Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways

Human Gene Therapy

Volumn 22, Issue 11, 2011, Pages 1453-1460

  Hirayama, Shin ^a   Sato, Masaaki ^a   Liu, Mingyao ^a   Loisel Meyer, Severine ^b   Yeung, Jonathan C ^a   Wagnetz, Dirk ^a   Cypel, Marcelo ^a   Zehong, Guan ^a   Medin, Jeffrey A ^b   Keshavjee, Shaf ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; LENTIVIRUS VECTOR;

AIRWAY; ALLOGRAFT; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; BRONCHIOLITIS OBLITERANS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNOFLUORESCENCE; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG PARENCHYMA; LUNG TRANSPLANTATION; MOUSE; NONHUMAN; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; BRONCHIOLITIS OBLITERANS; GREEN FLUORESCENT PROTEINS; HUMANS; INTERLEUKIN-10; LENTIVIRUS; LUNG; LUNG TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS;

LENTIVIRUS; MUS;

EID: 81855184513     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2010.225     Document Type: Article

References (33)

1. Bharat, A., Narayanan, K., Street, T., et al. (2007). Early posttransplant-inflammation promotes the development of alloimmunity-and chronic human lung allograft rejection. Transplantation 83, 150-158. (Pubitemid 46185205)
2. Boehler, A., Chamberlain, D., Xing, Z., et al. (1998). Adenovirusmediated-interleukin-10 gene transfer inhibits post-transplant-fibrous airway obliteration in an animal model of bronchiolitis-obliterans. Hum. Gene Ther. 9, 541-551. (Pubitemid 28149607)
3. Borok, Z., Harboe-Schmidt, J.E., Brody, S.L., et al. (2001). Vesicular-stomatitis virus G-pseudotyped lentivirus vectors mediate-efficient apical transduction of polarized quiescent-primary alveolar epithelial cells. J. Virol. 75, 11747-11754. (Pubitemid 33063265)
4. Bradford, M.M. (1976). A rapid and sensitive method for the-quantitation of microgram quantities of protein utilizing the-principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Buckley, S.M., Howe, S.J., Sheard, V., et al. (2008). Lentiviral-transduction of the murine lung provides efficient pseudotype-and developmental stage-dependent cell-specific transgene-expression. Gene Ther. 15, 1167-1175.
6. Cassivi, S.D., Cardella, J.A., Fischer, S., et al. (1999). Transtracheal-gene transfection of donor lungs prior to organ procurement-increases transgene levels at reperfusion and-following transplantation. J. Heart Lung Transplant. 18, 1181-1188.
7. Cypel, M., Liu, M., Rubacha, M., et al. (2009). Functional repair-of human donor lungs by IL-10 gene therapy. Sci. Transl. Med. 1, 4ra9.
8. Daud, S.A., Yusen, R.D., Meyers, B.F., et al. (2007). Impact of-immediate primary lung allograft dysfunction on bronchiolitis-obliterans syndrome. Am. J. Respir. Crit. Care Med. 175, 507-513. (Pubitemid 46354255)
9. de Perrot, M., Fischer, S., Liu, M., et al. (2003). Impact of human-interleukin-10 on vector-induced inflammation and early graft-function in rat lung transplantation. Am. J. Respir. Cell Mol. Biol. 28, 616-625. (Pubitemid 36543409)
10. Dutly, A.E., Andrade, C.F., Verkaik, R., et al. (2005). A novel-model for post-transplant obliterative airway disease reveals-angiogenesis from the pulmonary circulation. Am. J. Transplant. 5, 248-254. (Pubitemid 40179511)
11. Fischer, S., Liu, M., MacLean, A.A., et al. (2001). In vivo transtracheal-adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion-injury and improves early posttransplant graft function in the-rat. Hum. Gene Ther. 12, 1513-1526. (Pubitemid 34248287)
12. Fischer, S., de Perrot, M., Liu, M., et al. (2003). Interleukin 10-gene transfection of donor lungs ameliorates posttransplant-cell death by a switch from cellular necrosis to apoptosis. J. Thorac. Cardiovasc. Surg. 126, 1174-1180. (Pubitemid 37305708)
13. Groux, H., O'Garra, A., Bigler, M., et al. (1997). A CD4+ T-cell-subset inhibits antigen-specific T-cell responses and prevents-colitis. Nature 389, 737-742. (Pubitemid 27458961)
14. Huhn, R.D., Radwanski, E., O'Connell, S.M., et al. (1996). Pharmacokinetics-and immunomodulatory properties of intravenously-administered recombinant human interleukin-10 in-healthy volunteers. Blood 87, 699-705. (Pubitemid 26031078)
15. Kafri, T., Blomer, U., Peterson, D.A., et al. (1997). Sustained expression-of genes delivered directly into liver and muscle by-lentiviral vectors. Nat. Genet. 17, 314-317. (Pubitemid 27475995)
16. Leask, A., and Abraham, D.J. (2004). TGF-beta signaling and the-fibrotic response. FASEB J. 18, 816-827.
17. Mackenzie, T.C., Kobinger, G.P., Kootstra, N.A., et al. (2002). Efficient transduction of liver and muscle after in utero injection-of lentiviral vectors with different pseudotypes. Mol. Ther. 6, 349-358. (Pubitemid 36305337)
18. Martins, S., de Perrot, M., Imai, Y., et al. (2004). Transbronchial- administration of adenoviral-mediated interleukin-10 gene to-the donor improves function in a pig lung transplant model. Gene Ther. 11, 1786-1796. (Pubitemid 40028540)
19. Moore, K.W., De Waal Malefyt, R., Coffman, R.L., and O'Garra,-A. (2001). Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765. (Pubitemid 32368050)
20. Murphy, J., Summer, R., Wilson, A.A., et al. (2008). The prolonged-life-span of alveolar macrophages. Am. J. Respir. Cell. Mol. Biol. 38, 380-385.
21. Nakagome, K., Dohi, M., Okunishi, K., et al. (2006). In vivo IL-10-gene delivery attenuates bleomycin induced pulmonary fibrosis-by inhibiting the production and activation of TGF-beta-in the lung. Thorax 61, 886-894. (Pubitemid 44570310)
22. Nguyen, T.H., Birraux, J., Wildhaber, B., et al. (2006). Ex vivo-lentivirus transduction and immediate transplantation of uncultured-hepatocytes for treating hyperbilirubinemic Gunn-rat. Transplantation 82, 794-803. (Pubitemid 44470383)
23. Peranteau, W.H., Zhang, L., Muvarak, N., et al. (2008). IL-10-overexpression decreases inflammatory mediators and promotes-regenerative healing in an adult model of scar formation. J. Invest. Dermatol. 128, 1852-1860. (Pubitemid 351847365)
24. Sato, M., and Keshavjee, S. (2006). Gene therapy in lung transplantation. Curr. Gene Ther. 6, 439-458. (Pubitemid 44207819)
25. Sato, M., and Keshavjee, S. (2008). Bronchiolitis obliterans syndrome:-alloimmune-dependent and-independent injury with-aberrant tissue remodeling. Semin. Thorac. Cardiovasc. Surg. 20, 173-182.
26. Sato, M., Liu, M., Anraku, M., et al. (2008). Allograft airway-fibrosis in the pulmonary milieu: a disorder of tissue remodeling. Am. J. Transplant. 8, 517-528. (Pubitemid 351287538)
27. Sato, M., Keshavjee, S., and Liu, M. (2009). Translational research:-animal models of obliterative bronchiolitis after lung- transplantation. Am. J. Transplant. 9, 1981-1987.
28. Shoji, F., Yonemitsu, Y., Okano, S., et al. (2003). Airway-directed-gene transfer of interleukin-10 using recombinant Sendai virus-effectively prevents post-transplant fibrous airway obliteration-in mice. Gene Ther. 10, 213-218. (Pubitemid 36204409)
29. Silvertown, J.D., Walia, J.S., Summerlee, A.J., and Medin JA. (2006). Functional expression of mouse relaxin and mouse-relaxin-3 in the lung from an Ebola virus glycoproteinpseudotyped-lentivirus via tracheal delivery. Endocrinology-147, 3797-3808. (Pubitemid 44079384)
30. Trittibach, P., Barker, S.E., Broderick, C.A., et al. (2008). Lentiviral-vector-mediated expression of murine IL-1 receptor-antagonist or IL-10 reduces the severity of endotoxin-induced-uveitis. Gene Ther. 15, 1478-1488.
31. Trulock, E.P., Christie, J.D., Edwards, L.B., et al. (2007). Registry-of the International Society for Heart and Lung Transplantation:-twenty-fourth official adult lung and heart-lung-transplantation report-2007. J. Heart Lung Transplant. 26,-782-795. (Pubitemid 47199080)
32. Wilson, A.A., Murphy, G.J., Hamakawa, H., et al. (2010). Amelioration-of emphysema in mice through lentiviral transduction-of long-lived pulmonary alveolar macrophages. J. Clin. Invest. 120, 379-389.
33. Xing, Z., Ohkawara, Y., Jordana, M., et al. (1997). Adenoviral-vector- mediated interleukin-10 expression in vivo: intramuscular-gene transfer inhibits cytokine responses in endotoxemia. Gene Ther. 4, 140-149. (Pubitemid 27096138)