The mode of action of UK-2A and UK-3A, novel antifungal antibiotics from Streptomyces sp. 517-02

Journal of Antibiotics

Volumn 50, Issue 12, 1997, Pages 1052-1057

  Ufki, Masashi ^a   Taniguchi, Makoto ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; ANTIFUNGAL AGENT; ANTIMYCIN A3; GLUCOSE; MANNOSE; N,N,N',N' TETRAMETHYL 1,4 PHENYLENEDIAMINE; PHENYLALANINE; SUCCINIC ACID; THYMIDINE; UBIQUINOL CYTOCHROME C REDUCTASE; UK 2A; UK 3A; UNCLASSIFIED DRUG; URIDINE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL RESPIRATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; STREPTOMYCES; YEAST; YEAST CELL;

EID: 0031441824     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.1052     Document Type: Article

References (16)

1. UEKI, M.; K. ABE, M. HANAFI, K. SHIBATA, T. TANAKA & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation and biological properties. J. Antibiotics 49: 639-643, 1996
2. UEKI, M.; A. KUSUMOTO, M. HANAFI, K. SHIBATA & M. TANIGUCHI: UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Fermentation, isolation structural elucidation and biological properties. J. Antibiotics 50: 551-555, 1997
3. HANAFI, M.; K. SHIBATA, M. UEKI & M. TANIGUCHI: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structure elucidation. J. Antibiotics 49: 1095-1100, 1996
4. DEMAIN, A. L.: New applications of microbial products. Science 219: 709-714, 1983
5. DAUN, G.; P. C. BOHNI & G. SCHATZ: Import of proteins into mitochondria. J. Biol. Chem. 257: 13028-13033, 1982
6. MYERS, D. K. & E. C. SLATFR: The enzymatic hydrolysis of adenosine triphosphate by liver mitochondria. Biochem. J. 67: 558-572, 1957
7. BRADFORD, M. M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976
8. VAN ARK, G. & J. A. BERDEN: Binding of hqno to beef-heart sub-mitochondrial particles. Biochim. Biophys. Acta 459: 119-137, 1977
9. BERDEN, J. A. & E. C. SLATER: The allosteric binding of antimycin to cytochrome b in the mitochondrial membrane. Biochim. Biophys. Acta 256: 199-215, 1972
10. OHNISHI, T. & B. L. TRUMPOWER: Differential effects of antimycin on ubisemiquinone bound in different enviroments in isolated succinate-cytochromc c reductase complex. J. Biol. Chem. 255: 3278-3284, 1980
11. TOKUTAKE, N.; H. MIYOSHI, H. NAKAZATO & H. IWAMURA: Inhibition of electron transport of rat-liver mitochondria by synthesized antimycin A analogs. Biochim. Biophys. Acta 1142: 262-268, 1993
12. HARAGUCHI, H.; K. HASHIMOTO, K. SHIBATA, M. TANIGUCHI & S. OI: Mechanism of antifungal action of citrinin. Agric. Biol. Chem. 51: 1373-1378, 1987
13. TRIPATHI, R. K. & D. GOTTLIEB: Mechanism of action of the antifungal antibiotic pyrrolnitrin. J. Bacteriol. 100: 310-318, 1969
14. SUBIK, J.; M. BEHUN, P. SMIGAN & V. MUSILEK: Mode of action of mucidine, a new antifungal antibiotic produced by the basidiomycete Oudemansiella mesida. Biochim. Biophys. Acta 343: 363-370, 1974
15. MIYOSHI, H.; N. TOKUTAKE, Y. IMAEDA & T. AKAGI: A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues. Biochim. Biophys. Acta 1229: 149-154, 1995
16. TOKUTAKE, N.; H. MIYOSHI, T. SATOH, T. HATANO & H. IWAMURA: Structural factors of antimycin A molecule required for inhibitory action. Biochim. Biophys. Acta 1185: 271-278, 1994