Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Nakamura, Satoki ^a   Nagata, Yasuyuki ^a   Tan, Lin ^a   Takemura, Tomonari ^a   Shibata, Kiyoshi ^a   Fujie, Michio ^a   Fujisawa, Shinya ^b   Tanaka, Yasutaka ^c   Toda, Mitsuo ^c   Makita, Reiko ^c   Tsunekawa, Kenji ^c   Yamada, Manabu ^c   Yamaoka, Mayumi ^c   Yamashita, Junko ^c   Ohnishi, Kazunori ^a   Yamashita, Mitsuji ^c  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HAMAMATSU MEDICAL CENTER   (Japan)

^c SHIZUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALDEHYDE DEHYDROGENASE; AURORA B KINASE; CD34 ANTIGEN; CHECKPOINT KINASE 1; CYCLIN B1; MESSENGER RNA; NUCLEAR FACTOR Y; NUCLEAR FACTOR Y BETA; PROTEIN P300; PROTEIN TYROSINE PHOSPHATASE; SURVIVIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CCAAT BINDING FACTOR; E1A ASSOCIATED P300 PROTEIN; EP300 PROTEIN, HUMAN; IER5 PROTEIN, HUMAN; IMMEDIATE EARLY PROTEIN; NFYB PROTEIN, HUMAN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; IMMEDIATE EARLY GENE 5; INHIBITION KINETICS; LEUKEMIA CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSCRIPTION REGULATION; CELL SEPARATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; PATHOLOGY;

ANTIGENS, CD34; CCAAT-BINDING FACTOR; CDC25 PHOSPHATASES; CELL CYCLE; CELL PROLIFERATION; CELL SEPARATION; E1A-ASSOCIATED P300 PROTEIN; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMEDIATE-EARLY PROTEINS; LEUKEMIA, MYELOID, ACUTE; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR STEM CELL ASSAY;

EID: 81755171946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028011     Document Type: Article

References (38)

1. Nakamura S, Yamashita M, Yokota D, Hirano I, Ono T, et al. (2010) Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity. Invest New Drugs 28: 381-391.
2. Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, et al. (2010) The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis 31: 2012-2021.
3. Winkles JA, (1998) Serum- and polypeptide growth factor-inducible gene expression in mouse fibroblasts. Prog Nucleic Acid Res Mol Biol 58: 41-78.
4. Freter RR, Alberta JA, Hwang GY, Wrentmore AL, Stiles CD, (1996) Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator. J Biol Chem 271: 17417-17424.
5. Chung KC, Gomes I, Wang D, Lau LF, Rosner MR, (1998) Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as-dependent signaling pathways. Mol Cell Biol 18: 2272-2281.
6. Williams M, Lyu MS, Yang YL, Lin EP, Dunbrack R, et al. (1999) Ier5, a novel member of the slow-kinetics immediate-early genes. Genomics 55: 327-334.
7. Cirelli C, Tononi G, (2000) Gene expression in the brain across the sleep-waking cycle. Brain Res 885: 303-321.
8. Okada A, Kushima K, Aoki Y, Bialer M, Fujiwara M, (2005) Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth Defects Res A Clin Mol Teratol 73: 229-238.
9. Wang HP, Long XH, Sun ZZ, Rigaud O, Xu QZ, et al. (2006) Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of gamma-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity. Int J Radiat Biol 82: 181-190.
10. Long XH, Zhao ZQ, He XP, Wang HP, Xu QZ, et al. (2007) Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells. Int Mol Med 19: 607-615.
11. Ding KK, Shang ZF, Hao C, Xu QZ, Shen JJ, et al. (2009) Yang CJ, Xie YH, Qiao C, Wang Y, Xu LL, Zhou PK. Induced expression of the IER5 gene by gamma-ray irradiation and its involvement in cell cycle checkpoint control and survival. Radiat Environ Biophys 48: 205-213.
12. Rodriguez S, Khabir A, Keryer C, Perrot C, Drira M, et al. (2005) Conventional and array-based comparative genomic hybridization analysis of nasopharyngeal carcinomas from the Mediterranean area. Cancer Genet Cytogenet 157: 140-147.
13. Didier C, Cavelier C, Quaranta M, Galcera MO, Demur C, et al. (2008) G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress. Oncogene 27: 3811-3820.
14. Dalvai M, Mondesert O, Bourdon JC, Ducommun B, Dozier C, (2011) Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors. Oncogene 30: 2282-2288.
15. Mantovani R, (1999) The molecular biology of the CCAAT-binding factor NF-Y. Gene 239: 15-27.
16. Wierstra I, (2008) Sp1: emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophys Res Commun 372: 1-13.
17. Xu B, Kim ST, Lim DS, Kastan MB, (2002) Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 22: 1049-1059.
18. Korner K, Jerome V, Schmidt T, Muller R, (2001) Cell cycle regulation of the murine cdc25B promoter: essential role for nuclear factor-Y and a proximal repressor element. J Biol Chem 276: 9662-9669.
19. Didier C, Cavelier C, Quaranta M, Galcera MO, Demur C, et al. (2008) G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress. Oncogene 27: 3811-3820.
20. Bugler B, Quaranta M, Aressy B, Brezak MC, Prevost G, et al. (2006) Genotoxic-activated G2-M checkpoint exit is dependent on DCD25B phosphatase expression. Mol Cancer Ther 5: 1446-1451.
21. Boutros R, Lobjois V, Ducommun B, (2007) CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 7: 495-507.
22. Kristjánsdóttir K, Rudolph J, (2004) Cdc25 phosphatases and cancer. Chem Biol 11: 1043-1051.
23. Aressy B, Ducommun B, (2008) Cell cycle control by the CDC25 phosphatases. Anticancer Agents Med Chem 8: 818-824.
24. Lindqvist A, Källström H, Lundgren A, Barsoum E, Rosenthal CK, (2005) Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. J Cell Biol 171: 35-45.
25. Boutros R, Dozier C, Ducommun B, (2006) The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol 18: 185-191.
26. Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, et al. (2000) Rapid destruction of human Cdc25A in response to DNA damage. Science 288: 1425-1429.
27. van Vugt MA, Brás A, Medema RH, (2004) Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell 15: 799-811.
28. Bansal P, Lazo JS, (2007) Induction of Cdc25B regulates cell cycle resumption after genotoxic stress. Cancer Res 67: 3356-3363.
29. Sasaki H, Yukiue H, Kobayashi Y, Tanahashi M, Moriyama S, et al. (2001) Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer. Cancer Lett 173: 187-192.
30. Takemasa I, Yamamoto H, Sekimoto M, Ohue M, Noura S, et al. (2000) Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma. Cancer Res 60: 3043-3050.
31. Tsuda H, Hashiguchi Y, Inoue T, Yamamoto K, (2003) Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. Oncology 65: 159-166.
32. Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, et al. (1995) CDC25 phosphatases as potential human oncogenes. Science 269: 1575-1577.
33. Broggini M, Buraggi G, Brenna A, Riva L, Codegoni AM, et al. (2000) Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients. Anticancer Res 20: 4835-4840.
34. Nishioka K, Doki Y, Shiozaki H, Yamamoto H, Tamura S, et al. (2001) Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus. Br J Cancer 85: 412-421.
35. Miyata H, Doki Y, Shiozaki H, Inoue M, Yano M, et al. (2000) CDC25B and p53 are independently implicated in radiation sensitivity for human esophageal cancers. Clin Cancer Res 6: 4859-4865.
36. Ngan ES, Hashimoto Y, Ma ZQ, Tsai MJ, Tsai SY, (2003) Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene 22: 734-739.
37. Kudo Y, Yasui W, Ue T, Yamamoto S, Yokozaki H, et al. (1997) Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas. Jpn J Cancer Res 88: 947-952.
38. Guo J, Kleeff J, Li J, Ding J, Hammer J, Zhao Y, et al. (2004) Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma. Oncogene 23: 71-81.