Effect of ketamine on NF-kappa B activity and TNF-alpha production in endotoxin-treated rats

Annals of Clinical and Laboratory Science

Volumn 34, Issue 2, 2004, Pages 181-186

  Sun, Jie ^a   Li, Feng ^a   Chen, Jing ^a   Xu, Jianguo ^a,b  

^a NANJING UNIVERSITY   (China)

^b JINLING HOSPITAL   (China)

Author keywords

Endotoxin; Ketamine; NF KB; Sepsis; TNF

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETAMINE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; IN VIVO STUDY; INTESTINE; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SERUM;

ANIMALS; BASE SEQUENCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTOXINS; INTESTINES; KETAMINE; LIPOPOLYSACCHARIDES; LIVER; LUNG; MOLECULAR SEQUENCE DATA; NF-KAPPA B; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS NORVEGICUS;

EID: 2542440848     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Opal, SM, Cohen, J. Clinical Gram-positive sepsis: does it fundamentally differ from Grain-negative bacterial sepsis? Crit Care Med 1999;27:1608.
2. Lippmann M, Appel PL, Mok MS, Shoemaker WC. Sequential cardiorespiratory patterns of anesthetic induction with ketamine in critically ill patients. Crit Care Med 1983;11:730-734.
3. Yli-Hankala A, Kirvela M, Randell T, Lindgren L. Ketamine anaesthsia in a patient with septic shock. Acta Anaesthsiol Scand 1992;36:483-485.
4. Takenaka I, Ogata M, Koga K, Matsumoto T, Shigematsu A. Ketamine suppresses endotoxin-induced tumor necrosis factor alpha production in mice. Anesthesiology 1994;80:402-408.
5. Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematsu A. Ketamine suppresses tumor necrosis factor-α activity and mortality in carrageenan-sensitized endotoxin shock model. Circ Shock 1994;44:160-168.
6. Cavaillon JM, Munoz C, Fitting C, Misset B, Carlet J. Circulating cytokines: the tip of the iceberg? Circ Shock 1992;38:145-152.
7. Beutler BA, Milsark IW, Cerami A. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J Immunol 1985;135:3972-3977.
8. Keogh C, Fong Y, Marano MA, Seniuk S, He W, Barber A, Minei JP, Felsen D, Lowry SF, Moldawer LL. Identification of a novel tumor necrosis factor alpha/ cachectin from the livers of burned and infected rats. Arch Surg 1990;125:79-84.
9. Baldwin AS Jr. The NF-KB and IKB proteins: new discoveries and insights. Ann Rev Immunol 1996;14:649-681.
10. Yu Y, Zhou Z, Xu J, Liu Z, Wang Y. Ketamine reduces NF kappa B activation and TNF-alpha production in rat mononuclear cells induced by lipopolysaccharide in vitro. Ann Clin Lab Sci 2002;32:292-298.
11. Liu Z, Yu Y, Jiang Y, Li J. Growth hormone increases lung NF-kappa B activation and lung microvascular injury induced by lipopolysaccharide in rats. Ann Clin Lab Sci 2002;32:164-170.
12. Zhao X, Liu J, Guan R, Shen Y, Xu P, Xu J. Estrogen affects BDNF expression following chronic constriction nerve injury. Neuroreport 2003;14:1627-1631.
13. Blackwell TS, Yull FE, Chen CL, Venkatakrishnan A, Blackwell TR, Hicks DJ, Lancaster LH, Christman JW, Kerr LD. Use of genetically altered mice to investigate the role of nuclear factor-kappa B activation and cytokine gene expression in sepsis-induced ARDS. Chest 1999;116:73s-74s.
14. Browder W, Ha T, Chuanfu L, Kalbfleisch JH, Ferguson DA Jr, Williams DL. Early activation of pulmonary nuclear factor kappa B and nuclear factor interleukin-6 in polymicrobial sepsis. J Trauma 1999;46:590-596.
15. Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999;89:665-669.
16. Hawiger J, Veach RA, Liu XY, Timmons S, Ballard DW. IKB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Blood 1999;94:1711-1716.
17. Roytblat L, Talmor D, Rachinsky M, Greemberg L, Pekar A, Appelbaum A, Gurman G.M, Shapira Y, Duvdenani A. Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass. Anesth Analg 1998;87:266-271.
18. Williams JH Jr, Patel SK, Hatakeyama D, Arian R, Guo K, Hickey TJ, Liao SY, Ulich TR. Activated pulmonary vascular neutrophils as early mediators of endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol 1993;8:134-144.
19. Madej JA, Stanczyk JF. Effect of ketamine anaesthesia on enzyme activity in organs of dogs and cats. Anaesth Resusc Intensive Ther 1975;3:297-303.
20. Li CY, Chou TC, Wong CS, Ho ST, Wu CC, Yen MH, Ding YA. Ketamine inhibits nitric oxide synthase in lipopolysaccharide-treated rat alveolar macrophages. Can J Anaesth 1997;44:989-995.
21. Domino EF, Zsigmond EK, Domino LE, Domino KE, Kothary SP, Domino SE. Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentographic assay. Anesth Analg 1982;61:87-92.