UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VIII. Reactive oxygen species generated by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001

Journal of Antibiotics

Volumn 56, Issue 3, 2003, Pages 314-317

  Tani, Kazunori ^a   Usuki, Yoshinosuke ^a   Fujita, Ken Ichi ^a   Taniguchi, Makoto ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMPHOTERICIN B; ANTIFUNGAL AGENT; ANTIMYCIN A1; ASCORBIC ACID; GLUTATHIONE; LIPOSOME; NEW DRUG; POLYGODIAL; REACTIVE OXYGEN METABOLITE; TROLOX C; UK 2A;

ANTIFUNGAL ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; EUKARYOTIC CELL; LIPID PEROXIDATION; MEMBRANE DAMAGE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RHODOTORULA; SACCHAROMYCES CEREVISIAE; STREPTOMYCES; YEAST CELL;

RHODOTORULA MUCILAGINOSA; STREPTOMYCES;

EID: 0037363534     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.56.314     Document Type: Article

References (15)

1. UEKI, M.; K. ABE, M. HANAFI, K. SHIBATA, T. TANAKA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation and biological properties. J. Antibiotics 49: 639-643, 1996
2. HANAFI, M.; K. SHIBATA, M. UEKI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation. J. Antibiotics 49: 1226-1231, 1996
3. UEKI, M. & M. TANIGUCHI: The mode of action of UK-2A and UK-3A, novel antifungal antibiotics from Streptomyces sp. 517-02. J. Antibiotics 50: 1052-1057, 1997
4. USUKI, Y.; K. TANI, K. FUJITA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VI (1). Structure-activity relationship of UK-2A. J. Antibiotics 54: 600-602, 2001
5. TANI, K.; Y. USUKI, K. MOTOBA, K. FUJITA & M. TANIGUCHI: UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J. Antibiotics 55: 315-321, 2002
6. 3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. J. Antibiotics 52: 480-484, 1999
7. MACHIDA, K.; H. TAKIMOTO, H. MIYOSHI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. V. Inhibition mechanism of bovine heart mitochondrial cytochrome bc1 by the novel antibiotic UK-2A. J. Antibiotics 52: 748-753, 1999
8. SHIMANO, M.; T. SHIBATA & N. KAMEI: Enantioselective total synthesis of the antifungal dilactone, UK-2A: The determination of the relative and absolute configurations. Tetrahedron Lett. 39: 4363-4366, 1998
9. ELSKENS, M. T.; J. J. CHARLES & M. P. PENNINCKX: Glutathione as an endogenous sulphur source in the yeast. J. Gen. Microbiol. 137: 637-644, 1991
10. MACHIDA, K.; T. TANAKA, K. FUJITA & M. TANIGUCHI: Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. J. Bacteriol. 180: 4460-4465, 1998
11. KAMAT, J. P.; T. P. DEVASAGAYAM, K. I. PRIYADARSINI & H. MOHAN: Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications. Toxicology 155: 55-61, 2000
12. MACHIDA, K.; T. TANAKA & M. TANIGUCHI: Depletion of glutathione as a cause of the promotive effects of polygodial, a sesquiterpene on the production of reactive oxygen species in Saccharomyces cerevisiae. J. Biosci. Bioeng. 88: 526-530, 1999
13. OKAI, Y.; K. HIGASHI-OKAI, K. MACHIDA, H. NAKAMURA, K. NAKAYAMA, K. FUJITA, T. TANAKA, S. OTANI & M. TANIGUCHI: Protective effect of antioxidants against para-nonylphenol-induced inhibition of cell growth in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 185: 65-70, 2000
14. FUJITA, K. & I. KUBO: Plasma membrane injury induced by nonyl gallate in Saccharomyces cerevisiae. J. Appl. Microbiol. 92: 1035-1042, 2002
15. KUBO, I.; K. FUJITA & S. H. LEE: Antifungal mechanism of polygodial. J. Agric. Food Chem. 49: 1607-1611, 2001