BMP4 increases expression of HMGA2 in mesenchymal stem cells

Cytokine

Volumn 56, Issue 3, 2011, Pages 811-816

  Markowski, Dominique Nadine ^a,b   Helmke, Burkhard Maria ^c   Meyer, Frauke ^b   von Ahsen, Inga ^b   Nimzyk, Rolf ^a   Nolte, Ingo ^b   Bullerdiek, Jörn ^a,b  

^a UNIVERSITY OF BREMEN   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adipocytes; BMP4; Cytokines; HMGA2; Mesenchymal stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 1; HIGH MOBILITY GROUP A2 PROTEIN; MESSENGER RNA;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MESENCHYMAL STEM CELL; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 4; CELL PROLIFERATION; DOGS; FEMALE; FIBROBLAST GROWTH FACTOR 1; GENE EXPRESSION REGULATION; HMGA2 PROTEIN; HUMANS; MESENCHYMAL STEM CELLS; MYOMETRIUM; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 81455141218     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.09.025     Document Type: Article

References (29)

1. Ahrens M., Ankenbauer T., Schröder D., Hollnagel A., Mayer H., Gross G. Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA Cell Biol 1993, 12:871-880.
2. Bowers R.R., Kim J.W., Otto T.C., Lane M.D. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene. Proc Natl Acad Sci USA 2006, 103:13022-13027.
3. Tang Q.Q., Otto T.C., Lane M.D. Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 2004, 101:9607-9611.
4. Huang H., Song T.J., Li X., Hu L., He Q., Liu M., et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 2009, 106:12670-12675.
5. Nuttall M.E., Gimble J.M. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 2004, 4:290-294.
6. Gimble J.M., Zvonic S., Floyd Z.E., Kassem M., Nuttall M.E. Playing with bone and fat. J Cell Biochem 2006, 98:251-266.
7. Winkler S., Murua Escobar H., Meyer B., Simon D., Eberle N., Baumgartner W., et al. HMGA2 expression in a canine model of prostate cancer. Cancer Genet Cytogen 2007, 177:98-102.
8. Schmittgen T.D., Zakrajsek B.A. Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J Biochem Biophys Meth 2000, 46:69-81.
9. Gorzelniak K., Janke J., Engeli S., Sharma A.M. Validation of endogenous controls for gene expression studies in human adipocytes and preadipocytes. Horm Metab Res 2001, 33:625-627.
10. Arf-TP53-CDKNIA axis: a delicate balance in the growth of uterine leiomyomas. Gene Chromosome Canc 2010, 49:661-668.
11. Ayoubi T.A., Jansen E., Meulemans S.M., van de Ven W.J. Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development. Oncogene 1999, 18:5076-5087.
12. Chen J.C., Winn S.R., Gong X., Ozaki W.H. rhBMP-4 gene therapy in a juvenile canine alveolar defect model. Plast Reconstr Surg 2007, 120:1503-1509.
13. Nakashima M. Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix. Arch Oral Biol 1994, 39:1085-1089.
14. Roethy W., Fiehn E., Suehiro K., Gu A., Yi G.H., Shimizu J., et al. A growth factor mixture that significantly enhances angiogenesis in vivo. J Pharmacol Exp Ther 2001, 299:494-500.
15. Ashar H.R., Fejzo M.S., Tkachenko A., Zhou X., Fletcher J.A., Weremowicz S., et al. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 1995, 82:57-65.
16. Schoenmakers E.F., Wanschura S., Mols R., Bullerdiek J., Van den Berghe H., Van de Ven W.J. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 1995, 10:436-444.
17. Bartuma H., Panagopoulos I., Collin A., Trombetta D., Domanski H.A., Mandahl N., et al. Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups. Mol Cancer 2009, 8:36.
18. Rogalla P., Lemke I., Kazmierczak B., Bullerdiek J. An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). Gene Chromosome Canc 2000, 29:363-366.
19. Ligon A.H., Moore S.D., Parisi M.A., Mealiffe M.E., Harris D.J., Ferguson H.L., et al. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Am J Hum Genet 2005, 76:340-348.
20. Zhou X., Benson K.F., Ashar H.R., Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 1995, 376:771-774.
21. Anand A., Chada K. In vivo modulation of Hmgic reduces obesity. Nat Genet 2000, 24:377-380.
22. Battista S., Fidanza V., Fedele M., Klein-Szanto A.J., Outwater E., Brunner H., et al. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res 1999, 59:4793-4797.
23. Pasquali D., Pierantoni G.M., Fusco A., Staibano S., Colantuoni V., De Bellis A., et al. Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy. J Mol Endocrinol 2004, 33:133-143.
24. Mari F., Hermanns P., Giovannucci-Uzielli M.L., Galluzzi F., Scott D., Lee B., et al. Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosis. Eur J Hum Genet 2009, 17:1141-1147.
25. Buysse K., Reardon W., Mehta L., Costa T., Fagerstrom C., Kingsbury D.J., et al. The 12q14 microdeletion syndrome: additional patients and further evidence that HMGA2 is an important genetic determinant for human height. Eur J Med Genet 2009, 52:101-107.
26. Lynch S.A., Foulds N., Thuresson A.C., Collins A.L., Annerén G., Hedberg B.O., et al. The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth. Eur J Hum Genet 2011, 19:534-539.
27. Li O., Li J., Dröge P. DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett 2007, 581:3533-3537.
28. Sandberg A.A. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer Genet Cytogen 2005, 158:1-26.
29. Ono M., Maruyama T., Masuda H., Kajitani T., Nagashima T., Arase T., et al. Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc Natl Acad Sci USA 2007, 104:18700-18705.