Dietary fish oil alters the lysophospholipid metabolomic profile and decreases urinary 11-dehydro thromboxane B 2 concentration in healthy Beagles

Veterinary Immunology and Immunopathology

Volumn 144, Issue 3-4, 2011, Pages 355-365

  Hall, Jean A ^a   Brockman, Jeffrey A ^b   Jewell, Dennis E ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b Hill's Pet Nutrition Inc   (United States)

Author keywords

Cholesterol; Dog; Eicosapentaenoic acid (EPA); Serum fatty acids; Serum lysophospholipids; Serum metabolomics; Stepwise multiple regression analysis; Urine biomarkers; Vitamin E

Indexed keywords

1 ARACHIDONOYLGLYCEPHOSPHOETHANOLAMINE; 1 EICOSADIENOYL GLYCEROPHOSPHOCHOLINE; 1 EICOSATRIENOYL GLYCEROPHOSPHOCHOLINE; 1 LINOLEOYL GLYCEROPHOSPHOCHOLINE; 1 LINOLEOYL GLYCEROPHOSPHOETHANOLAMINE; 1 STEAROYL GLYCEROPHOSPHOCHOLINE; 11 OXOTHROMBOXANE B2; 2 ARACHIDONOYLGLYCEPHOSPHOETHANOLAMINE; 2 LINOLEOYL GLYCEROPHOSPHOCHOLINE; 2 LINOLEOYL GLYCEROPHOSPHOETHANOLAMINE; 2 STEAROYL GLYCEROPHOSPHOCHOLINE; ALPHA TOCOPHEROL; ARACHIDONIC ACID; ASCORBIC ACID; BIOLOGICAL MARKER; CHOLESTEROL; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; FATTY ACID; FISH OIL; GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LYSOPHOSPHOLIPID; STEARIDONIC ACID; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; DOG; FATTY ACID BLOOD LEVEL; FEMALE; FOOD COMPOSITION; FOOD INTAKE; LEAN BODY WEIGHT; LIPID COMPOSITION; MALE; METABOLOMICS; NONHUMAN; PHOSPHOLIPID METABOLISM; PROTEIN URINE LEVEL; TREATMENT DURATION; VITAMIN BLOOD LEVEL;

ANIMALS; ASCORBIC ACID; BIOLOGICAL MARKERS; CHOLESTEROL; DIET; DOGS; FATTY ACIDS; FEMALE; FISH OILS; LYSOPHOSPHOLIPIDS; MALE; METABOLOMICS; THROMBOXANE B2; VITAMIN E;

CANIS FAMILIARIS;

EID: 81555204413     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.08.007     Document Type: Article

References (29)

1. AAFCO, 2009. Association of American Feed Control Officials. Official Publication, Oxford, IN, pp. 138-142.
2. 2 excretion in dogs with gastric dilatation-volvulus. Am. J. Vet. Res. 2006, 67:78-83.
3. Bieri J.G., Evarts R.P., Thorp S. Factors affecting the exchange of tocopherol between red blood cells and plasma. Am. J. Clin. Nutr. 1977, 30:686-690.
4. Block R.C., Duff R., Lawrence P., Kakinami L., Brenna J.T., Shearer G.C., Meednu N., Mousa S., Friedman A., Harris W.S., Larson M., Georas S. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. Prostaglandins Leukot. Essent. Fatty Acids 2010, 82:87-95.
5. Calder P.C. Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie 2009, 91:791-795.
6. Calder P.C., Yaqoob P. Understanding omega-3 polyunsaturated fatty acids. Postgrad. Med. 2009, 121:148-157.
7. Chapkin R.S., Kim W., Lupton J.R., McMurray D.N. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot. Essent. Fatty Acids 2009, 81:187-191.
8. Choi J.W., Herr D.R., Noguchi K., Yung Y.C., Lee C.W., Mutoh T., Lin M.E., Teo S.T., Park K.E., Mosley A.N., Chun J. LPA receptors: subtypes and biological actions. Annu. Rev. Pharmacol. Toxicol. 2010, 50:157-186.
9. Evans A.M., DeHaven C.D., Barrett T., Mitchell M., Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal. Chem. 2009, 81:6656-6667.
10. 2. Prostaglandins Leukot. Essent. Fatty Acids 1993, 48:305-308.
11. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957, 226:497-509.
12. Hall J.A., Chinn R.M., Vorachek W.R., Gorman M.E., Greitl J.L., Joshi D.K., Jewell D.E. Influence of dietary antioxidants and fatty acids on neutrophil mediated bacterial killing and gene expression in healthy Beagles. Vet. Immunol. Immunopathol. 2011, 139:217-228.
13. Hall J.A., Henry L.R., Jha S., Skinner M.M., Jewell D.E., Wander R.C. Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles. Prostaglandins Leukot. Essent. Fatty Acids 2005, 73:335-341.
14. Hall J.A., Picton R.A., Skinner M.M., Jewell D.E., Wander R.C. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. J. Nutr. 2006, 136:2338-2344.
15. Hall J.A., Tooley K.A., Gradin J.L., Jewell D.E., Wander R.C. Influence of dietary long-chain n-3 fatty acids from Menhaden fish oil on plasma concentrations of α-tocopherol in geriatric Beagles. Am. J. Vet. Res. 2002, 63:104-110.
16. Hall J.A., Tooley K.A., Gradin J.L., Jewell D.E., Wander R.C. Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs. Am. J. Vet. Res. 2003, 64:762-772.
17. Hall J.A., Van Saun R.J., Wander R.C. Dietary (n-3) fatty acids from Menhaden fish oil alter plasma fatty acids and leukotriene B synthesis in healthy horses. J. Vet. Int. Med. 2004, 18:871-879.
18. Harris W.S. n-3 fatty acids and serum lipoproteins: animal studies. Am. J. Clin. Nutr. 1997, 65:1611S-1616S.
19. Hoehler D., Frohlich A.A., Marquardt R.R., Stelsovsky H. Extraction of α-tocopherol from serum prior to reversed-phase liquid chromatography. J. Agric. Food Chem. 1998, 46:973-978.
20. Horwitt M.K., Harvey C.C., Dahm C.H., Searcy M.T. Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy. Ann. N. Y. Acad. Sci. 1972, 203:223-236.
21. Huang L.S., Hung N.D., Sok D.E., Kim M.R. Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. Lipids 2010, 45:225-236.
22. Moore R.E., Kirwan J., Doherty M.K., Whitfield P.D. Biomarker discovery in animal health and disease: the application of post-genomic technologies. Biomark. Insights 2007, 2:185-196.
23. 2 and LTE4 excretion in patients with rheumatoid arthritis. Prostaglandins Leukot. Essent. Fatty Acids 2001, 65:301-306.
24. Roush J.K., Dodd C.E., Fritsch D.A., Allen T.A., Jewell D.E., Schoenherr W.D., Richardson D.C., Leventhal P.S., Hahn K.A. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J. Am. Vet. Med. Assoc. 2010, 236:59-66.
25. Shindou H., Hishikawa D., Harayama T., Yuki K., Shimizu T. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J. Lipid Res. 2009, 50:S46-S51.
26. Wander R.C., Hall J.A., Gradin J.L., Du S.H., Jewell D.E. The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation, and vitamin E status in aged dogs. J. Nutr. 1997, 127:1198-1205.
27. Whitfield P.D., German A.J., Noble P.J. Metabolomics: an emerging post-genomic tool for nutrition. Br. J. Nutr. 2004, 92:549-555.
28. 2 production in dogs. Prostaglandins 1993, 45:221-228.
29. Zhao Y., Natarajan V. Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling. Cell Signal. 2009, 2:367-377.