Physiology of Duct Cell Secretion

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery: Second Edition

Volumn , Issue , 2009, Pages 78-90

  Lee, Min Goo ^a   Muallem, Shmuel ^b  

^a Yonsei University College of Medicine   (South Korea)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alcohol associated diseases; Cystic fibrosis and chronic pancreatitis; Cystic fibrosis transmembrane conductance regulator; Duct cell secretion physiology; Ductal fluid and electrolyte secretion mechanism; Membrane transporter regulation; Sympathetic, splanchnic, aminergic network

Indexed keywords

EID: 84856849647     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444300123.ch7     Document Type: Chapter

References (95)

1. Steward MC, Ishiguro H, Case RM. Mechanisms of bicarbonate secretion in the pancreatic duct. Annu Rev Physiol 2005;67: 377-409.
2. Argent BE, Case RM. Pancreatic ducts. Cellular mechanism and control of bicarbonate secretion. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1994: 1473-97.
3. Wasle B, Edwardson JM. The regulation of exocytosis in the pancreatic acinar cell. Cell Signal 2002;14:191-7.
4. Taylor CJ, Aswani N. The pancreas in cystic fibrosis. Paediatr Respir Rev 2002;3:77-81.
5. Bornstein JD, Cohn JA. Cystic fibrosis in the pancreas: recent advances provide new insights. Curr Gastroenterol Rep 1999;1: 161-5.
6. Naruse S. Do CFTR gene polymorphisms determine the susceptibility to alcoholic chronic pancreatitis? Intern Med 2004;43:1093-4.
7. Case RM, Argent BE. Pancreatic duct cell secretion: control and mechanisms of transport. In: Go VLW, ed. The Pancreas: Biology, Pathobiology and Disease, 2nd edn. New York: Raven Press, 1993: 301-50.
8. Bonner-Weir S, Toschi E, Inada A et al. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes 2004;5:16-22.
9. Githens S. The pancreatic duct cell: proliferative capabilities, specific characteristics, metaplasia, isolation, and culture. J Pediatr Gastroenterol Nutr 1988;7:486-506.
10. Takahashi H. Scanning electron microscopy of the rat exocrine pancreas. Arch Histol Jpn 1984;47:387-404.
11. Mangos JA, McSherry NR. Micropuncture study of excretion of water and electrolytes by the pancreas. Am J Physiol 1971; 221:496-503.
12. Domschke S, Domschke W, Rosch W et al. Inhibition by somatostatin of secretin-stimulated pancreatic secretion in man: a study with pure pancreatic juice. Scand J Gastroenterol 1977;12:59-63.
13. Sewell WA, Young JA. Secretion of electrolytes by the pancreas of the anaesthetized rat. J Physiol 1975;252:379-96.
14. Case RM, Harper AA, Scratcherd T. The secretion of electrolytes and enzymes by the pancreas of the anaesthetized cat. J Physiol 1969;201:335-48.
15. Case RM. Pancreatic exocrine secretion: mechanisms and control. In: Beger HG, Warshaw AL, Büchler MW, Carr-Locke DL, Neoptolemos JP, Russell C, Sarr MG, eds. The Pancreas. Oxford: Blackwell Science, 1998: 63-100.
16. Case RM. Pancreatic secretion: cellular aspects. In: Duthie HL, Wormsley KG, eds. Scientific Basis of Gastroenterology. London: Churchill Livingstone, 1978: 163-98.
17. Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol 1902;28:325-53.
18. Pavlov IP. The Work of the Digestive Glands (translated by Thompson WH), 2nd edn. Philadelphia: Lippincott, 1910: 59-64.
19. Pandol SJ. Neurohumoral control of exocrine pancreatic secretion. Curr Opin Gastroenterol 2003;19:443-6.
20. Debas HT, Grossman MI. Pure cholecystokinin: pancreatic protein and bicarbonate response. Digestion 1973;9:469-81.
21. +-dependent transporters mediate HCO3- salvage across the luminal membrane of the main pancreatic duct. J Clin Invest 2000;105:1651-8.
22. Lee KY, Shiratori K, Chen YF, Chang TM, Chey WY. A hormonal mechanism for the interdigestive pancreatic secretion in dogs. Am J Physiol 1986;251:G759-G764.
23. Anagnostides A, Chadwick VS, Selden AC, Maton PN. Sham feeding and pancreatic secretion. Evidence for direct vagal stimulation of enzyme output. Gastroenterology 1984;87:109-14.
24. Cargill JM, Wormsley KG. Effect of gastric distension on human pancreatic secretion. Acta Hepatogastroenterol (Stuttg) 1979;26: 235-8.
25. Chey WY, Kim MS, Lee KY, Chang TM. Effect of rabbit antisecretin serum on postprandial pancreatic secretion in dogs. Gastroenterology 1979;77:1268-75.
26. Gyr K, Beglinger C, Fried M et al. Plasma secretin and pancreatic response to various stimulants including a meal. Am J Physiol 1984;246:G535-G542.
27. Grundy D, Hutson D, Scratcherd T. The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade. J Physiol 1983;342:517-26.
28. You CH, Rominger JM, Chey WY. Potentiation effect of cholecystokinin- octapeptide on pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin in humans. Gastroenterology 1983;85:40-5.
29. Lifson N, Kramlinger KG, Mayrand RR, Lender EJ. Blood flow to the rabbit pancreas with special reference to the islets of Langerhans. Gastroenterology 1980;79:466-73.
30. Ushiki T, Watanabe S. Distribution and ultrastructure of the autonomic nerves in the mouse pancreas. Microsc Res Tech 1997; 37:399-406.
31. Novak I. ATP as a signaling molecule: the exocrine focus. News Physiol Sci 2003;18:12-17.
32. Chey WY, Lee YH, Hendricks JG, Rhodes RA, Tai HH. Plasma secretin concentrations in fasting and postprandial state in man. Am J Dig Dis 1978;23:981-8.
33. Schaffalitzky de Muckadell OB, Fahrenkrug J, Watt-Boolsen S, Worning H. Pancreatic response and plasma secretin concentration during infusion of low dose secretin in man. Scand J Gastroenterol 1978;13:305-11.
34. Brooks AM, Grossman MI. Postprandial pH and neutralizing capacity of the proximal duodenum in dogs. Gastroenterology 1970;59:85-9.
35. Hanssen LE. Pure synthetic bile salts release immunoreactive secretin in man. Scand J Gastroenterol 1980;15:461-3.
36. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 2001;121:1380-90.
37. Reeve JR Jr, Wu SV, Keire DA et al. Differential bile-pancreatic secretory effects of CCK-58 and CCK-8. Am J Physiol 2004; 286:G395-G402.
38. Luo X, Zheng W, Yan M, Lee MG, Muallem S. Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells. Am J Physiol 1999;277: C205-C215.
39. +-activated Cl- channels can substitute for CFTR in stimulation of pancreatic duct bicarbonate secretion. FASEB J 2000;14:2345-56.
40. + activates cystic fibrosis transmembrane conductance regulator- and Cl--dependent HCO3 - transport in pancreatic duct cells. J Biol Chem 2003; 278:200-7.
41. Ishiguro H, Naruse S, Kitagawa M, Hayakawa T, Case RM, Steward MC. Luminal ATP stimulates fluid and HCO3 - secretion in guinea-pig pancreatic duct. J Physiol 1999;519:551-8.
42. Saito A, Williams JA, Kanno T. Potentiation of cholecystokinininduced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata. J Clin Invest 1980;65:777-82.
43. Domschke W, Tympner F, Domschke S, Demling L. Exocrine pancreatic function in juvenile diabetics. Digest Dis 1975;20:309-12.
44. Gyr K, Beglinger C, Kohler E, Trautzl U, Keller U, Bloom SR. Circulating somatostatin. Physiological regulator of pancreatic function? J Clin Invest 1987;79:1595-600.
45. Glad H, Svendsen P, Ainsworth MA, Olsen O, Rehfeld JF, Schaffalitzky de Muckadell OB. The effect of gastrin-releasing peptide on porcine pancreaticobiliary bicarbonate secretion is mediated by secretin. Scand J Gastroenterol 1994;29:195-202.
46. Gullo L, Pezzilli R, Tomassetti P, de Giorgio R. Plasma cholecystokinin and neurotensin after an ordinary meal in humans. A prolonged time study. Gastroenterol Clin Biol 1998;22:25-8.
47. Li Y, Hao Y, Zhu J, Owyang C. Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokininstimulated pancreatic secretion in rats. Gastroenterology 2000; 118:1197-207.
48. Suzuki A, Naruse S, Kitagawa M et al. 5-Hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells. J Clin Invest 2001;108:749-56.
49. Pappas TN, Debas HT, Taylor IL. Peptide YY: metabolism and effect on pancreatic secretion in dogs. Gastroenterology 1985; 89:1387-92.
50. Konturek SJ, Zabielski R, Konturek JW, Czarnecki J. Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion. Eur J Pharmacol 2003;481:1-14.
51. Li Y, Wu X, Zhu J, Yan J, Owyang C. Hypothalamic regulation of pancreatic secretion is mediated by central cholinergic pathways in the rat. J Physiol 2003;552:571-87.
52. Chey WY, Chang T. Neural hormonal regulation of exocrine pancreatic secretion. Pancreatology 2001;1:320-35.
53. Dunning BE, Havel PJ, Veith RC, Taborsky GJ Jr. Pancreatic and extrapancreatic galanin release during sympathetic neural activation. Am J Physiol 1990;258:E436-E444.
54. Lingard JM, Young JA. β-Adrenergic control of exocrine secretion by perfused rat pancreas in vitro. Am J Physiol 1983;245: G690-G696.
55. Holst JJ, Fahrenkrug J, Knuhtsen S et al. VIP and PHI in the pig pancreas: coexistence, corelease, and cooperative effects. Am J Physiol 1987;252:G182-G189.
56. + and HCO3 - transporters in the rat pancreatic duct. J Gen Physiol 1994;104:57-85.
57. +-HCO3 - cotransport isoform 3. J Biol Chem 2002;277:50503-9.
58. +-HCO3 - cotransport in interlobular ducts from guinea-pig pancreas. J Physiol 1996;495:169-78.
59. Choi JY, Muallem D, Kiselyov K, Lee MG, Thomas PJ, Muallem S. Aberrant CFTR-dependent HCO3 - transport in mutations associated with cystic fibrosis. Nature 2001;410:94-7.
60. Ko SBH, Zeng W, Dorwart MR et al. Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 2004;6:343-50.
61. Ahn W, Kim KH, Lee JA et al. Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3 - salvage mechanisms in model systems and the mouse pancreatic duct. J Biol Chem 2001;276:17236-43.
62. +- adenosine triphosphatase. Gastroenterology 1995;108:850-9.
63. Ishiguro H, Steward MC, Wilson RW, Case RM. Bicarbonate secretion in interlobular ducts from guinea-pig pancreas. J Physiol 1996;495:179-91.
64. Abuladze N, Lee I, Newman D et al. Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 1998;273:17689-95.
65. +, and Cl- transport in resting pancreatic acinar cells. J Gen Physiol 1995;106:1225-42.
66. Ishiguro H, Naruse S, Kitagawa M et al. CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreas. J Physiol 2000;528: 305-15.
67. Gross E, Fedotoff O, Pushkin A, Abuladze N, Newman D, Kurtz I. Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. J Physiol 2003;549: 673-82.
68. + secretion. Gastroenterology 1989;96:881-4.
69. Moseley RH, Hoglund P, Wu GD et al. Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea. Am J Physiol 1999;276:G185-G192.
70. + exchanger. J Biol Chem 1999;274:22855-61.
71. Shcheynikov N, Wang Y, Park M et al. Coupling modes and stoichiometry of Cl-/HCO3 - exchange by SLC26a3 and SLC26a6. J Gen Physiol 2006;127:511-24.
72. Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J. Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 2000;70:102-12.
73. Knauf F, Yang C-L, Thomson RB, Mentone SA, Giebisch G, Aronson PS. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci USA 2001;98:9425-30.
74. Short DB, Trotter KW, Reczek D et al. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 1998;273:19797-801.
75. Guggino WB. The cystic fibrosis transmembrane regulator forms macromolecular complexes with PDZ domain scaffold proteins. Proc Am Thorac Soc 2004;1:28-32.
76. Poulsen JH, Fischer H, Illek B, Machen TE. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 1994;91:5340-4.
77. Wright AM, Gong X, Verdon B et al. Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride. J Biol Chem 2004;279:41658-63.
78. Ko SBH, Shcheynikov N, Choi JY et al. A molecular mechanism for aberrant CFTR-dependent HCO3 - transport in cystic fibrosis. EMBO J 2002;21:5662-72.
79. +-ATPase in the exocrine pancreas and parotid of the dog. Am J Physiol 1987;253:G99-G109.
80. + channels on pancreatic duct cells by cyclic AMPdependent phosphorylation. J Membr Biol 1990;115:203-15.
81. Burghardt B, Elkaer ML, Kwon TH et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut 2003;52:1008-16.
82. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS, Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 1999;103:261-9.
83. Alvarez C, Regan JP, Merianos D, Bass BL. Protease-activated receptor-2 regulates bicarbonate secretion by pancreatic duct cells in vitro. Surgery 2004;136:669-76.
84. Hegyi P, Gray MA, Argent BE. Substance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger. Am J Physiol 2003;285:C268-C276.
85. Alvarez BV, Vilas GL, Casey JR. Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J 2005;24: 2499-511.
86. Dyck WP, Hightower NC, Janowitz HD. Effect of acetazolamide on human pancreatic secretion. Gastroenterology 1972;62: 547-52.
87. McMurtrie HL, Cleary HJ, Alvarez BV et al. The bicarbonate transport metabolon. J Enzyme Inhib Med Chem 2004;19:231-6.
88. Fanjul M, Salvador C, Alvarez L, Cantet S, Hollande E. Targeting of carbonic anhydrase IV to plasma membranes is altered in cultured human pancreatic duct cells expressing a mutated (deltaF508) CFTR. Eur J Cell Biol 2002;81:437-47.
89. Johansen PG, Anderson CM, Hadorn B. Cystic fibrosis of the pancreas. A generalised disturbance of water and electrolyte movement in exocrine tissues. Lancet 1968;i:455-60.
90. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 1998;339:653-8.
91. Lee JH, Choi JH, Namkung W et al. A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Hum Mol Genet 2003;12:2321-32.
92. Namkung W, Han W, Luo X et al. Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology 2004;126:1844-59.
93. Yamamoto A, Ishiguro H, Ko SB et al. Ethanol induces fluid hypersecretion from guinea-pig pancreatic duct cells. J Physiol 2003;551:917-26.
94. Migliori M, Pezzilli R, Tomassetti P, Gullo L. Exocrine pancreatic function after alcoholic or biliary acute pancreatitis. Pancreas 2004;28:359-63.
95. Nakamura Y, Ohmori T, Ishikawa A et al. Homozygous (TG)11 allele in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against bicarbonate decrease in pure pancreatic juice among Japanese male alcoholics. Intern Med 2004;43:1131-7.