Significance of DNA adducts at low dose: Shortening the time to spontaneous tumor occurrence

Regulatory Toxicology and Pharmacology

Volumn 23, Issue 1 I, 1996, Pages 29-34

  Lutz, Werner K ^a   Gaylor, David ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN;

CANCER; CANCER INCIDENCE; CANCER RISK; CARCINOGENESIS; CONFERENCE PAPER; DNA ADDUCT; DOSE RESPONSE; HERITABILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030004528     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1996.0005     Document Type: Conference Paper

References (40)

1. Ames, B. N., and Gold, L. S. (1991). Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 250(1-2), 3-16.
2. Beland, F. A., Fullerton, N. F., Kinouchi, T., and Poirier, M. C. (1988). DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations. IARC Sci. Publ. 89, 175-180.
3. Belinsky, S. A., White, C. M., Devereux, T. R., Swenberg, J. A., and Anderson, M. W. (1987). Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 47, 1143-1148.
4. Billen, D. (1994). Spontaneous DNA damage and its significance for the "negligible dose" controversy in radiation protection. Belle Newslett. 3, 8-11.
5. Bogen, K. T. (1994). Cancer potencies of heterocyclic amines found in cooked foods. Food Chem. Toxicol. 32, 505-515.
6. 4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine. Cancer Res. 47, 1577-1581.
7. Buss, P., Caviezel, M., and Lutz, W. K. (1990). Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B1. Carcinogenesis 11, 2133-2135.
8. Druckrey, H., Schildbach, A., Schmaehl, D., Preussmann, R., and Ivankovic, S. (1963). Quantitative Analyse der carcinogenen Wirkung von Diaethylnitrosamin. Arzneim.-Forsch. 13, 841-851.
9. Ehrenberg, L., and Tornqvist, M. (1991). Human health risk assessment and biological reactive intermediates: hemoglobin binding. Adv. Exp. Med. Biol. 283, 641-647.
10. Farmer, P. B., Bailey, E., Naylor, S., Anderson, D., Brooks, A., Cushnir, J., Lamb, J. H., Sepai, O., and Tang, Y. S. (1993). Identification of endogenous electrophiles by means of mass spectrometric determination of protein and DNA adducts. Environ. Health Perspect. 99, 19-24.
11. Frantz, C. E., Bangerter, C., Fultz, E., Mayer, K. M., Vogel, J. S., and Turteltaub, K. W. (1995). Dose-response studies of MelQx in rat liver and liver DNA at low doses. Carcinogenesis 16(2), 367-373.
12. Gaylor, D. W. (1992). Relationship between the shape of dose-response curves and background tumor rates. Regul. Toxicol. Pharmacol. 16, 2-9.
13. Gupta, R. C. (1996). Regul. Toxicol. Pharmacol. 23, 14-21.
14. Harris, C. C. (1989). Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair. Carcinogenesis 10, 1563-1566.
15. Hecker, E. (1991a). Wirkungs/Dosis-Beziehungen im Maeusehautmodell der Konditionalkanzerogenese mit dem Tumorpromotor 3-O-Tetradekanoylingenol als Umweltrisikofaktor - Hypothesen und praktische Konsequenzen. In Chemische Krebsrisikofaktoren der Umwelt (Schlatterer, B., Ed.), Vol. 6, pp. 177-196. Erich Schmidt Verlag, Berlin.
16. Hecker, E. (1991b). Wirkungs/Dosis-Beziehungen im Maeusehautmodell der Solitaerkanzerogenese mit dem Tumorinitiator 7, 12-Dimethylbenz[α]anthrazen als Umweltrisikofaktor - Hypothesen und praktische Konsequenzen. In Chemische Krebsrisikofaktoren der Umwelt (Schlatterer, B., Ed.), Vol. 6, pp. 1-39. Erich Schmidt Verlag, Berlin.
17. Jackson, C. D., Weis, C., and Shellenberger, T. E. (1980). Tissue binding of 2-acetylaminofluorene in BALB/c and C57B1/6 mice during chronic oral administration. Chem.-Biol. Interact. 32, 63-81.
18. Kitchin, K. T., and Brown, J. L. (1994). Dose-response relationship for rat liver DNA damage caused by 49 rodent carcinogens. Toxicology 88, 31-49.
19. Krewski, D., Gaylor, D. W., and Lutz, W. K. (1995). Additivity to background and linear extrapolation. In Low-Dose Extrapolation of Cancer Risks: Issues and Perspectives (S. Olin, W. Farland, C. Park, L. Rhomberg, R. Scheuplein, T. Starr, and J. Wilson, Eds.), pp. 105-121. ILSI/International Life Sciences Institute, Washington, DC.
20. 6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine. Cancer Res. 44, 196-200.
21. Littlefield, N. A., Farmer, J. H., and Gaylor, D. W. (1980). Effects of dose and time in a long-term, low-dose carcinogenic study. J. Environ. Pathol. Toxicol. 3, 17-34.
22. Loeb, L. A. (1989). Endogenous carcinogenesis: Molecular oncology into the twenty-first century - Presidential address. Cancer Res. 49, 5489-5496.
23. Lutz, W. K. (1987). Quantitative evaluation of DNA-binding data in vivo for low-dose extrapolations. Arch. Toxicol. 11(Suppl.), 66-74.
24. Lutz, W. K. (1990). Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis. Mutat. Res. 238, 287-295.
25. Lutz, W. K. (1991). Dose-response relationships in chemical carcinogenesis: From DNA adducts to tumor incidence. Adv. Exp. Med. Biol. 283, 151-156.
26. Lutz, W. K., Buss, P., Baertsch, A., and Caviezel, M. (1990). Evaluation of DNA binding in vivo for low dose extrapolation in chemical carcinogenesis. Environ. Sci. Res. 39, 331-341.
27. Marnett, L. J., and Burcham, P. C. (1993). Endogenous DNA adducts - potential and paradox. Chem. Res. Toxicol. 6(6), 771-785.
28. Nath, R. G. (1996). Regul. Toxicol. Pharmacol. 23, 22-28.
29. Peto, R., Gray, R., Brantom, P., and Grasso, P. (1991). Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res. 51, 6452-6469.
30. Poirier, M. C., and Beland, F. A. (1992). DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models - implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol. 5(6), 749-755.
31. Randerath, K., Li, D. H., Nath, R., and Randerath, E. (1992). Exogenous and endogenous DNA modifications as monitored by P-32-postlabeling - Relationships to cancer and aging. Exp. Gerontol. 27(5-6), 533-549.
32. Saul, R. L., and Ames, B. N. (1986). Background levels of DNA damage in the population. In Mechanisms of DNA Damage and Repair (Simic, M. G., Grossman, L., and Upton, A. C., Eds.), Vol. 38, pp. 529-535. Plenum, New York.
33. Schrager, T. F., Newberne, P. M., Pikul, A. H., and Groopman, J. D. (1990). Aflatoxin - DNA adduct formation in chronically dosed rats fed a choline-deficient diet. Carcinogenesis 11(1), 177-180.
34. Scrable, H. J., Sapienza, C., and Cavenee, W. K. (1990). Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv. Cancer Res. 54, 25-62.
35. Sone, H., Wakabayashi, K., Kushida, H., Ochiai, M., Sugimura, T., and Nagao, M. (1993). Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet. Jpn. J. Cancer Res. 84(8), 859-864.
36. Stevenson, D. E., Sielken, R. L., and Bretzlaff, R. S. (1994). Challenges to low-dose linearity in carcinogenesis from interactions among mechanistic components as exemplified by the concept of "invaders" and "defenders." Belle Newslett. 3(2), 1-8.
37. Swenberg, J. A., Richardson, F. C., Boucheron, J. A., Deal, F. H., Belinsky, S. A., Charbonneau, M., and Short, B. G. (1987). High to low dose extrapolation: Critical determinants involved in the dose response of carcinogenic substances. Environ. Health Perspect. 76, 57-63.
38. Walker, V. E., Fennell, T. R., Upton, P. B., Skopek, T. R., Prevost, V., Shuker, D. E. G., and Swenberg, J. A. (1992). Molecular dosimetry of ethylene oxide - Formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res. 52(16), 4328-4334.
39. Weber, E., and Bannasch, P. (1994). Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis 15, 1235-1242.
40. Yamashita, K., Adachi, M., Kato, S., Nakagama, H., Ochiai, M., Wakabayashi, K., Sato, S., Nagao, M., and Sugimura, T. (1990). DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: Dose-response on chronic administration. Jpn. J. Cancer Res. 81(5), 470-476.