Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses

Toxicology Letters

Volumn 177, Issue 3, 2008, Pages 215-222

  Pinton, Philippe ^a   Accensi, Francesc ^a   Beauchamp, Erwan ^a   Cossalter, Anne Marie ^a   Callu, Patrick ^b   Grosjean, François ^b   Oswald, Isabelle P ^a  

^a CEMAGREF   (France)

^b ARVALIS Institut du Vé tal   (France)

Author keywords

Cytokine; Deoxynivalenol; Immunoglobulin; Lymphocyte proliferation; Swine; Vaccination

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA; VOMITOXIN;

ANALYTICAL PARAMETERS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FOOD CONTAMINATION; HEMATOLOGICAL PARAMETERS; ILEUM; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MESENTERY LYMPH NODE; MITOGENICITY; NONHUMAN; PIGLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; UPREGULATION; VACCINATION;

ANIMAL FEED; ANIMALS; CYTOKINES; FOOD CONTAMINATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; RNA, MESSENGER; SWINE; TRICHOTHECENES; VACCINATION; VACCINES; WEIGHT GAIN;

ANIMALIA; FUSARIUM; SUIDAE;

EID: 40849094146     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.01.015     Document Type: Article

References (46)

1. Abouzied M.M., Azcona J.I., Braselton W.E., and Pestka J.J. Immunochemical assessment of mycotoxins in 1989 grain foods: evidence for deoxynivalenol (vomitoxin) contamination. Appl. Environ. Microbiol. 57 (1991) 672-677
2. Accensi F., Pinton P., Callu P., Abella-Bourges N., Guelfi J.F., Grosjean F., and Oswald I.P. Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J. Anim. Sci. 84 (2006) 1935-1942
3. Almond G.W. Research applications using pigs. Vet. Clin. North Am. Food Anim. Pract. 12 (1996) 707-716
4. Chowdhury S.R., Smith T.K., Boermans H.J., and Woodward B. Effects of feed-borne Fusarium mycotoxins on hematology and immunology of laying hens. Poult. Sci. 84 (2005) 1841-1850
5. Dänicke S., Valenta H., Klobasa F., Doll S., Ganter M., and Flachowsky G. Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch. Anim. Nutr. 58 (2004) 1-17
6. Döll S., Danicke S., Ueberschar K.H., Valenta H., Schnurrbusch U., Ganter M., Klobasa F., and Flachowsky G. Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch. Tierernahr. 57 (2003) 311-334
7. Drochner W., Schollenberger M., Gotz S., Lauber U., Tafaj M., and Piepho H.P. Subacute effects of moderate feed loads of isolated Fusarium toxin deoxynivalenol on selected parameters of metabolism in weaned growing piglets. J. Anim. Physiol. Anim. Nutr. 90 (2006) 421-428
8. Ehrlich K.C., and Daigle K.W. Protein synthesis inhibition by 8-oxo-12,13-epoxytrichothecenes. Biochim. Biophys. Acta 923 (1987) 206-213
9. Etienne, M., Wache, Y. 2008. Biological and physiological effects of deoxynivalenol (DON) in the pig. In: Oswald, I.P., Taranu, I. (Eds.), Mycotoxins in Farm Animals. Reseach Signpost, Kerala, pp. 113-130.
10. Fink-Gremmels J. Mycotoxins: their implications for human and animal health. Vet. Q. 21 (1999) 115-120
11. Germolec D.R. Sensitivity and predictivity in immunotoxicity testing: immune endpoints and disease resistance. Toxicol. Lett. 149 (2004) 109-114
12. Goyarts T., Danicke S., Tiemann U., and Rothkotter H.J. Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol. In Vitro 20 (2006) 858-867
13. Halloy D.J., Gustin P.G., Bouhet S., and Oswald I.P. Oral exposure to culture material extract containing fumonisins predisposes swine to the development of pneumonitis caused by Pasteurella multocida. Toxicology 213 (2005) 34-44
14. Harvey R.B., Kubena L.F., Huff W.E., Corrier D.E., Clark D.E., and Phillips T.D. Effects of aflatoxin, deoxynivalenol, and their combinations in the diet of growing pigs. Am. J. Vet. Res. 50 (1989) 602-607
15. Li M., Cuff C.F., and Pestka J.J. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Toxicol. Sci. 87 (2005) 134-145
16. Li M., Harkema J.R., Cuff C.F., and Pestka J.J. Deoxynivalenol exacerbates viral bronchopneumonia induced by Reovirus infection. Toxicol. Sci. 95 (2007) 412-426
17. Lun A.K., Young L.G., and Lumsden J.H. The effects of vomitoxin and feed intake on the performance and blood characteristics of young pigs. J. Anim. Sci. 61 (1985) 1178-1185
18. Marin D.E., Taranu I., Bunaciu P.R., Pascale F., Tudor D.S., Avram N., Sarca M., Cureu I., Criste R.D., Suta V., and Oswald I.P. Changes in performance, blood parameters, humoral and cellular immune response in weanling piglets exposed to low doses of Aflatoxin. J. Anim Sci. 80 (2002) 1250-1257
19. Marin D.E., Taranu I., Pascale F., Lionide A., Burlacu R., Bailly J.D., and Oswald I.P. Gender-related differences in the immune response of weaning piglets exposed to low dose of fumonisin extract. Br. J. Nutr. 95 (2006) 1185-1192
20. Meissonnier G.M., Laffitte J., Raymond I., Benoit E., Cossalter A.M., Pinton P., Bertin G., Oswald I.P. Galtier P. 2008. Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs. Toxicology., doi:10.1016/j.tox.2008.02.003, in press.
21. Nakamura S., Kozutsumi Y., Sun Y., Miyake Y., Fujita T., and Kawasaki T. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. J. Biol. Chem. 271 (1996) 1255-1257
22. Oswald I.P., and Comera C. Immunotoxicity of mycotoxins. Rev. Med. Vet. 149 (1998) 585-590
23. Oswald I.P., Dozois C.M., Barlagne R., Fournout S., Johansen M.V., and Bøgh H. Cytokine mRNA expression in pigs infected with Schistosoma japonicum. Parasitology 122 (2001) 299-307
24. 1 increases intestinal colonization by pathogenic Escherichia coli in pigs. Appl. Environ. Microbiol. 69 (2003) 5870-5874
25. Øvernes G., Matre T., Sivertsen T., Larsen H.J.S., Langseth L., Reitan L.J., and Jansen J.H. Effects of diet with graded levels of naturally doxynivalenol-contaminated oats on immune response in growing pigs. J. Vet. Med. A. 44 (1997) 539-550
26. Pestka J.J. Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicol. Lett. 140 (2003) 287-295
27. Pestka J.J., and Smolinski A.T. Deoxynivalenol: toxicology and potential effects on humans. J. Toxicol. Environ. Health B Crit. Rev. 8 (2005) 39-69
28. Pestka J.J., Moorman M.A., and Warner R.L. Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol). Toxicol. Lett. 50 (1990) 75-84
29. Pestka J.J., Zhou H.R., Moon Y., and Chung Y.J. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unravelling a paradox. Toxicol. Lett. 153 (2004) 61-73
30. Pestka J.J. Deoxynivalenol: toxicity, mechanisms and animal health risks. Anim. Feed Sci. Technol. 137 (2007) 283-298
31. Pie S., Lalles J.P., Blazy F., Laffitte J., Seve B., and Oswald I.P. Weaning is associated with an up-regulation of expression of inflammatory cytokines in the intestine of piglets. J. Nutr. 134 (2004) 641-647
32. Puri N., Weyand E.H., Abdel-Rahman S.M., and Sinko P.J. An investigation of the intradermal route as an effective means of immunization for microparticulate vaccine delivery systems. Vaccine 18 (2000) 2600-2612
33. Rothkotter H.J., Sowa E., and Pabst R. The pig as a model of developmental immunology. Hum. Exp. Toxicol. 21 (2002) 533-536
34. Rotter B.A., Prelusky D.B., and Pestka J.J. Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 48 (1996) 1-34
35. Rotter B.A., Thompson B.K., Lessard M., Trenholm H.L., and Tryphonas H. Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine. Fundam. Appl. Toxicol. 23 (1994) 117-124
36. Schollenberger M., Jara H.T., Suchy S., Drochner W., and Muller H.M. Fusarium toxins in wheat flour collected in an area in southwest Germany. Int. J. Food Microbiol. 72 (2002) 85-89
37. SCOOP, 2003. Collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states. Directorate-general health and consumer protection. http://europa.eu.int/comm/food/fs/scoop/ task3210.
38. In: Smith J.E., and Henderson R.S. (Eds). Mycotoxins and Animal Foods (1991), CRC Press, Boca Raton, USA 844
39. Swamy H.V.L.N., Smith T.K., MacDonald E.J., Boermans H.J., and Squires E.J. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J. Anim. Sci. 80 (2002) 3257-3267
40. Swamy H.V.L.N., Smith T.K., MacDonald E.J., Karrow N.A., Woodward B., and Boermans H.J. Effects of feeding a blend of grains naturally contamined with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J. Anim. Sci. 81 (2003) 2792-2803
41. 1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 84 (2005) 301-307
42. Techau M.E., Johansen M.V., Aasted B., Lind P., Ornbjerg N., and Oswald I.P. Cytokine mRNA profiles in pigs exposed prenatally and postnatally to Schistosoma japonicum. Vet. Res. 38 (2007) 25-36
43. Tiemann U., Brussow K.P., Jonas L., Pohland R., Schneider F., and Danicke S. Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts. J. Anim. Sci. 84 (2006) 236-245
44. Trenholm H.L., Hamilton R.M., Friend D.W., Thompson B.K., and Hartin K.E. Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle. J. Am. Vet. Med. Assoc. 185 (1984) 527-531
45. van Ginkel F.W., Wahl S.M., Kearney J.F., Kweon M.N., Fujihashi K., Burrows P.D., Kiyono H., and McGhee J.R. Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J. Immunol. 163 (1999) 1951-1957
46. Xiao, C., Rajput, Z.I., Hu, S., 2007. Improvement of a commercial foot-and-mouth disease vaccine by supplement of Quil A. Vaccine 25, 4795-4800.