MUC4: A novel prognostic factor of oral squamous cell carcinoma

International Journal of Cancer

Volumn 130, Issue 8, 2012, Pages 1768-1776

  Hamada, Tomofumi ^a   Wakamatsu, Tsunenobu ^b   Miyahara, Mayumi ^b   Nagata, Satoshi ^b   Nomura, Masahiro ^b   Kamikawa, Yoshiaki ^a   Yamada, Norishige ^c   Batra, Surinder K ^d   Yonezawa, Suguru ^c   Sugihara, Kazumasa ^a,b  

^a KAGOSHIMA UNIVERSITY HOSPITAL   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

immunohistochemistry; MUC4; mucin; oral cancer; prognosis

Indexed keywords

MUCIN 4;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CANCER LOCALIZATION; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DEATH; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECURRENT CANCER; RISK FACTOR; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; MUCIN-4; MULTIVARIATE ANALYSIS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 81855187244     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26187     Document Type: Article

References (50)

1. Parkin DM, Bray F, Ferlay J, Pisani P,. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Kowalski LP, Sanabria A,. Elective neck dissection in oral carcinoma: a critical review of the evidence. Acta Otorhinolaryngol Ital 2007; 27: 113-7.
3. Cheng A, Schmidt BL,. Management of the N0 neck in oral squamous cell carcinoma. Oral Maxillofac Surg Clin North Am 2008; 20: 477-97.
4. Hollingsworth MA, Swanson BJ,. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 2004; 4: 45-60.
5. Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK,. Structural organization and classification of the human mucin genes. Front Biosci 2001; 6: D1192-206.
6. Chaturvedi P, Singh AP, Batra SK,. Structure, evolution, and biology of the MUC4 mucin. FASEB J 2008; 22: 966-81.
7. Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M,. Significance of mucin expression in pancreatobiliary neoplasms. J Hepatobiliary Pancreat Sci 2010; 17: 108-24.
8. Moniaux N, Varshney GC, Chauhan SC, Copin MC, Jain M, Wittel UA, Andrianifahanana M, Aubert JP, Batra SK,. Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem 2004; 52: 253-61.
9. Munro EG, Jain M, Oliva E, Kamal N, Lele SM, Lynch MP, Guo L, Fu K, Sharma P, Remmenga S, Growdon WB, Davis JS, et al. Upregulation of MUC4 in cervical squamous cell carcinoma: pathologic significance. Int J Gynecol Pathol 2009; 28: 127-33.
10. Shibahara H, Tamada S, Higashi M, Goto M, Batra SK, Hollingsworth MA, Imai K, Yonezawa S,. MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Hepatology 2004; 39: 220-9.
11. Tamada S, Shibahara H, Higashi M, Goto M, Batra SK, Imai K, Yonezawa S,. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res 2006; 12: 4257-64.
12. Saitou M, Goto M, Horinouchi M, Tamada S, Nagata K, Hamada T, Osako M, Takao S, Batra SK, Aikou T, Imai K, Yonezawa S,. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol 2005; 58: 845-52.
13. Chauhan SC, Singh AP, Ruiz F, Johansson SL, Jain M, Smith LM, Moniaux N, Batra SK,. Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). Mod Pathol 2006; 19: 1386-94.
14. Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Wakimoto J, Batra SK, Imai K, Yonezawa S,. MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer 2007; 55: 195-203.
15. Singh AP, Chauhan SC, Bafna S, Johansson SL, Smith LM, Moniaux N, Lin MF, Batra SK,. Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. Prostate 2006; 66: 421-9.
16. Yonezawa S, Goto M, Yamada N, Higashi M, Nomoto M,. Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior. Proteomics 2008; 8: 3329-41.
17. Sobin LH, Wittekind C,. TNM classification of malignant tumours. 6th edn., Wiley-Liss: New York, 2002.
18. Yamamoto E, Kohama G, Sunakawa H, Iwai M, Hiratsuka H,. Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity. Cancer 1983; 51: 2175-80.
19. Swartz MJ, Batra SK, Varshney GC, Hollingsworth MA, Yeo CJ, Cameron JL, Wilentz RE, Hruban RH, Argani P,. MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol 2002; 117: 791-6.
20. Andrianifahanana M, Moniaux N, Schmied BM, Ringel J, Friess H, Hollingsworth MA, Buchler MW, Aubert JP, Batra SK,. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 2001; 7: 4033-40.
21. Aloysius MM, Zaitoun AM, Awad S, Ilyas M, Rowlands BJ, Lobo DN,. Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer. Br J Surg 2010; 97: 1269-78.
22. Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U,. Prognostic value of mucin 4 expression in colorectal adenocarcinomas. Cancer 2010; 116: 3577-86.
23. Carraway KL, Theodoropoulos G, Kozloski GA, Carothers Carraway CA,. Muc4/MUC4 functions and regulation in cancer. Future Oncol 2009; 5: 1631-40.
24. Chaturvedi P, Singh AP, Moniaux N, Senapati S, Chakraborty S, Meza JL, Batra SK,. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res 2007; 5: 309-20.
25. Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK,. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 2004; 64: 622-30.
26. Komatsu M, Jepson S, Arango ME, Carothers Carraway CA, Carraway KL,. Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene 2001; 20: 461-70.
27. Komatsu M, Tatum L, Altman NH, Carothers Carraway CA, Carraway KL,. Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein. Int J Cancer 2000; 87: 480-6.
28. Workman HC, Miller JK, Ingalla EQ, Kaur RP, Yamamoto DI, Beckett LA, Young LJ, Cardiff RD, Borowsky AD, Carraway KL, Sweeney C, Carraway KL, III,. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res 2009; 11: R70.
29. Hu YP, Haq B, Carraway KL, Savaraj N, Lampidis TJ,. Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells. Biochem Pharmacol 2003; 65: 1419-25.
30. Komatsu M, Yee L, Carraway KL,. Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Cancer Res 1999; 59: 2229-36.
31. Weed DT, Gomez-Fernandez C, Bonfante E, Lee TD, Pacheco J, Carvajal ME, Goodwin WJ, Carraway KL,. MUC4 (sialomucin complex) expression in salivary gland tumors and squamous cell carcinoma of the upper aerodigestive tract. Otolaryngol Head Neck Surg 2001; 124: 127-41.
32. Lopez-Ferrer A, Alameda F, Barranco C, Garrido M, de Bolos C,. MUC4 expression is increased in dysplastic cervical disorders. Hum Pathol 2001; 32: 1197-202.
33. Chakraborty S, Swanson BJ, Bonthu N, Batra SK,. Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases. J Clin Pathol 2010; 63: 579-84.
34. Kwon KY, Ro JY, Singhal N, Killen DE, Sienko A, Allen TC, Zander DS, Barrios R, Haque A, Cagle PT,. MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med 2007; 131: 593-8.
35. Bax DA, Haringsma J, Einerhand AW, van Dekken H, Blok P, Siersema PD, Kuipers EJ, Kusters JG,. MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio. J Clin Pathol 2004; 57: 1267-72.
36. Bafna S, Kaur S, Batra SK,. Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 2010; 29: 2893-904.
37. Hamada T, Matsukita S, Goto M, Kitajima S, Batra SK, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S,. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004; 57: 813-21.
38. Utsunomiya T, Yonezawa S, Sakamoto H, Kitamura H, Hokita S, Aiko T, Tanaka S, Irimura T, Kim YS, Sato E,. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 1998; 4: 2605-14.
39. Sagara M, Yonezawa S, Nagata K, Tezuka Y, Natsugoe S, Xing PX, McKenzie IF, Aikou T, Sato E,. Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: its relationship with prognosis. Int J Cancer 1999; 84: 251-7.
40. Tamada S, Goto M, Nomoto M, Nagata K, Shimizu T, Tanaka S, Sakoda K, Imai K, Yonezawa S,. Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis. Pathol Int 2002; 52: 713-23.
41. Carraway KL, Ramsauer VP, Haq B, Carothers Carraway CA,. Cell signaling through membrane mucins. Bioessays 2003; 25: 66-71.
42. Jepson S, Komatsu M, Haq B, Arango ME, Huang D, Carraway CA, Carraway KL,. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene 2002; 21: 7524-32.
43. Ramsauer VP, Pino V, Farooq A, Carothers Carraway CA, Salas PJ, Carraway KL,. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. Mol Biol Cell 2006; 17: 2931-41.
44. Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK,. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Res 2008; 68: 2065-70.
45. Bafna S, Kaur S, Momi N, Batra SK,. Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br J Cancer 2009; 101: 1155-61.
46. Vincent A, Ducourouble MP, Van Seuningen I,. Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J 2008; 22: 3035-45.
47. Yamada N, Nishida Y, Tsutsumida H, Goto M, Higashi M, Nomoto M, Yonezawa S,. Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer 2009; 100: 344-51
48. Choudhury A, Moniaux N, Winpenny JP, Hollingsworth MA, Aubert JP, Batra SK,. Human MUC4 mucin cDNA and its variants in pancreatic carcinoma. J Biochem 2000; 128: 233-43.
49. Moniaux N, Escande F, Batra SK, Porchet N, Laine A, Aubert JP,. Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins. Eur J Biochem 2000; 267: 4536-44.
50. Choudhury A, Moniaux N, Ringel J, King J, Moore E, Aubert JP, Batra SK,. Alternate splicing at the 3â€-end of the human pancreatic tumor-associated mucin MUC4 cDNA. Teratog Carcinog Mutagen 2001; 21: 83-96.