Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants

Chemical Research in Toxicology

Volumn 24, Issue 11, 2011, Pages 1937-1943

  Jeyabalan, Jeyaprakash ^a   Vadhanam, Manicka V ^a   Ravoori, Srivani ^a   Gupta, Ramesh C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ELECTROPHILE; NUCLEOTIDE; PHOSPHORUS 32; POLYCAPROLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST SARCOMA; CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; ENVIRONMENTAL EXPOSURE; FEMALE; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; LIVER; LUNG; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CARCINOGENS; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; DRUG IMPLANTS; FEMALE; GENE EXPRESSION; HUMANS; INJECTIONS, INTRAPERITONEAL; LIVER; LUNG; MAMMARY GLANDS, ANIMAL; PHOSPHORUS RADIOISOTOPES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 81755173049     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2002788     Document Type: Article

References (26)

1. Yamagiwa, K. and Ichikawa, K. (1918) Experimental study of the pathogenesis of carcinoma J. Cancer Res. 3, 1-29
2. Haddow, A. and Kon, G. A. (1947) Chemistry of carcinogenic compounds Br. Med. Bull. 4, 314-326
3. Kennaway, E. L. and Hieger, I. (1930) Carcinogenic substances and their fluorescence spectra BMJ 1, 1044-1046
4. Arif, J. M. and Gupta, R. C. (1996) Detection of DNA-reactive metabolites in serum and their tissue distribution in mice exposed to multiple doses of carcinogen mixtures: Role in human biomonitoring Carcinogenesis 17, 2213-2219 (Pubitemid 26372061)
5. Kerns, W. D., Pavkov, K. L., Donofrio, D. J., Gralla, E. J., and Swenberg, J. A. (1983) Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure Cancer Res. 43, 4382-4392 (Pubitemid 13041877)
6. Pegg, A. E. and Hui, G. (1978) Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine Biochem. J. 173, 739-748 (Pubitemid 9010966)
7. 32P-postlabeling for detection of DNA adducts. In Technologies for Detection of DNA Damage and Mutations (Pfeifer, G. P., Ed.) pp 45-61, Plenum Press, New York.
8. Gupta, R. C., Bansal, S. S., Aqil, F., Cao, P., Jeyabalan, J., Russell, G. K., Ravoori, S., and Vadhanam, M. V. (2009) A novel concept in delivering chemopreventive compounds. Proc. Am. Assoc. Cancer Res., 50, Abstract #944.
9. Bansal, S. S., Vadhanam, M. V., and Gupta, R. C. (2011) Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin Pharm. Res. 28, 1121-1130
10. Gupta, R. C. and Spencer-Beach, G. (1996) Natural and endogenous DNA adducts as detected by 32P-postlabeling Regul. Toxicol. Pharmacol. 23, 14-21
11. Ross, J., Nelson, G., Kligerman, A., Erexson, G., Bryant, M., Earley, K., Gupta, R., and Nesnow, S. (1990) Formation and persistence of novel benzo(a)pyrene adducts in rat lung, liver, and peripheral blood lymphocyte DNA Cancer Res. 50, 5088-5094 (Pubitemid 20257941)
12. Fang, A. H., Smith, W. A., Vouros, P., and Gupta, R. C. (2001) Identification and characterization of a novel benzo[a]pyrene-derived DNA adduct Biochem. Biophys. Res. Commun. 281, 383-389 (Pubitemid 32928167)
13. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F., Wakabayashi, K., and Totsuka, Y. (2002) Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine Jpn. J. Cancer Res. 93, 1076-1082 (Pubitemid 35314951)
14. Murai, T., Mori, S., Kang, J. S., Morimura, K., Wanibuchi, H., Totsuka, Y., and Fukushima, S. (2008) Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats Toxicol. Pathol. 36, 472-477
15. Neal, J. and Rigdon, R. H. (1967) Gastric tumors in mice fed benzo(a)pyrene: A quantitative study Tex. Rep. Biol. Med. 25, 553-557
16. Iwagawa, M., Maeda, T., Izumi, K., Otsuka, H., Nishifuji, K., Ohnishi, Y., and Aoki, S. (1989) Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats Carcinogenesis 10, 1285-1290 (Pubitemid 19177234)
17. Talaska, G., Jaeger, M., Reilman, R., Collins, T., and Warshawsky, D. (1996) Chronic, topical exposure to benzo[a]pyrene induces relatively high steady-state levels of DNA adducts in target tissues and alters kinetics of adduct loss Proc. Natl. Acad. Sci. U.S.A. 93, 7789-7793 (Pubitemid 26277116)
18. Ramesh, A. and Knuckles, M. E. (2006) Dose-dependent benzo(a)pyrene [B(a)P]-DNA adduct levels and persistence in F-344 rats following subchronic dietary exposure to B(a)P Cancer Lett. 240, 268-278 (Pubitemid 44093829)
19. Lutz, W. K. and Gaylor, D. (1996) Significance of DNA adducts at low dose: Shortening the time to spontaneous tumor occurrence Regul. Toxicol. Pharmacol. 23, 29-34 (Pubitemid 26142908)
20. Rodriguez, L. V., Dunsford, H. A., Steinberg, M., Chaloupka, K. K., Zhu, L., Safe, S., Womack, J. E., and Goldstein, L. S. (1997) Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice Carcinogenesis 18, 127-135 (Pubitemid 28134626)
21. Harris, D. L., Washington, M. K., Hood, D. B., Roberts, L. J., 2nd, and Ramesh, A. (2009) Dietary fat-influenced development of colon neoplasia in Apc Min mice exposed to benzo(a)pyrene Toxicol. Pathol. 37, 938-946
22. Shi, Z., Dragin, N., Miller, M. L., Stringer, K. F., Johansson, E., Chen, J., Uno, S., Gonzalez, F. J., Rubio, C. A., and Nebert, D. W. (2010) Oral benzo[a]pyrene-induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype Int. J. Cancer 127, 2334-2350
23. IARC (1984) Carbon Blacks, Mineral Oils (Lubricant Base Oils and Derived Products) and Some Nitroarenes. International Agency for Research on Cancer Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 33: Polynuclear Aromatic Compounds, Part 2, International Agency for Research on Cancer, Lyons, France.
24. Mumford, J. L., Li, X., Hu, F., Lu, X. B., and Chuang, J. C. (1995) Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke Carcinogenesis 16, 3031-3036 (Pubitemid 26004202)
25. Meireles, S. I., Esteves, G. H., Hirata, R., Jr., Peri, S., Devarajan, K., Slifker, M., Mosier, S. L., Peng, J., Vadhanam, M. V., Hurst, H. E., Neves, E. J., Reis, L. F., Gairola, C. G., Gupta, R. C., and Clapper, M. L. (2010) Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue Cancer Prev. Res. (Phila) 3, 707-717
26. Gupta, R. C., Arif, J. M., and Gairola, C. G. (1999) Enhancement of pre-existing DNA adducts in rodents exposed to cigarette smoke Mutat. Res. 424, 195-205 (Pubitemid 29101619)