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Volumn 27, Issue 4, 2011, Pages 287-293

Expression of immune relevant genes in pigs under the influence of low doses of deoxynivalenol (DON)

Author keywords

Cytokines; DON; Immune system; RT qPCR

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VOMITOXIN;

EID: 81855180647     PISSN: 01787888     EISSN: 18671632     Source Type: Journal    
DOI: 10.1007/s12550-011-0106-7     Document Type: Article
Times cited : (28)

References (26)
  • 1
    • 33745812825 scopus 로고    scopus 로고
    • Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets
    • DOI 10.2527/jas.2005-355
    • F Accensi P Pinton P Callu N bella-Bourges JF Guelfi F Grosjean IP Oswald 2006 Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets J Anim Sci 84 1935 1942 16775078 10.2527/jas.2005-355 1:CAS:528:DC%2BD28Xmt1aqtLg%3D (Pubitemid 44033983)
    • (2006) Journal of Animal Science , vol.84 , Issue.7 , pp. 1935-1942
    • Accensi, F.1    Pinton, P.2    Callu, P.3    Abella-Bourges, N.4    Guelfi, J.-F.5    Grosjean, F.6    Oswald, I.P.7
  • 2
    • 77649229497 scopus 로고    scopus 로고
    • MRNA and microRNA quality control for RT-qPCR analysis
    • 20079844 10.1016/j.ymeth.2010.01.010 1:CAS:528:DC%2BC3cXjtVCgu78%3D
    • C Becker A Hammerle-Fickinger I Riedmaier MW Pfaffl 2010 mRNA and microRNA quality control for RT-qPCR analysis Methods 50 237 243 20079844 10.1016/j.ymeth.2010.01.010 1:CAS:528:DC%2BC3cXjtVCgu78%3D
    • (2010) Methods , vol.50 , pp. 237-243
    • Becker, C.1    Hammerle-Fickinger, A.2    Riedmaier, I.3    Pfaffl, M.W.4
  • 3
    • 0027863962 scopus 로고
    • The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs
    • 8146954 10.1007/BF01839219 1:STN:280:DyaK2c7ps1Kqtg%3D%3D
    • B Bergsjo W Langseth I Nafstad JH Jansen HJ Larsen 1993 The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs Vet Res Commun 17 283 294 8146954 10.1007/BF01839219 1:STN:280:DyaK2c7ps1Kqtg%3D%3D
    • (1993) Vet Res Commun , vol.17 , pp. 283-294
    • Bergsjo, B.1    Langseth, W.2    Nafstad, I.3    Jansen, J.H.4    Larsen, H.J.5
  • 4
    • 20444479352 scopus 로고    scopus 로고
    • Mechanisms of nutrient modulation of the immune response
    • DOI 10.1016/j.jaci.2005.04.036, PII S0091674905012741
    • S Cunningham-Rundles DF McNeeley A Moon 2005 Mechanisms of nutrient modulation of the immune response J Allergy Clin Immunol 115 1119 1128 15940121 10.1016/j.jaci.2005.04.036 1:CAS:528:DC%2BD2MXltFaqsLY%3D (Pubitemid 40824577)
    • (2005) Journal of Allergy and Clinical Immunology , vol.115 , Issue.6 , pp. 1119-1129
    • Cunningham-Rundles, S.1    McNeeley, D.F.2    Moon, A.3
  • 5
    • 2342658494 scopus 로고    scopus 로고
    • Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics
    • DOI 10.1080/0003942031000161045
    • S Danicke H Valenta F Klobasa S Doll M Ganter G Flachowsky 2004 Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics Arch Anim Nutr 58 1 17 15085961 10.1080/0003942031000161045 1:STN:280:DC%2BD2c7ovF2ktA%3D%3D (Pubitemid 38597301)
    • (2004) Archives of Animal Nutrition , vol.58 , Issue.1 , pp. 1-17
    • Danicke, S.1    Valenta, H.2    Klobasa, F.3    Doll, S.4    Ganter, M.5    Flachowsky, G.6
  • 6
    • 17044452850 scopus 로고    scopus 로고
    • Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets
    • 14620906 1:STN:280:DC%2BD3srjvFGnsg%3D%3D
    • S Doll S Danicke KH Ueberschar H Valenta U Schnurrbusch M Ganter F Klobasa G Flachowsky 2003 Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets Arch Tierernahr 57 311 334 14620906 1:STN:280:DC%2BD3srjvFGnsg%3D%3D
    • (2003) Arch Tierernahr , vol.57 , pp. 311-334
    • Doll, S.1    Danicke, S.2    Ueberschar, K.H.3    Valenta, H.4    Schnurrbusch, U.5    Ganter, M.6    Klobasa, F.7    Flachowsky, G.8
  • 8
    • 0242539883 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of 3-acetyl DON in pigs
    • 14620907 1:CAS:528:DC%2BD3sXovFGksrc%3D
    • GS Eriksen H Pettersson JE Lindberg 2003 Absorption, metabolism and excretion of 3-acetyl DON in pigs Arch Tierernahr 57 335 345 14620907 1:CAS:528:DC%2BD3sXovFGksrc%3D
    • (2003) Arch Tierernahr , vol.57 , pp. 335-345
    • Eriksen, G.S.1    Pettersson, H.2    Lindberg, J.E.3
  • 9
    • 67649225494 scopus 로고    scopus 로고
    • The immunomodulatory effect of lactulose on Enterococcus faecium fed preruminant calves
    • 19098237 10.2527/jas.2007-0494 1:CAS:528:DC%2BD1MXlt1Ont70%3D
    • S Fleige W Preissinger HH Meyer MW Pfaffl 2009 The immunomodulatory effect of lactulose on Enterococcus faecium fed preruminant calves J Anim Sci 87 1731 1738 19098237 10.2527/jas.2007-0494 1:CAS:528:DC%2BD1MXlt1Ont70%3D
    • (2009) J Anim Sci , vol.87 , pp. 1731-1738
    • Fleige, S.1    Preissinger, W.2    Meyer, H.H.3    Pfaffl, M.W.4
  • 10
    • 26044436251 scopus 로고    scopus 로고
    • On the effects of a chronic deoxynivalenol intoxication on performance, haematological and serum parameters of pigs when diets are offered either for Ad Libitum consumption or fed restrictively
    • DOI 10.1111/j.1439-0442.2005.00734.x
    • T Goyarts S Danicke HJ Rothkotter J Spilke U Tiemann M Schollenberger 2005 On the effects of a chronic deoxynivalenol intoxication on performance, haematological and serum parameters of pigs when diets are offered either for ad libitum consumption or fed restrictively. J Vet Med A Physiol Pathol Clin Med 52 305 314 1:CAS:528:DC%2BD2MXhtVSltL7N (Pubitemid 41641059)
    • (2005) Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine , vol.52 , Issue.6 , pp. 305-314
    • Goyarts, T.1    Danicke, S.2    Rothkotter, H.-J.3    Spilke, J.4    Tiemann, U.5    Schollenberger, M.6
  • 11
    • 33745190944 scopus 로고    scopus 로고
    • Effect of the Fusarium toxin deoxynivalenol (DON) on IgA IgM and IgG concentrations and proliferation of porcine blood lymphocytes
    • 16480848 10.1016/j.tiv.2005.12.006 1:CAS:528:DC%2BD28Xmt1Ortbo%3D
    • T Goyarts S Danicke U Tiemann HJ Rothkotter 2006 Effect of the Fusarium toxin deoxynivalenol (DON) on IgA IgM and IgG concentrations and proliferation of porcine blood lymphocytes Toxicol In Vitro 20 858 867 16480848 10.1016/j.tiv.2005.12.006 1:CAS:528:DC%2BD28Xmt1Ortbo%3D
    • (2006) Toxicol in Vitro , vol.20 , pp. 858-867
    • Goyarts, T.1    Danicke, S.2    Tiemann, U.3    Rothkotter, H.J.4
  • 12
    • 4444249333 scopus 로고    scopus 로고
    • Workshop on trichothecenes with a focus on DON: Summary report
    • DOI 10.1016/j.toxlet.2004.04.020, PII S0378427404002383
    • JC Larsen J Hunt I Perrin P Ruckenbauer 2004 Workshop on trichothecenes with a focus on DON: summary report Toxicol Lett 153 1 22 15342076 10.1016/j.toxlet.2004.04.020 1:CAS:528:DC%2BD2cXntlGlt78%3D (Pubitemid 39165744)
    • (2004) Toxicology Letters , vol.153 , Issue.1 , pp. 1-22
    • Larsen, J.C.1    Hunt, J.2    Perrin, I.3    Ruckenbauer, P.4
  • 13
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 402 408 11846609 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 14
    • 77957802278 scopus 로고    scopus 로고
    • Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance
    • 20798930 10.1007/s00204-010-0579-8 1:CAS:528:DC%2BC3cXhtVOnurzE
    • JJ Pestka 2010 Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance Arch Toxicol 84 663 679 20798930 10.1007/s00204-010- 0579-8 1:CAS:528:DC%2BC3cXhtVOnurzE
    • (2010) Arch Toxicol , vol.84 , pp. 663-679
    • Pestka, J.J.1
  • 15
    • 0003029745 scopus 로고
    • Mycotoxin-induced immune modulation
    • Dean JH, Luser MI, Munson AE, and Kimber I (eds) 2nd edn. Raven Press, New York
    • Pestka JJ,Bondy GS (1994) Mycotoxin-induced immune modulation. In: Dean JH, Luser MI, Munson AE, and Kimber I (eds) Immunotoxicology and immunopharmacology, 2nd edn. Raven Press, New York
    • (1994) Immunotoxicology and Immunopharmacology
    • Pestka, J.J.1    Bondy, G.S.2
  • 16
    • 40849094146 scopus 로고    scopus 로고
    • Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses
    • 18329193 10.1016/j.toxlet.2008.01.015 1:CAS:528:DC%2BD1cXjs1Whtrw%3D
    • P Pinton F Accensi E Beauchamp AM Cossalter P Callu F Grosjean IP Oswald 2008 Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses Toxicol Lett 177 215 222 18329193 10.1016/j.toxlet.2008.01.015 1:CAS:528:DC%2BD1cXjs1Whtrw%3D
    • (2008) Toxicol Lett , vol.177 , pp. 215-222
    • Pinton, P.1    Accensi, F.2    Beauchamp, E.3    Cossalter, A.M.4    Callu, P.5    Grosjean, F.6    Oswald, I.P.7
  • 17
    • 0028304536 scopus 로고
    • Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig
    • DOI 10.1002/nt.2620020302
    • DB Prelusky RG Gerdes KL Underhill BA Rotter PY Jui HL Trenholm 1994 Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig Nat Toxins 2 97 104 8087437 10.1002/nt.2620020302 1:CAS:528:DyaK2cXlt1Ontbo%3D (Pubitemid 24186805)
    • (1994) Natural Toxins , vol.2 , Issue.3 , pp. 97-104
    • Prelusky, D.B.1    Gerdes, R.G.2    Underhill, K.L.3    Rotter, B.A.4    Jui, P.Y.5    Trenholm, H.L.6
  • 18
    • 19444365938 scopus 로고    scopus 로고
    • Effects of trichothecene mycotoxins on eukaryotic cells: A review
    • DOI 10.1080/02652030500058403
    • O Rocha K Ansari FM Doohan 2005 Effects of trichothecene mycotoxins on eukaryotic cells: a review Food Addit Contam 22 369 378 16019807 10.1080/02652030500058403 1:CAS:528:DC%2BD2MXkt1Srsrc%3D (Pubitemid 40723772)
    • (2005) Food Additives and Contaminants , vol.22 , Issue.4 , pp. 369-378
    • Rocha, O.1    Ansari, K.2    Doohan, F.M.3
  • 19
    • 77957187583 scopus 로고
    • Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine
    • DOI 10.1006/faat.1994.1087
    • BA Rotter BK Thompson M Lessard HL Trenholm H Tryphonas 1994 Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine Fundam Appl Toxicol 23 117 124 7958555 10.1006/faat.1994.1087 1:CAS:528:DyaK2cXlt1Oms7o%3D (Pubitemid 24247989)
    • (1994) Fundamental and Applied Toxicology , vol.23 , Issue.1 , pp. 117-124
    • Rotter, B.A.1    Thompson, B.K.2    Lessard, M.3    Trenholm, H.L.4    Tryphonas, H.5
  • 20
    • 0029939564 scopus 로고    scopus 로고
    • Toxicology of deoxynivalenol (vomitoxin)
    • 8637056 1:CAS:528:DyaK28XjtFajt74%3D
    • BA Rotter DB Prelusky JJ Pestka 1996 Toxicology of deoxynivalenol (vomitoxin) J Toxicol Environ Health 48 1 34 8637056 1:CAS:528: DyaK28XjtFajt74%3D
    • (1996) J Toxicol Environ Health , vol.48 , pp. 1-34
    • Rotter, B.A.1    Prelusky, D.B.2    Pestka, J.J.3
  • 21
    • 56649119186 scopus 로고    scopus 로고
    • Effect of insoluble fibre on intestinal morphology and mRNA expression pattern of inflammatory, cell cycle and growth marker genes in a piglet model
    • 19143227 10.1080/17450390802479349 1:CAS:528:DC%2BD1cXhtl2qu7fO
    • K Schedle MW Pfaffl C Plitzner HH Meyer W Windisch 2008 Effect of insoluble fibre on intestinal morphology and mRNA expression pattern of inflammatory, cell cycle and growth marker genes in a piglet model Arch Anim Nutr 62 427 438 19143227 10.1080/17450390802479349 1:CAS:528:DC%2BD1cXhtl2qu7fO
    • (2008) Arch Anim Nutr , vol.62 , pp. 427-438
    • Schedle, K.1    Pfaffl, M.W.2    Plitzner, C.3    Meyer, H.H.4    Windisch, W.5
  • 22
    • 1542757036 scopus 로고    scopus 로고
    • Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent
    • HV Swamy TK Smith EJ MacDonald NA Karrow B Woodward HJ Boermans 2003 Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent J Anim Sci 81 2792 2803 14601883 1:CAS:528:DC%2BD3sXosFOgu7g%3D (Pubitemid 38571624)
    • (2003) Journal of Animal Science , vol.81 , Issue.11 , pp. 2792-2803
    • Swamy, H.V.L.N.1    Smith, T.K.2    MacDonald, E.J.3    Karrow, N.A.4    Woodward, B.5    Boermans, H.J.6
  • 23
    • 0030789866 scopus 로고    scopus 로고
    • Potential role of IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin
    • DOI 10.1016/S0300-483X(97)00087-5, PII S0300483X97000875
    • D Yan HR Zhou KH Brooks JJ Pestka 1997 Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin Toxicology 122 145 158 9274810 10.1016/S0300-483X(97)00087- 5 1:CAS:528:DyaK2sXlsFeqsL8%3D (Pubitemid 27327034)
    • (1997) Toxicology , vol.122 , Issue.1-2 , pp. 145-158
    • Yan, D.1    Zhou, H.-R.2    Brooks, K.H.3    Pestka, J.J.4
  • 24
    • 0029032159 scopus 로고
    • Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition
    • 10.1006/taap.1995.1132
    • JI Zcona-Olivera Y Ouyang J Murtha FS Chu JJ Pestka 1995 Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition Toxicol Appl Pharmacol 133 109 120 10.1006/taap.1995.1132
    • (1995) Toxicol Appl Pharmacol , vol.133 , pp. 109-120
    • Zcona-Olivera, J.I.1    Ouyang, Y.2    Murtha, J.3    Chu, F.S.4    Pestka, J.J.5
  • 25
    • 0031172809 scopus 로고    scopus 로고
    • Differential cytokine mRNA expression in mice after oval exposure to the trichothecene vomitoxin (Deoxynivalenol): Dose response and time course
    • DOI 10.1006/taap.1997.8132
    • HR Zhou D Yan JJ Pestka 1997 Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course Toxicol Appl Pharmacol 144 294 305 9194413 10.1006/taap.1997.8132 1:CAS:528:DyaK2sXjsl2ltb8%3D (Pubitemid 27268351)
    • (1997) Toxicology and Applied Pharmacology , vol.144 , Issue.2 , pp. 294-305
    • Zhou, H.-R.1    Yan, D.2    Pestka, J.J.3
  • 26
    • 0037342456 scopus 로고    scopus 로고
    • Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin
    • DOI 10.1093/toxsci/kfg006
    • HR Zhou Z Islam JJ Pestka 2003 Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin Toxicol Sci 72 130 142 12604842 10.1093/toxsci/kfg006 1:CAS:528:DC%2BD3sXit1yrsrs%3D (Pubitemid 36336442)
    • (2003) Toxicological Sciences , vol.72 , Issue.1 , pp. 130-142
    • Zhou, H.-R.1    Islam, Z.2    Pestka, J.J.3


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