Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina

Experimental Eye Research

Volumn 93, Issue 5, 2011, Pages 580-585

  Ko, Mei Lan ^a,b   Chen, Chau Fong ^c   Peng, Pai Huei ^d,e   Peng, Yi Hao ^f  

^a Hsin Chu General Hospital   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Bax; Bcl 2; Ischemia reperfusion; Retinal ganglion cell; Simvastatin

Indexed keywords

FLUOROGOLD; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; FEMALE; INTRAOCULAR PRESSURE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; REPERFUSION INJURY; RETINA GANGLION CELL; RETINA ISCHEMIA; RETINA NERVE CELL; RETROGRADE LABELING; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL COUNT; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IN SITU NICK-END LABELING; INTRAVITREAL INJECTIONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REPERFUSION INJURY; RETINAL DISEASES; RETINAL GANGLION CELLS; SIMVASTATIN; STILBAMIDINES; UP-REGULATION;

EID: 81355149740     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.07.003     Document Type: Article

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