Rhinovirus-induced airway inflammation in asthma: Effect of treatment with inhaled corticosteroids before and during experimental infection

American Journal of Respiratory and Critical Care Medicine

Volumn 164, Issue 10 I, 2001, Pages 1816-1822

  Grünberg, Katrien ^b   Sharon, Raphaël F ^b   Sont, Jacob K ^b   In 'T Veen, Johannes C C M ^b   Van Schadewijk, W Annemarie A M ^b   De Klerk, Erik P A ^b   Dick, Claire R ^b   Van Krieken, J Han J M ^b   Sterk, Peter J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

Asthma; Corticosteroids; Inflammation; Rhinoviruses

Indexed keywords

BUDESONIDE; CORTICOSTEROID; PLACEBO;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; ATOPY; BRONCHUS BIOPSY; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; EOSINOPHIL; EXPERIMENTAL INFECTION; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE COUNT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOVIRUS; T LYMPHOCYTE;

EID: 0035891605     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.164.10.2102118     Document Type: Article

References (42)

1. Respiratory viruses and exacerbations of asthma in adults
2. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
3. Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo
4. Effects of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo
5. Experimental rhinovirus 16 infection causes variable airways obstruction in atopic asthmatic subjects
6. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects
7. Kinins are generated during experimental rhinovirus colds
8. Experimental rhinovirus 16 infection: Effects on cell differentials and soluble markers in sputum in asthmatic subjects
9. Experimental rhinovirus-16 infection increases intercellular adhesion molecule-1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment
10. Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects
11. Global initiative for asthma. Global strategy for asthma management and prevention
12. Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promotor activation on respiratory epithelial cells
13. Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells
14. Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma
15. Oral prednisone therapy in experimental rhinovirus infections
16. Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: Randomized double blind placebo controlled trial
17. Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections
18. Treatment of acute asthmatic exacerbations with increased dose of inhaled steroid
19. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma
20. Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions
21. Updated recommendations for safety-testing of viral inocula used in volunteer experiments on rhinovirus colds
22. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults
23. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment
24. Automated assessment of inflammatory cell counts in bronchial biopsy specimens: Repeatability and agreement with interactive point counting
25. Repeatability of measures of inflammatory cell number in bronchial biopsies in atopic asthma
26. Lung volumes and forced ventilatory flows
27. Bronchial inflammation and the common cold: A comparison of atopic and non-atopic individuals
28. Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation
29. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma
30. Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide
31. Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection
32. Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus
33. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure
34. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection
35. Rhinoviruses infect the lower airways
36. Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
37. Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytes
38. The Th1 and Th2 cytokines IFN-gamma and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: Involvement of IL-1
39. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds
40. Rhinovirus enters but does not replicate inside monocytes and airway macrophages
41. Rhinovirus inhibits antigen-specific T cell proliferation through an intercellular adhesion molecule-1 dependant mechanism
42. Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10