In Vivo transtracheal adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion injury and improves early posttransplant graft function in the rat

Human Gene Therapy

Volumn 12, Issue 12, 2001, Pages 1513-1526

  Fischer, Stefan ^a   Liu, Mingyao ^a   MacLean, Alexandra A ^a   De Perrot, Marc ^a   Ho, Michael ^a   Cardella, Jonathan A ^a   Zhang, Xiao Ming ^a   Bai, Xiao Hui ^a   Suga, Michiharu ^a   Imai, Yumiko ^a   Keshavjee, Shaf ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GAMMA INTERFERON; INTERLEUKIN 10; MYELOPEROXIDASE; SUCROSE; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGENATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; LUNG FUNCTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MALE; NONHUMAN; ORGAN DONOR; ORGAN PRESERVATION; OXYGEN TENSION; POSTOPERATIVE CARE; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; RESPIRATORY EPITHELIUM; TISSUE LEVEL; TRANSGENE;

ADENOVIRIDAE; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENE TRANSFER TECHNIQUES; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; LUNG; LUNG TRANSPLANTATION; MALE; OXYGEN; PEROXIDASE; RANDOM ALLOCATION; RATS; RATS, INBRED LEW; REPERFUSION INJURY; TIME FACTORS; TRACHEA; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

ADENOVIRIDAE; ANIMALIA;

EID: 0035572948     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340152480249     Document Type: Article

References (41)

1. Adenovirus-mediated interleukin-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10
4. Transtracheal gene transfection of donor lungs prior to organ procurement increases trans-gene levels at reperfusion and following transplantation
5. Transgene expression after adenovirus-mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression
6. Gene therapy in lung transplantation: Feasibility of ex vivo adenovirus-mediated gene transfer to the graft
7. Immune responses to adenovirus and adeno-associated virus in humans
8. IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity
9. The impact of reperfusion injury on the long term development of obliterative bronchiolitis (OB) in lung transplantation
10. Gene therapy for donor hearts: Ex vivo liposome-mediated transfection
11. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
12. Progress and potential for gene-based medicines
13. Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury
14. Regulatory effects of interleukin-10 on lung ischemia-reperfusion injury
15. Mediators of ischemia-reperfusion injury of rat lung
16. Adenovirus induction of an interferon-regulatory factor during entry into the late phase of infection
17. IL-10 inhibits cytokine production by activated macrophages
18. Cell death in human lung transplantation: Apoptosis induction in human lungs during ischemia and after transplantation
19. Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation
20. Raffinose improves the function of rat pulmonary grafts stored for 24 hr in low potassium dextran solution
21. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
22. Pre-steady-state kinetics of the microtubule-kinesin ATPase
23. Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice
24. Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion
25. Expression of naked DNA in human, pig, and mouse skin
26. The Registry of the International Society for Heart and Lung Transplantation: Seventeenth official report-2000
27. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
28. Tumor necrosis factor-alpha in ischemia and reperfusion injury in rat lungs
29. Genetic targeting of adenoviral vectors
30. Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production
31. Interleukin-10
32. Epstein-Barr virus BCRF1 gene product (viral interleukin 10) inhibits superoxide anion production by human monocytes
33. Perialveolar interstitial resistance and compliance in isolated rat lung
34. Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation
35. Prolonged ischemia is associated with more pronounced rejection in the lung allograft
36. IL-10 reduces rat brain injury following focal stroke
37. Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients
38. Assay method for myeloperoxidase in human polymorphonuclear leukocytes
39. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
40. Major histocompatibility complex expression and lung ischemia-reperfusion in rats
41. Chronic rejection following lung transplantation. Incidence, time pattern and consequences