Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs

Twin Research and Human Genetics

Volumn 10, Issue 6, 2007, Pages 812-820

  De Moor, Marleen H M ^a   Spector, Tim D ^b   Cherkas, Lynn F ^b   Falchi, Mario ^b   Hottenga, Jouke Jan ^a   Boomsma, Dorret I ^a   De Geus, Eco J C ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA;

ADULT; AGED; ARTICLE; ATHLETE; CHROMOSOME 3Q; CHROMOSOME 4Q; CONTROLLED STUDY; FABP2 GENE; FEMALE; FITNESS; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOTYPE; HUMAN; MONOZYGOTIC TWINS; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGISTER; SLC9A9 GENE; SPORT; TWINS; UNITED KINGDOM;

ADULT; AGED; AGED, 80 AND OVER; ATHLETIC PERFORMANCE; FEMALE; GENOME, HUMAN; GREAT BRITAIN; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; REGISTRIES; TWINS, DIZYGOTIC;

EID: 37349126086     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1375/twin.10.6.812     Document Type: Article

References (40)

1. Abecasis, G. R., Cherny, S. S., Cookson, W. O., & Cardon, L. R. (2002). Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics, 30, 97-101.
2. Abecasis, G. R. & Wigginton, J. E. (2005). Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers. American Journal of Human Genetics, 77, 754-767.
3. Boomsma, D. I., Cacioppo, J. T., Slagboom, P. E., & Posthuma, D. (2006). Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24. Behavior Genetics, 36, 137-146.
4. Bouchard, C., An, P., Rice, T., Skinner, J. S., Wilmore, J. H., Gagnon, J., Perusse, L., Leon, A. S., & Rao, D. C. (1999). Familial aggregation of VO2max response to exercise training: Results from the HERITAGE Family Study. Journal of Applied Physiology, 87, 1003-1008.
5. Bouchard, C., Daw, E. W., Rice, T., Perusse, L., Gagnon, J., Province, M. A., Leon, A. S., Rao, D. C., Skinner, J. S., & Wilmore, J. H. (1998). Familial resemblance for VO2max in the sedentary state: The HERITAGE Family Study. Medicine and Science in Sports and Exercise, 30, 252-258.
6. Bouchard, C. & Malina, R. M. (1998). Genetics of physiological fitness and motor performance. Exercise and Sport Sciences Reviews, 11, 306-339.
7. Bouchard, C., Rankinen, T., Chagnon, Y. C., Rice, T., Perusse, L., Gagnon, J., Borecki, I., An, P., Leon, A. S., Skinner, J. S., Wilmore, J. H., Province, M., & Rao, D. C. (2000). Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. Journal of Applied Physiology, 88, 551-559.
8. Brutsaert, T. D. & Parra, E. J. (2006). What makes a champion? Explaining variation in human athletic performance. Respiratory Physiology and Neurobiology, 151, 109-123.
9. De Mars, G., Thomis, M. A. I., Windelinckx, A., Van Leemputte, M., Maes, H. H., Blimkie, C. J., Claessens, A. L., Vlietinck, R., & Beunen, G. (2007). Covariance of isometric and dynamic arm contractions: Multivariate genetic analysis. Twin Research and Human Genetics, 10, 180-190.
10. De Silva, M. G., Elliott, K., Dahl, H. H., Fitzpatrick, E., Wilcox, S., Delatycki, M., Williamson, R., Efron, D., Lynch, M., & Forrest, S. (2003). Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. Journal of Medical Genetics, 40, 733-740.
11. Duffy, D. L. (2006). An integrated genetic map for linkage analysis. Behavior Genetics, 36, 4-6.
12. Lorentzon, M., Lorentzon, R., Lerner, U. H., & Nordstrom, P. (2001). Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls. European Journal of Endocrinology, 144, 257-261.
13. MacArthur, D. & North, K. (2005). Genes and human elite athletic performance. Human Genetics, 116, 331-339.
14. MacArthur, D. G. & North, K. N. (2007). ACTN3: A genetic influence on muscle function and athletic performance. Exercise and Sport Sciences Reviews, 35, 30-34.
15. MacArthur, D. G., Seto, J. T., Raftery, J. M., Quinlan, K. G., Huttley, G. A., Hook, J. W., Lemckert, F. A., Kee, A. J., Edwards, M. R., Berman, Y., Hardeman, E. C., Gunning, P. W., Easteal, S., Yang, N., & North, K. N. (2007). Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nature Genetics, Published online.
16. Moore, G. E., Shuldiner, A. R., Zmuda, J. M., Ferrell, R. E., Mccole, S. D., & Hagberg, J. M. (2001). Obesity gene variant and elite endurance performance. Metabolism-Clinical and Experimental, 50, 1391-1392.
17. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statistical modeling. (6th ed.) Richmond, Virginia: Department of Psychiatry, Virginia Commonwealth University.
18. Neale, M. C. & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publishers.
19. Neale, M. C., Eaves, L. J., & Kendler, K. S. (1994). The power of the classical twin study to resolve variation in threshold traits. Behavior Genetics, 24, 239-258.
20. Paparini, A., Ripani, M., Giordano, G. D., Santoni, D., Pigozzi, F., & Romano-Spica, V. (2007). ACTN3 genotyping by real-time PCR in the Italian population and athletes. Medicine and Science in Sports and Exercise, 39, 810-815.
21. Perusse, L., Gagnon, J., Province, M. A., Rao, D. C., Wilmore, J. H., Leon, A. S., Bouchard, C., & Skinner, J. S. (2001). Familial aggregation of submaximal aerobic performance in the HERITAGE Family study. Medicine and Science in Sports and Exercise, 33, 597-604.
22. Perusse, L., Rankinen, T., Rauramaa, R., Rivera, M. A., Wolfarth, B., & Bouchard, C. (2003). The human gene map for performance and health-related fitness phenotypes: The 2002 update. Medicine and Science in Sports and Exercise, 35, 1248-1264.
23. Rankinen, T., Perusse, L., Rauramaa, R., Rivera, M. A., Wolfarth, B., & Bouchard, C. (2001). The human gene map for performance and health-related fitness phenotypes. Medicine and Science in Sports and Exercise, 33, 855-867.
24. Rankinen, T., Perusse, L., Rauramaa, R., Rivera, M. A., Wolfarth, B., & Bouchard, C. (2002). The human gene map for performance and health-related fitness phenotypes: The 2001 update. Medicine and Science in Sports and Exercise, 34, 1219-1233.
25. Rankinen, T., Perusse, L., Rauramaa, R., Rivera, M. A., Wolfarth, B., & Bouchard, C. (2004). The human gene map for performance and health-related fitness phenotypes: The 2003 update. Medicine and Science in Sports and Exercise, 36, 1451-1469.
26. Sham, P. (1998). Statistics in human genetics. London: Arnold Applications of Statistics.
27. Simonen, R. L., Perusse, L., Rankinen, T., Rice, T., Rao, D. C., & Bouchard, C. (2002). Familial aggregation of physical activity levels in the Quebec family study. Medicine and Science in Sports and Exercise, 34, 1137-1142.
28. Simonen, R. L., Rankinen, T., Perusse, L., Rice, T., Rao, D. C., Chagnon, Y., & Bouchard, C. (2003). Genome-wide linkage scan for physical activity levels in the Quebec family study. Medicine and Science in Sports and Exercise, 35, 1355-1359.
29. Spector, T. D., Cicuttini, F., Baker, J., Loughlin, J., & Hart, D. (1996). Genetic influences on osteoarthritis in women: A twin study. British Medical Journal, 312, 940-943.
30. Spector, T. D. & Williams, F. M. K. (2006). The UK Adult Twin Registry (TwinsUK). Twin Research and Human Genetics, 9, 899-906.
31. Stubbe, J. H., Boomsma, D. I., Vink, J. M., Cornes, B. K., Martin, N. G., Skytthe, A., Kyvik, K. O., Rose, R. J., Kujala, U. M., Kaprio, J., Harris, J. R., Pedersen, N. L., Hunkin, J., Spector, T. D., & de Geus, E. J. C. (2006). Genetic influences on exercise participation: A comparative study in adult twin samples from seven countries. PLoS ONE, 1, e22. doi:10.1371/journal. pone.0000022.
32. Thomis, M. A. I., Beunen, G. P., Maes, H. H., Blimkie, C. J., Van Leemputte, M., Claessens, A. L., Marchal, G., Willems, E., & Vlietinck, R. F. (1998). Strength training: Importance of genetic factors. Medicine and Science in Sports and Exercise, 30, 724-731.
33. Williams, A. G., Dhamrait, S. S., Wootton, P. T. E., Day, S. H., Hawe, E., Payne, J. R., Myerson, S. G., World, M., Budgett, R., Humphries, S. E., & Montgomery, H. E. (2004). Bradykinin receptor gene variant and human physical performance. Journal of Applied Physiology, 96, 938-942.
34. Williams, A. G., Rayson, M. P., Jubb, M., World, M., Woods, D. R., Hayward, M., Martin, J., Humphries, S. E., & Montgomery, H. E. (2000). Physiology: The ACE gene and muscle performance. Nature, 403, 614.
35. Wilmore, J. H. & Costill, D. L. (2004). Physiology of sport and exercise. Champaign, IL: Human Kinetics.
36. Wilson, S. G., Reed, P. W., Bansal, A., Chiano, M., Lindersson, M., Langdown, M., Prince, R. L., Thompson, D., Thompson, E., Bailey, M., Kleyn, P. W., Sambrook, P., Shi, M. M., & Spector, T. D. (2003). Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. American Journal of Human Genetics, 72, 144-155.
37. Wolfarth, B., Bray, M. S., Hagberg, J. M., Perusse, L., Rauramaa, R., Rivera, M. A., Roth, S. M., Rankinen, T., & Bouchard, C. (2005). The human gene map for performance and health-related fitness phenotypes: The 2004 update. Medicine and Science in Sports and Exercise, 37, 881-903.
38. Wolfarth, B., Rivera, M. A., Oppert, J. M., Boulay, M. R., Dionne, F. T., Chagnon, M., Gagnon, J., Chagnon, Y., Perusse, L., Keul, J., & Bouchard, C. (2000). A polymorphism in the alpha(2a)-adrenoceptor gene and endurance athlete status. Medicine and Science in Sports and Exercise, 32, 1709-1712.
39. Woods, D. R., Humphries, S. E., & Montgomery, H. E. (2000). The ACE I/D polymorphism and human physical performance. Trends in Endocrinology and Metabolism, 11, 416-420.
40. Yang, N., MacArthur, D. G., Gulbin, J. P., Hahn, A. G., Beggs, A. H., Easteal, S., & North, K. (2003). ACTN3 genotype is associated with human elite athletic performance. American Journal of Human Genetics, 73, 627-631.