Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary

Journal of Neuroendocrinology

Volumn 18, Issue 2, 2006, Pages 129-138

  Ginsberg, Abegail B ^a,b   Frank, M G ^a   Francis, A B ^a   Rubin, B A ^a   O'Connor, K A ^a   Spencer, R L ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

c fos; Glucocorticoid; POMC; Rat; Stress; zif268

Indexed keywords

11BETA,17BETA DIHYDROXY 6 METHYL 17ALPHA (1 PROPYNYL)ANDROSTA 1,4,6 TRIEN 3 ONE; CORTICOSTERONE; CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; HETEROGENEOUS NUCLEAR RNA; MESSENGER RNA; PROOPIOMELANOCORTIN; PROTEIN C FOS;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORTICOSTERONE RELEASE; CORTICOTROPIN RELEASE; DOSE TIME EFFECT RELATION; DRUG RESPONSE; FOLLOW UP; GENE EXPRESSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NEUROHYPOPHYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADRENOCORTICOTROPIC HORMONE; ANDROSTANOLS; ANIMALS; CORTICOSTERONE; EARLY GROWTH RESPONSE PROTEIN 1; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY GLAND; PITUITARY-ADRENAL SYSTEM; PRO-OPIOMELANOCORTIN; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RNA, HETEROGENEOUS NUCLEAR; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 33645865540     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01396.x     Document Type: Article

References (46)

1. Dallman M, Akana S, Cascio C, Darlington D, Jacobson L, Levin N. Regulation of ACTH secretion: Variations on a theme of B. Recent Prog Horm Res 1987; 43: 113-173.
2. Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 1984; 5: 1-24.
3. Buckingham JC, Hodges JR. The influence of some neurotransmitter substances and drugs on the secretion of corticotrophin releasing hormone by the rat hypothalamus in vitro [proceedings]. J Physiol 1979; 290: 40P-41P.
4. Ginsberg AB, Campeau S, Day HE, Spencer RL. Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus. J Neuroendocrinol 2003; 15: 1075-1083.
5. Jones MT, Hillhouse EW. Structure-activity relationship and the mode of action of corticosteroid feedback on the secretion of corticotrophin-releasing factor (corticoliberin). J Steroid Biochem 1976; 7: 1189-1202.
6. Keller-Wood ME, Shinsako J, Dallman MF. Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs. J Clin Invest 1983; 71: 859-866.
7. Kovacs KJ, Makara GB. Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 1988; 474: 205-210.
8. Dayanithi G, Antoni FA. Rapid as well as delayed inhibitory effects of glucocorticoid hormones on pituitary adrenocorticotropic hormone release are mediated by type II glucocorticoid receptors and require newly synthesized messenger ribonucleic acid as well as protein. Endocrinology 1989; 125: 308-313.
9. Shipston M. Mechanism(s) of early glucocorticoid inhibition of adrenocorticotropin secretion from anterior pituitary corticotropes. Trends Endocrinol Metab 1995; 6: 261-266.
10. de Kloet E, Oitzl M, Joels M. Functional implications of brain corticosteroid receptor diversity. Cell Mol Neurobiol 1993; 13: 433-455.
11. de Kloet ER, Vreugdenhil E, Oitzl M, Joels M. Brain corticosteroid receptor balance in health and disease. Endocr Rev 1998; 19: 269-301.
12. Honkaniemi J, Kononen J, Kainu T, Pyykonen I, Pelto-Huikko M. Induction of multiple immediate early genes in rat hypothalamic paraventricular nucleus after stress. Brain Res Mol Brain Res 1994; 25: 234-241.
13. Kovacs KJ, Sawchenko PE. Regulation of stress-induced transcriptional changes in the hypothalamic neurosecretory neurons. J Mol Neurosci 1996; 7: 125-133.
14. Ginsberg A, O'Connor KA, Spencer RL. Negative feedback effects of glucocortioid receptor agonist RU28362 on stress-induced gene expression in the PVN and pituitary. Abstract Viewer/Itinerary Planner. Washington, DC: Society for NeuroscienPe, 2003: program no. 28217.
15. Autelitano DJ. Stress-induced stimulation of pituitary POMC gene expression is associated with activation of transcription factor AP-1 in hypothalamus and pituitary. Brain Res Bull 1998; 45: 75-82.
16. Autelitano DJ, van den Buuse M. Concomitant up-regulation of proopiomelanocortin and dopamine D2-receptor gene expression in the pituitary intermediate lobe of the spontaneously hypertensive rat. J Neuroendocrinol 1997; 9: 255-262.
17. Umemoto S, Kawai Y, Ueyama T, Senba E. Chronic glucocorticoid administration as well as repeated stress affects the subsequent acute immobilization stress-induced expression of immediate early genes but not that of NGFI-A. Neuroscience 1997; 80: 763-773.
18. McGimsey WC, Cidlowski JA, Stumpf WE, Sar M. Immunocytochemical localization of the glucocorticoid receptor in rat brain, pituitary, liver, and thymus with two new polyclonal antipeptide antibodies. Endocrinology 1991; 129: 3064-3072.
19. Ozawa H, Ito T, Ochiai I, Kawata M. Cellular localization and distribution of glucocorticoid receptor immunoreactivity and the expression of glucocorticoid receptor messenger RNA in rat pituitary gland. A combined double immunohistochemistry study and in situ hybridization histochemical analysis. Cell Tissue Res 1999; 295: 207-214.
20. Baumann CT, Lim CS, Hager GL. Intracellular localization and trafficking of steroid receptors. Cell Biochem Biophys 1999; 31: 119-127.
21. Nicholson WE, Davis DR, Sherrel BJ, Orth DN. Rapid radioimmunoassay for corticotropin in unextracted human placenta. Clin Chem 1984; 30: 259-265.
22. Cidlowski JA, Bellingham DL, Powell-Oliver FE, Lubahn DB, Sar M. Novel antipeptide antibodies to the human glucocorticoid receptor. recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol 1990; 4: 1427-1437.
23. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
24. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
25. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: E45.
26. Aoki Y, Iwasaki Y, Katahira M, Oiso Y, Saito H. Regulation of the rat proopiomelanocortin gene expression in AtT-20 cells. II. Effects of the pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide. Endocrinology 1997; 138: 1930-1934.
27. Feldman S, Weidenfeld J. Further evidence for the central effect of dexamethasone at the hypothalamic level in the negative feedback mechanism. Brain Res 2002; 958: 291-296.
28. Hinz B, Hirschelmann R. Rapid non-genomic feedback effects of glucocorticoids on CRF-induced ACTH secretion in rats. Pharm Res 2000; 17: 1273-1277.
29. Dayas CV, Buller KM, Crane JW, Xu Y, Day TA. Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci 2001; 14: 1143-1152.
30. Autelitano DJ, Blum M, Lopingco M, Allen RG, Roberts JL. Corticotropin-releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo. Neuroendocrinology 1990; 51: 123-130.
31. Boutillier AL, Sassone-Corsi P, Loeffler JP. The protooncogene c-fos is induced by corticotropin-releasing factor and stimulates proopiomelanocortin gene transcription in pituitary cells. Mol Endocrinol 1991; 5: 1301-1310.
32. Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin. structure, function, and regulation of secretion. Physiol Rev 2000; 80: 1523-1631.
33. Morales T, Hinuma S, Sawchenko PE. Prolactin-releasing peptide is expressed in afferents to the endocrine hypothalamus, but not in neurosecretory neurones. J Neuroendocrinol 2000; 12: 131-140.
34. Minamitani N, Minamitani T, Lechan RM, Bollinger-Gruber J, Reichlin S. Paraventricular nucleus mediates prolactin secretory responses to restraint stress, ether stress, and 5-hydroxy-L-tryptophan injection in the rat. Endocrinology 1987; 120: 860-867.
35. Plotsky PM, Otto S, Sapolsky RM. Inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation by delayed glucocorticoid feedback. Endocrinology 1986; 119: 1126-1130.
36. Fink G. Mechanisms of negative and positive feedback of steroids in the hypothalamic-pituitary system. In Bittar EE, Bittar N, eds. Principles of Medical Biology, Vol. 10A: Molecular and Cellular Endocrinology. Greenwich. CT: JAI Press, 1997.
37. Tierney T, Christian HC, Morris JF, Solito E, Buckingham JC. Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release. J Neuroendocrinol 2003; 15: 1134-1143.
38. Drouin J, Sun YL, Chamberland M, Gauthier Y, De Lean A, Nemer M, Schmidt TJ. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993; 12: 145-156.
39. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schutz G. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998 93 531-541
40. Lookingland KJ, Gunnet JW, Moore KE. Stress-induced secretion of alpha-melanocyte-stimulating hormone is accompanied by a decrease in the activity of tuberohypophysial dopaminergic neurons. Neuroendocrinology 1991; 53: 91-96.
41. Jingami H, Matsukura S, Numa S, Imura H. Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/beta-lipotropin precursor mRNA in the pituitary in rats. Endocrinology 1985; 117: 1314 - 1320.
42. Kjaer A, Knigge U, Bach FW, Warberg J. Stress-induced secretion of pro-opiomelanocortin-derived peptides in rats: Relative importance of the anterior and intermediate pituitary lobes. Neuroendocrinology 1995; 61: 167-172.
43. Proulx-Ferland L, Labrie F, Dumont D, Cote J, Coy DH, Sveiraf J. Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary. Science 1982; 217: 62-63.
44. Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 1998; 28: 370-490.
45. Kovacs K, Foldes A, Sawchenko P. Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons. J Neurosci 2000; 20: 3843-3852.
46. Sebens J, Middelveld R, Koch T, Ter Horst G, Koff J. Clozapine-induced Fos-protein expression in rat forebrain regions. differential effects of adrenalectomy and corticosterone. Eur J Pharmacol 2001; 417: 149-155.