Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge

Respiration

Volumn 74, Issue 4, 2007, Pages 411-417

  Louw, C ^a   Williams, Z ^a   Venter, L ^b   Leichtl, S ^c   Schmid Wirlitsch, C ^c   Bredenbroker D ^c   Bardin, P G ^d,e  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b Altana Madaus (Pty) Ltd   (South Africa)

^c ALTANA PHARMA AG   (Germany)

^d MONASH UNIVERSITY   (Australia)

^e MONASH MEDICAL CENTRE   (Australia)

Author keywords

Airway hyperresponsiveness; Asthma; Bronchial provocation; Inflammation; Phosphodiesterase 4 inhibitor

Indexed keywords

ALLERGEN; HISTAMINE; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; ROFLUMILAST;

ABDOMINAL PAIN; ADULT; ALLERGIC ASTHMA; ARTICLE; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; NAUSEA; NERVOUSNESS; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; STATISTICAL SIGNIFICANCE; TACHYCARDIA;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ALLERGENS; AMINOPYRIDINES; BENZAMIDES; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; CROSS-OVER STUDIES; CYCLOPROPANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PILOT PROJECTS; TREATMENT OUTCOME;

EID: 34447623738     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095677     Document Type: Article

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