Sugimoto K, Itoi K. Differential effects of forced swim-stress on the corticotropin-releasing hormone and vasopressin gene transcription in the parvocellular division of the paraventricular nucleus of rat hypothalamus. Neurosci Lett 2004; 358: 201-204.
39. Ma XM, Aguilera G. Differential regulation of corticotropin-releasing hormone and vasopressin transcription by glucocorticoids. Endocrinology 1999; 140: 5642-5650.
40. Guardiola-Diaz HM, Kolinske JS, Gates LH, Seasholtz AF. Negative glucorticoid regulation of cyclic adenosine 3', 5'-monophosphate-stimulated corticotropin-releasing hormone-reporter expression in AtT-20 cells. Mol Endocrinol 1996; 10: 317-329.
41. Yamamori E, Iwasaki Y, Taguchi T, Nishiyama M, Yoshida M, Asai M, Oiso Y, Itoi K, Kambayashi M, Hashimoto K. Molecular mechanisms for corticotropin-releasing hormone gene repression by glucocorticoid in BE(2)C neuronal cell line. Mol Cell Endocrinol 2007; 264: 142-148.
42. Dostert A, Heinzel T. Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 2004; 10: 2807-2816.
43. Ma XM, Camacho C, Aguilera G. Regulation of corticotropin-releasing hormone (CRH) transcription and CRH mRNA stability by glucocorticoids. Cell Mol Neurobiol 2001; 21: 465-475.
44. Herman JP, Cullinan WE, Ziegler DR, Tasker JG. Role of the paraventricular nucleus microenvironment in stress integration. Eur J Neurosci 2002; 16: 381-385.
45. Verkuyl JM, Karst H, Joels M. GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stress. Eur J Neurosci 2005; 21: 113-121.
46. Uht RM, McKelvy JF, Harrison RW, Bohn MC. Demonstration of glucocorticoid receptor-like immunoreactivity in glucocorticoid-sensitive vasopressin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus. J Neurosci Res 1988; 19: 405-411.
47. Bali B, Ferenczi S, Kovacs KJ. Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures. J Neuroendocrinol 2008; 20: 1045-1051.
48. Autelitano DJ, Lundblad JR, Blum M, Roberts JL. Hormonal regulation of POMC gene expression. Annu Rev Physiol 1989; 51: 715-726.
49. Levin N, Blum M, Roberts JL. Modulation of basal and corticotropin-releasing factor-stimulated proopiomelanocortin gene expression by vasopressin in rat anterior pituitary. Endocrinology 1989; 125: 2957-2966.
50. Takigami S, Fujiwara K, Kikuchi M, Yashiro T. In vivo correlation between c-Fos expression and corticotroph stimulation by adrenocorticotrophic hormone secretagogues in rat anterior pituitary gland. Cell Tissue Res 2008; 331: 589-594.