Adenovirus-mediated interleukin-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans

Human Gene Therapy

Volumn 9, Issue 4, 1998, Pages 541-551

  Boehler, A ^a,c   Chamberlain, D ^a   Xing, Z ^b   Slutsky, A S ^a   Jordana, M ^b   Gauldie, J ^b   Liu, M ^a   Keshavjee, S ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; VIRUS VECTOR;

ADENOVIRUS; AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BRONCHIOLITIS; CONTROLLED STUDY; GENE TRANSFER; GENETIC TRANSFECTION; GRAFT REJECTION; MALE; NONHUMAN; OSMOTIC MINIPUMP; RAT; T LYMPHOCYTE; TRACHEA SURGERY;

ADENOVIRIDAE; ANIMALIA;

EID: 0032032971     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.4-541     Document Type: Article

References (6)

1. AMKRAUT, A., ECKENHOFF, J.B., and NICHOLS, K. (1990). Osmotic delivery of peptides and macromolecules. Adv. Drug Deliv. Rev. 4, 255-276.
2. AZUMA, H., HEEMANN, U.W., TULLIUS, S.G., and TILNEY, N.L. (1994). Cytokines and adhesion molecules in chronic rejection. Clin. Transpl. 8, 168-180.
3. BACCHETTA, R., BIGLER, M., TOURAINE, J., PARKMAN, R., TOVO, P., ABRAMS, J., DE, W.M.R., DE, V.J., and RONCAROLO, M. (1994). High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J. Exp. Med. 179, 493-502.
4. BACH, F.H., FERRAN, C., HECHENLEITNER, P., MARK, W., KOYAMADA, N., MIYATAKE, T., WINKLER, H., B ADRICHANI, A., CANDINAS, D., and HANCOCK, W.W. (1997). Accommodation of vascularized xenografts: Expression of protective genes by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3, 196-204.
5. XING, Z., OHKAWARA, Y., JORDANA, M., GRAHAM, F.L., and GAULDIE, J. (1997). Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Ther. 4, 140-149.
6. YOUSEM, S.A. (1993). Lymphocytic bronchitis/bronchiolitis in lung allograft recipients. Am. J. Surg. Pathol. 17, 491-496.