Direct Inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures

Journal of Neuroendocrinology

Volumn 20, Issue 9, 2008, Pages 1045-1051

  Bali, B ^a   Ferenczi, S ^a   Kovács, Krisztina J ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Corticosterone; Dexamethasone; DRB; Forskolin; In vitro; Tetrodotoxin

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; FORSKOLIN; MESSENGER RNA; TETRODOTOXIN; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; CONTROLLED STUDY; EXPLANT; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; HISTOCHEMISTRY; HORMONE ACTION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IN SITU HYBRIDIZATION; IN VITRO STUDY; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CORTICOTROPIN-RELEASING HORMONE; DOWN-REGULATION; FORSKOLIN; GLUCOCORTICOIDS; MODELS, BIOLOGICAL; NEURONS; ORGAN CULTURE TECHNIQUES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RECEPTORS, STEROID; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 49449107185     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01759.x     Document Type: Article

References (54)

1. Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 1984; 5: 1-24.
2. Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N. Regulation of ACTH secretion: Variations on a theme of B. Recent Prog Horm Res 1987; 43: 113-173.
3. Di S, Malcher-Lopes R, Halmos KC, Tasker JG. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism. J. Neurosci 2003; 23: 4850-4857.
4. Kovacs KJ, Makara GB. Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 1988; 474: 205-210.
5. Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation. Endocrinology 1985; 117: 2505-2511.
6. Reul JM, de Kloet ER. Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis. J. Steroid Biochem 1986; 24: 269-272.
7. Reul JM, van den Bosch FR, de Kloet ER. Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: Functional implications. J. Endocrinol 1987; 115: 459-467.
8. Ratka A, Sutanto W, Bloemers M, de Kloet ER. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology 1989; 50: 117-123.
9. Bohus B, Endroeczi E. Effect of intracerebral implantation of hydrocortisone on adrenocortical secretion and adrenal weight after unilateral adrenalectomy. Acta Physiol Acad Sci Hung 1964; 25: 11-19.
10. Hedge GA, Smelik PG. Corticotropin release: Inhibition by intrahypothalamic implantation of atropine. Science (NY) 1968; 159: 891-892.
11. Davidson JM, Jones LE, Levine S. Feedback regulation of adrenocorticotropin secretion in 'basal'and 'stress'conditions: Acute and chronic effects of intrahypothalamic corticoid implantation. Endocrinology 1968; 82: 655-663.
12. Smelik PG. The effect of a CRF preparation on ACTH release in rats bearing hypothalamic dexamethasone implants: A study on the 'implantation paradox'. Neuroendocrinology 1969; 5: 193-204.
13. Kovacs K, Kiss JZ, Makara GB. Glucocorticoid implants around the hypothalamic paraventricular nucleus prevent the increase of corticotropin-releasing factor and arginine vasopressin immunostaining induced by adrenalectomy. Neuroendocrinology 1986; 44: 229-234.
14. Kovacs KJ, Mezey E. Dexamethasone inhibits corticotropin-releasing factor gene expression in the rat paraventricular nucleus. Neuroendocrinology 1987; 46: 365-368.
15. House SB, Thomas A, Kusano K, Gainer H. Stationary organotypic cultures of oxytocin and vasopressin magnocellular neurones from rat and mouse hypothalamus. J. Neuroendocrinol 1998; 10: 849-861.
16. Bali B, Kovacs KJ. GABAergic control of neuropeptide gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus. Eur J Neurosci 2003; 18: 1518-1526.
17. Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J. Histotechnol 1989; 12: 169-181.
18. Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. J. Neurosci 2003; 23: 10231-10237.
19. Kovacs KJ, Foldes A, Sawchenko PE. Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons. J. Neurosci 2000; 20: 3843-3852.
20. Sawchenko PE, Arias CA, Mortrud MT. Local tetrodotoxin blocks chronic stress effects on corticotropin-releasing factor and vasopressin messenger ribonucleic acids in hypophysiotropic neurons. J. Neuroendocrinol 1993; 5: 341-348.
21. Boudaba C, Schrader LA, Tasker JG. Physiological evidence for local excitatory synaptic circuits in the rat hypothalamus. J. Neurophysiol 1997; 77: 3396-3400.
22. Herman JP, Cullinan WE, Ziegler DR, Tasker JG. Role of the paraventricular nucleus microenvironment in stress integration. Eur J Neurosci 2002; 16: 381-385.
23. Herman JP, Tasker JG, Ziegler DR, Cullinan WE. Local circuit regulation of paraventricular nucleus stress integration. Glutamate-GABA connections. Pharmacol Biochem Behav 2002; 71: 457-468.
24. Bartanusz V, Muller D, Gaillard RC, Streit P, Vutskits L, Kiss JZ. Local gamma-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus. Eur J Neurosci 2004; 19: 777-782.
25. Verkuyl JM, Joels M. Effect of adrenalectomy on miniature inhibitory postsynaptic currents in the paraventricular nucleus of the hypothalamus. J. Neurophysiol 2003; 89: 237-245.
26. Miklos IH, Kovacs KJ. GABAergic innervation of corticotropin-releasing hormone (CRH)- secreting parvocellular neurons and its plasticity as demonstrated by quantitative immunoelectron microscopy. Neuroscience 2002; 113: 581-592.
27. Cole RL, Sawchenko PE. Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hypothalamus. J. Neurosci 2002; 22: 959-969.
28. Kiss JZ, Mezey E, Skirboll L. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy. Proc Natl Acad Sci USA 1984; 81: 1854-1858.
29. Sawchenko PE, Swanson LW, Vale WW. Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat. Proc Natl Acad Sci USA 1984; 81: 1883-1887.
30. Young WS III, Mezey E, Siegel RE. Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in rats. Neurosci Lett 1986; 70: 198-203.
31. Swanson LW, Simmons DM. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: A hybridization histochemical study in the rat. J. Comp Neurol 1989; 285: 413-435.
32. Cintra A, Fuxe K, Harfstrand A, Agnati LF, Wikstrom AC, Okret S, Vale W, Gustafsson JA. Presence of glucocorticoid receptor immunoreactivity in corticotrophin releasing factor and in growth hormone releasing factor immunoreactive neurons of the rat di- and telencephalon. Neurosci Lett 1987; 77: 25-30.
33. Uht RM, McKelvy JF, Harrison RW, Bohn MC. Demonstration of glucocorticoid receptor-like immunoreactivity in glucocorticoid-sensitive vasopressin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus. J. Neurosci Res 1988; 19: 405-411, 68-69.
34. Ceccatelli S, Cintra A, Hokfelt T, Fuxe K, Wikstrom AC, Gustafsson JA. Coexistence of glucocorticoid receptor-like immunoreactivity with neuropeptides in the hypothalamic paraventricular nucleus. Exp Brain Res 1989; 78: 33-42.
35. Guardiola-Diaz HM, Kolinske JS, Gates LH, Seasholtz AF. Negative glucorticoid regulation of cyclic adenosine 3′, 5′-monophosphate-stimulated corticotropin-releasing hormone-reporter expression in AtT-20 cells. Mol Endocrinol 1996; 10: 317-329.
36. Malkoski SP, Handanos CM, Dorin RI. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol Cell Endocrinol 1997; 127: 189-199.
37. Van LP, Spengler DH, Holsboer F. Glucocorticoid repression of 3′,5′-cyclic-adenosine monophosphate-dependent human corticotropin-releasing-hormone gene promoter activity in a transfected mouse anterior pituitary cell line. Endocrinology 1990; 127: 1412-1418.
38. Yamamori E, Iwasaki Y, Taguchi T, Nishiyama M, Yoshida M, Asai M, Oiso Y, Itoi K, Kambayashi M, Hashimoto K. Molecular mechanisms for corticotropin-releasing hormone gene repression by glucocorticoid in BE(2)C neuronal cell line. Mol Cell Endocrinol 2007; 264: 142-148.
39. Legradi G, Holzer D, Kapcala LP, Lechan RM. Glucocorticoids inhibit stress-induced phosphorylation of CREB in corticotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus. Neuroendocrinology 1997; 66: 86-97.
40. Sheppard KA, Phelps KM, Williams AJ, Thanos D, Glass CK, Rosenfeld MG, Gerritsen ME, Collins T. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J. Biol Chem 1998; 273: 29291-29294.
41. Kagoshima M, Wilcke T, Ito K, Tsaprouni L, Barnes PJ, Punchard N, Adcock IM. Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Eur J Pharmacol 2001; 429: 327-334.
42. Shepard JD, Liu Y, Sassone-Corsi P, Aguilera G. Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress. J. Neurosci 2005; 25: 4073-4081.
43. Liu Y, Kalintchenko N, Sassone-Corsi P, Aguilera G. Inhibition of corticotrophin-releasing hormone transcription by inducible cAMP-early repressor in the hypothalamic cell line, 4B. J. Neuroendocrinol 2006; 18: 42-49.
44. Aguilera G, Kiss A, Liu Y, Kamitakahara A. Negative regulation of corticotropin releasing factor expression and limitation of stress response. Stress 2007; 10: 153-161.
45. Autelitano DJ. Glucocorticoid regulation of c-fos, c-jun and transcription factor AP-1 in the AtT-20 corticotrope cell. J. Neuroendocrinol 1994; 6: 627-637.
46. Dostert A, Heinzel T. Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 2004; 10: 2807-2816.
47. Merchenthaler I. Corticotropin releasing factor (CRF)-like immunoreactivity in the rat central nervous system. Extrahypothalamic distribution. Peptides 1984; 5 (Suppl): 153-169.
48. Watts AG, Sanchez-Watts G. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J. Physiol 1995; 484: 721-736.
49. Robinson BG, Emanuel RL, Frim DM, Majzoub JA. Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci USA 1988; 85: 5244-5248.
50. Cheng YH, Nicholson RC, King B, Chan EC, Fitter JT, Smith R. Glucocorticoid stimulation of corticotropin-releasing hormone gene expression requires a cyclic adenosine 3′,5′-monophosphate regulatory element in human primary placental cytotrophoblast cells. J. Clin Endocrinol Metabol 2000; 85: 1937-1945.
51. King BR, Smith R, Nicholson RC. The regulation of human corticotrophin-releasing hormone gene expression in the placenta. Peptides 2001; 22: 1941-1947.
52. King BR, Smith R, Nicholson RC. Novel glucocorticoid and cAMP interactions on the CRH gene promoter. Mol Cell Endocrinol 2002; 194: 19-28.
53. van der Laan S, Lachize SB, Vreugendhil E, de Kloet ER, Meijer OC. Nuclear receptor coregulators differentially modulate CREB-mediated induction and glucocorticoid receptor mediated repression of the CRH gene. Endocrinology 2008; 149: 725-732.
54. Vamvakopoulos NC, Chrousos GP. Regulated activity of the distal promoter-like element of the human corticotropin-releasing hormone gene and secondary structural features of its corresponding transcripts. Mol Cell Endocrinol 1993; 94: 73-78.