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Volumn 111, Issue 5, 2011, Pages 1380-1390

Long-term treadmill exercise induces neuroprotective molecular changes in rat brain

Author keywords

Forced treadmill; Mitochondrial biogenesis; Moderate exercise; Neurodegeneration; Sirtuin 1; ; Tau

Indexed keywords

AMP ACTIVATED PROTEIN KINASE KINASE; AMP-ACTIVATED PROTEIN KINASE KINASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN LIKE GROWTH FACTOR 1, RAT; INSULIN-LIKE GROWTH FACTOR-1, RAT; NEUROPROTECTIVE AGENT; PPARGC1A PROTEIN, RAT; PROTEIN KINASE; RNA BINDING PROTEIN; SIRTUIN 1; SOMATOMEDIN C; TAU PROTEIN; TRANSCRIPTION FACTOR;

EID: 81355150447     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00425.2011     Document Type: Article
Times cited : (76)

References (38)
  • 1
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • DOI 10.1038/nature02998
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431: 805-810, 2004. (Pubitemid 39434070)
    • (2004) Nature , vol.431 , Issue.7010 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 2
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • Canto C, Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20: 98-105, 2009.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 98-105
    • Canto, C.1    Auwerx, J.2
  • 4
    • 73449125908 scopus 로고    scopus 로고
    • Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
    • Chabi B, Adhihetty PJ, O'Leary MF, Menzies KJ, Hood DA. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. J Appl Physiol 107: 1730-1735, 2009.
    • (2009) J Appl Physiol , vol.107 , pp. 1730-1735
    • Chabi, B.1    Adhihetty, P.J.2    O'leary, M.F.3    Menzies, K.J.4    Hood, D.A.5
  • 5
    • 55049110863 scopus 로고    scopus 로고
    • Relationship of serum brain-derived neurotrophic factor (BDNF) and health-related lifestyle in healthy human subjects
    • Chan KL, Tong KY, Yip SP. Relationship of serum brain-derived neurotrophic factor (BDNF) and health-related lifestyle in healthy human subjects. Neurosci Lett 447: 124-128, 2008.
    • (2008) Neurosci Lett , vol.447 , pp. 124-128
    • Chan, K.L.1    Tong, K.Y.2    Yip, S.P.3
  • 8
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: key roles of growth factor cascades and inflammation
    • DOI 10.1016/j.tins.2007.06.011, PII S0166223607001786
    • Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30: 464-472, 2007. (Pubitemid 47374831)
    • (2007) Trends in Neurosciences , vol.30 , Issue.9 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.-A.3
  • 9
    • 54849438798 scopus 로고    scopus 로고
    • Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation
    • Dietrich MO, Andrews ZB, Horvath TL. Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci 28:10766-10771, 2008.
    • (2008) J Neurosci , vol.28 , pp. 10766-10771
    • Dietrich, M.O.1    Andrews, Z.B.2    Horvath, T.L.3
  • 10
    • 56749180855 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    • Gomez-Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 28: 2278-2287, 2008.
    • (2008) Eur J Neurosci , vol.28 , pp. 2278-2287
    • Gomez-Pinilla, F.1    Vaynman, S.2    Ying, Z.3
  • 11
    • 5344237365 scopus 로고    scopus 로고
    • The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis
    • DOI 10.1016/j.apmr.2004.03.019, PII S0003999304003971
    • Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 85: 1694-1704, 2004. (Pubitemid 39349417)
    • (2004) Archives of Physical Medicine and Rehabilitation , vol.85 , Issue.10 , pp. 1694-1704
    • Heyn, P.1    Abreu, B.C.2    Ottenbacher, K.J.3
  • 12
    • 33947668326 scopus 로고    scopus 로고
    • Dietary restriction, glycolysis, hormesis and ageing
    • DOI 10.1007/s10522-006-9034-x
    • Hipkiss AR. Dietary restriction, glycolysis, hormesis and ageing. Biogerontology 8: 221-224, 2007. (Pubitemid 46487989)
    • (2007) Biogerontology , vol.8 , Issue.2 , pp. 221-224
    • Hipkiss, A.R.1
  • 13
    • 21644473127 scopus 로고    scopus 로고
    • Invited review: Exercise-induced increase in muscle insulin sensitivity
    • DOI 10.1152/japplphysiol.00123.2005
    • Holloszy JO. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol 99: 338-343, 2005. (Pubitemid 40934500)
    • (2005) Journal of Applied Physiology , vol.99 , Issue.1 , pp. 338-343
    • Holloszy, J.O.1
  • 16
    • 78049510856 scopus 로고    scopus 로고
    • Exercise and physical activity: Clinical outcomes and applications
    • Kokkinos P, Myers J. Exercise and physical activity: clinical outcomes and applications. Circulation 122: 1637-1648, 2010.
    • (2010) Circulation , vol.122 , pp. 1637-1648
    • Kokkinos, P.1    Myers, J.2
  • 18
    • 79251472766 scopus 로고    scopus 로고
    • Sirtuins: A family of proteins with implications for human performance and exercise physiology
    • Lappalainen Z. Sirtuins: a family of proteins with implications for human performance and exercise physiology. Res Sports Med 19: 53-65, 2011.
    • (2011) Res Sports Med , vol.19 , pp. 53-65
    • Lappalainen, Z.1
  • 20
    • 45549096918 scopus 로고    scopus 로고
    • SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
    • DOI 10.1016/j.cmet.2008.05.004, PII S1550413108001484
    • Li Y, Xu W, McBurney MW, Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8: 38-48, 2008. (Pubitemid 351859225)
    • (2008) Cell Metabolism , vol.8 , Issue.1 , pp. 38-48
    • Li, Y.1    Xu, W.2    McBurney, M.W.3    Longo, V.D.4
  • 21
    • 77952547357 scopus 로고    scopus 로고
    • Exercise modulates insulin-like growth factor 1-dependent and-independent effects on adult hippocampal neurogenesis and behaviour
    • Llorens-Martin M, Torres-Aleman I, Trejo JL. Exercise modulates insulin-like growth factor 1-dependent and-independent effects on adult hippocampal neurogenesis and behaviour. Mol Cell Neurosci 44: 109-117, 2010.
    • (2010) Mol Cell Neurosci , vol.44 , pp. 109-117
    • Llorens-Martin, M.1    Torres-Aleman, I.2    Trejo, J.L.3
  • 24
    • 33845283925 scopus 로고    scopus 로고
    • The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
    • DOI 10.1016/j.bbr.2006.10.018, PII S0166432806005626
    • O'Callaghan RM, Ohle R, Kelly AM. The effects of forced exercise on hippocampal plasticity in the rat: a comparison of LTP, spatial-and non-spatial learning. Behav Brain Res 176: 362-366, 2007. (Pubitemid 44880096)
    • (2007) Behavioural Brain Research , vol.176 , Issue.2 , pp. 362-366
    • O'Callaghan, R.M.1    Ohle, R.2    Kelly, A.M.3
  • 25
    • 70349451730 scopus 로고    scopus 로고
    • Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus
    • O'Callaghan RM, Griffin EW, Kelly AM. Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus. Hippocampus 19: 1019-1029, 2009.
    • (2009) Hippocampus , vol.19 , pp. 1019-1029
    • O'callaghan, R.M.1    Griffin, E.W.2    Kelly, A.M.3
  • 26
    • 33750885775 scopus 로고    scopus 로고
    • Molecular and biochemical features in Alzheimer's disease
    • DOI 10.2174/138161206778792967
    • Pallas M, Camins A. Molecular and biochemical features in Alzheimer's disease. Curr Pharm Des 12: 4389-4408, 2006. (Pubitemid 44718296)
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.33 , pp. 4389-4408
    • Pallas, M.1    Camins, A.2
  • 27
    • 33746378378 scopus 로고    scopus 로고
    • The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain
    • DOI 10.1016/j.neuint.2006.02.004, PII S0197018606000957
    • Radak Z, Toldy A, Szabo Z, Siamilis S, Nyakas C, Silye G, Jakus J, Goto S. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int 49: 387-392, 2006. (Pubitemid 44119045)
    • (2006) Neurochemistry International , vol.49 , Issue.4 , pp. 387-392
    • Radak, Z.1    Toldy, A.2    Szabo, Z.3    Siamilis, S.4    Nyakas, C.5    Silye, G.6    Jakus, J.7    Goto, S.8
  • 28
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    • DOI 10.1038/nature03354
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118, 2005. (Pubitemid 40349395)
    • (2005) Nature , vol.434 , Issue.7029 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 29
    • 42449142360 scopus 로고    scopus 로고
    • Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
    • Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci 65: 1049-1058, 2008.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1049-1058
    • Salminen, A.1    Ojala, J.2    Huuskonen, J.3    Kauppinen, A.4    Suuronen, T.5    Kaarniranta, K.6
  • 30
    • 28844439785 scopus 로고    scopus 로고
    • Exercise-induced changes in cardiac gene expression and its relation to spatial maze performance
    • DOI 10.1016/j.neuint.2005.08.006, PII S0197018605002159
    • Schweitzer NB, Alessio HM, Berry SD, Roeske K, Hagerman AE. Exercise-induced changes in cardiac gene expression and its relation to spatial maze performance. Neurochem Int 48: 9-16, 2006. (Pubitemid 41774274)
    • (2006) Neurochemistry International , vol.48 , Issue.1 , pp. 9-16
    • Schweitzer, N.B.1    Alessio, H.M.2    Berry, S.D.3    Roeske, K.4    Hagerman, A.E.5
  • 31
    • 0036709074 scopus 로고    scopus 로고
    • Human Sir2 and the 'silencing' of p53 activity
    • DOI 10.1016/S0962-8924(02)02342-5, PII S0962892402023425
    • Smith J. Human Sir2 and the 'silencing' of p53 activity. Trends Cell Biol 12: 404-406, 2002. (Pubitemid 35239940)
    • (2002) Trends in Cell Biology , vol.12 , Issue.9 , pp. 404-406
    • Smith, J.S.1
  • 32
    • 44949188628 scopus 로고    scopus 로고
    • Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
    • DOI 10.1016/j.metabol.2008.02.017, PII S0026049508000887
    • Suwa M, Nakano H, Radak Z, Kumagai S. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism 57: 986-998, 2008. (Pubitemid 351814692)
    • (2008) Metabolism: Clinical and Experimental , vol.57 , Issue.7 , pp. 986-998
    • Suwa, M.1    Nakano, H.2    Radak, Z.3    Kumagai, S.4
  • 33
    • 53949111613 scopus 로고    scopus 로고
    • New insights into brain BDNF function in normal aging and Alzheimer disease
    • Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 59: 201-220, 2008.
    • (2008) Brain Res Rev , vol.59 , pp. 201-220
    • Tapia-Arancibia, L.1    Aliaga, E.2    Silhol, M.3    Arancibia, S.4
  • 34
    • 38649115676 scopus 로고    scopus 로고
    • The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
    • Trejo JL, Llorens-Martin MV, Torres-Aleman I. The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis. Mol Cell Neurosci 37: 402-411, 2008.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 402-411
    • Trejo, J.L.1    Llorens-Martin, M.V.2    Torres-Aleman, I.3
  • 35
    • 65449188292 scopus 로고    scopus 로고
    • Exercise and the brain: Something to chew on
    • van Praag H. Exercise and the brain: something to chew on. Trends Neurosci 32: 283-290, 2009.
    • (2009) Trends Neurosci , vol.32 , pp. 283-290
    • Van Praag, H.1
  • 36
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • DOI 10.1523/JNEUROSCI.1731-05.2005
    • van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25: 8680-8685, 2005. (Pubitemid 41362045)
    • (2005) Journal of Neuroscience , vol.25 , Issue.38 , pp. 8680-8685
    • Van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 37
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • DOI 10.1111/j.1460-9568.2004.03720.x
    • Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20: 2580-2590, 2004. (Pubitemid 39573773)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.10 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 38
    • 33646150195 scopus 로고    scopus 로고
    • Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factormediated synaptic plasticity
    • Vaynman S, Ying Z, Wu A, Gomez-Pinilla F. Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factormediated synaptic plasticity. Neuroscience 139: 1221-1234, 2006.
    • (2006) Neuroscience , vol.139 , pp. 1221-1234
    • Vaynman, S.1    Ying, Z.2    Wu, A.3    Gomez-Pinilla, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.