Evidence of a Threshold-Effect for 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline Liver Carcinogenicity in F344/DuCrj Rats

Toxicologic Pathology

Volumn 36, Issue 3, 2008, Pages 472-477

  Murai, Takshi ^a   Mori, Satoru ^b   Kang, Jin Seok ^b   Morimura, Keiichirou ^b   Wanibuchi, Hideki ^b   Totsuka, Yukari ^c   Fukushima, Shoji ^b,d  

^a SHIONOGI AND CO LTD   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

2 amino 3,8 dimethylimidazo 4,5 f quinoxaline; heterocyclic amine; low dose carcinogenicity; MeIQx; threshold

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO(4,5 F)QUINOXALINE; 2-AMINO-3,8-DIMETHYLIMIDAZO(4,5-F)QUINOXALINE; 8 HYDROXYDEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; CARCINOGEN; DEOXYGUANOSINE; DRUG DERIVATIVE; GLUTATHIONE TRANSFERASE; QUINOXALINE DERIVATIVE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE;

ANIMAL; ANIMAL FOOD; ARTICLE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DNA ADDUCT; DOSE RESPONSE; DRUG EFFECT; DRUG SURVEILLANCE PROGRAM; ENZYMOLOGY; FISCHER 344 RAT; LIVER; LIVER ADENOMA; LIVER CELL CARCINOMA; LIVER TUMOR; LONGEVITY; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PRECANCER; RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BREAST FIBROADENOMA; CANCER INCIDENCE; CANCER SURVIVAL; CARCINOGEN TESTING; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

ADENOMA, LIVER CELL; ADMINISTRATION, ORAL; ANIMAL FEED; ANIMALS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; DEOXYGUANOSINE; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; LIVER; LIVER NEOPLASMS; LONGEVITY; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PRECANCEROUS CONDITIONS; QUINOXALINES; RATS; RATS, INBRED F344;

RATTUS;

EID: 48549106666     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623308315671     Document Type: Article

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