UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells

Journal of Antibiotics

Volumn 57, Issue 10, 2004, Pages 687-690

  Fujita, Ken Ichi ^a   Kiso, Tetsuo ^a   Usuki, Yoshinosuke ^a   Tanaka, Toshio ^a   Taniguchi, Makoto ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 FORMAMIDOSALICYCLIC ACID DERIVATIVE; 3 FORMAMIDOSALICYLIC DERIVATIVE; 3 HYDROXY 4 METHOXYPICOLINIC DERIVATIVE; BH3 PROTEIN; CASPASE; CYTOCHROME B; CYTOCHROME C1; DICHLOROFLUORESCEIN; DNA FRAGMENT; LACTONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UBIQUINOL CYTOCHROME C REDUCTASE; UK 2A; UK 2B; UK 2C; UK 2D; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY CHAIN; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; STREPTOMYCES; STREPTOMYCES 517 02 VI; STRUCTURE ACTIVITY RELATION;

STREPTOMYCES;

EID: 8144219648     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.687     Document Type: Article

References (19)

1. UEKI, M.; K. ABE, M. HANAFI, K. SHIBATA, T. TANAKA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation and biological properties. J. Antibiotics 49: 639-643, 1996
2. HANAFI, M.; K. SHIBATA, M. UEKI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation. J. Antibiotics 49: 1226-1231, 1996
3. UEKI, M. & M. TANIGUCHI: The mode of action of UK-2A and UK-3AÅCnovel antifungal antibiotics from Streptomyces sp. 517-02. J. Antibiotics 50: 1052-1057, 1997
4. TOKUTAKE, N.; H. MIYOSHI, T. SATOH, T. HATANO & H. IWAMURA: Structural factors of antimycin A molecule required for inhibitory action. Biochim. Biophys. Acta 1185: 271-278, 1994
5. SHIBATA, K.; M. HANAFI, J. FUJII, O. SAKANAKA, K. IINUMA, M. UEKI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. III. Absolute configuration of an antifungal antibiotic, UK-2A and consideration of its conformation. J. Antibiotics 51: 1113-1116, 1998
6. 3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J. Antibiotics 52: 480-484, 1999
7. 1, by the novel antibiotic UK-2A. J. Antibiotics 52: 748-753, 1999
8. UEKI, M.; K. MACHIDA & M. TANIGUCHI: Antifungal inhibitors of mitochondrial respiration: discovery and prospects for development. Current Opinion in Anti-infective Investigational Drugs. 2: 387-398, 2000
9. USUKI, Y.; K. TANI, K. FUJITA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VI (1). Structure-activity relationships of UK-2A. J. Antibiotics 54: 600-602, 2001
10. TANI, K.; Y. USUKI, K. MOTOBA, K. FUJITA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A in Rhodotorula mucilaginosa IFO 0001. J. Antibiotics 55: 315-321, 2002
11. USUKI, Y.; K. GOTO, T. KISO, K. TANI, X. PING, K. FUJITA, H. IIO & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VI (2). Structure-activity relationships of UK-2A. J. Antibiotics 55: 607-610, 2002
12. TANI, K.; Y. USUKI, K. FUJITA & M. TANIGUCHI: UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VIII. Reactive oxygen species generated by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J. Antibiotics 56: 314-317, 2003
13. FUJITA, K.; K. TANI, Y. USUKI, T. TANAKA & M. TANIGUCHI: Growth inhibition dependent on reactive oxygen species generated by C9-UK-2A, a derivative of the antifungal antibiotic UK-2A, in Saccharomyces cerevisiae. J. Antibiotics 57: 511-517, 2004
14. CHEN, Q.; E. J. VAZQUEZ, S. MOGHADDAS, C. L. HOPPEL & E. J. LESNEFSKY: Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 278: 36027-36031, 2003
15. YOUNG, T. A.; C. C. CUNNINGHAM & S. M. BAILEY: Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol. Arch. Biochem. Biophys. 405: 65-72, 2002
16. KAUSHAL, G. P.; N. UEDA & S. V. SHAH: Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney Int. 52: 438-445, 1997
17. L regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J. 18: 632-643, 1999
18. TZUNG, S. P.; K. M. KIM, G. BASANEZ, C. D. GIEDT, J. SIMON, J. ZIMMERBERG, K. Y. ZHANG & D. M. HOCKENBERY: Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nat. Cell Biol. 3: 183-191, 2001
19. L mutations suppress cellular sensitivity to antimycin A. J. Biol. Chem. 279: 2159-2165, 2004