Common genetic variation in the IGF1 associates with maximal force output

Medicine and Science in Sports and Exercise

Volumn 43, Issue 12, 2011, Pages 2368-2374

  Huuskonen, Antti ^a   Lappalainen, Jani ^a   Oksala, Niku ^a,b   Santtila, Matti ^c   Häkkinen, Keijo ^d   Kyröläinen, Heikki ^d   Atalay, Mustafa ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c FINNISH DEFENCE FORCES   (Finland)

^d UNIVERSITY OF JYVÄSKYLÄ   (Finland)

Author keywords

cytokines; Genetic variation; skeletal muscle; V O 2max

Indexed keywords

IGFBP3 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL6R PROTEIN, HUMAN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; ARTICLE; BLOOD; BODY MASS; GENETIC VARIABILITY; GENETICS; HUMAN; LEG; MALE; MUSCLE STRENGTH; OBESITY; OXYGEN CONSUMPTION; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE;

ADIPOSITY; ADULT; BODY MASS INDEX; GENETIC VARIATION; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; LEG; MALE; MUSCLE STRENGTH; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; YOUNG ADULT;

EID: 81355147797     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e3182220179     Document Type: Article

References (46)

1. Adams GR. Insulin-like growth factor I signaling in skeletal muscle and the potential for cytokine interactions. Med Sci Sports Exerc. 2010;42(1):50-7.
2. Baldwin KM, Haddad F. Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigms. Am J Phys Med Rehabil. 2002;81(11 suppl):S40-51. (Pubitemid 35192965)
3. Bojsen-Moller J, Magnusson SP, Rasmussen LR, Kjaer M, Aagaard P. Muscle performance during maximal isometric and dynamic contractions is influenced by the stiffness of the tendinous structures. J Appl Physiol. 2005;99(3):986-94. (Pubitemid 41214513)
4. D'Aloisio AA, Schroeder JC, North KE, et al. IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. Cancer Epidemiol Biomarkers Prev. 2009;18(3):954-66.
5. De Moor MH, Spector TD, Cherkas LF, et al. Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet. 2007;10(6):812-20. (Pubitemid 350292294)
6. Deal C, Ma J, Wilkin F, et al. Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators. J Clin Endocrinol Metab. 2001;86(3):1274-80. (Pubitemid 32323016)
7. Delbono O. Neural control of aging skeletal muscle. Aging Cell. 2003;2(1):21-9.
8. Demura S, Sato S, Kitabayashi T. Percentage of total body fat as estimated by three automatic bioelectrical impedance analyzers. J Physiol Anthropol Appl Human Sci. 2004;23(3):93-9. (Pubitemid 39178989)
9. Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM. IGF-II gene region polymorphisms related to exertional muscle damage. J Appl Physiol. 2007;102(5): 1815-23. (Pubitemid 46701949)
10. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J. 2002; 16(11):1335-47. (Pubitemid 34913306)
11. Gaunt TR, Rodriguez S, Zapata C. IN Day. MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics. 2006;7:227.
12. Grounds MD. Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling. Biogerontology. 2002; 3(1-2):19-24. (Pubitemid 34284971)
13. Hakkinen A, Rinne M, Vasankari T, Santtila M, Hakkinen K, Kyrolainen H. Association of physical fitness with health-related quality of life in Finnish young men. Health Qual Life Outcomes. 2010;8:15.
14. Hakkinen K, Kallinen M, Izquierdo M, et al. Changes in agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people. J Appl Physiol. 1998;84(4): 1341-9. (Pubitemid 28158701)
15. Hand BD, Kostek MC, Ferrell RE, et al. Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. J Appl Physiol. 2007;103(5):1678-87. (Pubitemid 350033853)
16. Huuskonen A, Tanskanen M, Lappalainen J, Oksala N, Kyröläinen H, Atalay M. A common variation in the promoter region of interleukin-6 gene shows association with exercise performance. J Sports Sci Med. 2009;8(2):271-7.
17. Huygens W, Thomis MA, Peeters MW, Vlietinck RF, Beunen GP. Determinants and upper-limit heritabilities of skeletal muscle mass and strength. Can J Appl Physiol. 2004;29(2):186-200. (Pubitemid 38497247)
18. Johansson M,McKay JD, Wiklund F, et al. Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. J Clin Endocrinol Metab. 2007;92(12): 4820-6. (Pubitemid 350223465)
19. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16(1):3-34.
20. Kostek MC, Delmonico MJ, Reichel JB, et al. Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. J Appl Physiol. 2005;98(6): 2147-54. (Pubitemid 40726909)
21. Liu Y, Heinichen M, Wirth K, Schmidtbleicher D, Steinacker JM. Response of growth and myogenic factors in human skeletal muscle to strength training. Br J Sports Med. 2008;42(12):989-93.
22. Lopez-Alarcon M, Hunter GR, Gower BA, Fernandez JR. IGF-I polymorphism is associated with lean mass, exercise economy, and exercise performance among premenopausal women. Arch Med Res. 2007;38(1):56-63. (Pubitemid 44894609)
23. Lucia A, Moran M, Zihong H, Ruiz JR. Elite athletes: are the genes the champions? Int J Sports Physiol Perform. 2010;5(1):98-102.
24. Manetta J, Brun JF, Fedou C, Maimoun L, Prefaut C, Mercier J. Serum levels of insulin-like growth factor-I (IGF-I), and IGFbinding proteins-1 and-3 in middle-aged and young athletes versus sedentary men: relationship with glucose disposal. Metabolism. 2003;52(7):821-6. (Pubitemid 36949542)
25. Medici G, Mussi C, Fantuzzi AL, Malavolti M, Albertazzi A, Bedogni G. Accuracy of eight-polar bioelectrical impedance analysis for the assessment of total and appendicular body composition in peritoneal dialysis patients. Eur J Clin Nutr. 2005; 59(8):932-7. (Pubitemid 41195209)
26. Musaro A, Dobrowolny G, Rosenthal N. The neuroprotective effects of a locally acting IGF-1 isoform. Exp Gerontol. 2007;42(1-2): 76-80. (Pubitemid 44937819)
27. Nemet D, Eliakim A, Zaldivar F, Cooper DM. Effect of rhIL-6 infusion on GHYIGF-I axis mediators in humans. Am J Physiol Regul Integr Comp Physiol. 2006;291(6):R1663-8. (Pubitemid 44904133)
28. Nindl BC. Insulin-like growth factor-I, physical activity, and control of cellular anabolism. Med Sci Sports Exerc. 2010;42(1):35-8.
29. Nindl BC, Alemany JA, Tuckow AP, et al. Circulating bioactive and immunoreactive IGF-I remain stable in women, despite physical fitness improvements after 8 weeks of resistance, aerobic, and combined exercise training. J Appl Physiol. 2010;109(1):112-20.
30. Ortlepp JR, Metrikat J, Vesper K, et al. The interleukin-6 promoter polymorphism is associated with elevated leukocyte, lymphocyte, and monocyte counts and reduced physical fitness in young healthy smokers. J Mol Med. 2003;81(9):578-84. (Pubitemid 37214996)
31. Ostrander EA, Huson HJ, Ostrander GK. Genetics of athletic performance. Annu Rev Genomics Hum Genet. 2009;10:407-29.
32. Pedersen BK, Febbraio MA. Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol. 2007;102(2):814-6.
33. Pedersen BK, Steensberg A, Fischer C, et al. Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil. 2003;24(2-3):113-9. (Pubitemid 37323614)
34. Pedersen BK, Steensberg A, Keller P, et al. Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects. Pflugers Arch. 2003;446(1):9-16. (Pubitemid 36539527)
35. Rafiq S, Frayling TM, Murray A, et al. A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun. 2007;8(7):552-9. (Pubitemid 350011687)
36. Rarick KR, Pikosky MA, Grediagin A, et al. Energy flux, more so than energy balance, protein intake, or fitness level, influences insulin-like growth factor-I system responses during 7 days of increased physical activity. J Appl Physiol. 2007;103(5):1613-21. (Pubitemid 350033845)
37. Rosendal L, Langberg H, Flyvbjerg A, Frystyk J, Orskov H, Kjaer M. Physical capacity influences the response of insulin-like growth factor and its binding proteins to training. J Appl Physiol. 2002; 93(5):1669-75. (Pubitemid 36082978)
38. Ruiz JR, Buxens A, Artieda M, et al. The j174 G/C polymorphism of the IL6 gene is associated with elite power performance. J Sci Med Sport. 2010;13(4):549-53.
39. Sartorio A, Malavolti M, Agosti F, et al. Body water distribution in severe obesity and its assessment from eight-polar bioelectrical impedance analysis. Eur J Clin Nutr. 2005;59(2):155-60. (Pubitemid 40268311)
40. Sui X, Lee DC, Matthews CE, et al. Influence of cardiorespiratory fitness on lung cancer mortality. Med Sci Sports Exerc. 2010;42(5): 872-8.
41. Suleiman MS, Singh RJ, Stewart CE. Apoptosis and the cardiac action of insulin-like growth factor I. Pharmacol Ther. 2007;114(3): 278-94. (Pubitemid 46843252)
42. Verheus M, McKay JD, Kaaks R, et al. Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density. Breast Cancer Res Treat. 2008;112(1):109-22.
43. Viitasalo JT, Saukkonen S, Komi PV. Reproducibility of measurements of selected neuromuscular performance variables in man. Electromyogr Clin Neurophysiol. 1980;20(6):487-501. (Pubitemid 11129484)
44. Woodhouse LJ, Mukherjee A, Shalet SM, Ezzat S. The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. Endocr Rev. 2006;27(3):287-317.
45. Wypasek E, Undas A, Sniezek-Maciejewska M, et al. The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6 j174G9C gene polymorphism. Ann Clin Biochem. 2010;47(Pt 4):343-9.
46. Uitenbroek DG. SISA sample size calculator Web site [Internet]. Southampton, UK: D.G. Uitenbroek [cited 2004 Jan 1]. Available from: http://www.quantitativeskills.com/sisa/calculations/samsize.htm.