An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)

Genes Chromosomes and Cancer

Volumn 29, Issue 4, 2000, Pages 363-366

  Rogalla, Piere ^a   Lemke, Inga ^a   Kazmierczak, Bernd ^a   Bullerdiek, Jörn ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL HETEROGENEITY; EXON; FUSION GENE; GENE EXPRESSION; GENE STRUCTURE; GENETIC VARIABILITY; HAMARTOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIPOMA; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033767548     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<1::AID-GCC1043>3.0.CO;2-N     Document Type: Article

References (21)

1. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K. 1995. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82:57-65.
2. Belge G, Kazmierczak B, Meyer-Bolte K, Bartnitzke S, Bullerdiek J. 1992. Expression of SV40 T-antigen in lipoma cells with a chromosomal translocation t(3;12) is not sufficient for direct immortalization. Cell Biol Intern Rep 16:339-347.
3. Dawid IB, Breen JJ, Toyama R. 1998. LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet 14:156-162.
4. Geurts JMW, Schoenmakers EFPM, Röijer E, Stenman G, Van de Ven WJM. 1997. Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. Cancer Res 57:13-17.
5. Geurts JM, Schoenmakers EF, Roijer E, Astrom AK, Stenman G, van de Ven WJ. 1998. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Oncogene 16:865-872.
6. Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J. 1995. Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res 55:6038-6039.
7. Kazmierczak B, Rosigkeit J, Wanschura S, Meyer-Bolte K, Van de Ven WJM, Kayser K, Krieghoff B, Kastendiek H, Bartnitzke S, Bullerdiek J. 1996. HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene 12:515-521.
8. Kazmierczak B, Meyer-Bolte K, Tran KH, Wöckel W, Breightman I, Rosigkeit J, Bartnitzke S, Bullerdiek J. 1999a. A high frequency of tumors with rearrangements of genes of the HMGI(Y) family in a series of 191 pulmonary chondroid hamartomas. Genes Chromosomes Cancer 26:125-133.
9. Kazmierczak B, Kayser K, Meyer-Bolte K, Thode E, Bullerdiek J. 1999b. Results of cytogenetic analyses on 317 pulmonary chondroid hamartomas point to their pathogenesis. Electr J Pathol 5.4.
10. Kurose K, Mine N, Doi D, Ota Y, Yoneyama K, Konishi H, Araki T, Emi M. 2000. Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. Genes Chromosomes Cancer 27:303-307.
11. Melo JV. 1996. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 88:2375-2384.
12. Petit MMR, Mols R, Schoenmakers EFPM, Mandahl N, Van de Ven WJM. 1996. LLP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36:118-129.
13. Petit MMR, Schoenmakers EFPM, Huysmans C, Geurts JMW, Mandahl N, Van de Ven WJM. 1999. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Genomics 57:438-441.
14. Rogalla P, Rohen C, Hennig Y, Deichert U, Bonk U, Bullerdiek J. 1995. Telomere repeat fragment sizes do not limit the growth potential of uterine leiomyomas. Biochem Biophys Res Commun 211:175-182.
15. Rogalla P, Drechsler K, Frey G, Hennig Y, Helmke B, Bonk U, Bullerdiek J. 1996. HMGI-C expression patterns in human tissues: implications for the genesis of frequent mesenchymal tumors. Am J Pathol 149:775-779.
16. Rogalla P, Kazmierczak B, Meyer-Bolte K, Tran KH, Bullerdiek J. 1998. The t(3;12)(q27;q14-15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. Genes Chromosomes Cancer 22:100-104.
17. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven W. 1995. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10:436-444.
18. Schoenmakers EFPM, Huysmans C, Van de Ven WJM. 1999. Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res 59: 19-23.
19. Sreekantaiah C, Leong SPL, Karakousis CP, McGee DL, Rappaport WD, Villar HV, Neal D, Fleming S, Wankel A, Herrington PN, Carmona R, Sandberg AA. 1991. Cytogenetic profile of 109 lipomas. Cancer Res 51:422-433.
20. Ture-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA. 1986. Cytogenetic studies of adipose tissue tumors I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14). Cancer Genet Cytogenet 23:283-289.
21. Wanschura S, Belge G, Stenman G, Kools PFJ, Dal Cin P, Schoenmakers EFPM, Huysmans C, Bartnitzke S, Van de Ven WJM, Bullerdiek J. 1996. Mapping of the translocation breakpoints of primary pleomorphic adenomas and lipomas within a common region of chromosome 12. Cancer Genet Cytogenet 86:39-45.