Emerging role for epithelial polarity proteins of the crumbs family as potential tumor suppressors

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Laprise, Patrick ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CRB1 PROTEIN; CRB2 PROTEIN; CRB3 PROTEIN; CRB3B PROTEIN; CRUMBS PROTEIN; CYCLIN D1; CYCLIN E; DROSOPHILA INHIBITOR OF APOPTOSIS 1; EPITHELIAL POLARITY PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; SMAD PROTEIN; TRANSCRIPTION FACTOR E2F1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; CRB1 PROTEIN, HUMAN; CRUMBS PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; EYE PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN;

APOPTOSIS; BINDING SITE; CANCER INVASION; CARCINOGENESIS; CELL ADHESION; CELL POLARITY; CELL PROLIFERATION; CELL STRUCTURE; DROSOPHILA; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HYPERPLASIA; INTRACELLULAR SIGNALING; MAMMAL; MESENCHYME; METASTASIS; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; REVIEW; TISSUE GROWTH; TUMOR GROWTH; VERTEBRATE; ANIMAL; PHYSIOLOGY;

VERTEBRATA;

ANIMALS; CELL POLARITY; DROSOPHILA PROTEINS; EPITHELIAL CELLS; EYE PROTEINS; HUMANS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 81555226033     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/868217     Document Type: Review

References (101)

1. Laprise P., Tepass U., Novel insights into epithelial polarity proteins in Drosophila Trends in Cell Biology 2011 21 7 401 408
2. Dow L. E., Humbert P. O., Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis International Review of Cytology 2007 262 253 302 (Pubitemid 47031311)
3. Coradini D., Casarsa C., Oriana S., Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment Acta Pharmacologica Sinica 2011 32 5 552 564
4. Bazellieres E., Assemat E., Arsanto J. P., Le Bivic A., Massey-Harroche D., Crumbs proteins in epithelial morphogenesis Frontiers in Bioscience 2009 14 2149 2169
5. Bulgakova N. A., Knust E., The Crumbs complex: from epithelial-cell polarity to retinal degeneration Journal of Cell Science 2009 122 15 2587 2596
6. Pieczynski J., Margolis B., Protein complexes that control renal epithelial polarity The American Journal of PhysiologyRenal Physiology 2011 300 3 F589 F601
7. Tepass U., Theres C., Knust E., crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia Cell 1990 61 5 787 799
8. Wodarz A., Hinz U., Engelbert M., Knust E., Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila Cell 1995 82 1 67 76
9. Tanentzapf G., Tepass U., Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization Nature Cell Biology 2003 5 1 46 52 (Pubitemid 36054328)
10. Bilder D., Schober M., Perrimon N., Integrated activity of PDZ protein complexes regulates epithelial polarity Nature Cell Biology 2003 5 1 53 58 (Pubitemid 36054329)
11. Laprise P., Beronja S., Silva-Gagliardi N. F., Pellikka M., Jensen A. M., McGlade C. J., Tepass U., The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size Developmental Cell 2006 11 3 363 374 (Pubitemid 44283938)
12. Laprise P., Lau K. M., Harris K. P., Silva-Gagliardi N. F., Paul S. M., Beronja S., Beitel G. J., McGlade C. J., Tepass U., Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins Nature 2009 459 7250 1141 1145
13. Laprise P., Paul S. M., Boulanger J., Robbins R. M., Beitel G. J., Tepass U., Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway Current Biology 2010 20 1 55 61
14. den Hollander A. I., ten Brink J. B., de Kok Y. J. M., Van Soest S., Van Den Born L. I., Van Driel M. A., Van De Pol D. J. R., Payne A. M., Bhattacharya S. S., Kellner U., Hoyng C. B., Westerveld A., Brunner H. G., Bleeker-Wagemakers E. M., Deutman A. F., Heckenlively J. R., Cremers F. P. M., Bergen A. A. B., Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12) Nature Genetics 1999 23 2 217 221 (Pubitemid 29455397)
15. den Hollander A. I., Ghiani M., de Kok Y. J. M., Wijnholds J., Ballabio A., Cremers F. P. M., Broccoli V., Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain Mechanisms of Development 2001 110 1-2 203 207 (Pubitemid 34020642)
16. Beyer J., Zhao X. C., Yee R., Khaliq S., McMahon T. T., Ying H., Yue B. Y., Malicki J. J., The role of crumbs genes in the vertebrate cornea Investigative Ophthalmology amp; Visual Science 2010 51 9 4549 4556
17. Mehalow A. K., Kameya S., Smith R. S., Hawes N. L., Denegre J. M., Young J. A., Bechtold L., Haider N. B., Tepass U., Heckenlively J. R., Chang B., Naggert J. K., Nishina P. M., CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina Human Molecular Genetics 2003 12 17 2179 2189 (Pubitemid 37098988)
18. van de Pavert S. A., Meuleman J., Malysheva A., Aartsen W. M., Versteeg I., Tonagel F., Kamphuis W., McCabe C. J., Seeliger M. W., Wijnholds J., A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1 Journal of Neuroscience 2007 27 3 564 573 (Pubitemid 46143760)
19. Richard M., Roepman R., Aartsen W. M., van Rossum A. G. S. H., den Hollander A. I., Knust E., Wijnholds J., Cremers F. P. M., Towards understanding CRUMBS function in retinal dystrophies Human Molecular Genetics 2006 15 2 R235 R243 (Pubitemid 44446799)
20. Johnson K., Grawe F., Grzeschik N., Knust E., Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration Current Biology 2002 12 19 1675 1680 (Pubitemid 35161922)
21. van den Hurk J. A., Rashbass P., Roepman R., Davis J., Voesenek K. E. J., Arends M. L., Zonneveld M. N., van Roekel M. H. G., Cameron K., Rohrschneider K., Heckenlively J. R., Koenekoop R. K., Hoyng C. B., Cremers F. P. M., den Hollander A. I., Characterization of the Crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis Molecular Vision 2005 11 263 273 (Pubitemid 41358283)
22. Makarova O., Roh M. H., Liu C. J., Laurinec S., Margolis B., Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1) Gene 2003 302 1-2 21 29 (Pubitemid 36078394)
23. Lemmers C., Michel D., Lane-Guermonprez L., Delgrossi M. H., Médina E., Arsanto J. P., Le Bivic A., CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells Molecular Biology of the Cell 2004 15 3 1324 1333 (Pubitemid 38316238)
24. Hurd T. W., Gao L., Roh M. H., Macara I. G., Margolis B., Direct interaction of two polarity complexes implicated in epthelial tight junction assembly Nature Cell Biology 2003 5 2 137 142 (Pubitemid 36210848)
25. Roh M. H., Fan S., Liu C. J., Margolis B., The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells Journal of Cell Science 2003 116 14 2895 2906 (Pubitemid 36926979)
26. Fan S., Fogg V., Wang Q., Chen X. W., Liu C. J., Margolis B., A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions Journal of Cell Biology 2007 178 3 387 398 (Pubitemid 47196148)
27. Klebes A., Knust E., A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila Current Biology 2000 10 2 76 85 (Pubitemid 30079192)
28. Médina E., Williams J., Klipfell E., Zarnescu D., Thomas G., Bivic A. L., Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila Journal of Cell Biology 2002 158 5 941 951 (Pubitemid 35001084)
29. Bachmann A., Schneider M., Theilenberg E., Grawe F., Knust E., Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity Nature 2001 414 6864 638 643 (Pubitemid 33151259)
30. Bulgakova N. A., Kempkens O., Knust E., Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila Journal of Cell Science 2008 121 12 2018 2026 (Pubitemid 352015199)
31. Roh M. H., Makarova O., Liu C. J., Shin K., Lee S., Laurinec S., Goyal M., Wiggins R., Margolis B., The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost Journal of Cell Biology 2002 157 1 161 172 (Pubitemid 34847838)
32. Tepass U., Knust E., Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster Developmental Biology 1993 159 1 311 326 (Pubitemid 23287244)
33. Hong Y., Stronach B., Perrimon N., Jan L. Y., Jan Y. N., Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts Nature 2001 414 6864 634 638 (Pubitemid 33151258)
34. Straight S. W., Shin K., Fogg V. C., Fan S., Liu C. J., Roh M., Margolis B., Loss of PALS1 expression leads to tight junction and polarity defects Molecular Biology of the Cell 2004 15 4 1981 1990 (Pubitemid 38401844)
35. Michel D., Arsanto J. P., Massey-Harroche D., Béclin C., Wijnholds J., Le Bivic A., PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells Journal of Cell Science 2005 118 17 4049 4057 (Pubitemid 41410286)
36. Richard M., Grawe F., Knust E., DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye Developmental Dynamics 2006 235 4 895 907
37. Shin K., Straight S., Margolis B., PATJ regulates tight junction formation and polarity in mammalian epithelial cells Journal of Cell Biology 2005 168 5 705 711 (Pubitemid 40328155)
38. Thiery J. P., Acloque H., Huang R. Y., Nieto M. A., Epithelial- mesenchymal transitions in development and disease Cell 2009 139 5 871 890
39. Bilder D., Epithelial polarity and proliferation control: links from the Drosophila neoplastictumor suppressors Genes and Development 2004 18 16 1909 1925 (Pubitemid 39071572)
40. Zhan L., Rosenberg A., Bergami K. C., Yu M., Xuan Z., Jaffe A. B., Allred C., Muthuswamy S. K., Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma Cell 2008 135 5 865 878
41. Huang L., Muthuswamy S. K., Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators Current Opinion in Genetics and Development 2010 20 1 41 50
42. Herrmann J. L., Byekova Y., Elmets C. A., Athar M., Liver Kinase B1 (LKB1) in the pathogenesis of epithelial cancers Cancer Letters 2011 306 1 1 9
43. Karp C. M., Ting T. T., Mathew R., Nelson D., Mukherjee C., Degenhardt K., Karantza-Wadsworth V., White E., Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression Cancer Research 2008 68 11 4105 4115
44. Aigner K., Dampier B., Descovich L., Mikula M., Sultan A., Schreiber M., Mikulits W., Brabletz T., Strand D., Obrist P., Sommergruber W., Schweifer N., Wernitznig A., Beug H., Foisner R., Eger A., The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity Oncogene 2007 26 49 6979 6988 (Pubitemid 350014612)
45. Spaderna S., Schmalhofer O., Wahlbuhl M., Dimmler A., Bauer K., Sultan A., Hlubek F., Jung A., Strand D., Eger A., Kirchner T., Behrens J., Brabletz T., The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer Cancer Research 2008 68 2 537 544 (Pubitemid 351380082)
46. Whiteman E. L., Liu C. J., Fearon E. R., Margolis B., The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes Oncogene 2008 27 27 3875 3879 (Pubitemid 351862065)
47. Browne G., Sayan A. E., Tulchinsky E., ZEB proteins link cell motility with cell cycle control and cell survival in cancer Cell Cycle 2010 9 5 886 891
48. Wu Y., Zhou B. P., Snail: more than EMT Cell Adhesion and Migration 2010 4 2 199 203
49. Wu Y., Zhou B. P., TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion The British Journal of Cancer 2010 102 4 639 644
50. Genevet A., Tapon N., The Hippo pathway and apico-basal cell polarity The Biochemical Journal 2011 436 2 213 224
51. Badouel C., Garg A., McNeill H., Herding Hippos: regulating growth in flies and man Current Opinion in Cell Biology 2009 21 6 837 843
52. Badouel C., Gardano L., Amin N., Garg A., Rosenfeld R., Le Bihan T., McNeill H., The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie Developmental Cell 2009 16 3 411 420
53. Bennett F. C., Harvey K. F., Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway Current Biology 2006 16 21 2101 2110 (Pubitemid 44692100)
54. Silva E., Tsatskis Y., Gardano L., Tapon N., McNeill H., The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway Current Biology 2006 16 21 2081 2089 (Pubitemid 44692094)
55. Willecke M., Hamaratoglu F., Kango-Singh M., Udan R., Chen C. L., Tao C., Zhang X., Halder G., The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size Current Biology 2006 16 21 2090 2100 (Pubitemid 44692095)
56. Overholtzer M., Zhang J., Smolen G. A., Muir B., Li W., Sgroi D. C., Deng C. X., Brugge J. S., Haber D. A., Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon Proceedings of the National Academy of Sciences of the United States of America 2006 103 33 12405 12410 (Pubitemid 44267272)
57. Dong J., Feldmann G., Huang J., Wu S., Zhang N., Comerford S. A., Gayyed M., Anders R. A., Maitra A., Pan D., Elucidation of a universal size-control mechanism in Drosophila and mammals Cell 2007 130 6 1120 1133 (Pubitemid 47410268)
58. Camargo F. D., Gokhale S., Johnnidis J. B., Fu D., Bell G. W., Jaenisch R., Brummelkamp T. R., YAP1 increases organ size and expands undifferentiated progenitor cells Current Biology 2007 17 23 2054 2060 (Pubitemid 350180465)
59. St John M. A., Tao W., Fei X., Fukumoto R., Carcangiu M. L., Brownstein D. G., Parlow A. F., McGrath J., Xu T., Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction Nature Genetics 1999 21 2 182 186 (Pubitemid 29070363)
60. Lee J. H., Kim T. S., Yang T. H., Koo B. K., Oh S. P., Lee K. P., Oh H. J., Lee S. H., Kong Y. Y., Kim J. M., Lim D. S., A crucial role of WW45 in developing epithelial tissues in the mouse The EMBO Journal 2008 27 8 1231 1242
61. Tapon N., Harvey K. F., Bell D. W., Wahrer D. C. R., Schiripo T. A., Haber D. A., Hariharan I. K., salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines Cell 2002 110 4 467 478 (Pubitemid 35232290)
62. Lai Z. C., Wei X., Shimizu T., Ramos E., Rohrbaugh M., Nikolaidis N., Ho L. L., Li Y., Control of cell proliferation and apoptosis by mob as tumor suppressor, mats Cell 2005 120 5 675 685 (Pubitemid 40343079)
63. Ling C., Zheng Y., Yin F., Yu J., Huang J., Hong Y., Wu S., Pan D., The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded Proceedings of the National Academy of Sciences of the United States of America 2010 107 23 10532 10537
64. Chen C. L., Gajewski K. M., Hamaratoglu F., Bossuyt W., Sansores-Garcia L., Tao C., Halder G., The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila Proceedings of the National Academy of Sciences of the United States of America 2010 107 36 15810 15815
65. Richardson E. C., Pichaud F., Crumbs is required to achieve proper organ size control during Drosophila head development Development 2010 137 4 641 650
66. Robinson B. S., Huang J., Hong Y., Moberg K. H., Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded Current Biology 2010 20 7 582 590
67. Lu H., Bilder D., Endocytic control of epithelial polarity and proliferation in Drosophila Nature Cell Biology 2005 7 12 1132 1139 (Pubitemid 41741736)
68. Grzeschik N. A., Parsons L. M., Allott M. L., Harvey K. F., Richardson H. E., Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms Current Biology 2010 20 7 573 581
69. Nishioka N., Inoue K. I., Adachi K., Kiyonari H., Ota M., Ralston A., Yabuta N., Hirahara S., Stephenson R. O., Ogonuki N., Makita R., Kurihara H., Morin-Kensicki E. M., Nojima H., Rossant J., Nakao K., Niwa H., Sasaki H., The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass Developmental Cell 2009 16 3 398 410
70. Tao S., Sampath K., Alternative splicing of SMADs in differentiation and tissue homeostasis Development Growth and Differentiation 2010 52 4 335 342
71. Varelas X., Samavarchi-Tehrani P., Narimatsu M., Weiss A., Cockburn K., Larsen B. G., Rossant J., Wrana J. L., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway Developmental Cell 2010 19 6 831 844
72. Kopan R., Ilagan M. X., The canonical Notch signaling pathway: unfolding the activation mechanism Cell 2009 137 2 216 233
73. Guo S., Liu M., Gonzalez-Perez R. R., Role of Notch and its oncogenic signaling crosstalk in breast cancer Biochimica et Biophysica ActaReviews on Cancer 2011 1815 2 197 213
74. Herranz H., Stamataki E., Feiguin F., Miln M., Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity The EMBO Reports 2006 7 3 297 302
75. Klueg K. M., Muskavitch M. A., Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila Journal of Cell Science 1999 112, part 19 3289 3297 (Pubitemid 29507209)
76. Parks A. L., Klueg K. M., Stout J. R., Muskavitch M. A., Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development 2000 127 7 1373 1385 (Pubitemid 30232589)
77. Mitsuishi Y., Hasegawa H., Matsuo A., Araki W., Suzuki T., Tagami S., Okochi M., Takeda M., Roepman R., Nishimura M., Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex Journal of Biological Chemistry 2010 285 20 14920 14931
78. Ohata S., Aoki R., Kinoshita S., Yamaguchi M., Tsuruoka-Kinoshita S., Tanaka H., Wada H., Watabe S., Tsuboi T., Masai I., Okamoto H., Dual roles of notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells Neuron 2011 69 2 215 230
79. Genevet A., Polesello C., Blight K., Robertson F., Collinson L. M., Pichaud F., Tapon N., The Hippo pathway regulates apical-domain size independently of its growth-control function Journal of Cell Science 2009 122 14 2360 2370
80. Polesello C., Tapon N., Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch Current Biology 2007 17 21 1864 1870 (Pubitemid 350016921)
81. Yu J., Poulton J., Huang Y. C., Deng W. M., The Hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity PLoS ONE 2008 3 3, article e1761
82. Harris T. J., Tepass U., Adherens junctions: from molecules to morphogenesis Nature Reviews Molecular Cell Biology 2010 11 7 502 514
83. Tepass U., Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila Developmental Biology 1996 177 1 217 225 (Pubitemid 26252493)
84. Pellikka M., Tanentzapf G., Pinto M., Smith C., McGlade C. J., Ready D. F., Tepass U., Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis Nature 2002 416 6877 143 149 (Pubitemid 34246466)
85. Morais-de-S E., Mirouse V., St Johnston D., aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells Cell 2010 141 3 509 523
86. McGill M. A., McKinley R. F., Harris T. J., Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions Journal of Cell Biology 2009 185 5 787 796
87. Harris T. J., Peifer M., The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila Journal of Cell Biology 2005 170 5 813 823 (Pubitemid 41242113)
88. Walther R. F., Pichaud F., Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling Current Biology 2010 20 12 1065 1074
89. Berx G., van Roy F., Involvement of members of the cadherin superfamily in cancer Cold Spring Harbor Perspectives in Biology 2009 1, article a003129
90. Harris K. P., Tepass U., Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis Journal of Cell Biology 2008 183 6 1129 1143
91. Blankenship J. T., Fuller M. T., Zallen J. A., The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity Journal of Cell Science 2007 120 17 3099 3110 (Pubitemid 47517092)
92. Banerjee S., Sousa A. D., Bhat M. A., Organization and function of septate junctions: an evolutionary perspective Cell Biochemistry and Biophysics 2006 46 1 65 77 (Pubitemid 44326230)
93. Tsukita S., Furuse M., Itoh M., Multifunctional strands in tight junctions Nature Reviews Molecular Cell Biology 2001 2 4 285 293 (Pubitemid 33676971)
94. Turksen K., Troy T. C., Junctions gone bad: Claudins and loss of the barrier in cancer Biochimica et Biophysica ActaReviews on Cancer 2011 1816 1 73 79
95. Fogg V. C., Liu C. J., Margolis B., Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells Journal of Cell Science 2005 118 13 2859 2869 (Pubitemid 41136363)
96. Balda M. S., Garrett M. D., Matter K., The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density Journal of Cell Biology 2003 160 3 423 432 (Pubitemid 36182732)
97. Hoover K. B., Liao S. Y., Bryant P. J., Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity The American Journal of Pathology 1998 153 6 1767 1773 (Pubitemid 28550664)
98. Kleeff J., Shi X., Bode H. P., Hoover K., Shrikhande S., Bryant P. J., Korc M., Bchler M. W., Friess H., Altered expression and localization of the tight junction protein ZO-1 in primary and metastatic pancreatic cancer Pancreas 2001 23 3 259 265 (Pubitemid 32910974)
99. Balda M. S., Matter K., The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression The EMBO Journal 2000 19 9 2024 2033 (Pubitemid 30237578)
100. Sourisseau T., Georgiadis A., Tsapara A., Ali R. R., Pestell R., Matter K., Balda M. S., Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA Molecular and Cellular Biology 2006 26 6 2387 2398 (Pubitemid 43346937)
101. Huerta M., Muoz R., Tapia R., Soto-Reyes E., Ramrez L., Recillas-Targa F., Gonzlez-Mariscal L., Lpez-Bayghen E., Cyclin D1 is transcriptionally down-regulated by ZO-2 via an E box and the transcription factor c-Myc Molecular Biology of the Cell 2007 18 12 4826 4836 (Pubitemid 350246685)