On the effects of a chronic deoxynivalenol intoxication on performance, haematological and serum parameters of pigs when diets are offered either for Ad Libitum consumption or fed restrictively

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 52, Issue 6, 2005, Pages 305-314

  Goyarts, T ^a   Danicke S ^a   Rothkotter H J ^a,b   Spilke, J ^a,c   Tiemann, U ^a,d   Schollenberger, M ^a,e  

^a INSTITUTE FOR EPIDEMIOLOGY AND PATHOGEN DIAGNOSTICS   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^e UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; FUSARIUM; SUS SCROFA; TRITICUM AESTIVUM;

TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANIMAL; ANIMAL FOOD; ARTICLE; BLOOD; CHEMISTRY; FEMALE; FOOD CONTAMINATION; FUSARIUM; MALE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; RANDOMIZATION; SWINE; WEIGHT GAIN; WHEAT;

ANIMAL FEED; ANIMALS; FEMALE; FOOD CONTAMINATION; FUSARIUM; MALE; RANDOM ALLOCATION; SWINE; TRICHOTHECENES; TRITICUM; WEIGHT GAIN;

EID: 26044436251     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0442.2005.00734.x     Document Type: Article

References (38)

1. Bergsjø, B.. T. Matre, and I. Nafstad, 1992: Effects of diets with graded levels of deoxynivalenol on performance in growing pigs. J. Vet. Med. A 39, 752-758.
2. Bergsjø, B., W. Langseth, I. Nafstad, J. H. Jansen, and H. J. Larsen, 1993: The effects on naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs. Vet. Res. Commun. 17, 283-294.
3. Chavez, E. R., and J. A. Rheaume, 1986: The significance of the: reduced feed consumption observed in growing pigs fed vomitoxin-contaminated diets. Can. J. Anim. Sci. 66, 277-287.
4. Cote, L. M., V. R. Beasley, P. M. Bratich, S. P. Swanson, H. L. Shivaprasad, and W. B. Buck, 1985: Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. J. Anim. Sci. 61, 942-950.
5. Dänicke, S., T. Goyarts, H. Valenta, E. Razzazi, and J. Böhm, 2004a: On the effects of deoxynivalenol (DON) in pig feed on growth performance, nutrients utilization and DON metabolism. J. Anim. Feed Sci. 13, 539-556.
6. Dänicke, S., H. Valenta, and S. Döll, 2004b: On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch. Anim. Nutr. 58, 169-180.
7. Dänicke, S., H. Valenta, S. Döll, M. Ganter, and G. Flachowsky, 2004c: On the effectiveness of a detoxifying agent in preventing fusario-toxicosis in fattening pigs. Anim. Feed Sci. Technol. 114, 141-157.
8. Dänicke, S., H. Valenta, F. Klobasa, S. Döll, M. Ganter, and G. Flachowsky, 2004d: Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch. Anim. Nutr. 58, 1-17.
9. Davis, B. D., 1980: Microbiology: Including Immunology and Molecular Genetics, 3 edn. Harper & Row, Cambrigde.
10. Döll, S., S. Dänicke, K. H. Ueberschär, H. Valenta, U. Schnurrbusch, M. Ganter, F. Klobasa, and G. Flachowsky, 2003: Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch. Anim. Nutr. 57, 311-334.
11. Drochner, W., M. Schollenberger, H.-P. Piepho, S. Götz, U. Lauber, M. Tafaj, F. Klobasa, U. Weiler, R. Claus, and M. Steffl, 2004: Serum IgA-promoting effects induced by feed loads containing isolated deoxynivalenol (DON) in growing piglets. J. Toxicol. Environ. Health A 67, 1051-1067.
12. Farries, F. E., and H. J. Oslage, 1961: Zur Technik langfristiger Stoffwechselversuche an wachsenden Schweinen. Z. Tierphysiol. Tierernähr. Futtermittelkd. 16, 11-18.
13. 1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem. Toxicol. 24, 213-219.
14. Friend, D. W., H. L. Trenholm, B. K. Thompson, D. B. Prelusky, and K. E. Hartin, 1986: Effect of deoxynivalenol (DON)-contaminated diet fed to growing-finishing pigs on their performance at market weight, nitrogen retention and DON excretion. Can. J. Anim. Sci. 66, 1075-1085.
15. Gesellschaft für Ernährungsphysiologie (GfE), 1987: Energie- und Nährstoffbedarf Landwirtschaftlicher Nutztiere, Nr. 4 Schweine. Ausschuss für Bedarfsnormen, DLG-Verlag, Frankfurt (Main), Germany.
16. Greene, D. M., G. S. Bondy, J. I. Azcona-Olivera, and J. J. Pestka, 1994a: Role of gender and strain in vomitoxin-induced dysregulation of IgA production and IgA nephropathy in the mouse. J. Toxicol. Environ. Health 43, 37-50.
17. Greene, D. M., J. I. Azcona-Olivera, and J. J. Pestka, 1994b: Vomitoxin (deoxynivalenol)-induced IgA nephropathie in the B6C3F1 mouse: dose response and male predilection. Toxicology 92, 245-260.
18. Greene, D. M., J. I. Azcona-Olivera, J. M. Murtha, and J. J. Pestka, 1995: Effects of dihydrotestosterone and estradiol on experimental IgA nephropathy induced by vomitoxin. Fundam. Appl. Toxicol. 26, 107-116.
19. Jain, N. C., 1986: The neutrophils. In: Jain, N. C. (ed.), Schalm's Veterinary Hematology, 4th edn, pp.676-730. Lean and Febinger, Philadelphia, PA.
20. Kenward, M. G., and M. G. Roger, 1997: Small sample inference for fixed effects from restricted maximum likelihood. Biometrics 53, 983-997.
21. Matthäus, K., S. Dänicke, W. Vahjen, O. Simon, J. Wang, H. Valenta, K. Meyer, A. Strumpf, H. Zieseniß, and G. Flachowsky, 2004: Progression of mycotoxin and nutrient concentrations in wheat after inoculation with Fusarium culmorum. Arch. Anim. Nutr. 58, 19-35.
22. Naumann, C., and R. Bassler, 1993: Die Chemische Untersuchung Von Futtermitteln. VDLUFA-Verlag, Darmstadt, Germany.
23. Oldenburg, E., H. Valenta, and Ch. Sator, 2000: Risikoabschätzung und Vermeidungsstrategien bei der Futtermittelerzeugung. In: Dänicke, S. and Oldenberg, E. (eds), Risikofaktoren für die Fusariumtoxinbildung und Vermeidungsstrategien bei der Futtermittelerzeugung und Fütterung, Vol. 216, pp. 5-34. Landbauforsch. Völk., Sonderheft.
24. Øvernes, G., T. Matre, T. Sivertsen, H. J. S. Larsen, W. Langseth, L. J. Reitan, and J. H. Jansen, 1997: Effects of diets with graded levels of naturally deoxynivalenol-contaminated oats on immune response in growing pigs. J. Vet. Med. A 44, 539-550.
25. Rotter, B. A., B. K. Thompson, H. L. Trenholm, D. B. Prelusky, K. E. Hartin, and J. D. Miller, 1992: A preliminary examination of potential interactions between deoxynivalenol (DON) and other selected Fusarium metabolites in growing pigs. Can. J. Anim. Sci. 72, 107-116.
26. Rotter, B. A., B. K. Thompson, M. Lessard, H. L. Trenholm, and H. Tryphonas, 1994: Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine. Fundam. Appl. Toxicol. 23, 117-124.
27. Rotter, B. A., B. K. Thompson, and M. Lessard, 1995: Effects of deoxynivalenol-contaminated diet on performance and blood parameters in growing swine. Can. J. Anim. Sci. 75, 297-302.
28. Rotter, B. A., D. B. Prelusky, and J. J. Pestka, 1996: Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 48, 1-34.
29. Schiemann, R., 1981: Methodische Richtlinien zur Durchführung von Verdauungsversuchen für die Futterwertschätzung. Arch. Anim. Nutr. 31, 13-18.
30. Schollenberger, M., U. Lauber, H. Terry Jara, S. Suchy, W. Drochner, and H.-M. Müller, 1998: Determination of eight trichothecenes by gas chromatography-mass spectrometry after sample clean-up by a two-stage solid-phase extraction. J. Chromatogr. A 815, 123-132.
31. Smith, T. K., E. G. McMillan, and J. B. Castillo, 1997: Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine. J. Anim. Sci. 75, 2184-2191.
32. Swamy, H. V., T. K. Smith, E. J. MacDonald, H. J. Boermans, and E. J. Squires, 2002: Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J. Anim. Sci. 80, 3257-3267.
33. Swamy, H. V., T. K. Smith, E. J. MacDonald, N. A. Karrow, B. Woodward, and H. J. Boemians, 2003: Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J. Anim. Sci. 81, 2792-2803.
34. Trenholm, H. L., R. M. G. Hamilton, D. W. Friend, B. K. Thompson, and K. E. Hartin, 1984: Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: Effects on swine, poultry, and dairy cattle. JAVMA 185, 527-531.
35. Trenholm, H. L., B. C. Foster, L. L. Charmley, B. K. Thompson, K. E. Hartin, R. W. Coppock, and M. A. Albassam, 1994: Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol in growing pigs. Can. J. Anim. Sci. 74, 361-369.
36. Valenta, H., S. Dänicke, and J. Wolff, 2002: Vergleich Einer HPLC-und Einer ELISA-methode zur Bestimmung von Deoxynivalenol in Mühlenstäuben, Kleien und Getreide, pp. 675-679. VDLUFA- Kongreßband 2002, VDLUFA-Schriftenreihe, Leipzig, Germany.
37. Valenta, H., S. Dänicke, and S. Döll, 2003: Analysis of deoxynivalenol and de-epoxy-deoxynivalenol in animal tissues by liquid chromatography after clean-up with an immunoaffinity column. Mycotoxin Res. 19A, 51-55.
38. Young, L. G., L. McGirr, V. E. Valli, J. H. Lumsden, and A. Lun, 1983: Vomitoxin in corn fed to young pigs. J. Anim. Sci. 57, 655-664.